Featured Publications
Detecting model misconducts in decentralized healthcare federated learning
. Detecting model misconducts in decentralized healthcare federated learning. International Journal Of Medical Informatics 2021, 158: 104658. PMID: 34923447, PMCID: PMC10017272, DOI: 10.1016/j.ijmedinf.2021.104658.Peer-Reviewed Original Research
2024
Distributed management of patient data-sharing informed consents for clinical research
. Distributed management of patient data-sharing informed consents for clinical research. Computers In Biology And Medicine 2024, 180: 108956. PMID: 39121682, DOI: 10.1016/j.compbiomed.2024.108956.Peer-Reviewed Original ResearchBiomedical blockchain with practical implementations and quantitative evaluations: a systematic review
Lacson R, Yu Y, Kuo T, Ohno-Machado L. Biomedical blockchain with practical implementations and quantitative evaluations: a systematic review. Journal Of The American Medical Informatics Association 2024, 31: 1423-1435. PMID: 38726710, PMCID: PMC11105130, DOI: 10.1093/jamia/ocae084.Peer-Reviewed Original ResearchConceptsElectronic health recordsSystematic reviewData sharingMedical data sharingSpeed metricsPreferred Reporting ItemsCertificate storageDecentralized InternetNetwork permissionsBlockchain platformBlockchain applicationsEvaluation metricsBiomedical domainBlockchainBiomedical data managementHealth recordsData managementData storageReporting ItemsHealth sectorQuantitative metricsMedical facilitiesMetricsTrial managementClinical trial managementEarly prediction of long hospital stay for Intensive Care units readmission patients using medication information
. Early prediction of long hospital stay for Intensive Care units readmission patients using medication information. Computers In Biology And Medicine 2024, 174: 108451. PMID: 38603899, DOI: 10.1016/j.compbiomed.2024.108451.Peer-Reviewed Original Research
2023
Editorial: Blockchain and distributed ledger technology—enabled architectures for improving healthcare
Kuo T, Zhang P. Editorial: Blockchain and distributed ledger technology—enabled architectures for improving healthcare. Frontiers In Blockchain 2023, 6: 1275474. DOI: 10.3389/fbloc.2023.1275474.Peer-Reviewed Original ResearchBlockchain-enabled immutable, distributed, and highly available clinical research activity logging system for federated COVID-19 data analysis from multiple institutions
Kuo T, Pham A, Edelson M, Kim J, Chan J, Gupta Y, Ohno-Machado L, Anderson D, Balacha C, Bath T, Baxter S, Becker-Pennrich A, Bell D, Bernstam E, Ngan C, Day M, Doctor J, DuVall S, El-Kareh R, Florian R, Follett R, Geisler B, Ghigi A, Gottlieb A, Hinske L, Hu Z, Ir D, Jiang X, Kim K, Kim J, Knight T, Koola J, Kuo T, Lee N, Mansmann U, Matheny M, Meeker D, Mou Z, Neumann L, Nguyen N, Nick A, Ohno-Machado L, Park E, Paul P, Pletcher M, Post K, Rieder C, Scherer C, Schilling L, Soares A, SooHoo S, Soysal E, Steven C, Tep B, Toy B, Wang B, Wu Z, Xu H, Yong C, Zheng K, Zhou Y, Zucker R. Blockchain-enabled immutable, distributed, and highly available clinical research activity logging system for federated COVID-19 data analysis from multiple institutions. Journal Of The American Medical Informatics Association 2023, 30: 1167-1178. PMID: 36916740, PMCID: PMC10198529, DOI: 10.1093/jamia/ocad049.Peer-Reviewed Original ResearchConceptsFederated data analysisUser activity logsSmart contract deploymentRun-time efficiencyData analysis systemData analysis activitiesActivity logsData discoveryQuerying timeBlockchain systemBlockchain technologyNetwork transactionsCOVID-19 data analysisMultiple institutionsLow deploymentBlockchainGitHub repositoryMultiple nodesLarge networksQueriesAnalysis activitiesHigh availabilityLanguage codeBaseline solutionData analysisA hierarchical strategy to minimize privacy risk when linking “De-identified” data in biomedical research consortia
Ohno-Machado L, Jiang X, Kuo T, Tao S, Chen L, Ram P, Zhang G, Xu H. A hierarchical strategy to minimize privacy risk when linking “De-identified” data in biomedical research consortia. Journal Of Biomedical Informatics 2023, 139: 104322. PMID: 36806328, PMCID: PMC10975485, DOI: 10.1016/j.jbi.2023.104322.Peer-Reviewed Original ResearchConceptsPrivacy of individualsAppropriate privacy protectionData-driven modelsPrivacy protectionPrivacy risksData Coordination CenterData hubData repositoryHierarchical strategyPrivacyBiomedical discoveryData setsRecord linkageData Coordinating CenterRepositoryComplex strategiesCoordination centerTechnologyTechniqueDataPartiesSetHierarchyEditorial: Blockchain and distributed ledger technology—enabled architectures for improving healthcare
Kuo T-T, Zhang P. Editorial: Blockchain and distributed ledger technology—enabled architectures for improving healthcare. Frontiers in Blockchain. 2023;6. DOI: 10.3389/fbloc.2023.1275474.Commentaries, Editorials and Letters
2022
Quorum-based model learning on a blockchain hierarchical clinical research network using smart contracts
. Quorum-based model learning on a blockchain hierarchical clinical research network using smart contracts. International Journal Of Medical Informatics 2022, 169: 104924. PMID: 36402113, PMCID: PMC9984225, DOI: 10.1016/j.ijmedinf.2022.104924.Peer-Reviewed Original ResearchThe evolving privacy and security concerns for genomic data analysis and sharing as observed from the iDASH competition
Kuo T, Jiang X, Tang H, Wang X, Harmanci A, Kim M, Post K, Bu D, Bath T, Kim J, Liu W, Chen H, Ohno-Machado L. The evolving privacy and security concerns for genomic data analysis and sharing as observed from the iDASH competition. Journal Of The American Medical Informatics Association 2022, 29: 2182-2190. PMID: 36164820, PMCID: PMC9667175, DOI: 10.1093/jamia/ocac165.Peer-Reviewed Original ResearchConceptsSensitive personal informationGenomic data analysisPotential future research directionsPersonal informationSecurity concernsGenomics data repositoryData repositoryReport lessonsProtection techniquesFuture research directionsPrivacyResearch directionsData usePractical challengesGenomic dataData analysisAnonymizationCommunity effortsRepositorySecurityBiomedical researchInformationDataChallengesPredicting COVID-19 county-level case number trend by combining demographic characteristics and social distancing policies
. Predicting COVID-19 county-level case number trend by combining demographic characteristics and social distancing policies. JAMIA Open 2022, 5: ooac056. PMID: 35855422, PMCID: PMC9278037, DOI: 10.1093/jamiaopen/ooac056.Peer-Reviewed Original ResearchNLM’s sponsorship of research in biomedical informatics (1985–2016)
Kuo T, Ohno-Machado L. NLM’s sponsorship of research in biomedical informatics (1985–2016). Information Services & Use 2022, 42: 61-70. PMID: 35600120, PMCID: PMC9108565, DOI: 10.3233/isu-210137.Peer-Reviewed Original ResearchGeneralizable prediction of COVID-19 mortality on worldwide patient data
. Generalizable prediction of COVID-19 mortality on worldwide patient data. JAMIA Open 2022, 5: ooac036. PMID: 35663116, PMCID: PMC9129227, DOI: 10.1093/jamiaopen/ooac036.Peer-Reviewed Original ResearchNLM's Sponsorship of Research in Biomedical Informatics (1985-2016).
Kuo T, Ohno-Machado L. NLM's Sponsorship of Research in Biomedical Informatics (1985-2016). Studies In Health Technology And Informatics 2022, 288: 64-73. PMID: 35102829, DOI: 10.3233/shti210982.Peer-Reviewed Original ResearchCertificateChain: decentralized healthcare training certificate management system using blockchain and smart contracts
. CertificateChain: decentralized healthcare training certificate management system using blockchain and smart contracts. JAMIA Open 2022, 5: ooac019. PMID: 35571362, PMCID: PMC9097703, DOI: 10.1093/jamiaopen/ooac019.Peer-Reviewed Original Research
2021
Previewable Contract-Based On-Chain X-Ray Image Sharing Framework for Clinical Research
. Previewable Contract-Based On-Chain X-Ray Image Sharing Framework for Clinical Research. International Journal Of Medical Informatics 2021, 156: 104599. PMID: 34628257, PMCID: PMC8479449, DOI: 10.1016/j.ijmedinf.2021.104599.Peer-Reviewed Original ResearchBenchmarking blockchain-based gene-drug interaction data sharing methods: A case study from the iDASH 2019 secure genome analysis competition blockchain track
Kuo T, Bath T, Ma S, Pattengale N, Yang M, Cao Y, Hudson C, Kim J, Post K, Xiong L, Ohno-Machado L. Benchmarking blockchain-based gene-drug interaction data sharing methods: A case study from the iDASH 2019 secure genome analysis competition blockchain track. International Journal Of Medical Informatics 2021, 154: 104559. PMID: 34474309, PMCID: PMC9933142, DOI: 10.1016/j.ijmedinf.2021.104559.Peer-Reviewed Original ResearchConceptsSecure genome analysis competitionData retrieval queriesBlockchain-based methodData sharing methodReal-world problemsQuery indexType of sharingRetrieval queriesBlockchain technologyLedger technologySource codeBlockchain utilizationBlockchain strategyHealthcare applicationsInteraction recordsSharing methodTest datasetSharing recordsBiomedical research applicationsConsortium resourcesNew platformPatient recordsBlockchainQueriesTechnologyHypertension prevalence in the All of Us Research Program among groups traditionally underrepresented in medical research
Chandler P, Clark C, Zhou G, Noel N, Achilike C, Mendez L, Ramirez A, Loperena-Cortes R, Mayo K, Cohn E, Ohno-Machado L, Boerwinkle E, Cicek M, Qian J, Schully S, Ratsimbazafy F, Mockrin S, Gebo K, Dedier J, Murphy S, Smoller J, Karlson E. Hypertension prevalence in the All of Us Research Program among groups traditionally underrepresented in medical research. Scientific Reports 2021, 11: 12849. PMID: 34158555, PMCID: PMC8219813, DOI: 10.1038/s41598-021-92143-w.Peer-Reviewed Original ResearchConceptsPrevalence of hypertensionHTN prevalenceUs Research ProgramMajor public health concernBlood pressure medicationsPopulation-based studyNutrition Examination SurveyBlood pressure measurementsPopulation-based surveyEHR dataPatient measurementsPublic health concernAntihypertensive medicationsEHR cohortHTN medicationsHypertension prevalenceCrude prevalenceHypertension casesHypertension treatmentExamination SurveyNational HealthHypertensionBilling codesMedicationsCohortPrivacy-protecting, reliable response data discovery using COVID-19 patient observations
Kim J, Neumann L, Paul P, Day M, Aratow M, Bell D, Doctor J, Hinske L, Jiang X, Kim K, Matheny M, Meeker D, Pletcher M, Schilling L, SooHoo S, Xu H, Zheng K, Ohno-Machado L, Anderson D, Anderson N, Balacha C, Bath T, Baxter S, Becker-Pennrich A, Bernstam E, Carter W, Chau N, Choi Y, Covington S, DuVall S, El-Kareh R, Florian R, Follett R, Geisler B, Ghigi A, Gottlieb A, Hu Z, Ir D, Knight T, Koola J, Kuo T, Lee N, Mansmann U, Mou Z, Murphy R, Neumann L, Nguyen N, Niedermayer S, Park E, Perkins A, Post K, Rieder C, Scherer C, Soares A, Soysal E, Tep B, Toy B, Wang B, Wu Z, Zhou Y, Zucker R. Privacy-protecting, reliable response data discovery using COVID-19 patient observations. Journal Of The American Medical Informatics Association 2021, 28: 1765-1776. PMID: 34051088, PMCID: PMC8194878, DOI: 10.1093/jamia/ocab054.Peer-Reviewed Original ResearchThe Feasibility and Significance of Employing Blockchain-Based Identity Solutions in Health Care
Zhang P, Kuo T. The Feasibility and Significance of Employing Blockchain-Based Identity Solutions in Health Care. Smart Innovation, Systems And Technologies 2021, 219: 189-208. DOI: 10.1007/978-981-33-6470-7_11.Peer-Reviewed Original ResearchBlockchain-based identityAdoption of wireless communicationMonitoring user activitiesSelf-sovereign identityDistributed ledger technologyAdvancement of blockchainWealth of servicesHealth care domainOnboard usersPrivacy levelCryptographic principlesLogin credentialsUser activityMobile devicesAuthentication approachDecentralized identityWireless communicationDecentralized infrastructureDecentralized applicationsLedger technologyDecentralized mannerCentralized counterpartOnline credentialsCommunity of researchersPersonal data