2024
Indirect 1H–[13C] MRS of the human brain at 7 T using a 13C‐birdcage coil and eight transmit–receive 1H‐dipole antennas with a 32‐channel 1H‐receive array
Jacobs S, Prompers J, van der Kemp W, van der Velden T, Gosselink M, Meliadò E, Hoogduin H, Mason G, de Graaf R, Miller C, Bredael G, van der Kolk A, Alborahal C, Klomp D, Wiegers E. Indirect 1H–[13C] MRS of the human brain at 7 T using a 13C‐birdcage coil and eight transmit–receive 1H‐dipole antennas with a 32‐channel 1H‐receive array. NMR In Biomedicine 2024, e5195. PMID: 38845018, DOI: 10.1002/nbm.5195.Peer-Reviewed Original ResearchStimulated echo acquisition modeSignal-to-noise ratioSlice-selective excitationAdiabatic selective refocusingUltra-high fieldIncreased spectral dispersionEcho acquisition modeSpectral dispersionVoxel positionSemi-localPhantomAcquisition modeElectromagnetic simulationsHuman brainSAR limitsExcitationBi-frontalSLASERHealthy volunteersSpectraLipid removal in deuterium metabolic imaging (DMI) using spatial prior knowledge
de Graaf R, Liu Y, Corbin Z, De Feyter H. Lipid removal in deuterium metabolic imaging (DMI) using spatial prior knowledge. Magnetic Resonance 2024, 5: 21-31. DOI: 10.5194/mr-5-21-2024.Peer-Reviewed Original Research
2023
Measurement of neuro‐energetics and neurotransmission in the rat olfactory bulb using 1H and 1H–[13C] NMR spectroscopy
Chowdhury G, Behar K, Mason G, Rothman D, de Graaf R. Measurement of neuro‐energetics and neurotransmission in the rat olfactory bulb using 1H and 1H–[13C] NMR spectroscopy. NMR In Biomedicine 2023, 37: e4957. PMID: 37088548, PMCID: PMC10590826, DOI: 10.1002/nbm.4957.Peer-Reviewed Original ResearchDesign and realization of a multi‐coil array for B0 field control in a compact 1.5T head‐only MRI scanner
Theilenberg S, Shang Y, Ghazouani J, Kumaragamage C, Nixon T, McIntyre S, Vaughan J, Parkinson B, Garwood M, de Graaf R, Juchem C. Design and realization of a multi‐coil array for B0 field control in a compact 1.5T head‐only MRI scanner. Magnetic Resonance In Medicine 2023, 90: 1228-1241. PMID: 37145035, PMCID: PMC10330274, DOI: 10.1002/mrm.29692.Peer-Reviewed Original ResearchConceptsMulti-coil arraysMC arraysDuty cycleGeneration capabilityT headNonlinear magnetic fieldHigh duty cycleThermal behaviorBench testingField controlRamp timeResidual imperfectionField generationScanner designMagnetic fieldMC hardwareLinear gradientMRI scannerArrayCapabilityDesignHardwareImage encodingFieldMagnetsMapping of exogenous choline uptake and metabolism in rat glioblastoma using deuterium metabolic imaging (DMI)
Ip K, Thomas M, Behar K, de Graaf R, De Feyter H. Mapping of exogenous choline uptake and metabolism in rat glioblastoma using deuterium metabolic imaging (DMI). Frontiers In Cellular Neuroscience 2023, 17: 1130816. PMID: 37187610, PMCID: PMC10175635, DOI: 10.3389/fncel.2023.1130816.Peer-Reviewed Original ResearchBrain tumorsNormal brainHigh tumorCholine uptakeRG2 cellsCholine infusionMetabolic imagingExogenous cholineMetabolic imaging techniquesDeuterium metabolic imagingIntravenous infusionRG2 tumorsTumor lesionsAnimal modelsCholine metabolismTumorsInfusionRat glioblastomaIntracellular cholineFree cholineHigh uptakeLesionsCholineRatsDeuterated cholineIn vivo imaging of cerebral glucose metabolism informs on subacute to chronic post-stroke tissue status – A pilot study combining PET and deuterium metabolic imaging
Meerwaldt A, Straathof M, Oosterveld W, van Heijningen C, van Leent M, Toner Y, Munitz J, Teunissen A, Daemen C, van der Toorn A, van Vliet G, van Tilborg G, De Feyter H, de Graaf R, Hol E, Mulder W, Dijkhuizen R. In vivo imaging of cerebral glucose metabolism informs on subacute to chronic post-stroke tissue status – A pilot study combining PET and deuterium metabolic imaging. Cerebrovascular And Brain Metabolism Reviews 2023, 43: 778-790. PMID: 36606595, PMCID: PMC10108187, DOI: 10.1177/0271678x221148970.Peer-Reviewed Original ResearchConceptsTransient middle cerebral artery occlusionPositron emission tomographyGlucose metabolismPost-ischemic brain tissueMiddle cerebral artery occlusionFDG positron emission tomographyFluorodeoxyglucose positron emission tomographyMetabolic imagingSignificant glial activationAcute ischemic strokeCerebral artery occlusionCerebral energy metabolismDeuterium metabolic imagingActive glucose metabolismGlial activationRecanalization therapyArtery occlusionIschemic strokeStroke severityCerebral perfusionC57BL/6 micePoor outcomeElevated lactate productionPathophysiological changesBaseline values
2022
Flow-Based Visual Quality Enhancer for Super-Resolution Magnetic Resonance Spectroscopic Imaging
Dong S, Hangel G, Chen E, Sun S, Bogner W, Widhalm G, You C, Onofrey J, de Graaf R, Duncan J. Flow-Based Visual Quality Enhancer for Super-Resolution Magnetic Resonance Spectroscopic Imaging. Lecture Notes In Computer Science 2022, 13609: 3-13. DOI: 10.1007/978-3-031-18576-2_1.Peer-Reviewed Original ResearchAdversarial networkVisual qualityDeep learning-based super-resolution methodsLearning-based super-resolution methodsFlow-based modelImage visual qualityGenerative adversarial networkHigh visual qualitySuper-resolution methodSuper-resolved imagesGenerative modelHigh-resolution imagesImage modalitiesFlow-based methodNetworkLow spatial resolutionUncertainty estimationImagesPromising resultsEnhancer networkAnatomical informationHigh fidelityEssential toolDatasetQuality adjustmentMulti-scale Super-Resolution Magnetic Resonance Spectroscopic Imaging with Adjustable Sharpness
Dong S, Hangel G, Bogner W, Widhalm G, Rössler K, Trattnig S, You C, de Graaf R, Onofrey J, Duncan J. Multi-scale Super-Resolution Magnetic Resonance Spectroscopic Imaging with Adjustable Sharpness. Lecture Notes In Computer Science 2022, 13436: 410-420. DOI: 10.1007/978-3-031-16446-0_39.Peer-Reviewed Original ResearchDeuterium metabolic imaging of the human brain in vivo at 7 T
Roig E, De Feyter HM, Nixon TW, Ruhm L, Nikulin AV, Scheffler K, Avdievich NI, Henning A, de Graaf R. Deuterium metabolic imaging of the human brain in vivo at 7 T. Magnetic Resonance In Medicine 2022, 89: 29-39. PMID: 36063499, PMCID: PMC9756916, DOI: 10.1002/mrm.29439.Peer-Reviewed Original ResearchHuman brain POCE MRS at 7T using a 13C birdcage coil and 8 transmit-receive 1H antennas with a 32-channel 1H receive array
Jacobs S, Prompers J, van der Kemp W, van der Velden T, Gosselink M, Meliadò E, Hoogduin H, Mason G, de Graaf R, van der Kolk A, Alborahal C, Klomp D, Wiegers E. Human brain POCE MRS at 7T using a 13C birdcage coil and 8 transmit-receive 1H antennas with a 32-channel 1H receive array. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2022 DOI: 10.58530/2022/1536.Peer-Reviewed Original ResearchInterleaved fluid‐attenuated inversion recovery (FLAIR) MRI and deuterium metabolic imaging (DMI) on human brain in vivo
Liu Y, De Feyter HM, Fulbright RK, McIntyre S, Nixon TW, de Graaf R. Interleaved fluid‐attenuated inversion recovery (FLAIR) MRI and deuterium metabolic imaging (DMI) on human brain in vivo. Magnetic Resonance In Medicine 2022, 88: 28-37. PMID: 35225375, PMCID: PMC9924309, DOI: 10.1002/mrm.29196.Peer-Reviewed Original Research
2021
NMR visibility of deuterium‐labeled liver glycogen in vivo
De Feyter HM, Thomas MA, Behar KL, de Graaf R. NMR visibility of deuterium‐labeled liver glycogen in vivo. Magnetic Resonance In Medicine 2021, 86: 62-68. PMID: 33590529, PMCID: PMC8005460, DOI: 10.1002/mrm.28717.Peer-Reviewed Original ResearchMethods | 13C MRS Measurements of in Vivo Rates of the Glutamate/Glutamine and GABA/Glutamine Neurotransmitter Cycles
Rothman D, De Feyter H, Mason G, de Graaf R, Hyder F, Behar K. Methods | 13C MRS Measurements of in Vivo Rates of the Glutamate/Glutamine and GABA/Glutamine Neurotransmitter Cycles. 2021, 688-700. DOI: 10.1016/b978-0-12-819460-7.00341-8.Chapters
2020
Water and lipid suppression techniques for advanced 1H MRS and MRSI of the human brain: Experts' consensus recommendations
Tkáč I, Deelchand D, Dreher W, Hetherington H, Kreis R, Kumaragamage C, Považan M, Spielman DM, Strasser B, de Graaf R. Water and lipid suppression techniques for advanced 1H MRS and MRSI of the human brain: Experts' consensus recommendations. NMR In Biomedicine 2020, 34: e4459. PMID: 33327042, PMCID: PMC8569948, DOI: 10.1002/nbm.4459.Peer-Reviewed Original ResearchContribution of macromolecules to brain 1H MR spectra: Experts' consensus recommendations
Cudalbu C, Behar KL, Bhattacharyya PK, Bogner W, Borbath T, de Graaf R, Gruetter R, Henning A, Juchem C, Kreis R, Lee P, Lei H, Marjańska M, Mekle R, Murali‐Manohar S, Považan M, Rackayová V, Simicic D, Slotboom J, Soher BJ, Starčuk Z, Starčuková J, Tkáč I, Williams S, Wilson M, Wright AM, Xin L, Mlynárik V. Contribution of macromolecules to brain 1H MR spectra: Experts' consensus recommendations. NMR In Biomedicine 2020, 34: e4393. PMID: 33236818, PMCID: PMC10072289, DOI: 10.1002/nbm.4393.Peer-Reviewed Original ResearchECLIPSE utilizing gradient‐modulated offset‐independent adiabaticity (GOIA) pulses for highly selective human brain proton MRSI
Kumaragamage C, De Feyter HM, Brown P, McIntyre S, Nixon TW, de Graaf R. ECLIPSE utilizing gradient‐modulated offset‐independent adiabaticity (GOIA) pulses for highly selective human brain proton MRSI. NMR In Biomedicine 2020, 34: e4415. PMID: 33001485, PMCID: PMC9472321, DOI: 10.1002/nbm.4415.Peer-Reviewed Original ResearchSpectral editing in 1H magnetic resonance spectroscopy: Experts' consensus recommendations
Choi I, Andronesi O, Barker P, Bogner W, Edden R, Kaiser L, Lee P, Marjańska M, Terpstra M, de Graaf R. Spectral editing in 1H magnetic resonance spectroscopy: Experts' consensus recommendations. NMR In Biomedicine 2020, 34: e4411. PMID: 32946145, PMCID: PMC8557623, DOI: 10.1002/nbm.4411.Peer-Reviewed Original ResearchConceptsSpectral editingIn vivo<sup>1</sup>H MRS, paMulticenter clinical trialSpectral fittingExpert consensus recommendationsD-2-hydroxyglutarateJ-couplingG-aminobutyric acidH-MRSFrequency driftClinical trialsSignal overlapConsensus recommendationsMagnetic resonance spectroscopyMetabolite signalsResonance spectroscopyResonanceExpert recommendationsSequence parametersTerminology and concepts for the characterization of in vivo MR spectroscopy methods and MR spectra: Background and experts' consensus recommendations
Kreis R, Boer V, Choi I, Cudalbu C, de Graaf R, Gasparovic C, Heerschap A, Krššák M, Lanz B, Maudsley A, Meyerspeer M, Near J, Öz G, Posse S, Slotboom J, Terpstra M, Tkáč I, Wilson M, Bogner W, Spectroscopy E. Terminology and concepts for the characterization of in vivo MR spectroscopy methods and MR spectra: Background and experts' consensus recommendations. NMR In Biomedicine 2020, 34: e4347. PMID: 32808407, PMCID: PMC7887137, DOI: 10.1002/nbm.4347.Peer-Reviewed Original ResearchB0 shimming for in vivo magnetic resonance spectroscopy: Experts' consensus recommendations
Juchem C, Cudalbu C, de Graaf R, Gruetter R, Henning A, Hetherington H, Boer V. B0 shimming for in vivo magnetic resonance spectroscopy: Experts' consensus recommendations. NMR In Biomedicine 2020, 34: e4350. PMID: 32596978, DOI: 10.1002/nbm.4350.Peer-Reviewed Original ResearchDynamic multicoil technique (DYNAMITE) MRI on human brain
Juchem C, Theilenberg S, Kumaragamage C, Mullen M, DelaBarre L, Adriany G, Brown PB, McIntyre S, Nixon TW, Garwood M, de Graaf R. Dynamic multicoil technique (DYNAMITE) MRI on human brain. Magnetic Resonance In Medicine 2020, 84: 2953-2963. PMID: 32544274, PMCID: PMC8168279, DOI: 10.1002/mrm.28323.Peer-Reviewed Original ResearchConceptsGradient coilsConventional gradient coilsField controlMagnetic field gradientImage fidelityShim systemBiot-Savart lawFirst realizationCylindrical surfaceCoil technologyGradient technologyImage distortion correctionGradient fieldGradient errorsField imperfectionsHuman headCoilGeometric deformationMR environmentField gradientLinear xDistortion correctionResolution phantomSpatial encodingNumerical integration