2024
Combined neuromodulation and resection for functional cortex epilepsy: a case series.
Merenzon M, Sivaraju A, Herlopian A, Gerrard J, Quraishi I, Hirsch L, Spencer D, Damisah E. Combined neuromodulation and resection for functional cortex epilepsy: a case series. Journal Of Neurosurgery 2024, 1-9. PMID: 38848588, DOI: 10.3171/2024.3.jns24122.Peer-Reviewed Original ResearchMedically refractory epilepsySeizure onset zoneFunctional cortexSeizure outcomeRefractory epilepsyMonths of follow-up dataMaximal safe resectionMedian follow-upTreated with resectionImprove seizure outcomeFocal neuromodulationFollow-up dataPreservation of functionRetrospective analysis of individualsSafe resectionPartial resectionMedian intervalCase seriesPreoperative assessmentSurgical interventionRNS deviceNeurological deficitsNo significant changesResectionRetrospective analysisNon-lesional Bilateral Mesial Temporal Lobe Epilpesy
Quraishi I, Herlopian A. Non-lesional Bilateral Mesial Temporal Lobe Epilpesy. 2024, 781-818. DOI: 10.1007/978-3-031-23828-4_32.Peer-Reviewed Original ResearchMultifocal Epilepsy and Non-dominant Cingulate Lesion
Herlopian A, Gray T, Quraishi I. Multifocal Epilepsy and Non-dominant Cingulate Lesion. 2024, 393-429. DOI: 10.1007/978-3-031-23828-4_18.Peer-Reviewed Original ResearchMultifocal epilepsyEEG findings of patientsFindings of patientsAnti-seizure medicationsPrognostic roleSurgical outcomesEEG findingsEEG changesCingulate epilepsyHabitual seizuresIctal tachycardiaAnterior cingulate gyrusEpilepsy monitoring unitVascular lesionsIctal speechPredictive valueOutcome determinantsPatientsMonitor unitsCingulate cortexEpilepsyCingulate gyrusCingulateCortexEEGSystematic 1 Hz direct electrical stimulation for seizure induction: A reliable method for localizing seizure onset zone and predicting seizure freedom
Sivaraju A, Quraishi I, Collins E, McGrath H, Ramos A, Turk-Browne N, Zaveri H, Damisah E, Spencer D, Hirsch L. Systematic 1 Hz direct electrical stimulation for seizure induction: A reliable method for localizing seizure onset zone and predicting seizure freedom. Brain Stimulation 2024, 17: 339-345. PMID: 38490472, DOI: 10.1016/j.brs.2024.03.011.Peer-Reviewed Original ResearchSeizure inductionSeizure onset zoneSurgical outcomesHabitual seizuresOnset zonePredicting seizure freedomExcellent surgical outcomesProspective cohort studyMann-Whitney testConsecutive patientsFisher's exactSeizure freedomRefractory epilepsyCohort studyPost-surgeryInsular regionsMann-WhitneyPatientsIntracranial EEGSeizuresLocalizing seizure onset zonesStimulationElectrical stimulationMedial temporal regionsTemporal regionsDisease-causing Slack potassium channel mutations produce opposite effects on excitability of excitatory and inhibitory neurons
Wu J, Quraishi I, Zhang Y, Bromwich M, Kaczmarek L. Disease-causing Slack potassium channel mutations produce opposite effects on excitability of excitatory and inhibitory neurons. Cell Reports 2024, 43: 113904. PMID: 38457342, PMCID: PMC11013952, DOI: 10.1016/j.celrep.2024.113904.Peer-Reviewed Original ResearchInhibitory neuronsRegulation of neuronal excitabilityPotassium channel mutationsVoltage-dependent sodiumInhibitory cortical neuronsGain-of-function mutationsAxon initial segmentKCNT1 geneNeuronal excitabilityChannel subunitsChannel mutationsNetwork hyperexcitabilityMouse modelNeuron typesCortical neuronsTreat epilepsyNeuronsExcitable neuronsNeurological disordersSevere intellectual disabilityMutationsInitial segmentKCNT1ExpressionHyperexcitabilitySlack (KCNT1) potassium channels regulate levels of proteins of the inner mitochondrial membrane
Wang H, Wu J, Sun F, Wu S, Jafar-nejad P, Quraishi I, Pedram M, Kaczmarek L. Slack (KCNT1) potassium channels regulate levels of proteins of the inner mitochondrial membrane. Biophysical Journal 2024, 123: 250a. DOI: 10.1016/j.bpj.2023.11.1582.Peer-Reviewed Original Research
2023
Subacute combined degeneration of the spinal cord in a patient with nitrous oxide use and autoimmune atrophic gastritis
Gardin T, Yang A, Moeller J, Quraishi I. Subacute combined degeneration of the spinal cord in a patient with nitrous oxide use and autoimmune atrophic gastritis. BMJ Case Reports 2023, 16: e254727. PMID: 38035681, PMCID: PMC10689362, DOI: 10.1136/bcr-2023-254727.Peer-Reviewed Original ResearchConceptsAutoimmune atrophic gastritisNitrous oxide useAtrophic gastritisCombined degenerationSpinal cordRecreational nitrous oxide useSubacute combined degenerationVitamin B12 deficiencySubstance use disordersConcomitant etiologiesNeuropsychiatric manifestationsB12 deficiencyNeuropsychiatric sequelaePsychiatric comorbiditySecondary causesClinical pearlsDifferential diagnosisTimely treatmentUse disordersCommon drugsNutritional deficienciesVitamin B12Myelin sheathAlternative causesYoung adultsA multicenter retrospective study of patients treated in the thalamus with responsive neurostimulation
Fields M, Eka O, Schreckinger C, Dugan P, Asaad W, Blum A, Bullinger K, Willie J, Burdette D, Anderson C, Quraishi I, Gerrard J, Singh A, Lee K, Yoo J, Ghatan S, Panov F, Marcuse L. A multicenter retrospective study of patients treated in the thalamus with responsive neurostimulation. Frontiers In Neurology 2023, 14: 1202631. PMID: 37745648, PMCID: PMC10516547, DOI: 10.3389/fneur.2023.1202631.Peer-Reviewed Original ResearchAnterior thalamic nucleiSerious adverse eventsGlobal Clinical Impression ScaleVagal nerve stimulationDrug-resistant epilepsyDeep brain stimulationAdverse eventsMost patientsResponsive neurostimulationSeizure reductionResective surgeryResistant epilepsyImpression ScaleSide effectsMedian baseline seizure frequencyDrug-resistant epilepsy patientsRare serious adverse eventsAnti-seizure medicationsDifferent epilepsy centersMeaningful seizure reductionMedian seizure reductionMedication regimen changesBaseline seizure frequencyMulticenter retrospective studyRetrospective multicenter studyIs MORE better? Accumulating Evidence for ANT DBS in Epilepsy
Quraishi I. Is MORE better? Accumulating Evidence for ANT DBS in Epilepsy. Epilepsy Currents 2023, 23: 357-359. PMID: 38269353, PMCID: PMC10805093, DOI: 10.1177/15357597231197086.Commentaries, Editorials and LettersDecoding Features of Real-world Navigation from the Human Hippocampus
Graves K, Letrou A, Gray T, Quraishi I, Turk-Browne N. Decoding Features of Real-world Navigation from the Human Hippocampus. Journal Of Vision 2023, 23: 4753. DOI: 10.1167/jov.23.9.4753.Peer-Reviewed Original ResearchIntracranial Entrainment Reveals Statistical Learning across Levels of Abstraction
Sherman B, Aljishi A, Graves K, Quraishi I, Sivaraju A, Damisah E, Turk-Browne N. Intracranial Entrainment Reveals Statistical Learning across Levels of Abstraction. Journal Of Cognitive Neuroscience 2023, 35: 1312-1328. PMID: 37262357, DOI: 10.1162/jocn_a_02012.Peer-Reviewed Original ResearchIctal Thalamic Recordings in Patients with Deep Brain Stimulation Targeting Thalamic NucleiIdentify whether ictal thalamic EEG signals could be derived from ambulatory recordings in patients with pharmacoresistant epilepsy treated with deep brain stimulation (DBS) targeting either bilateral anterior thalamic nuclei (ATN) or centromedian nuclei (CMN). (P5-1.008)
Saab L, Jiang J, Quraishi I, Herlopian A. Ictal Thalamic Recordings in Patients with Deep Brain Stimulation Targeting Thalamic NucleiIdentify whether ictal thalamic EEG signals could be derived from ambulatory recordings in patients with pharmacoresistant epilepsy treated with deep brain stimulation (DBS) targeting either bilateral anterior thalamic nuclei (ATN) or centromedian nuclei (CMN). (P5-1.008). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000204225.Peer-Reviewed Original ResearchNonquantal transmission at the vestibular hair cell–calyx synapse: KLV currents modulate fast electrical and slow K+ potentials
Govindaraju A, Quraishi I, Lysakowski A, Eatock R, Raphael R. Nonquantal transmission at the vestibular hair cell–calyx synapse: KLV currents modulate fast electrical and slow K+ potentials. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2207466120. PMID: 36595693, PMCID: PMC9926171, DOI: 10.1073/pnas.2207466120.Peer-Reviewed Original ResearchConceptsNonquantal transmissionAfferent neuronsHair cellsPresynaptic hair cellsPrimary afferent neuronsAction potential latencyVestibular hair cellsCalyx afferentsPotential latencySynaptic terminalsVestibular signalsSynaptic cleftNeural circuitsHead positionPossible roleGap junctionsNeuronsSynapsesSynapseCleftCellsCalyxAfferents
2022
Temporal Dynamics of Competition between Statistical Learning and Episodic Memory in Intracranial Recordings of Human Visual Cortex
Sherman B, Graves K, Huberdeau D, Quraishi I, Damisah E, Turk-Browne N. Temporal Dynamics of Competition between Statistical Learning and Episodic Memory in Intracranial Recordings of Human Visual Cortex. Journal Of Neuroscience 2022, 42: 9053-9068. PMID: 36344264, PMCID: PMC9732826, DOI: 10.1523/jneurosci.0708-22.2022.Peer-Reviewed Original ResearchConceptsVisual cortexStatistical learningIntracranial recordingsStatistical learning taskBehavioural Memory TestMultivariate pattern analysisLong-term memoryExpense of memoryEncoding of informationHuman visual cortexStorage of experienceNew experiencesEpisodic memoryMemory researchMemory testFrequency taggingRapid streamGuide behaviorLearning taskNew predictive relationshipNeural predictionHuman intracranial EEGWeak expectationsNeural activityMemory formationElectronic seizure diaries for clinical care and research
Gray TE, Hirsch LJ, Quraishi IH. Electronic seizure diaries for clinical care and research. Epileptic Disorders 2022, 24: 803-811. PMID: 35811431, DOI: 10.1684/epd.2022.1451.Peer-Reviewed Original ResearchEvaluating consciousness and awareness during focal seizures: responsiveness testing versus recall testing
Ramirez V, Litvinov B, Gunawardane NA, Zhao CW, Yotter C, Quraishi IH, Blumenfeld H. Evaluating consciousness and awareness during focal seizures: responsiveness testing versus recall testing. Epileptic Disorders 2022, 24: 899-905. PMID: 35904040, PMCID: PMC10042123, DOI: 10.1684/epd.2022.1472.Peer-Reviewed Original ResearchConceptsFocal seizuresResponsiveness testingCurrent International LeagueClinical practice settingEEG-video monitoringEpilepsy monitoring unitImportant clinical settingsEpilepsy guidelinesPatient groupFocal epilepsyIctal eventsClinical careInternational LeagueSeizuresPatientsClinical settingPractice settingsClassification guidelinesFurther studiesEpilepsyResponsivenessRecall of experiencesPreliminary findingsRecall testingSettingRemembering the pattern: A longitudinal case study on statistical learning in spatial navigation and memory consolidation
Graves KN, Sherman BE, Huberdeau D, Damisah E, Quraishi IH, Turk-Browne NB. Remembering the pattern: A longitudinal case study on statistical learning in spatial navigation and memory consolidation. Neuropsychologia 2022, 174: 108341. PMID: 35961387, PMCID: PMC9578695, DOI: 10.1016/j.neuropsychologia.2022.108341.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexStatistical learningSpatial navigationBrain systemsDistinct brain systemsIntracranial electroencephalographyOffline consolidationPerceptual experienceCortical consolidationMemory consolidationPrefrontal cortexCortical regionsFuture behaviorLearningLongitudinal case studySame patientHippocampusConsolidationProlonged retentionRapid acquisitionWeeksElectroencephalographyCortexDifferent timescalesRegularityHippocampal recording via the RNS system reveals marked ipsilateral activation of epileptiform activity during Wada testing
Quraishi IH, Brown FC, Johnson MH, Hirsch LJ. Hippocampal recording via the RNS system reveals marked ipsilateral activation of epileptiform activity during Wada testing. Epilepsy & Behavior 2022, 134: 108854. PMID: 35905518, DOI: 10.1016/j.yebeh.2022.108854.Peer-Reviewed Original ResearchConceptsResponsive neurostimulation systemWada testingEpileptiform activityElicitation of seizuresTemporal lobe resectionInternal carotid arteryMedial temporal structuresHippocampal vasculatureIpsilateral activationLobe resectionPosterior circulationElectrographic seizuresTemporal lobectomyElectrographic changesIntractable epilepsyClinical correlatesWada testCarotid arteryHippocampal spikesNegative findingsNeurostimulation systemHippocampal EEGHippocampal activityPatientsTransient increaseTemporal dynamics of competition between statistical learning and episodic memory in intracranial recordings of human visual cortex
Sherman BE, Graves KN, Huberdeau DM, Quraishi IH, Damisah EC, Turk-Browne NB. Temporal dynamics of competition between statistical learning and episodic memory in intracranial recordings of human visual cortex. BioRxiv 2022.03.14.484293Peer-Reviewed Original Research In Press
2021
Suppression of Kv3.3 channels by antisense oligonucleotides reverses biochemical effects and motor impairment in spinocerebellar ataxia type 13 mice
Zhang Y, Quraishi IH, McClure H, Williams LA, Cheng Y, Kale S, Dempsey GT, Agrawal S, Gerber DJ, McManus OB, Kaczmarek LK. Suppression of Kv3.3 channels by antisense oligonucleotides reverses biochemical effects and motor impairment in spinocerebellar ataxia type 13 mice. The FASEB Journal 2021, 35: e22053. PMID: 34820911, PMCID: PMC8630780, DOI: 10.1096/fj.202101356r.Peer-Reviewed Original ResearchConceptsHAX-1Wild-type animalsMultivesicular bodiesKv3.3 channelsLate endosomes/multivesicular bodiesTank Binding Kinase 1Type animalsCell survival proteinsDisease-causing mutationsVoltage-dependent potassium channelsSpinocerebellar ataxia type 13Survival proteinsKinase 1Mature intact animalsTBK1 activationAge-matched wild-type animalsLevels of CD63Progressive cerebellar degenerationWild-type miceMutationsProtein levelsMutant micePotassium channelsDependent potassium channelsType mice