2024
315-OR: Task-Induced Alterations in the Salience Network amongst Patients with Type 1 Diabetes
SANCHEZ RANGEL E, BELFORT-DEAGUIAR R, LACADIE C, CHUNG T, SCHEINOST D, MASON G, HWANG J. 315-OR: Task-Induced Alterations in the Salience Network amongst Patients with Type 1 Diabetes. Diabetes 2024, 73 DOI: 10.2337/db24-315-or.Peer-Reviewed Original ResearchSalience networkFunctional connectivityCognitive tasksBrain responsesType 1 diabetesBrain functional connectivityResting stateMild hypoglycemiaWorking memoryBrain regionsSalienceContinuous performanceRewardBrainCounterregulatory hormonesStandard preprocessingTaskIndividual traitsMemoryPatientsHypoglycemiaT1DGradCPTStimuliAttention
2013
Lactate preserves neuronal metabolism and function following antecedent recurrent hypoglycemia
Herzog RI, Jiang L, Herman P, Zhao C, Sanganahalli BG, Mason GF, Hyder F, Rothman DL, Sherwin RS, Behar KL. Lactate preserves neuronal metabolism and function following antecedent recurrent hypoglycemia. Journal Of Clinical Investigation 2013, 123: 1988-1998. PMID: 23543056, PMCID: PMC3638906, DOI: 10.1172/jci65105.Peer-Reviewed Original ResearchConceptsAntecedent recurrent hypoglycemiaRecurrent hypoglycemiaHypoglycemic conditionsIntensive insulin therapyTight glycemic controlType 2 diabetesInsulin therapyGlycemic controlBrain metabolismElevated lactateNeuronal metabolismRodent modelsNeuronal activityGlucose metabolismHypoglycemiaLactate uptakeNeuronal functionType 1Metabolic regulatorOxidative capacityModest incrementLactateMetabolismUnexpected findingBrain
2006
Increased Brain Monocarboxylic Acid Transport and Utilization in Type 1 Diabetes
Mason GF, Petersen KF, Lebon V, Rothman DL, Shulman GI. Increased Brain Monocarboxylic Acid Transport and Utilization in Type 1 Diabetes. Diabetes 2006, 55: 929-934. PMID: 16567513, PMCID: PMC2995526, DOI: 10.2337/diabetes.55.04.06.db05-1325.Peer-Reviewed Original ResearchConceptsType 1 diabetesDiabetic subjectsControl subjectsType 1 diabetic subjectsInsulin-induced hypoglycemiaNondiabetic control subjectsMonocarboxylic acid transportBrain utilizationSimilar twofold increaseBrain energeticsHypoglycemiaType 1DiabetesOxidative metabolismNonglucose substratesBrainMetabolic substratesUpregulationPatientsAcid transportTwofold increaseSubjectsMagnetic resonance spectroscopyLactateMetabolism