2022
Clinical Research on Transcatheter Aortic Valve Replacement for Bicuspid Aortic Valve Disease: Principles, Challenges, and an Agenda for the Future
Ahmad Y, Madhavan M, Baron S, Forrest J, Borger M, Leipsic J, Cavalcante J, Wang D, McCarthy P, Szerlip M, Kapadia S, Makkar R, Mack M, Leon M, Cohen D. Clinical Research on Transcatheter Aortic Valve Replacement for Bicuspid Aortic Valve Disease: Principles, Challenges, and an Agenda for the Future. Structural Heart 2022, 7: 100102. PMID: 37275317, PMCID: PMC10236801, DOI: 10.1016/j.shj.2022.100102.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementBicuspid aortic valve diseaseSurgical aortic valve replacementAortic valve replacementAortic valve diseaseValve replacementClinical researchValve diseaseValvular heart diseaseDesign of RCTsProcedural therapiesProspective registryHeart diseaseExclusion criteriaRisk scorePatientsRCTsDiseaseCardiovascular communityMultidisciplinary workshopSelection biasTrialsInternational expertsPotential studiesRegistry
2019
Right ventricular pacing for hypertrophic obstructive cardiomyopathy: meta-analysis and meta-regression of clinical trials
Arnold AD, Howard JP, Chiew K, Kerrigan WJ, de Vere F, Johns HT, Churlilov L, Ahmad Y, Keene D, Shun-Shin MJ, Cole GD, Kanagaratnam P, Sohaib SMA, Varnava A, Francis DP, Whinnett ZI. Right ventricular pacing for hypertrophic obstructive cardiomyopathy: meta-analysis and meta-regression of clinical trials. European Heart Journal - Quality Of Care And Clinical Outcomes 2019, 5: 321-333. PMID: 30715300, PMCID: PMC6775860, DOI: 10.1093/ehjqcco/qcz006.Peer-Reviewed Original ResearchConceptsNYHA classObservational studyLeft ventricular outflow tract gradient reductionNew York Heart Association classVentricular outflow tract gradient reductionUnblinded observational studyHypertrophic obstructive cardiomyopathyRight ventricular pacingGenuine treatment effectNon-significant trendObstructive cardiomyopathyAssociation classFunctional outcomeBlinded RCTVentricular pacingClinical trialsEligibility criteriaRCTsGradient reductionGreater reductionTreatment effectsTrialsPatientsCardiomyopathyPacing
2016
97 Multi-vessel Angioplasty at the Time of STEMI has Equivalent Mortality to a Culprit Only Strategy: Resolving The Paradox of Randomised Controlled Trials and Observational Studies in Multivessel Disease and STEMI
Ahmad Y, Cook C, Petraco R, Nijjer S, Al-Lamee R, Shun-Shin M, Keene D, Balu A, Malik I, Baker C, Mikhail G, Sethi A, Foale R, Davies J, Mayet J, Francis D, Sen S. 97 Multi-vessel Angioplasty at the Time of STEMI has Equivalent Mortality to a Culprit Only Strategy: Resolving The Paradox of Randomised Controlled Trials and Observational Studies in Multivessel Disease and STEMI. Heart 2016, 102: a68. DOI: 10.1136/heartjnl-2016-309890.97.Peer-Reviewed Original ResearchHigh-risk patientsLarge observational studiesObservational studyResidual diseaseEquivalent mortalityPrimary percutaneous coronary interventionST-elevation myocardial infarctionMulti-vessel diseasePercutaneous coronary interventionRandomised Controlled TrialsAllocation biasMultivessel diseaseCoronary interventionRisk patientsControlled TrialsMyocardial infarctionSmall RCTsPatientsHigh mortalitySTEMIMortalityDiseaseConflicting resultsRCTsPPCI
2015
CRT-177 Why Is Demonstrating A Mortality Reduction For New STEMI Therapies Increasingly Difficult With Conventional RCTs? A Meta-analysis Of 10,375 Patients In Thrombus Aspiration Trials
Keene D, Ahmad Y, Francis D. CRT-177 Why Is Demonstrating A Mortality Reduction For New STEMI Therapies Increasingly Difficult With Conventional RCTs? A Meta-analysis Of 10,375 Patients In Thrombus Aspiration Trials. JACC Cardiovascular Interventions 2015, 8: s31. DOI: 10.1016/j.jcin.2014.12.118.Peer-Reviewed Original Research