2024
Association between Long-Term Exposure to PM2.5 Inorganic Chemical Compositions and Cardiopulmonary Mortality: A 22-Year Cohort Study in Northern China
Sun H, Chen X, Huang W, Wei J, Yang X, Shan A, Zhang L, Zhang H, He J, Pan C, Li J, Wu J, Wang T, Chen J, Guo Y, Tong S, Dong G, Tang N. Association between Long-Term Exposure to PM2.5 Inorganic Chemical Compositions and Cardiopulmonary Mortality: A 22-Year Cohort Study in Northern China. Environment & Health 2024 DOI: 10.1021/envhealth.4c00020.Peer-Reviewed Original ResearchNonmalignant respiratory diseasesNonaccidental causesCardiorespiratory mortalityCardiopulmonary mortalityCardiovascular diseaseInorganic chemical compositionCohort studyInterquartile rangeTime-varying Cox proportional hazards modelsLow educational levelRespiratory diseaseProspective cohort studyCox proportional hazards modelsIncreased cardiopulmonary mortalityProportional hazards modelAssociated with mortalityPremature mortalityLong-term exposure to high levelsStratified analysisEducation levelVulnerable subpopulationsHigher pollutant concentrationsHigher incomeExposure to high levelsSignificant air pollutionHigh-dimensional generalized median adaptive lasso with application to omics data
Liu Y, Gao Q, Wei K, Huang C, Wang C, Yu Y, Qin G, Wang T. High-dimensional generalized median adaptive lasso with application to omics data. Briefings In Bioinformatics 2024, 25: bbae059. PMID: 38436558, PMCID: PMC10939310, DOI: 10.1093/bib/bbae059.Peer-Reviewed Original ResearchConceptsAccuracy of variable selectionVariable selectionContext of high-dimensional dataAdaptive lassoHigh-dimensional dataAccurate estimates of causal effectsEstimation of causal effectsMedian regression modelsPenalty weightSimulation resultsCovariate selectionSymmetric distributionEffect estimatesRoot mean square errorCausal effectsLASSOAccuracyEstimationDatasetAccurate estimationMethodInitiative databaseSuperioritySelectionInferenceGenetic evidence for the causal relations between metabolic syndrome and psychiatric disorders: a Mendelian randomization study
Gao X, Qin Y, Jiao S, Hao J, Zhao J, Wang J, Wen Y, Wang T. Genetic evidence for the causal relations between metabolic syndrome and psychiatric disorders: a Mendelian randomization study. Translational Psychiatry 2024, 14: 46. PMID: 38245519, PMCID: PMC10799927, DOI: 10.1038/s41398-024-02759-5.Peer-Reviewed Original ResearchConceptsPsychiatric disordersBody mass indexMendelian randomizationMR analysisPrimary analysisAttention-deficit/hyperactivity disorder(ADHDHeritability of psychiatric disordersEffects of ADHDInverse variance weighted methodLinkage disequilibrium score regressionMultivariable MR analysisMendelian randomization studiesVariance weighted methodMetabolic syndromeCorrelates of MetSAttention-deficit/hyperactivityADHDScore regressionEffect of MetSClinical interventionsModifiable targetsGenetic correlationsMass indexCausal effectsDisorders
2023
Psoriasis and gut microbiota: A Mendelian randomization study
Wu R, Zhao L, Wu Z, Liu X, Li J, Wang T, Zhang L. Psoriasis and gut microbiota: A Mendelian randomization study. Journal Of Cellular And Molecular Medicine 2023, 28: e18023. PMID: 38146147, PMCID: PMC10805496, DOI: 10.1111/jcmm.18023.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesGut microbiota compositionMendelian randomization analysisGut microbiotaMicrobiota compositionGenome-wide association study studiesRandomization analysisTwo-sample Mendelian randomization analysisMiBioGen consortiumFamily VeillonellaceaeAssociation studiesHorizontal pleiotropyMR-EggerGWAS studiesIVW resultsInverse varianceMicrobiotaMicrobiota groupsGutGenusObservational studyExposure factorsSensitivity analysisAssociationDisease outcomeIndividual and joint associations of long-term exposure to air pollutants and cardiopulmonary mortality: A 22-year cohort study in Northern China
Huang W, Zhou Y, Chen X, Zeng X, Knibbs L, Jalaludin B, Dharmage S, Morawska L, Guo Y, Yang X, Zhang L, Shan A, Chen J, Wang T, Heinrich J, Gao M, Lin L, Xiao X, Zhou P, Yu Y, Tang N, Dong G. Individual and joint associations of long-term exposure to air pollutants and cardiopulmonary mortality: A 22-year cohort study in Northern China. ISEE Conference Abstracts 2023, 2023 DOI: 10.1289/isee.2023.op-058.Peer-Reviewed Original ResearchHigh dietary K+ intake inhibits proximal tubule transport
Wang T, Liu T, Xu S, Frindt G, Weinstein A, Palmer L. High dietary K+ intake inhibits proximal tubule transport. American Journal Of Physiology. Renal Physiology 2023, 325: f224-f234. PMID: 37318989, PMCID: PMC10396284, DOI: 10.1152/ajprenal.00013.2023.Peer-Reviewed Original ResearchConceptsGlomerular filtration rateFree-flow micropunctureFiltration rateUrine volumeFractional NaNephron segmentsOverall kidney functionProximal tubule transportProximal tubule functionNHE3 protein expressionExchanger isoform 3HK animalsKCl dietFraction excretionKidney functionHigh dietaryTubule functionKidney microsomesTubule transportAnesthetized animalsProximal tubulesVolume reabsorptionExcretionWestern blotControl dietHigh Dietary K Intake Inhibits Proximal Tubule Transport and Reduces GFR
Wang T, Liu T, Xu S, Frindt G, Palmer L, Weinstein A. High Dietary K Intake Inhibits Proximal Tubule Transport and Reduces GFR. Physiology 2023, 38: 5731363. DOI: 10.1152/physiol.2023.38.s1.5731363.Peer-Reviewed Original ResearchGlomerular filtration rateTF/PProximal tubulesUrine volumeTubular fluidDistal NaFractional NaReduction of GFRNephron segmentsFree-flow micropunctureOverall kidney functionDistal nephron segmentsProximal nephron segmentsKidney functionFiltration ratePt-NaFiltered loadLate DCTProximal adjustmentsModulation of NaTubule transportFractional deliveryFluid absorptionPT transportRats
2022
Regulation of glomerulotubular balance. IV. Implication of aquaporin 1 in flow-dependent proximal tubule transport and cell volume
Du Z, Yan Q, Shen E, Weinstein A, Wang T. Regulation of glomerulotubular balance. IV. Implication of aquaporin 1 in flow-dependent proximal tubule transport and cell volume. American Journal Of Physiology. Renal Physiology 2022, 323: f642-f653. PMID: 36108052, PMCID: PMC9705020, DOI: 10.1152/ajprenal.00167.2022.Peer-Reviewed Original ResearchConceptsKO miceProximal tubulesMouse proximal tubulesWater reabsorptionAcid-base parametersKnockout miceAquaporin 1 knockout miceAquaporin-1Rat kidneyRenal clearance experimentsProximal tubule transportWater channel aquaporin-1Significant differencesHigh urine flowRat proximal tubuleKidney proximal tubulesWT miceUrine flowClearance experimentsGlomerulotubular balanceBlood pHTubule transportAQP1 knockout miceMiceFluid absorption
2021
Sex difference in kidney electrolyte transport III: Impact of low K intake on thiazide-sensitive cation excretion in male and female mice
Xu S, Li J, Yang L, Wang CJ, Liu T, Weinstein AM, Palmer LG, Wang T. Sex difference in kidney electrolyte transport III: Impact of low K intake on thiazide-sensitive cation excretion in male and female mice. Pflügers Archiv - European Journal Of Physiology 2021, 473: 1749-1760. PMID: 34455480, PMCID: PMC8528772, DOI: 10.1007/s00424-021-02611-5.Peer-Reviewed Original ResearchConceptsGlomerular filtration rateFemale miceUrine volumeNaCl cotransporterLow K intakeMeasurement of functionSex differencesNatriuretic responseFractional excretionK intakeTransport protein expressionFiltration rateNCC abundanceNCC expressionRenal clearanceDistal nephronLK dietCation excretionPlasma KNCC proteinNKCC2 expressionWestern blottingProtein expressionMiceFENaRestoration of proximal tubule flow-activated transport prevents cyst growth in polycystic kidney disease
Du Z, Tian X, Ma M, Somlo S, Weinstein AM, Wang T. Restoration of proximal tubule flow-activated transport prevents cyst growth in polycystic kidney disease. JCI Insight 2021, 6: e146041. PMID: 33886508, PMCID: PMC8262298, DOI: 10.1172/jci.insight.146041.Peer-Reviewed Original ResearchConceptsGlomerular filtration rateGlomerulotubular balanceRenal cyst formationCyst formationReceptor 1 antagonistPolycystic kidney diseaseKidney weightUntreated miceDA1 antagonistControl miceKidney diseaseFiltration rateFractional reabsorptionCystic indexMouse modelCyst growthConditional KOHCO3- absorptionHeterozygous miceSame antagonistsMicePT transportAntagonistEpithelial ciliaHCO3- transportDeletion of Cdh16 Ksp-cadherin leads to a developmental delay in the ability to maximally concentrate urine in mouse
Thomson R, Dynia DW, Burlein S, Thomson BR, Booth C, Knauf F, Wang T, Aronson P. Deletion of Cdh16 Ksp-cadherin leads to a developmental delay in the ability to maximally concentrate urine in mouse. American Journal Of Physiology. Renal Physiology 2021, 320: f1106-f1122. PMID: 33938239, PMCID: PMC8285649, DOI: 10.1152/ajprenal.00556.2020.Peer-Reviewed Original ResearchConceptsKsp-cadherinCell adhesion moleculeAtypical memberKidney developmentMammalian kidneyAdult mammalian kidneyBasolateral membraneNormal kidney developmentEpithelial cellsAdhesion moleculesMutant animalsExpression analysisSpecific expressionE-cadherin expressionWestern blot analysisEpithelial phenotypePrincipal proteinE-cadherinBlot analysisMouse linesAquaporin-2CadherinCritical roleDevelopmental delayKnockout mice
2020
Replicated risk CACNA1C variants for major psychiatric disorders may serve as potential therapeutic targets for the shared depressive endophenotype.
Guo X, Fu Y, Zhang Y, Wang T, Lu L, Luo X, Wang K, Huang J, Xie T, Zheng C, Yang K, Tong J, Zuo L, Kang L, Tan Y, Jiang K, Li CR, Luo X. Replicated risk CACNA1C variants for major psychiatric disorders may serve as potential therapeutic targets for the shared depressive endophenotype. 2020, 4 PMID: 34046650, PMCID: PMC8153461.Peer-Reviewed Original ResearchMajor psychiatric disordersGenome-wide association studiesL-type voltage-gated calcium channelsMajor depressive disorderMRNA expression regulationPsychiatric disordersTherapeutic targetBipolar disorderChronic mild stress (CMS) ratsHuman hippocampusExpression regulationDepressive endophenotypeType voltage-gated calcium channelsRole of venlafaxineVoltage-gated calcium channelsPotential therapeutic targetRisk genesSignificant mRNA expressionVenlafaxine treatmentDepressive disorderStress ratsDepressive symptomsIndependent cohortCalcium channelsMRNA expressionSex Difference In Kidney Electrolyte Transport III: Impact of Low K intake on Thiazide‐Sensitive Cation Excretion in Male and Female Mice
Xu S, Li J, Yang L, Wang C, Liu T, Weinstein A, Palmer L, Wang T. Sex Difference In Kidney Electrolyte Transport III: Impact of Low K intake on Thiazide‐Sensitive Cation Excretion in Male and Female Mice. The FASEB Journal 2020, 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.04495.Peer-Reviewed Original ResearchGlomerular filtration rateFemale miceUrine volumeCation excretionNCC proteinNCC activityDietary potassium intakeLow K intakeRole of NCCMeasurement of functionSex differencesNatriuretic responsePotassium intakeK intakeFiltration rateMale miceNCC abundanceNCC expressionDistal tubulesDistal nephronElectrolyte homeostasisLK dietSodium absorptionHCTZK restriction
2019
Associations between dietary patterns and 10-year cardiovascular disease risk score levels among Chinese coal miners——a cross-sectional study
Sun Q, Ma J, Wang H, Xu S, Zhao J, Gao Q, Huang J, Wang T. Associations between dietary patterns and 10-year cardiovascular disease risk score levels among Chinese coal miners——a cross-sectional study. BMC Public Health 2019, 19: 1704. PMID: 31856787, PMCID: PMC6923962, DOI: 10.1186/s12889-019-8070-9.Peer-Reviewed Original ResearchConceptsRisk score levelDietary patternsCardiovascular diseaseValid semi-quantitative food frequency questionnaireSemi-quantitative food frequency questionnaireEffective dietary guidelinesFood frequency questionnaireHigh-risk populationCross-sectional studyLarge health burdenCoal minersFrequency questionnaireDietary intakeHealth burdenDietary guidelinesMethodsThe studyLogistic regressionConclusionsThis studySocioeconomic factorsScore levelDiseaseDietary structureAssociationChinese coal minersGround workersThe bidirectional causal relationships of insomnia with five major psychiatric disorders: A Mendelian randomization study
Gao X, Meng L, Ma K, Liang J, Wang H, Gao Q, Wang T. The bidirectional causal relationships of insomnia with five major psychiatric disorders: A Mendelian randomization study. European Psychiatry 2019, 60: 79-85. PMID: 31234011, DOI: 10.1016/j.eurpsy.2019.05.004.Peer-Reviewed Original ResearchConceptsMajor psychiatric disordersPsychiatric disordersBipolar disorderAssociation of insomniaMendelian randomization studyAutism spectrum disorderOdds ratioObservational studySpectrum disorderInsomniaRandomization studyEffective interventionsCausal relationshipEgger regressionDisordersDisease modelsCausal roleMendelian randomizationConvincing evidenceGenome-wide association studiesAssociation
2016
Hydronephrosis and Urinary Bladder Hypertrophy in ROMK Bartter's Mouse
Kim J, Guo X, Hu H, Xu S, Wang T. Hydronephrosis and Urinary Bladder Hypertrophy in ROMK Bartter's Mouse. The FASEB Journal 2016, 30 DOI: 10.1096/fasebj.30.1_supplement.1224.30.Peer-Reviewed Original ResearchThickness of urotheliumKO miceROMK expressionBladder capacityBladder weightWT miceKnockout miceRenal outer medullary potassium channelLuminal membraneROMK knockout miceUrinary bladder hypertrophyLow K intakeWestern blottingLow potassium dietSmooth muscle layerMonths of ageNormal KBladder hypertrophyDetrusor muscleMouse bladderBartter's syndromePotassium dietK intakeROMKUrinary bladderExpression of KCNJ1 (ROMK) in the Gastrointestinal Tract
Han J, Lee S, Ishikawa Y, Guo X, Xu S, Wang T. Expression of KCNJ1 (ROMK) in the Gastrointestinal Tract. The FASEB Journal 2016, 30 DOI: 10.1096/fasebj.30.1_supplement.1224.31.Peer-Reviewed Original ResearchROMK expressionDistal colonMRNA expressionKO miceRenal outer medullary potassium channelEpithelial cellsGI tractGastric acid secretionGastrointestinal (GI) tractHK intakeROMK channelsWT miceDistal nephronReal-time PCRApical membraneROMKPotassium channelsAcid secretionParietal cellsIF stainingRenal tubulesQ-PCR dataEsophagusDiet animalsGastrointestinal tract
2013
REGULATION OF GLOMERULOTUBULAR BALANCE IV: IMPLICATION OF AQUAPORIN 1 IN FLOW‐DEPENDENT TRANSPORT AND CELL VOLUME
Du Z, Yan Q, Weinbaum S, Weinstein A, Wang T. REGULATION OF GLOMERULOTUBULAR BALANCE IV: IMPLICATION OF AQUAPORIN 1 IN FLOW‐DEPENDENT TRANSPORT AND CELL VOLUME. The FASEB Journal 2013, 27: 912.27-912.27. DOI: 10.1096/fasebj.27.1_supplement.912.27.Peer-Reviewed Original ResearchKO miceProximal tubulesAQP-1Proximal NaPerfusion rateWT miceFlow-dependent changesCell volumeVolume reabsorptionWater reabsorptionMiceMouse kidneyHCO-3ReabsorptionPeritubular membraneSignificant differencesTubulesAquaporin-1Flow-dependent transportKOH-ATPaseKidneyPrincipal pathwayMicroperfusionPathwayProximal tubule specific knockout of the Na+/H+ exchanger NHE3: effects on bicarbonate absorption and ammonium excretion
Li H, Du Z, Barone S, Rubera I, McDonough A, Tauc M, Zahedi K, Wang T, Soleimani M. Proximal tubule specific knockout of the Na+/H+ exchanger NHE3: effects on bicarbonate absorption and ammonium excretion. Journal Of Molecular Medicine 2013, 91: 951-963. PMID: 23508938, PMCID: PMC3730089, DOI: 10.1007/s00109-013-1015-3.Peer-Reviewed Original ResearchConceptsKO miceMetabolic acidosisBicarbonate reabsorptionAcid loadNHE3 knockout miceProximal tubule NHE3Mild metabolic acidosisCre transgenic miceExchanger NHE3NH4Cl acid loadMicroperfusion studiesWT miceKnockout miceFloxed miceTransgenic micePathophysiologic statesExcretion rateBicarbonate absorptionNH4Cl loadingMutant miceVolume reabsorptionWestern blotMiceSpecific knockoutAbsorption defect
2012
Regulation of glomerulotubular balance. II. Impact of angiotensin II on flow-dependent transport
Du Z, Wan L, Yan Q, Weinbaum S, Weinstein AM, Wang T. Regulation of glomerulotubular balance. II. Impact of angiotensin II on flow-dependent transport. American Journal Of Physiology. Renal Physiology 2012, 303: f1507-f1516. PMID: 22952281, PMCID: PMC3532483, DOI: 10.1152/ajprenal.00277.2012.Peer-Reviewed Original ResearchAngiotensin IIAngiotensin II Type 1 Receptor BlockersAnimalsBicarbonatesBiological TransportEnzyme InhibitorsFemaleHemostasisIn Vitro TechniquesKidney GlomerulusKidney TubulesLosartanMacrolidesMiceMice, KnockoutModels, AnimalProton-Translocating ATPasesReceptor, Angiotensin, Type 1SodiumSodium-Hydrogen Exchanger 3Sodium-Hydrogen Exchangers