2018
Presurgical language fMRI: Technical practices in epilepsy surgical planning
Benjamin CFA, Dhingra I, Li AX, Blumenfeld H, Alkawadri R, Bickel S, Helmstaedter C, Meletti S, Bronen RA, Warfield SK, Peters JM, Reutens D, Połczyńska MM, Hirsch LJ, Spencer DD. Presurgical language fMRI: Technical practices in epilepsy surgical planning. Human Brain Mapping 2018, 39: 4032-4042. PMID: 29962111, PMCID: PMC6175127, DOI: 10.1002/hbm.24229.Peer-Reviewed Original ResearchConceptsLanguage functional MRIFunctional MRISurgical planningEpilepsy surgical planningEpilepsy surgical programsGeneral linear modelingBlood flowClinical practicePatient careSurgical programsRoutine useMarked heterogeneityClinical applicationVerbal fluencyData highlightFMRI dataMost programsPatientsWidespread useEpilepsyIndividualsMRICare
2009
Frequency, prognosis and surgical treatment of structural abnormalities seen with magnetic resonance imaging in childhood epilepsy
Berg AT, Mathern GW, Bronen RA, Fulbright RK, DiMario F, Testa FM, Levy SR. Frequency, prognosis and surgical treatment of structural abnormalities seen with magnetic resonance imaging in childhood epilepsy. Brain 2009, 132: 2785-2797. PMID: 19638447, PMCID: PMC2759335, DOI: 10.1093/brain/awp187.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge of OnsetAnticonvulsantsBrainChildChild, PreschoolCognitionCohort StudiesDrug ResistanceEpilepsyFemaleFunctional LateralityHumansImage Processing, Computer-AssistedInfantLogistic ModelsMagnetic Resonance ImagingMaleNeurologic ExaminationNeuropsychological TestsNeurosurgical ProceduresPrognosisSclerosisTomography, X-Ray ComputedConceptsMagnetic resonance imagingPositive MRI scansEpilepsy patientsMRI scansEpilepsy syndromesEpilepsy evaluationSurgical proceduresMultiple logistic regression analysisUse of MRIComprehensive epilepsy evaluationNon-idiopathic patientsPediatric epilepsy patientsComprehensive Epilepsy CenterPositive MRI findingsCommunity-based cohortNormal neurological examPre-surgical evaluationLogistic regression analysisIdiopathic epilepsy syndromesFrequency of lesionsClinical factorsMRI abnormalitiesMRI findingsNeurological examSurgical treatment
2006
Increased Number of Subcortical Hyperintensities on MRI in Children and Adolescents With Tourettes Syndrome, Obsessive-Compulsive Disorder, and Attention Deficit Hyperactivity Disorder
Amat JA, Bronen RA, Saluja S, Sato N, Zhu H, Gorman DA, Royal J, Peterson BS. Increased Number of Subcortical Hyperintensities on MRI in Children and Adolescents With Tourettes Syndrome, Obsessive-Compulsive Disorder, and Attention Deficit Hyperactivity Disorder. American Journal Of Psychiatry 2006, 163: 1106-1108. PMID: 16741215, PMCID: PMC2367225, DOI: 10.1176/ajp.2006.163.6.1106.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderCerebral hyperintensitiesObsessive-compulsive disorderHealthy comparison subjectsTourette syndromeDeficit hyperactivity disorderMagnetic resonance imagesComparison subjectsHyperactivity disorderT2-weighted magnetic resonance imagesChildhood neuropsychiatric disordersSubcortical injuryPatient groupSubcortical hyperintensitiesHyperintensitySyndromeDiagnostic groupsChildhood diagnosisNeuropsychiatric disordersDisordersResonance imagesSubcortexSubjectsChildrenAdolescents
2004
Long-term outcome after epilepsy surgery for focal cortical dysplasia.
Cohen-Gadol AA, Ozduman K, Bronen RA, Kim JH, Spencer DD. Long-term outcome after epilepsy surgery for focal cortical dysplasia. Journal Of Neurosurgery 2004, 101: 55-65. PMID: 15255252, DOI: 10.3171/jns.2004.101.1.0055.Peer-Reviewed Original ResearchConceptsFocal cortical dysplasiaImproved seizure outcomeLong-term outcomesCortical dysplasiaClear marginsEpileptogenic zoneSeizure outcomeMean ageMean durationRisk factorsCortical developmentIntracranial monitoringObvious risk factorsRare disabling seizuresTransient sensorimotor deficitsMultiple subpial transectionsSubgroup of patientsExtent of resectionVisual field defectsInclusion of patientsNormal functional anatomyReports of outcomesMagnetic resonance imagingFunctional MR imagingPartial lesionectomy
2003
Basal Ganglia Volumes in Patients With Gilles de la Tourette Syndrome
Peterson BS, Thomas P, Kane MJ, Scahill L, Zhang H, Bronen R, King RA, Leckman JF, Staib L. Basal Ganglia Volumes in Patients With Gilles de la Tourette Syndrome. JAMA Psychiatry 2003, 60: 415-424. PMID: 12695320, DOI: 10.1001/archpsyc.60.4.415.Peer-Reviewed Original ResearchConceptsBasal ganglia volumesBasal gangliaCaudate nucleus volumeTourette syndromeGanglia volumesObsessive-compulsive disorderLenticular nucleus volumesTic symptomsNucleus volumeGilles dePathophysiology of TSPrior neuroleptic exposureHealthy control subjectsSeverity of ticsComorbid obsessive-compulsive disorderGreat clinical relevanceAttention-deficit/hyperactivity disorder (ADHD) symptomsHyperactivity disorder symptomsRepeated-measures analysisNeuroleptic exposureControl subjectsFunctional disturbancesTrait abnormalityClinical relevanceGanglia
2002
Childhood Trauma Associated With Smaller Hippocampal Volume in Women With Major Depression
Vythilingam M, Heim C, Newport J, Miller AH, Anderson E, Bronen R, Brummer M, Staib L, Vermetten E, Charney DS, Nemeroff CB, Bremner JD. Childhood Trauma Associated With Smaller Hippocampal Volume in Women With Major Depression. American Journal Of Psychiatry 2002, 159: 2072-2080. PMID: 12450959, PMCID: PMC3230324, DOI: 10.1176/appi.ajp.159.12.2072.Peer-Reviewed Original ResearchConceptsSmaller hippocampal volumesMajor depressive disorderHippocampal volumeDepressive disorderDepressed subjectsDepressed womenHealthy subjectsChildhood abuseUnipolar major depressive disorderRight hippocampal volumeCoronal MRI scansAdrenal axisDepressed patientsMajor depressionControl brain regionsTemporal lobeWhole hippocampusComparison subjectsMRI scansTrauma AssociatedEarly childhood traumaFemale volunteersWhole brainBrain regionsStudy participants
2000
Choroid plexus changes after temporal lobectomy.
Saluja S, Sato N, Kawamura Y, Coughlin W, Putman C, Spencer D, Sze G, Bronen R. Choroid plexus changes after temporal lobectomy. American Journal Of Neuroradiology 2000, 21: 1650-3. PMID: 11039344, PMCID: PMC8174865.Peer-Reviewed Original ResearchConceptsTemporal lobectomyChoroid plexusPostoperative changesResection siteNormal postoperative changesRecurrent brain tumorsContrast-enhanced T1-weighted imagesPresence of infectionContrast-enhanced MR imagingDegree of enhancementT1-weighted imagesChoroid plexus changesHippocampal sclerosisRecurrent tumorsIntractable epilepsyNodular patternPathologic changesPostoperative siteLobectomyBrain tumorsEnhancement patternSurgical manipulationPlexusMorphologic changesMR imagingMR Imaging and Histologic Features of Subinsular Bright Spots on T2-weighted MR Images: Virchow-Robin Spaces of the Extreme Capsule and Insular Cortex
Song C, Kim J, Kier E, Bronen R. MR Imaging and Histologic Features of Subinsular Bright Spots on T2-weighted MR Images: Virchow-Robin Spaces of the Extreme Capsule and Insular Cortex. Radiology 2000, 214: 671-677. PMID: 10715028, DOI: 10.1148/radiology.214.3.r00mr17671.Peer-Reviewed Original ResearchConceptsInsular cortexExtreme capsuleMR imagingControl subjectsBrain specimensPerivascular spacesFormalin-fixed brain specimensFluid-attenuated inversion recovery sequencesVirchow-Robin spacesT2-weighted magnetic resonance imagesCoronal T2-weighted imagesT2-weighted imagesCoronal MR imagesHigh signal intensityT2-weighted MR imagesInversion recovery sequenceHistologic featuresHistologic findingsCerebrospinal fluidMR imagesPatientsWhite matterPathologic conditionsGross anatomic inspectionMagnetic resonance imagesCerebrospinal Fluid Cleft with Cortical Dimple: MR Imaging Marker for Focal Cortical Dysgenesis
Bronen RA, Spencer DD, Fulbright RK. Cerebrospinal Fluid Cleft with Cortical Dimple: MR Imaging Marker for Focal Cortical Dysgenesis. Radiology 2000, 214: 657-63. PMID: 10715026, DOI: 10.1148/radiology.214.3.r00mr40657.Peer-Reviewed Original ResearchAspergers Disorder
Volkmar F, Klin A, Schultz R, Rubin E, Bronen R. Aspergers Disorder. American Journal Of Psychiatry 2000, 157: 262-267. PMID: 10671397, DOI: 10.1176/appi.ajp.157.2.262.Peer-Reviewed Educational Materials
1997
Postoperative changes in the brain: MR imaging findings in patients without neoplasms.
Sato N, Bronen R, Sze G, Kawamura Y, Coughlin W, Putman C, Spencer D. Postoperative changes in the brain: MR imaging findings in patients without neoplasms. Radiology 1997, 204: 839-46. PMID: 9280269, DOI: 10.1148/radiology.204.3.9280269.Peer-Reviewed Original ResearchConceptsPostoperative MR imagesPostoperative changesDural enhancementEnhancement patternThin linear enhancementContrast enhancement patternMagnetic resonance imagingMR imagesSurgical marginsTemporal lobectomyNeoplastic changesExtraaxial fluidIntracranial airContrast material-enhanced MR imagesDay 5Day 51Day 30Resonance imagingSurgeryBrainPatientsTime courseContrast enhancementLinear enhancementDaysQualitative MR imaging of refractory temporal lobe epilepsy requiring surgery: correlation with pathology and seizure outcome after surgery.
Bronen RA, Fulbright RK, King D, Kim JH, Spencer SS, Spencer DD, Lange RC. Qualitative MR imaging of refractory temporal lobe epilepsy requiring surgery: correlation with pathology and seizure outcome after surgery. American Journal Of Roentgenology 1997, 169: 875-82. PMID: 9275915, DOI: 10.2214/ajr.169.3.9275915.Peer-Reviewed Original ResearchConceptsFebrile seizure historyTemporal lobe epilepsyRefractory temporal lobe epilepsyHippocampal sclerosisSeizure historySeizure outcomeLobe epilepsyHistologic findingsNonspecific gliosisHippocampal atrophyIntractable temporal lobe epilepsyMild hippocampal atrophySimilar clinical conditionsMR imaging diagnosisPositive predictive valueMR imagesSignal intensity changesSegmental findingsNormal findingsClinical parametersNeuronal densityRetrospective studyClinical conditionsSclerosisSurgeryFocal cortical dysplasia of Taylor, balloon cell subtype: MR differentiation from low-grade tumors.
Bronen RA, Vives KP, Kim JH, Fulbright RK, Spencer SS, Spencer DD. Focal cortical dysplasia of Taylor, balloon cell subtype: MR differentiation from low-grade tumors. American Journal Of Neuroradiology 1997, 18: 1141-51. PMID: 9194442, PMCID: PMC8337292.Peer-Reviewed Original ResearchConceptsFocal cortical dysplasiaLow-grade tumorsCortical dysplasiaMR findingsLobe locationLow-grade glial neoplasmTemporal lobe locationSubcortical white matterFrontal lobe locationSurgical resectionCortical thickeningClinical variablesIntractable epilepsyGlial neoplasmsHyperintense signalLateral ventricleMR featuresWhite matterNeoplastic tissueCell subtypesDysplasiaPatientsMR variablesNeoplasmsSurgical planningMagnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—a preliminary report
Bremner J, Randall P, Vermetten E, Staib L, Bronen R, Mazure C, Capelli S, McCarthy G, Innis R, Charney D. Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—a preliminary report. Biological Psychiatry 1997, 41: 23-32. PMID: 8988792, PMCID: PMC3229101, DOI: 10.1016/s0006-3223(96)00162-x.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderLeft hippocampal volumeHippocampal volumeChildhood abuseAdult survivorsSmaller left hippocampal volumeAbuse-related posttraumatic stress disorderStress disorderSmaller hippocampal volumesCombat-related posttraumatic stress disorderMagnetic resonance imagingShort-term memoryHealthy subjectsYears of educationAlcohol abuseMagnetic resonance imaging-based measurementsComparison subjectsPTSD patientsImaging-based measurementsResonance imagingPatientsSexual abusePreliminary reportSurvivorsComparison regionEconomic impact of replacing CT with MR imaging for refractory epilepsy
Bronen R, Fulbright R, Spencer S, Spencer D, Kim J, Lange R. Economic impact of replacing CT with MR imaging for refractory epilepsy. Magnetic Resonance Imaging 1997, 15: 857-862. PMID: 9309616, DOI: 10.1016/s0730-725x(97)00047-7.Peer-Reviewed Original ResearchConceptsPreoperative evaluationRefractory epilepsyPositive imaging findingsRefractory epilepsy patientsPositive magnetic resonanceMagnetic resonanceIntracranial electroencephalogram monitoringSurgical ameliorationNormal CTImaging findingsPreoperative localizationIntractable epilepsyVascular lesionsEpileptogenic zoneElectroencephalogram monitoringPreoperative CTEpilepsy patientsPatientsMR imagingEpilepsyCTVascular substratesHealth costsLesionsSurgery
1996
Three cases of symptom change in Tourette's syndrome and obsessive-compulsive disorder associated with paediatric cerebral malignancies.
Peterson B, Bronen R, Duncan C. Three cases of symptom change in Tourette's syndrome and obsessive-compulsive disorder associated with paediatric cerebral malignancies. Journal Of Neurology Neurosurgery & Psychiatry 1996, 61: 497. PMID: 8937345, PMCID: PMC1074048, DOI: 10.1136/jnnp.61.5.497.Peer-Reviewed Case Reports and Technical NotesConceptsGilles de la Tourette's syndromeObsessive-compulsive disorderCerebral malignanciesTourette syndromeTumor progressionNeurobiology of OCDLa Tourette's syndromeImportant neural substrateChart reviewNeuropsychiatric symptomsTic symptomsTumor locationSpecialty clinicCorpus callosumRadiographic documentationSymptom generationLimbic systemCaudate nucleusIntracranial lesionsSymptom changeBrain regionsSymptom severitySyndromeVentral striatumMalignancyRefractory epilepsy: comparison of MR imaging, CT, and histopathologic findings in 117 patients.
Bronen RA, Fulbright RK, Spencer DD, Spencer SS, Kim JH, Lange RC, Sutilla C. Refractory epilepsy: comparison of MR imaging, CT, and histopathologic findings in 117 patients. Radiology 1996, 201: 97-105. PMID: 8816528, DOI: 10.1148/radiology.201.1.8816528.Peer-Reviewed Original Research
1989
MR imaging of the cranial meninges with emphasis on contrast enhancement and meningeal carcinomatosis.
Sze G, Soletsky S, Bronen R, Krol G. MR imaging of the cranial meninges with emphasis on contrast enhancement and meningeal carcinomatosis. American Journal Of Roentgenology 1989, 153: 1039-49. PMID: 2801423, DOI: 10.2214/ajr.153.5.1039.Peer-Reviewed Original ResearchConceptsContrast-enhanced CTAbnormal meningeal enhancementMeningeal carcinomatosisMeningeal enhancementInner tableMR imagingGroup of patientsDiffuse meningeal enhancementContrast-enhanced MRAbnormal findingsLeptomeningeal tumorSubdural hematomaInflammatory conditionsGroup 2Postoperative defectsGroup 1CarcinomatosisSkull lesionsGroup 3Pathologic conditionsNormal meningesMeningesPatientsCranial meningesHead scansMR imaging of the cranial meninges with emphasis on contrast enhancement and meningeal carcinomatosis.
Sze G, Soletsky S, Bronen R, Krol G. MR imaging of the cranial meninges with emphasis on contrast enhancement and meningeal carcinomatosis. American Journal Of Neuroradiology 1989, 10: 965-75. PMID: 2505542, PMCID: PMC8335283.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBrainBrain DiseasesCarcinomaChildChild, PreschoolContrast MediaFemaleGadoliniumGadolinium DTPAHumansImage EnhancementInfantMagnetic Resonance ImagingMaleMeningeal NeoplasmsMeningesMiddle AgedOrganometallic CompoundsPentetic AcidProspective StudiesRadiographyRetrospective StudiesConceptsContrast-enhanced CTAbnormal meningeal enhancementMeningeal carcinomatosisMeningeal enhancementInner tableMR imagingGroup of patientsDiffuse meningeal enhancementContrast-enhanced MRAbnormal findingsLeptomeningeal tumorSubdural hematomaInflammatory conditionsGroup 2Postoperative defectsGroup 1CarcinomatosisSkull lesionsGroup 3Pathologic conditionsNormal meningesMeningesPatientsCranial meningesHead scans