2015
Burden of transmitted multidrug resistance in epidemics of tuberculosis: a transmission modelling analysis
Kendall EA, Fofana MO, Dowdy DW. Burden of transmitted multidrug resistance in epidemics of tuberculosis: a transmission modelling analysis. The Lancet Respiratory Medicine 2015, 3: 963-972. PMID: 26597127, PMCID: PMC4684734, DOI: 10.1016/s2213-2600(15)00458-0.Peer-Reviewed Original ResearchConceptsMDR tuberculosisDynamic transmission modelPerson transmissionTuberculosis incidenceTuberculosis treatmentTuberculosis epidemicMDR tuberculosis casesDrug-susceptible tuberculosisFirst-line treatmentHigh-burden settingsMultidrug-resistant tuberculosisEpidemic of tuberculosisDrug regimensTuberculosis casesMDR prevalenceTuberculosis notificationsTuberculosis prevalenceNotification dataMDR acquisitionMDR transmissionTuberculosisMultidrug resistanceDe novo mutationsMelinda Gates FoundationNational Institute
2014
Population-Level Impact of Shorter-Course Regimens for Tuberculosis: A Model-Based Analysis
Fofana MO, Knight GM, Gomez GB, White RG, Dowdy DW. Population-Level Impact of Shorter-Course Regimens for Tuberculosis: A Model-Based Analysis. PLOS ONE 2014, 9: e96389. PMID: 24816692, PMCID: PMC4015982, DOI: 10.1371/journal.pone.0096389.Peer-Reviewed Original ResearchConceptsShort-course regimensTB incidenceTreatment completionTreatment successFirst-line treatment regimensFour-month regimenFour-month regimensLower treatment completionProportion of patientsPopulation-level incidenceSix-month therapyGlobal tuberculosis incidenceDynamic transmission modelPopulation-level transmissionCourse regimensTB diseaseTB patientsNew regimensRelapse rateTB mortalityTB transmissionTreatment regimensTuberculosis incidenceClinical trialsRegimens