2024
Lung Transcriptomics Links Emphysema to Barrier Dysfunction and Macrophage Subpopulations.
Lu R, Gregory A, Suryadevara R, Xu Z, Jain D, Morrow J, Hobbs B, Yun J, Lichtblau N, Chase R, Curtis J, Sauler M, Bartholmai B, Silverman E, Hersh C, Castaldi P, Boueiz A. Lung Transcriptomics Links Emphysema to Barrier Dysfunction and Macrophage Subpopulations. American Journal Of Respiratory And Critical Care Medicine 2024 PMID: 38935868, DOI: 10.1164/rccm.202305-0793oc.Peer-Reviewed Original ResearchRNA sequencing dataAlternative splicingExpressed genesFunctional pathwaysCell typesBiological pathwaysGene expressionTranscriptomic featuresGene regulatory processesDysregulated pathwaysSingle-cell RNA sequencing dataRNA-seq analysisLung cell typesLung Tissue Research ConsortiumTranscriptome analysisGenesCell-typeDifferential expressionMultiple lung cell typesPathway activationTranscriptomic signaturesPathway dysregulationRegulatory processesSplicingPathway
2013
Lung endothelial HO‐1 targeting in vivo using lentiviral miRNA regulates apoptosis and autophagy during oxidant injury
Zhang Y, Jiang G, Sauler M, Lee PJ. Lung endothelial HO‐1 targeting in vivo using lentiviral miRNA regulates apoptosis and autophagy during oxidant injury. The FASEB Journal 2013, 27: 4041-4058. PMID: 23771928, PMCID: PMC4046184, DOI: 10.1096/fj.13-231225.Peer-Reviewed Original ResearchConceptsEndothelial HO-1Murine lung endothelial cellsHO-1Lung endotheliumHeme oxygenase-1 inductionHO-1 knockdownLung endothelial cellsOxygenase-1 inductionLung cell typesLung injuryWT miceMultiple lung cell typesVascular endothelium cadherinOxidant injuryCrucial defense mechanismHyperoxiaEndothelial cellsOxidative stressOxidant challengeEndotheliumMajor targetROS generationInjuryLentiviral vectorsVivo