1997
Administration of Methylprednisolone for 24 or 48 Hours or Tirilazad Mesylate for 48 Hours in the Treatment of Acute Spinal Cord Injury: Results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial
Bracken M, Shepard M, Holford T, Leo-Summers L, Aldrich E, Fazl M, Fehlings M, Herr D, Hitchon P, Marshall L, Nockels R, Pascale V, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H, Young W. Administration of Methylprednisolone for 24 or 48 Hours or Tirilazad Mesylate for 48 Hours in the Treatment of Acute Spinal Cord Injury: Results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial. JAMA 1997, 277: 1597-1604. DOI: 10.1001/jama.1997.03540440031029.Peer-Reviewed Original ResearchAcute spinal cord injurySpinal cord injuryNational Acute Spinal Cord Injury StudyFunctional Independence MeasureHours of injuryCord injuryTirilazad groupRegimen groupTirilazad mesylateMethylprednisolone infusionAcute Spinal Cord Injury StudySpinal Cord Injury StudySpinal cord injury centerEfficacy of methylprednisoloneImproved motor recoveryMotor recovery rateAdministration of methylprednisoloneMotor function changesSteroid therapyMethylprednisolone groupSevere sepsisMotor recoveryControlled TrialsInitial presentationIntravenous bolusAdministration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. Results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial. National Acute Spinal Cord Injury Study.
Bracken MB, Shepard MJ, Holford TR, Leo-Summers L, Aldrich EF, Fazl M, Fehlings M, Herr DL, Hitchon PW, Marshall LF, Nockels RP, Pascale V, Perot PL, Piepmeier J, Sonntag VK, Wagner F, Wilberger JE, Winn HR, Young W. Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. Results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial. National Acute Spinal Cord Injury Study. JAMA 1997, 277: 1597-604. PMID: 9168289, DOI: 10.1001/jama.277.20.1597.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryNational Acute Spinal Cord Injury StudyFunctional Independence MeasureHours of injuryCord injuryTirilazad groupRegimen groupMethylprednisolone infusionAcute Spinal Cord Injury StudySpinal Cord Injury StudySpinal cord injury centerEfficacy of methylprednisoloneImproved motor recoveryMotor recovery rateAdministration of methylprednisoloneMotor function changesSteroid therapyMethylprednisolone groupSevere sepsisTirilazad mesylateMotor recoveryControlled TrialsInitial presentationIntravenous bolus
1992
Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. Results of the second National Acute Spinal Cord Injury Study.
Bracken M, Shepard M, Collins W, Holford T, Baskin D, Eisenberg H, Flamm E, Leo-Summers L, Maroon J, Marshall L, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H, Young W. Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. Results of the second National Acute Spinal Cord Injury Study. Journal Of Neurosurgery 1992, 76: 23-31. PMID: 1727165, DOI: 10.3171/jns.1992.76.1.0023.Peer-Reviewed Original ResearchConceptsHours of injuryAcute spinal cord injurySpinal cord injuryNaloxone treatmentCord injuryMotor functionSecond National Acute Spinal Cord Injury StudyNational Acute Spinal Cord Injury StudyAcute Spinal Cord Injury StudySpinal Cord Injury StudyAcute spinal cord traumaPreservation of motorTrial of methylprednisoloneSpinal cord traumaTotal sensoryPlacebo groupCord traumaNeurological functionStudy doseEmergency roomMethylprednisoloneInjury studiesMortality ratePatientsSensory function