1992
Oxygen transport during anemic hypoxia in pigs: effects of digoxin on metabolism
Saltiel A, Sanfilippo DJ, Hendler R, Lister G. Oxygen transport during anemic hypoxia in pigs: effects of digoxin on metabolism. American Journal Of Physiology 1992, 263: h208-h217. PMID: 1636760, DOI: 10.1152/ajpheart.1992.263.1.h208.Peer-Reviewed Original ResearchConceptsTissue hypoxiaO2 extractionBlood flowHigh-output cardiac failureWhole-body O2 consumptionO2 deficitFemoral venous lactateNormal ventricular functionEffect of digoxinHindlimb blood flowRelease of catecholaminesWhole bodyO2 consumptionDigoxin groupCatecholamine responsesSerum catecholaminesVenous lactateCardiac failureVentricular functionArterial lactateSevere anemiaCardiac outputCatecholamine secretionAnemic hypoxiaO2 demand
1982
Physiologic Effects of Increasing Hemoglobin Concentration in Left-to-Right Shunting in Infants with Ventricular Septal Defects
Lister G, Hellenbrand W, Kleinman C, Talner N. Physiologic Effects of Increasing Hemoglobin Concentration in Left-to-Right Shunting in Infants with Ventricular Septal Defects. New England Journal Of Medicine 1982, 306: 502-506. PMID: 7057857, DOI: 10.1056/nejm198203043060902.Peer-Reviewed Original ResearchConceptsPulmonary vascular resistanceVentricular septal defectRight shuntVascular resistanceHemoglobin concentrationSeptal defectBlood flowLarge ventricular septal defectLeft ventricular stroke workSystemic blood flowVentricular stroke workPulmonary blood flowSystemic oxygen transportIsovolemic exchange transfusionHigher hemoglobin concentrationRight shuntingExchange transfusionStroke workClinical signsAcute effectsPhysiologic effectsSystemic circulationPostnatal declineIsolated circulationNormal fall