1992
Oxygen transport during anemic hypoxia in pigs: effects of digoxin on metabolism
Saltiel A, Sanfilippo DJ, Hendler R, Lister G. Oxygen transport during anemic hypoxia in pigs: effects of digoxin on metabolism. American Journal Of Physiology 1992, 263: h208-h217. PMID: 1636760, DOI: 10.1152/ajpheart.1992.263.1.h208.Peer-Reviewed Original ResearchConceptsTissue hypoxiaO2 extractionBlood flowHigh-output cardiac failureWhole-body O2 consumptionO2 deficitFemoral venous lactateNormal ventricular functionEffect of digoxinHindlimb blood flowRelease of catecholaminesWhole bodyO2 consumptionDigoxin groupCatecholamine responsesSerum catecholaminesVenous lactateCardiac failureVentricular functionArterial lactateSevere anemiaCardiac outputCatecholamine secretionAnemic hypoxiaO2 demand
1988
Hypoxanthine and lactate concentrations in lambs during hypoxic and stagnant hypoxia
Moss M, Kurzner S, Razlog Y, Lister G. Hypoxanthine and lactate concentrations in lambs during hypoxic and stagnant hypoxia. American Journal Of Physiology 1988, 255: h53-h59. PMID: 3394825, DOI: 10.1152/ajpheart.1988.255.1.h53.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAnimalsCardiac OutputHypoxanthineHypoxanthinesHypoxiaLactatesLactic AcidOxygen ConsumptionSheepConceptsLow cardiac outputCardiac outputForms of hypoxiaPlasma hypoxanthineTissue hypoxiaO2 deficitHypoxanthine concentrationsPlasma hypoxanthine concentrationBlood lactate concentrationO2 deprivationRate of eliminationHypoxic hypoxiaKetamine sedationStagnant hypoxiaReliable markerHypoxemiaLactate concentrationHypoxiaComparable reductionDeficitsMarkersHypoxanthineO2 transportDeprivationLambs
1987
Oxygen Transport and Metabolism in the Conscious Lamb: The Effects of Hypoxemia
Moss M, Moreau G, Lister G. Oxygen Transport and Metabolism in the Conscious Lamb: The Effects of Hypoxemia. Pediatric Research 1987, 22: 177-183. PMID: 3658543, DOI: 10.1203/00006450-198708000-00016.Peer-Reviewed Original ResearchConceptsSystemic O2 transportRespiratory exchange ratioBase deficitLactate concentrationArterial blood lactate concentrationAge groupsO2 consumptionExchange ratioEffects of hypoxemiaBlood lactate concentrationO2 transportAge related differencesConscious lambsSevere hypoxemiaAlveolar hypoxiaTissue hypoxiaAccumulation of lactateBaseline valuesBlood lactateHypoxemiaNewborn lambsMetabolic consequencesMetabolic responseHypoxiaRelated differences
1985
A simple method for reducing cardiac output in the conscious lamb
Fahey J, Lister G. A simple method for reducing cardiac output in the conscious lamb. American Journal Of Physiology 1985, 249: h188-h192. PMID: 4014483, DOI: 10.1152/ajpheart.1985.249.1.h188.Peer-Reviewed Original ResearchConceptsCardiac outputBalloon inflationBalloon-tipped catheterSystemic venous returnArterial lactate concentrationSystemic blood flowResting cardiac outputSmall neck incisionStable cardiac outputDays of ageUnsedated lambsConscious lambsBlood pressureVenous returnBalloon deflationNeck incisionRight atriumJugular veinMetabolic variablesO2 extractionBlood flowAnimal survivalLactate concentrationO2 consumptionLambs