1992
Oxygen transport during anemic hypoxia in pigs: effects of digoxin on metabolism
Saltiel A, Sanfilippo DJ, Hendler R, Lister G. Oxygen transport during anemic hypoxia in pigs: effects of digoxin on metabolism. American Journal Of Physiology 1992, 263: h208-h217. PMID: 1636760, DOI: 10.1152/ajpheart.1992.263.1.h208.Peer-Reviewed Original ResearchConceptsTissue hypoxiaO2 extractionBlood flowHigh-output cardiac failureWhole-body O2 consumptionO2 deficitFemoral venous lactateNormal ventricular functionEffect of digoxinHindlimb blood flowRelease of catecholaminesWhole bodyO2 consumptionDigoxin groupCatecholamine responsesSerum catecholaminesVenous lactateCardiac failureVentricular functionArterial lactateSevere anemiaCardiac outputCatecholamine secretionAnemic hypoxiaO2 demand
1989
Response to Low Cardiac Output: Developmental Differences in Metabolism during Oxygen Deficit and Recovery in Lambs
Fahey J, Lister G. Response to Low Cardiac Output: Developmental Differences in Metabolism during Oxygen Deficit and Recovery in Lambs. Pediatric Research 1989, 26: 180-187. PMID: 2587117, DOI: 10.1203/00006450-198909000-00003.Peer-Reviewed Original ResearchConceptsLow cardiac outputCardiac outputAge groupsPulmonary artery blood pressureO2 deficitOld lambsO2 consumptionArtery blood pressureArterial lactate concentrationMin of recoveryRespective study periodsVenous HbBlood pressureFoley catheterRight atriumO2 saturationLactate concentrationStudy periodYoung lambsAge 2Potential mechanismsYoung animalsHypoxic stressComparable deficitsMetabolic demands
1988
Hypoxanthine and lactate concentrations in lambs during hypoxic and stagnant hypoxia
Moss M, Kurzner S, Razlog Y, Lister G. Hypoxanthine and lactate concentrations in lambs during hypoxic and stagnant hypoxia. American Journal Of Physiology 1988, 255: h53-h59. PMID: 3394825, DOI: 10.1152/ajpheart.1988.255.1.h53.Peer-Reviewed Original ResearchConceptsLow cardiac outputCardiac outputForms of hypoxiaPlasma hypoxanthineTissue hypoxiaO2 deficitHypoxanthine concentrationsPlasma hypoxanthine concentrationBlood lactate concentrationO2 deprivationRate of eliminationHypoxic hypoxiaKetamine sedationStagnant hypoxiaReliable markerHypoxemiaLactate concentrationHypoxiaComparable reductionDeficitsMarkersHypoxanthineO2 transportDeprivationLambs