1997
Hepatic and Gastrointestinal Oxygen and Lactate Metabolism during Low Cardiac Output in Lambs
Fahey J, Lister G, Sanfilippo D, Edelstone D. Hepatic and Gastrointestinal Oxygen and Lactate Metabolism during Low Cardiac Output in Lambs. Pediatric Research 1997, 41: 842-851. PMID: 9167197, DOI: 10.1203/00006450-199706000-00008.Peer-Reviewed Original ResearchConceptsHepatic lactate uptakeHepatic O2 deliveryCardiac outputO2 deliveryHepatic O2 consumptionLactate uptakeLactate accumulationLactic acidosisGI tractNet hepatic lactate uptakeLow cardiac outputGastrointestinal blood flowYoung lambsSystemic O2 deliveryLactate productionExtraction of lactateGreater percent decreaseNet lactate productionO2 consumptionConscious lambsHepatic dysfunctionLactate deliveryO2/minBlood flowAdult subjects
1992
Oxygen transport during anemic hypoxia in pigs: effects of digoxin on metabolism
Saltiel A, Sanfilippo DJ, Hendler R, Lister G. Oxygen transport during anemic hypoxia in pigs: effects of digoxin on metabolism. American Journal Of Physiology 1992, 263: h208-h217. PMID: 1636760, DOI: 10.1152/ajpheart.1992.263.1.h208.Peer-Reviewed Original ResearchConceptsTissue hypoxiaO2 extractionBlood flowHigh-output cardiac failureWhole-body O2 consumptionO2 deficitFemoral venous lactateNormal ventricular functionEffect of digoxinHindlimb blood flowRelease of catecholaminesWhole bodyO2 consumptionDigoxin groupCatecholamine responsesSerum catecholaminesVenous lactateCardiac failureVentricular functionArterial lactateSevere anemiaCardiac outputCatecholamine secretionAnemic hypoxiaO2 demand
1989
Response to Low Cardiac Output: Developmental Differences in Metabolism during Oxygen Deficit and Recovery in Lambs
Fahey J, Lister G. Response to Low Cardiac Output: Developmental Differences in Metabolism during Oxygen Deficit and Recovery in Lambs. Pediatric Research 1989, 26: 180-187. PMID: 2587117, DOI: 10.1203/00006450-198909000-00003.Peer-Reviewed Original ResearchConceptsLow cardiac outputCardiac outputAge groupsPulmonary artery blood pressureO2 deficitOld lambsO2 consumptionArtery blood pressureArterial lactate concentrationMin of recoveryRespective study periodsVenous HbBlood pressureFoley catheterRight atriumO2 saturationLactate concentrationStudy periodYoung lambsAge 2Potential mechanismsYoung animalsHypoxic stressComparable deficitsMetabolic demandsEffect of hemoglobin concentration on critical cardiac output and oxygen transport
Heusser F, Fahey JT, Lister G. Effect of hemoglobin concentration on critical cardiac output and oxygen transport. American Journal Of Physiology 1989, 256: h527-h532. PMID: 2916686, DOI: 10.1152/ajpheart.1989.256.2.h527.Peer-Reviewed Original ResearchConceptsSystemic O2 transportPeripheral O2 extractionCardiac outputO2 extractionFractional O2 extractionHemoglobin concentrationArterial blood lactate concentrationBase-line cardiac outputBalloon-tipped catheterPacked red cellsBlood lactate concentrationO2 transportPhysiological anaemiaExchange transfusionAcute reductionRight atriumVenous PO2Relative anemiaLactate concentrationOld lambsRed cellsAnemiaProgressive decreaseBase lineO2 consumption
1987
Oxygen Transport and Metabolism in the Conscious Lamb: The Effects of Hypoxemia
Moss M, Moreau G, Lister G. Oxygen Transport and Metabolism in the Conscious Lamb: The Effects of Hypoxemia. Pediatric Research 1987, 22: 177-183. PMID: 3658543, DOI: 10.1203/00006450-198708000-00016.Peer-Reviewed Original ResearchConceptsSystemic O2 transportRespiratory exchange ratioBase deficitLactate concentrationArterial blood lactate concentrationAge groupsO2 consumptionExchange ratioEffects of hypoxemiaBlood lactate concentrationO2 transportAge related differencesConscious lambsSevere hypoxemiaAlveolar hypoxiaTissue hypoxiaAccumulation of lactateBaseline valuesBlood lactateHypoxemiaNewborn lambsMetabolic consequencesMetabolic responseHypoxiaRelated differences
1985
A simple method for reducing cardiac output in the conscious lamb
Fahey J, Lister G. A simple method for reducing cardiac output in the conscious lamb. American Journal Of Physiology 1985, 249: h188-h192. PMID: 4014483, DOI: 10.1152/ajpheart.1985.249.1.h188.Peer-Reviewed Original ResearchConceptsCardiac outputBalloon inflationBalloon-tipped catheterSystemic venous returnArterial lactate concentrationSystemic blood flowResting cardiac outputSmall neck incisionStable cardiac outputDays of ageUnsedated lambsConscious lambsBlood pressureVenous returnBalloon deflationNeck incisionRight atriumJugular veinMetabolic variablesO2 extractionBlood flowAnimal survivalLactate concentrationO2 consumptionLambs