1997
Venous and arterial reflex responses to positive-pressure breathing and lower body negative pressure
Peters J, Lister G, Nadel E, Mack G. Venous and arterial reflex responses to positive-pressure breathing and lower body negative pressure. Journal Of Applied Physiology 1997, 82: 1889-1896. PMID: 9173955, DOI: 10.1152/jappl.1997.82.6.1889.Peer-Reviewed Original ResearchConceptsRight atrial transmural pressureAtrial transmural pressureVascular resistanceCardiac outputReflex responsesLower body negative pressureVenous reflex responseForearm vascular resistanceSystemic vascular resistanceTransmural pressurePositive pressure breathingBody negative pressureVenomotor responsesVenous responsesArterial pressureVenous engorgementHealthy subjectsVenous fillingLBNPPEEPSustained increaseTissue 1Comparable reductionGreater reductionMmHgHepatic and Gastrointestinal Oxygen and Lactate Metabolism during Low Cardiac Output in Lambs
Fahey J, Lister G, Sanfilippo D, Edelstone D. Hepatic and Gastrointestinal Oxygen and Lactate Metabolism during Low Cardiac Output in Lambs. Pediatric Research 1997, 41: 842-851. PMID: 9167197, DOI: 10.1203/00006450-199706000-00008.Peer-Reviewed Original ResearchConceptsHepatic lactate uptakeHepatic O2 deliveryCardiac outputO2 deliveryHepatic O2 consumptionLactate uptakeLactate accumulationLactic acidosisGI tractNet hepatic lactate uptakeLow cardiac outputGastrointestinal blood flowYoung lambsSystemic O2 deliveryLactate productionExtraction of lactateGreater percent decreaseNet lactate productionO2 consumptionConscious lambsHepatic dysfunctionLactate deliveryO2/minBlood flowAdult subjects
1992
Oxygen transport during anemic hypoxia in pigs: effects of digoxin on metabolism
Saltiel A, Sanfilippo DJ, Hendler R, Lister G. Oxygen transport during anemic hypoxia in pigs: effects of digoxin on metabolism. American Journal Of Physiology 1992, 263: h208-h217. PMID: 1636760, DOI: 10.1152/ajpheart.1992.263.1.h208.Peer-Reviewed Original ResearchConceptsTissue hypoxiaO2 extractionBlood flowHigh-output cardiac failureWhole-body O2 consumptionO2 deficitFemoral venous lactateNormal ventricular functionEffect of digoxinHindlimb blood flowRelease of catecholaminesWhole bodyO2 consumptionDigoxin groupCatecholamine responsesSerum catecholaminesVenous lactateCardiac failureVentricular functionArterial lactateSevere anemiaCardiac outputCatecholamine secretionAnemic hypoxiaO2 demand
1989
Response to Low Cardiac Output: Developmental Differences in Metabolism during Oxygen Deficit and Recovery in Lambs
Fahey J, Lister G. Response to Low Cardiac Output: Developmental Differences in Metabolism during Oxygen Deficit and Recovery in Lambs. Pediatric Research 1989, 26: 180-187. PMID: 2587117, DOI: 10.1203/00006450-198909000-00003.Peer-Reviewed Original ResearchConceptsLow cardiac outputCardiac outputAge groupsPulmonary artery blood pressureO2 deficitOld lambsO2 consumptionArtery blood pressureArterial lactate concentrationMin of recoveryRespective study periodsVenous HbBlood pressureFoley catheterRight atriumO2 saturationLactate concentrationStudy periodYoung lambsAge 2Potential mechanismsYoung animalsHypoxic stressComparable deficitsMetabolic demandsEffect of hemoglobin concentration on critical cardiac output and oxygen transport
Heusser F, Fahey JT, Lister G. Effect of hemoglobin concentration on critical cardiac output and oxygen transport. American Journal Of Physiology 1989, 256: h527-h532. PMID: 2916686, DOI: 10.1152/ajpheart.1989.256.2.h527.Peer-Reviewed Original ResearchConceptsSystemic O2 transportPeripheral O2 extractionCardiac outputO2 extractionFractional O2 extractionHemoglobin concentrationArterial blood lactate concentrationBase-line cardiac outputBalloon-tipped catheterPacked red cellsBlood lactate concentrationO2 transportPhysiological anaemiaExchange transfusionAcute reductionRight atriumVenous PO2Relative anemiaLactate concentrationOld lambsRed cellsAnemiaProgressive decreaseBase lineO2 consumption
1988
Hypoxanthine and lactate concentrations in lambs during hypoxic and stagnant hypoxia
Moss M, Kurzner S, Razlog Y, Lister G. Hypoxanthine and lactate concentrations in lambs during hypoxic and stagnant hypoxia. American Journal Of Physiology 1988, 255: h53-h59. PMID: 3394825, DOI: 10.1152/ajpheart.1988.255.1.h53.Peer-Reviewed Original ResearchConceptsLow cardiac outputCardiac outputForms of hypoxiaPlasma hypoxanthineTissue hypoxiaO2 deficitHypoxanthine concentrationsPlasma hypoxanthine concentrationBlood lactate concentrationO2 deprivationRate of eliminationHypoxic hypoxiaKetamine sedationStagnant hypoxiaReliable markerHypoxemiaLactate concentrationHypoxiaComparable reductionDeficitsMarkersHypoxanthineO2 transportDeprivationLambs
1987
Postnatal changes in critical cardiac output and oxygen transport in conscious lambs
Fahey J, Lister G. Postnatal changes in critical cardiac output and oxygen transport in conscious lambs. American Journal Of Physiology 1987, 253: h100-h106. PMID: 3605355, DOI: 10.1152/ajpheart.1987.253.1.h100.Peer-Reviewed Original ResearchConceptsSystemic oxygen transportCardiac outputFractional oxygen extractionOxygen extractionOld lambsBalloon-tipped catheterSystemic oxygen deliveryBase-line valuesWk of ageIncremental inflationUnsedated lambsConscious lambsBlood pressureArterial lactateRight atriumAcute decreaseLactic acid accumulationOxygen deliveryPostnatal changesOxygen transportOxygen consumption
1985
A simple method for reducing cardiac output in the conscious lamb
Fahey J, Lister G. A simple method for reducing cardiac output in the conscious lamb. American Journal Of Physiology 1985, 249: h188-h192. PMID: 4014483, DOI: 10.1152/ajpheart.1985.249.1.h188.Peer-Reviewed Original ResearchConceptsCardiac outputBalloon inflationBalloon-tipped catheterSystemic venous returnArterial lactate concentrationSystemic blood flowResting cardiac outputSmall neck incisionStable cardiac outputDays of ageUnsedated lambsConscious lambsBlood pressureVenous returnBalloon deflationNeck incisionRight atriumJugular veinMetabolic variablesO2 extractionBlood flowAnimal survivalLactate concentrationO2 consumptionLambs