1989
Response to Low Cardiac Output: Developmental Differences in Metabolism during Oxygen Deficit and Recovery in Lambs
Fahey J, Lister G. Response to Low Cardiac Output: Developmental Differences in Metabolism during Oxygen Deficit and Recovery in Lambs. Pediatric Research 1989, 26: 180-187. PMID: 2587117, DOI: 10.1203/00006450-198909000-00003.Peer-Reviewed Original ResearchConceptsLow cardiac outputCardiac outputAge groupsPulmonary artery blood pressureO2 deficitOld lambsO2 consumptionArtery blood pressureArterial lactate concentrationMin of recoveryRespective study periodsVenous HbBlood pressureFoley catheterRight atriumO2 saturationLactate concentrationStudy periodYoung lambsAge 2Potential mechanismsYoung animalsHypoxic stressComparable deficitsMetabolic demands
1987
Oxygen Transport and Metabolism in the Conscious Lamb: The Effects of Hypoxemia
Moss M, Moreau G, Lister G. Oxygen Transport and Metabolism in the Conscious Lamb: The Effects of Hypoxemia. Pediatric Research 1987, 22: 177-183. PMID: 3658543, DOI: 10.1203/00006450-198708000-00016.Peer-Reviewed Original ResearchConceptsSystemic O2 transportRespiratory exchange ratioBase deficitLactate concentrationArterial blood lactate concentrationAge groupsO2 consumptionExchange ratioEffects of hypoxemiaBlood lactate concentrationO2 transportAge related differencesConscious lambsSevere hypoxemiaAlveolar hypoxiaTissue hypoxiaAccumulation of lactateBaseline valuesBlood lactateHypoxemiaNewborn lambsMetabolic consequencesMetabolic responseHypoxiaRelated differencesCorrelation of pulmonary ACE activity and capillary surface area during postnatal development
Pitt B, Lister G, Davies P, Reid L. Correlation of pulmonary ACE activity and capillary surface area during postnatal development. Journal Of Applied Physiology 1987, 62: 2031-2041. PMID: 3036759, DOI: 10.1152/jappl.1987.62.5.2031.Peer-Reviewed Original ResearchConceptsPulmonary ACE activityEndothelial cell surface areaACE activityPostnatal developmentDifferential postnatal developmentPulmonary arterial circulationAge-dependent increaseCO diffusing capacityCell surface areaDays of ageSeptal dimensionAtrial pressureVentilated lambsCapillary surface areaLung volumeArterial circulationAlveolar septaPulmonary microcirculationBenzoyl-phenylalanylFunctional assessmentPulmonary angiotensinDiffusing capacityDLCOAge groupsFunctional manifestations