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Robin de Graaf, PhD

Professor of Radiology and Biomedical Imaging
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Contact Info

Radiology & Biomedical Imaging

PO Box 208042, Tompkin's East 2

New Haven, CT 06520-8042

United States

About

Titles

Professor of Radiology and Biomedical Imaging

Appointments

Other Departments & Organizations

Education & Training

PhD
Utrecht University (1998)
Ph.D. student
Utrecht University (1994)

Research

Overview

The main focus of Dr. Robin de Graaf's research is the study of cerebral energy metabolism and its relationship to functional activation in human and animal brains. NMR spectroscopy (proton, (inverse) carbon-13, oxygen-17 and phosphorus-31) is the most important tool in the study of metabolic processes and fluxes, non-invasively in vivo. Besides studying brain energy metabolism, a significant part of the research is reserved for technological and methodological improvements to the technique of NMR spectroscopy. These include methods for better water suppression, spatial localization, spectral editing, quantification, and shimming. Dr. de Graaf's current research focus covers areas that are all related to tackling the challenges and grasping the opportunities of MR at very high magnetic fields. Developing methods to achieve magnetic field uniformity throughout the human and animal brain are central to the technological innovation of his research. The problem of magnetic field inhomogeneity is tackled through dynamic shimming and through the use of novel electrical coil element arrays. 13C NMR methods have been pioneered at the Yale MRRC and part of his research is to extend those methods to achieve 3D coverage, higher sensitivity (through 1H detection), and higher specificity (e.g., GABA turnover detection).

Software Download:

1. Multi-coil shimming of the human brain at 7 T.

2. 3D metabolic flux mapping on rat brain in situ.

3. Development of 1H[13C] NMR methods at 7 T.

4. Compensation of gradient-related magnetic field perturbations.

5. 1H NMR-based metabolomics.

Medical Subject Headings (MeSH)

Biomedical Engineering; Energy Metabolism; Magnetic Resonance Spectroscopy; Radiology

Research at a Glance

Yale Co-Authors

Frequent collaborators of Robin de Graaf's published research.

Publications

2024

2023

Clinical Trials

Current Trials

Academic Achievements & Community Involvement

  • activity

    NMR at High Magnetic Fields

  • activity

    In vivo NMR spectroscopy at high magnetic fields

  • activity

    Energetic costs associated with glutamatergic and GABAergic neurotransmission

  • activity

    Theory of adiabatic RF pulses

Get In Touch

Contacts

Mailing Address

Radiology & Biomedical Imaging

PO Box 208042, Tompkin's East 2

New Haven, CT 06520-8042

United States