Georges El Fakhri, PhD, DABR
Elizabeth Mears and House Jameson Professor of Radiology and Biomedical Imaging and of Biomedical Informatics & Data ScienceCards
Appointments
Additional Titles
Director, PET Center
Vice Chair Scientific Research, Radiology & Biomedical Imaging
Contact Info
Radiology & Biomedical Imaging
330 Cedar ST, P.O. Box 208042
New Haven, CT 06520
United States
Appointments
Additional Titles
Director, PET Center
Vice Chair Scientific Research, Radiology & Biomedical Imaging
Contact Info
Radiology & Biomedical Imaging
330 Cedar ST, P.O. Box 208042
New Haven, CT 06520
United States
Appointments
Additional Titles
Director, PET Center
Vice Chair Scientific Research, Radiology & Biomedical Imaging
Contact Info
Radiology & Biomedical Imaging
330 Cedar ST, P.O. Box 208042
New Haven, CT 06520
United States
About
Titles
Elizabeth Mears and House Jameson Professor of Radiology and Biomedical Imaging and of Biomedical Informatics & Data Science
Director, PET Center; Vice Chair Scientific Research, Radiology & Biomedical Imaging
Appointments
Biomedical Informatics & Data Science
ProfessorFully JointRadiology & Biomedical Imaging
ProfessorFully Joint
Other Departments & Organizations
- Bioimaging Sciences
- Biomedical Informatics & Data Science
- Center for Molecular Imaging Technology and Translation (CMITT)
- MR Center
- Positron Emission Tomography (PET)
- Radiology & Biomedical Imaging
Education & Training
- PhD
- University of Paris XI, Medical Physics
- MMSc
- University of Paris XI, Physiology, Neuroscience
- MSc
- University of Paris XI, Biomedical Engineering
- MSc
- University of Texas, Electrical & Computer Eng.
- ME
- Ecole Centrale, Electronics, Mechanics
Research
Research at a Glance
Yale Co-Authors
Marc David Normandin, PhD
Xiaofeng Liu
Publications
2023
Association of Pathologic and Volumetric Biomarker Changes With Cognitive Decline in Clinically Normal Adults
Hanseeuw B, Jacobs H, Schultz A, Buckley R, Farrell M, Guehl N, Becker J, Properzi M, Sanchez J, Quiroz Y, Vannini P, Sepulcre J, Yang H, Chhatwal J, Gatchel J, Marshall G, Amariglio R, Papp K, Rentz D, Normandin M, Price J, Healy B, El Fakhri G, Sperling R, Johnson K. Association of Pathologic and Volumetric Biomarker Changes With Cognitive Decline in Clinically Normal Adults. Neurology 2023, 101: e2533-e2544. PMID: 37968130, PMCID: PMC10791053, DOI: 10.1212/wnl.0000000000207962.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAssociated with cognitive declineOlder adultsNon-AD pathologyCognitive declineHippocampal volumeCognitive dataPreclinical Alzheimer Cognitive CompositeInferior temporal tauProspective cohort studyClinically normal older adultsHarvard Aging Brain StudyPittsburgh compound B PET scansOvert cognitive impairmentAnalyzed dataNormal older adultsAging Brain StudyClinically normal adultsLongitudinal associationsAlzheimer's diseaseCohort studyMemory impairmentCognitive compositeCognitive impairmentHippocampal atrophyCognitionTau Positron Emission Tomography and Neurocognitive Function Among Former Professional American-Style Football Players
Dhaynaut M, Grashow R, Normandin M, Wu O, Marengi D, Terry D, Sanchez J, Weisskopf M, Speizer F, Taylor H, Guehl N, Seshadri S, Beiser A, Daneshvar D, Johnson K, Iverson G, Zafonte R, Fakhri G, Baggish A. Tau Positron Emission Tomography and Neurocognitive Function Among Former Professional American-Style Football Players. Journal Of Neurotrauma 2023, 40: 1614-1624. PMID: 37282582, PMCID: PMC10458363, DOI: 10.1089/neu.2022.0454.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPositron emission tomographyDistribution volume ratioNeuropsychological testsNeurocognitive functionStandardized uptake value ratioControl participantsMeasures of neurocognitive functionStructural magnetic resonance imagingMeasures of memoryDepressive symptom severityMale control participantsEmission tomographyCerebellar gray matterNeuropsychological measuresTau positron emission tomographyExecutive functionSymptom severityBrain regionsEntorhinal cortexRepetitive head impactsP-tauReference regionFormer playersRepetitive head impact exposureMale controls
2022
Structure-aware unsupervised tagged-to-cine MRI synthesis with self disentanglement
Liu X, Xing F, Prince J, Stone M, El Fakhri G, Woo J. Structure-aware unsupervised tagged-to-cine MRI synthesis with self disentanglement. Proceedings Of SPIE--the International Society For Optical Engineering 2022, 12032: 120321q-120321q-7. PMID: 36203947, PMCID: PMC9533681, DOI: 10.1117/12.2610655.Peer-Reviewed Original ResearchCitationsConceptsStructure feature extractorImage style transferSelf-training schemeStyle transferFeature extractorAdversarial gameSynthesized imagesInformation w.Superior performanceStructural consistencyTask-specificCycle reconstructionStructural encodingImagesDiscoGANCycleGANEncodingExtractorExtraction stepNetworkSchemeGameInputUnsupervised domain adaptation for segmentation with black-box source model
Liu X, Yoo C, Xing F, Kuo C, El Fakhri G, Kang J, Woo J. Unsupervised domain adaptation for segmentation with black-box source model. Proceedings Of SPIE--the International Society For Optical Engineering 2022, 12032: 1203210-1203210-6. PMID: 35983176, PMCID: PMC9385170, DOI: 10.1117/12.2607895.Peer-Reviewed Original ResearchCitationsConceptsUnsupervised domain adaptationSource domainDomain adaptationTarget-specific representationsLabeled source domainUnlabeled target domainTarget domain dataWell-labeled dataKnowledge distillation schemeTrained model parametersModel adaptation approachOriginal source dataDifficulty of labelingTarget domainSegmentation modelDomain dataTransfer knowledgeEntropy minimizationAdaptive approachSource dataConventional solutionsPractical solutionDistillation schemePrivacyLarge-scale
2020
Positron annihilation localization by nanoscale magnetization
Gholami Y, Yuan H, Wilks M, Josephson L, El Fakhri G, Normandin M, Kuncic Z. Positron annihilation localization by nanoscale magnetization. Scientific Reports 2020, 10: 20262. PMID: 33219274, PMCID: PMC7680104, DOI: 10.1038/s41598-020-76980-9.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsNanoscale magnetsSpatial resolution of PET imagesImproved dose localizationPositron emitting sourcesResolution of PET imagesPositron emission tomography instrumentationSpatial resolutionPositron emission tomographyAnnihilation quantaPhoton pairsPositron rangeDose localizationPositron annihilationCharged particlesOrtho-positroniumAnnihilationSuperparamagnetic iron oxide nanoparticlesCancer theranostic strategyPositron emission tomography scanPositronElectronic placesImage blurringPET imagingPET-MRITreatment outcomesIn vivo quantification of mitochondrial membrane potential
Alpert N, Pelletier-Galarneau M, Petibon Y, Normandin M, El Fakhri G. In vivo quantification of mitochondrial membrane potential. Nature 2020, 583: e17-e18. PMID: 32641811, PMCID: PMC7357846, DOI: 10.1038/s41586-020-2366-x.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords
Get In Touch
Contacts
Radiology & Biomedical Imaging
330 Cedar ST, P.O. Box 208042
New Haven, CT 06520
United States