2024
The role of parvalbumin interneuron dysfunction across neurodegenerative dementias
Smeralda C, Pandit S, Turrini S, Reilly J, Palmisano A, Sprugnoli G, Hampel H, Benussi A, Borroni B, Press D, Rotenberg A, El Fakhri G, Koch G, Rossi S, Santarnecchi E. The role of parvalbumin interneuron dysfunction across neurodegenerative dementias. Ageing Research Reviews 2024, 102509. PMID: 39306248, DOI: 10.1016/j.arr.2024.102509.Peer-Reviewed Original ResearchInterneuron dysfunctionCortical hyperexcitabilityTherapeutic targetCortical excitation/inhibition balanceRhythm disruptionFast-spikingPV+ cellsBasket neuronsPotential therapeutic targetInhibitory interneuronsExcitation/inhibition balanceOscillatory disruptionsSymptom onsetNovel biomarkersHyperexcitabilityDysfunctionNeuronal deathOscillatory activityDementia with Lewy bodiesPathophysiological frameworkClinical symptom onsetFrontotemporal dementiaDesign Optimisation of a Flat-Panel, Limited-Angle TOF-PET Scanner: A Simulation Study
Orehar M, Dolenec R, Fakhri G, Korpar S, Križan P, Razdevšek G, Marin T, Žontar D, Pestotnik R. Design Optimisation of a Flat-Panel, Limited-Angle TOF-PET Scanner: A Simulation Study. Diagnostics 2024, 14: 1976. PMID: 39272760, DOI: 10.3390/diagnostics14171976.Peer-Reviewed Original ResearchTime-of-flight positron emission tomographyTOF-PET scannerNEMA NU 2Evaluate spatial resolutionPET detectorsNU 2Scintillation materialsBiograph VisionRing scannerLimited-angleScanner designReadout levelsPoint sourcesFlat panel geometryClinical scannerSpatial resolutionReadout strategySingle-crystalImage qualityScintillationScannerFlat panelDesign parametersDetectorDesign optimisationInvestigating muscle coordination patterns with Granger causality analysis in protrusive motion from tagged and diffusion MRI
Park H, Xing F, Stone M, Kang H, Liu X, Zhuo J, Fels S, Reese T, Wedeen V, Fakhri G, Prince J, Woo J. Investigating muscle coordination patterns with Granger causality analysis in protrusive motion from tagged and diffusion MRI. JASA Express Letters 2024, 4: 095201. PMID: 39240196, PMCID: PMC11384280, DOI: 10.1121/10.0028500.Peer-Reviewed Original ResearchThe United States Department of Energy and National Institutes of Health Collaboration: Medical Care Advances by Discovery in Radiation Detection
Buchsbaum J, Capala J, Obcemea C, Keppel C, Asai M, Chen G, Christy M, Fakhri G, Gueye P, Pogue B, Ruckman L, Tourassi G, Vetter K, Zhao W, Squires A, Saboury B, Wang G, Domurat‐Sousa K, Weisenberger A. The United States Department of Energy and National Institutes of Health Collaboration: Medical Care Advances by Discovery in Radiation Detection. Medical Physics 2024 PMID: 39177300, DOI: 10.1002/mp.17333.Peer-Reviewed Original ResearchNational Institutes of HealthState-of-the-artApplication of artificial intelligenceDOE Office of ScienceArtificial intelligenceMedical care advancesImage reconstructionIn-person workshopsOffice of ScienceRadiation detectionHealth collaborationInstitutes of HealthCare advancesIn-personAreas of successEffects of List-Mode Based Intra-Frame Motion Correction in Dynamic Brain PET Imaging
Tiss A, Chemli Y, Guehl N, Marin T, Johnson K, Fakhri G, Ouyang J. Effects of List-Mode Based Intra-Frame Motion Correction in Dynamic Brain PET Imaging. IEEE Transactions On Radiation And Plasma Medical Sciences 2024, PP: 1-1. DOI: 10.1109/trpms.2024.3432322.Peer-Reviewed Original ResearchAssociations of cerebral amyloid beta and tau with cognition from midlife
Gonzales M, O'Donnell A, Ghosh S, Thibault E, Tanner J, Satizabal C, Decarli C, Fakhri G, Johnson K, Beiser A, Seshadri S, Pase M. Associations of cerebral amyloid beta and tau with cognition from midlife. Alzheimer's & Dementia 2024 PMID: 39039896, DOI: 10.1002/alz.14060.Peer-Reviewed Original ResearchApolipoprotein E e4Associated with cognitionTau positron emission tomographyPositron emission tomographyWorsening cognitionCommunity-based cohortYoung adultsApolipoprotein EStudy investigated associationsPoor visuospatial skillsDementia preventionTargeted early interventionE4 statusCerebral amyloid-betaEffect modifiersHigher amyloidAPOE e4 carriersCognitive vulnerabilityAssociation of amyloidVisuospatial skillsResilience factorsEarly interventionYounger ageCognitionE4 carriersAdvances and Insights in Positron Emission Tomography Tracers for Metabotropic Glutamate Receptor 4 Imaging
Wang J, Li Y, Fakhri G. Advances and Insights in Positron Emission Tomography Tracers for Metabotropic Glutamate Receptor 4 Imaging. Journal Of Medicinal Chemistry 2024, 67: 10517-10529. PMID: 38924702, PMCID: PMC11290609, DOI: 10.1021/acs.jmedchem.3c02431.Peer-Reviewed Original ResearchConceptsPositive allosteric modulatorsPositron emission tomographyPositron emission tomography radioligandsAllosteric modulatorsMGluR4 positive allosteric modulatorsMetabotropic glutamate receptor subtype 4PET ligandNeurological disordersPositron emission tomography tracersEmission tomographySubtype 4Molecular imaging modalitiesEffective treatmentMetabotropicDisordersParent drugImaging modalitiesPET tracersMGluR4Therapeutic targetPositron emitting radioisotopesSelection of lead compoundsLiving subjectsPositronQuantitative accuracyAccelerated 3D metabolite T1 mapping of the brain using variable‐flip‐angle SPICE
Zhao Y, Li Y, Guo R, Jin W, Sutton B, Ma C, Fakhri G, Li Y, Luo J, Liang Z. Accelerated 3D metabolite T1 mapping of the brain using variable‐flip‐angle SPICE. Magnetic Resonance In Medicine 2024, 92: 1310-1322. PMID: 38923032, DOI: 10.1002/mrm.30200.Peer-Reviewed Original ResearchConceptsLow-rank tensor modelGeneralized series modelMetabolite TExperimental resultsBrain metabolitesClinically acceptable scan timeEfficient encodingPhantom experimental resultsAcceptable scan timeNoisy dataSparse samplingImaging problemsData processingHealthy subject dataVariable flip angleFlip angleTensor modelSaturation effectsQuantitative metabolic imagingMRSI techniquePhantomScan timeData acquisitionMetabolic imagingT1 mappingAssociation of T-cell subtypes with macrophage-specific arterial infiltration in PWH.
Schnittman S, Talathi R, Wilks M, Hedgire S, Lu M, Fourman L, Alagpulinsa D, Stockman S, White K, Wallis Z, Autissier P, Stanley T, Lee H, Honigberg M, El-Fakhri G, Williams K, Zanni M, Grinspoon S, Toribio M. Association of T-cell subtypes with macrophage-specific arterial infiltration in PWH. AIDS 2024 PMID: 38905489, DOI: 10.1097/qad.0000000000003967.Peer-Reviewed Original ResearchArterial infiltrationCardiovascular diseaseIncreased risk of cardiovascular diseaseHuman immunodeficiency virusT cell subtypesT lymphocyte subpopulationsRisk of cardiovascular diseaseSystemic monocyte activationCardiovascular disease riskImmunodeficiency virusMonocyte activationHIV statusIncreased riskRelevant to atherogenesisHIVInfiltrationGeneral populationPWHEvidence of interactionSubtypesDiseaseSubpopulationsAtherogenesisDiffusion Model-Based Posterior Distribution Prediction for Kinetic Parameter Estimation in Dynamic PET
Djebra Y, Liu X, Marin T, Tiss A, Dhaynaut M, Guehl N, Johnson K, Fakhri G, Ma C, Ouyang J. Diffusion Model-Based Posterior Distribution Prediction for Kinetic Parameter Estimation in Dynamic PET. 2024, 00: 1-5. DOI: 10.1109/isbi56570.2024.10635805.Peer-Reviewed Original ResearchPosterior distributions of kinetic parametersDenoising diffusion probabilistic modelHyperphosphorylated tauP-tauDiffusion probabilistic modelAlzheimer's diseaseNeurodegenerative diseasesKinetic parametersPosterior distributionInference efficiencyComputational needsEstimate kinetic parametersProbabilistic modelComputation timeSparsity Constrained Linear Tangent Space Alignment Model (LTSA) for 3d Cardiac Extracellular Volume Mapping
Mounime I, Lee W, Marin T, Han P, Djebra Y, Eslahi S, Gori P, Angelini E, Fakhri G, Ma C. Sparsity Constrained Linear Tangent Space Alignment Model (LTSA) for 3d Cardiac Extracellular Volume Mapping. 2024, 00: 1-5. DOI: 10.1109/isbi56570.2024.10635692.Peer-Reviewed Original ResearchT)-space dataExtracellular volume mappingIntrinsic low-dimensional manifold structureCardiac tissue propertiesImproved image reconstructionLow-dimensional manifold structureExtracellular volumeFast MRI methodSparsity constraintModel-based methodsSuperior performanceSpace alignmentT1 mappingManifold structureImage reconstructionT)-spacePost-contrast T1 mappingTissue propertiesFree breathingConcentration of contrast agentLongitudinal relaxation timeAlignment modelDynamic MR imagingSparsityAlignment matrixExploring Backdoor Attacks in Off-the-Shelf Unsupervised Domain Adaptation for Securing Cardiac MRI-Based Diagnosis
Liu X, Xing F, Gaggin H, Kuo C, Fakhri G, Woo J. Exploring Backdoor Attacks in Off-the-Shelf Unsupervised Domain Adaptation for Securing Cardiac MRI-Based Diagnosis. 2024, 00: 1-5. DOI: 10.1109/isbi56570.2024.10635403.Peer-Reviewed Original ResearchUnsupervised domain adaptationTarget domain modelBackdoor attacksDomain adaptationTraining dataLabeled source domain dataSusceptible to backdoor attacksAccurate pseudo labelsDomain modelSource domain dataPatient data privacyTarget training dataOff-the-shelfPseudo-labelsData privacySource domainMulti-vendorRandom initializationTraining phaseDomain dataDiagnosis modelTarget modelMulti-diseaseAttacksAuxiliary model593: Using [18F]-FDG PET Radiomics to Predict Survival After Reirradiation in Head and Neck Cancer
Beddok A, Grogg K, Rozenblum L, Nioche C, Orhlac F, Calugaru V, Crehange G, Shih H, Marin T, Fakhri G, Buvat I. 593: Using [18F]-FDG PET Radiomics to Predict Survival After Reirradiation in Head and Neck Cancer. Radiotherapy And Oncology 2024, 194: s1210-s1212. DOI: 10.1016/s0167-8140(24)01168-x.Peer-Reviewed Original ResearchRadiosynthesis automation, non-human primate biodistribution and dosimetry of K+ channel tracer [11C]3MeO4AP
Zhou Y, Wilks M, Dhaynaut M, Guehl N, Vesper D, Moon S, Rice P, El Fakhri G, Normandin M, Brugarolas P. Radiosynthesis automation, non-human primate biodistribution and dosimetry of K+ channel tracer [11C]3MeO4AP. EJNMMI Research 2024, 14: 43. PMID: 38683467, PMCID: PMC11058135, DOI: 10.1186/s13550-024-01092-8.Peer-Reviewed Original ResearchRadiation dosimetryAverage effective doseWhole-body biodistributionTotal scan timeNon-decayEffective doseNon-human primatesSymptomatic treatment of multiple sclerosisIn vivo binding affinityBed positionTreatment of multiple sclerosisHigh-resolution CTDynamic acquisition protocolDosimetryPET dataAdult rhesus macaquesScan timeImaging demyelinationOLINDA softwareRadiationAcquisition protocolsPreclinical studiesNo significant changesHigh dosesPET imagingCross noise level PET denoising with continuous adversarial domain generalization
Liu X, Eslahi S, Marin T, Tiss A, Chemli Y, Huang Y, Johnson K, Fakhri G, Ouyang J. Cross noise level PET denoising with continuous adversarial domain generalization. Physics In Medicine And Biology 2024, 69: 085001. PMID: 38484401, PMCID: PMC11195012, DOI: 10.1088/1361-6560/ad341a.Peer-Reviewed Original ResearchDomain generalization techniqueDomain generalizationDenoising performanceSuperior denoising performanceLatent feature representationGeneral techniqueDistribution shiftsAdversarial trainingDenoised imageFeature representationDomain labelsDistribution divergenceNoise levelDeep learningImage spaceDenoisingPerformance degradationCore ideaNoise realizationsCD methodNoiseImage volumesPerformanceImagesPSNREvaluation of few-shot detection of head and neck anatomy in CT
Lee K, Cho J, Lee J, Xing F, Liu X, Bae H, Lee K, Hwang J, Park J, Fakhri G, Jee K, Woo J. Evaluation of few-shot detection of head and neck anatomy in CT. Progress In Biomedical Optics And Imaging 2024, 12927: 1292716-1292716-7. DOI: 10.1117/12.3006895.Peer-Reviewed Original ResearchFew-shot object detection methodMedical image dataFew-shot object detectionObject detection methodsObject detectionImage dataObject detection approachState-of-the-artFaster R-CNNFine-tuning stageDeep learning modelsDetection methodFew-shotDetection of anatomical structuresDownstream tasksNatural imagesR-CNNDetect objectsDetection headDetection approachPreprocessing stepDetect anatomical structuresLearning modelsExperimental resultsClinical workflowTreatment-wise glioblastoma survival Inference with multi-parametric preoperative MRI
Liu X, Shusharina N, Shih H, Kuo C, Fakhri G, Woo J. Treatment-wise glioblastoma survival Inference with multi-parametric preoperative MRI. Progress In Biomedical Optics And Imaging 2024, 12927: 129272h-129272h-5. DOI: 10.1117/12.3006897.Peer-Reviewed Original ResearchDisentangled multimodal brain MR image translation via transformer-based modality infuser
Cho J, Liu X, Xing F, Ouyang J, Fakhri G, Park J, Woo J. Disentangled multimodal brain MR image translation via transformer-based modality infuser. Progress In Biomedical Optics And Imaging 2024, 12926: 129262h-129262h-6. DOI: 10.1117/12.3006502.Peer-Reviewed Original ResearchConvolutional neural networkBrain tumor segmentation taskModality-specific featuresTumor segmentation taskImage translationAdversarial networkSegmentation taskSynthesis qualityBrain MR imagesNeural networkMR modalitiesAcquired imagesExperimental resultsNetworkGlobal relationshipsDisease diagnosisImagesEncodingBraTSDatasetFeaturesTaskMethodSuperiorityMR imagingPET imaging of M4 muscarinic acetylcholine receptors in rhesus macaques using [11C]MK-6884: Quantification with kinetic modeling and receptor occupancy by CVL-231 (emraclidine), a novel positive allosteric modulator
Belov V, Guehl N, Duvvuri S, Iredale P, Moon S, Dhaynaut M, Chakilam S, MacDonagh A, Rice P, Yokell D, Renger J, Fakhri G, Normandin M. PET imaging of M4 muscarinic acetylcholine receptors in rhesus macaques using [11C]MK-6884: Quantification with kinetic modeling and receptor occupancy by CVL-231 (emraclidine), a novel positive allosteric modulator. Cerebrovascular And Brain Metabolism Reviews 2024, 44: 1329-1342. PMID: 38477292, PMCID: PMC11342722, DOI: 10.1177/0271678x241238820.Peer-Reviewed Original ResearchConceptsPositive allosteric modulatorsReceptor occupancyNon-human primatesBinding potentialPositron emission tomographyMuscarinic acetylcholine receptorsAllosteric modulatorsNon-human primate brainM4 muscarinic acetylcholine receptorStriatal hyperdopaminergiaAcetylcholine receptorsBrain regionsCaudate nucleusTotal volume of distributionDose-dependent blockReference regionVolume of distributionPositron emission tomography imagingEmission tomographyReceptor levelsFunction of dosePET scansClinical trialsBlood-basedRhesus macaquesThe role of 18F-FDG PET in minimizing variability in gross tumor volume delineation of soft tissue sarcomas
Najem E, Marin T, Zhuo Y, Lahoud R, Tian F, Beddok A, Rozenblum L, Xing F, Moteabbed M, Lim R, Liu X, Woo J, Lostetter S, Lamane A, Chen Y, Ma C, El Fakhri G. The role of 18F-FDG PET in minimizing variability in gross tumor volume delineation of soft tissue sarcomas. Radiotherapy And Oncology 2024, 194: 110186. PMID: 38412906, PMCID: PMC11042980, DOI: 10.1016/j.radonc.2024.110186.Peer-Reviewed Original ResearchGross tumor volume delineationGross tumor volumeDice similarity coefficientF-FDG PET imagingSoft tissue sarcomasInter-reader variabilityGTV delineationRadiation therapy treatment planningF-FDGF-FDG PETTherapy treatment planningPerformance level estimationTumor volume delineationTissue sarcomasPET imagingVolume delineationSimultaneous truthHausdorff distanceDice similarity coefficient scoreAccurate gross tumor volumeImaging modality groupsWilcoxon signed-rank testStatistically significant decreaseSigned-rank testTumor volume