Jeffery Kocsis, PhD
Professor of Neurology and of NeuroscienceDownloadHi-Res Photo
Cards
Appointments
Neurology
Primary
Neuroscience
Secondary
Additional Titles
Director , Postdoctoral Studies
Associate Director, Yale Center for Neuroscience and Regeneration Research
Senior Medical Research Career Scientist, Department of Veterans Affairs
Contact Info
Appointments
Neurology
Primary
Neuroscience
Secondary
Additional Titles
Director , Postdoctoral Studies
Associate Director, Yale Center for Neuroscience and Regeneration Research
Senior Medical Research Career Scientist, Department of Veterans Affairs
Contact Info
Appointments
Neurology
Primary
Neuroscience
Secondary
Additional Titles
Director , Postdoctoral Studies
Associate Director, Yale Center for Neuroscience and Regeneration Research
Senior Medical Research Career Scientist, Department of Veterans Affairs
Contact Info
About
Titles
Professor of Neurology and of Neuroscience
Director , Postdoctoral Studies; Associate Director, Yale Center for Neuroscience and Regeneration Research; Senior Medical Research Career Scientist, Department of Veterans Affairs
Appointments
Neurology
ProfessorPrimaryNeuroscience
ProfessorSecondary
Other Departments & Organizations
- Center for Neuroscience and Regeneration Research
- Interdepartmental Neuroscience Program
- Neural Disorders
- Neurology
- Neuroscience
- Neuroscience Track
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Stem Cell Center
- Yale Ventures
Education & Training
- Postdoctoral Fellow
- Harvard Medical School and MIT (1977)
- PhD
- Wayne State University (1976)
Research
Overview
Medical Research Interests
Cell Transplantation; Central Nervous System; Ion Channels; Nerve Regeneration; Neurology; Neurosciences; Spinal Cord; Spinal Cord Injuries; Veterans
ORCID
0000-0002-3780-7719
Research at a Glance
Yale Co-Authors
Frequent collaborators of Jeffery Kocsis's published research.
Publications Timeline
A big-picture view of Jeffery Kocsis's research output by year.
Research Interests
Research topics Jeffery Kocsis is interested in exploring.
Stephen Waxman, MD, PhD
Masanori Sasaki, MD, PhD
Karen L Lankford, PhD
Osamu Honmou, MD, PhD
Stephen Strittmatter, MD, PhD, AB
Hal Blumenfeld, MD, PhD
141Publications
7,689Citations
Nerve Regeneration
Spinal Cord
Ion Channels
Spinal Cord Injuries
Cell Transplantation
Central Nervous System
Publications
2024
Multiple intravenous infusions versus a single infusion of mesenchymal stem cells in a rat model of cerebral ischemia.
Yokoyama T, Sasaki M, Nagahama H, Kataoka-Sasaki Y, Ukai R, Oka S, Kocsis J, Honmou O. Multiple intravenous infusions versus a single infusion of mesenchymal stem cells in a rat model of cerebral ischemia. Journal Of Neurosurgery 2024, 1-9. PMID: 39454218, DOI: 10.3171/2024.6.jns241111.Peer-Reviewed Original ResearchConceptsInfusion of mesenchymal stem cellsMiddle cerebral artery occlusionMiddle cerebral artery occlusion inductionMesenchymal stem cellsCorpus callosumSystemic infusion of mesenchymal stem cellsMultiple infusionsAcute phaseMesenchymal stem cell infusionCerebral ischemiaStem cellsMultiple intravenous infusionsRat model of cerebral ischemiaHigh-dose infusionPermanent middle cerebral artery occlusionIschemic lesion volumeModels of cerebral ischemiaCC thicknessRandomized clinical trialsCerebral artery occlusionNeural tractsAcute cerebral strokeFunctional recovery outcomesMRI diffusion tensor imagingMSC-3Intravenous Infusion of Autologous Mesenchymal Stem Cells Expanded in Auto Serum for Chronic Spinal Cord Injury Patients: A Case Series
Hirota R, Sasaki M, Iyama S, Kurihara K, Fukushi R, Obara H, Oshigiri T, Morita T, Nakazaki M, Namioka T, Namioka A, Onodera R, Kataoka-Sasaki Y, Oka S, Takemura M, Ukai R, Yokoyama T, Sasaki Y, Yamashita T, Kobayashi M, Okuma Y, Kondo R, Aichi R, Ohmatsu S, Kawashima N, Ito Y, Kobune M, Takada K, Ishiai S, Ogata T, Teramoto A, Yamashita T, Kocsis J, Honmou O. Intravenous Infusion of Autologous Mesenchymal Stem Cells Expanded in Auto Serum for Chronic Spinal Cord Injury Patients: A Case Series. Journal Of Clinical Medicine 2024, 13: 6072. PMID: 39458022, PMCID: PMC11509003, DOI: 10.3390/jcm13206072.Peer-Reviewed Original ResearchConceptsAmerican Spinal Injury Association Impairment ScaleSevere spinal cord injuryMesenchymal stem cell infusionAutologous mesenchymal stem cellsIntravenous infusionCase seriesMesenchymal stem cellsQuality of lifeAuto-serumSpinal cord injuryFunctional improvementChronic spinal cord injury patientsIntravenous infusion of mesenchymal stem cellsInfusion of mesenchymal stem cellsStem cellsCord injurySpinal Cord Independence Measure IIIAmerican Spinal Injury Association Impairment Scale grades CSpinal cord injury patientsChronic SCI patientsClassification of Spinal Cord InjuryNeurological Classification of Spinal Cord InjurySignificant functional improvementAssociation Impairment ScaleInternational Standards for Neurological Classification of Spinal Cord InjuryIntravenous infusion of auto-serum-expanded autologous mesenchymal stem cells into chronic severe brain injury patients
Yamaki T, Oka S, Iyama S, Sasaki M, Onodera R, Kataoka-Sasaki Y, Namioka T, Namioka A, Nakazaki M, Takemura M, Ukai R, Yokoyama T, Sasaki Y, Yamashita T, Kobayashi M, Yamaguchi M, Fukino M, Takazawa T, Hayasaka M, Owaku T, Funakura M, Onodera S, Ito Y, Kobune M, Kato J, Ishiai S, Kocsis J, Odaki M, Iwadate Y, Kobayashi S, Honmou O. Intravenous infusion of auto-serum-expanded autologous mesenchymal stem cells into chronic severe brain injury patients. Interdisciplinary Neurosurgery 2024, 36: 101927. DOI: 10.1016/j.inat.2023.101927.Peer-Reviewed Original ResearchCitationsConceptsSevere brain injury patientsAutologous mesenchymal stem cellsBrain injury patientsIntravenous infusionMesenchymal stem cellsAdverse eventsInjury patientsInfused mesenchymal stem cellsHealth Stroke ScaleSerious adverse eventsFugl-Meyer AssessmentInitial case seriesBrain metabolic activityStem cellsMSC infusionStroke ScaleNeurological deteriorationBarthel IndexCase seriesCNS tumorsNeurological functionFunctional statusFunctional improvementChronic patientsPlacebo effectA surgical protocol for establishing spinal cord ischemia with extended lifespan and low complication rates in rats
Yasuda N, Sasaki M, Kocsis J, Kawaharada N, Honmou O. A surgical protocol for establishing spinal cord ischemia with extended lifespan and low complication rates in rats. World Neurosurgery 2024, 188: e349-e356. PMID: 38789035, DOI: 10.1016/j.wneu.2024.05.114.Peer-Reviewed Original ResearchConceptsIschemic spinal cord injurySpinal cord ischemiaCord ischemiaComplication rateRat modelTherapeutic strategiesEvaluate new therapeutic strategiesFunctional recoveryMale Sprague-Dawley ratsLow complication rateSprague-Dawley ratsSpecialized surgical equipmentExperimental animal modelsImprove functional recoveryPromote functional recoverySpinal cord injuryCross-clampingSevere neurological disordersAzygos veinSurgical protocolDescending aortaBulldog clampsLumbar levelsSpinal cordIschemic lesions
2023
Rehabilitation facilitates functional improvement following intravenous infusion of mesenchymal stem cells in the chronic phase of cerebral ischemia in rats
Yamashita T, Sasaki M, Sasaki Y, Nagahama H, Oka S, Kataoka-Sasaki Y, Ukai R, Yokoyama T, Kobayashi M, Kakizawa M, Kocsis J, Honmou O. Rehabilitation facilitates functional improvement following intravenous infusion of mesenchymal stem cells in the chronic phase of cerebral ischemia in rats. Brain Research 2023, 1825: 148709. PMID: 38072373, DOI: 10.1016/j.brainres.2023.148709.Peer-Reviewed Original ResearchCitationsRepeated intravenous infusion of mesenchymal stem cells enhances recovery of motor function in a rat model with chronic spinal cord injury
Kurihara K, Sasaki M, Nagahama H, Obara H, Fukushi R, Hirota R, Yoshimoto M, Teramoto A, Kocsis J, Yamashita T, Honmou O. Repeated intravenous infusion of mesenchymal stem cells enhances recovery of motor function in a rat model with chronic spinal cord injury. Brain Research 2023, 1817: 148484. PMID: 37442249, DOI: 10.1016/j.brainres.2023.148484.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsSpinal cord injuryInfusion of MSCsChronic spinal cord injuryMesenchymal stem cellsAxonal sproutingCord injuryHD-MSCsIntravenous infusionMotor functionVehicle groupWeek 6Single high-dose infusionInjection of MSCsChronic SCI ratsSingle MSC injectionGreater functional recoveryRat SCI modelSingle intravenous infusionHigh-dose infusionLimited treatment optionsGreater functional improvementSingle high doseHigh disease burdenVivo diffusion tensor imagingEx vivo diffusion tensor imagingTherapeutic efficacy of intravenous infusion of mesenchymal stem cells in rat perinatal brain injury
Terada K, Sasaki M, Nagahama H, Kataoka-Sasaki Y, Oka S, Ukai R, Yokoyama T, Iizuka Y, Sakai T, Fukumura S, Tsugawa T, Kocsis J, Honmou O. Therapeutic efficacy of intravenous infusion of mesenchymal stem cells in rat perinatal brain injury. Pediatric Research 2023, 94: 1921-1928. PMID: 37422495, DOI: 10.1038/s41390-023-02717-9.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsPerinatal brain injuryBrain injuryMesenchymal stem cellsIntravenous infusionVehicle groupBrain volumeTherapeutic efficacyInfused mesenchymal stem cellsLeft common carotid arteryHistological analysisNon-ischemic hemispherePostnatal day 7Common carotid arteryEmbryonic day 18Stem cellsHypoxia-ischemiaMSC infusionPreterm infantsGABAergic cellsNeurological functionSignificant complicationsCortical synapsesFunctional improvementCarotid arteryIntravenous administrationHuman mesenchymal stem‐derived extracellular vesicles improve body growth and motor function following severe spinal cord injury in rat
Nakazaki M, Lankford K, Yamamoto H, Mae Y, Kocsis J. Human mesenchymal stem‐derived extracellular vesicles improve body growth and motor function following severe spinal cord injury in rat. Clinical And Translational Medicine 2023, 13: e1284. PMID: 37323108, PMCID: PMC10272923, DOI: 10.1002/ctm2.1284.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSpinal cord injurySevere spinal cord injuryFunctional motor recoveryYoung adult ratsMotor recoveryMesenchymal stem/stromal cellsSmall extracellular vesiclesMSC-sEVsCord injuryM2 macrophagesMotor functionAdult ratsBody growthPro-inflammatory cytokine tumor necrosisAdult spinal cord injuryDay 7 post-SCISystemic pro-inflammatory cytokinesIGF-1 levelsPro-inflammatory cytokinesCytokine tumor necrosisSystemic serum levelsBroad therapeutic benefitsNormal body growthExtracellular vesiclesDifferent treatment groupsDeriving Schwann cells from hPSCs enables disease modeling and drug discovery for diabetic peripheral neuropathy
Majd H, Amin S, Ghazizadeh Z, Cesiulis A, Arroyo E, Lankford K, Majd A, Farahvashi S, Chemel A, Okoye M, Scantlen M, Tchieu J, Calder E, Le Rouzic V, Shibata B, Arab A, Goodarzi H, Pasternak G, Kocsis J, Chen S, Studer L, Fattahi F. Deriving Schwann cells from hPSCs enables disease modeling and drug discovery for diabetic peripheral neuropathy. Cell Stem Cell 2023, 30: 632-647.e10. PMID: 37146583, PMCID: PMC10249419, DOI: 10.1016/j.stem.2023.04.006.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDiabetic peripheral neuropathySchwann cellsPeripheral neuropathyPeripheral nervous systemPrimary Schwann cellsBupropion treatmentDiabetic patientsMyelin damageSensory dysfunctionPrimary gliaSelective vulnerabilityAntidepressant drugsHyperglycemic miceLower incidenceRetrospective analysisHuman pluripotent stem cellsSC deathNervous systemTherapeutic candidateHigh glucoseNeuropathyHealth recordsMolecular featuresStem cellsPluripotent stem cellsA practical protocol for high-spatial-resolution magnetic resonance angiography for cerebral arteries in rats
Nagahama H, Sasaki M, Komatsu K, Sato K, Katagiri Y, Kamagata M, Kataoka-Sasaki Y, Oka S, Ukai R, Yokoyama T, Terada K, Kobayashi M, Kocsis J, Honmou O. A practical protocol for high-spatial-resolution magnetic resonance angiography for cerebral arteries in rats. Journal Of Neuroscience Methods 2023, 386: 109784. PMID: 36608904, DOI: 10.1016/j.jneumeth.2023.109784.Peer-Reviewed Original Research
News
News
- July 05, 2020
Healing Neurological Damage After Stroke or Spinal Cord Injury: Axon Regeneration Could Be Key to Rebuilding Neural Connections
- November 08, 2016Source: Yale Medicine
Yale Stem Cell Center’s strategic bet on fundamental scientific research is paying off
- June 18, 2012Source: Hartford Courant
State Awards $9.8 Million For Stem Cell Projects
- March 01, 2009
Hope sustains center’s research on paralysis
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