Publications

Featured Publications

Beta cell-derived cholecystokinin drives obesity-associated pancreatic adenocarcinoma development
Garcia C, Venkat A, McQuaid D, Agabiti S, Tong A, Mathew B, Cardone R, Starble R, Ruiz C, Zheng C, Sogunro A, Jacox J, Loh K, Kibbey R, Krishnaswamy S, Muzumdar M. Beta cell-derived cholecystokinin drives obesity-associated pancreatic adenocarcinoma development. Nature Communications 2026, 17: 3292. PMID: 41760660, PMCID: PMC13066563, DOI: 10.1038/s41467-026-69821-2.
Peer-Reviewed Original Research
This study investigates how obesity-induced cholecystokinin (CCK) expression in pancreatic beta cells drives pancreatic cancer development by altering cellular signaling within the environment of arising tumors, suggesting potential therapeutic targets.
Full Summary
Diet-induced phospholipid remodeling dictates ferroptosis sensitivity and tumorigenesis in the pancreas.
Ruiz C, Ge X, McDonnell R, Agabiti S, McQuaid D, Tang A, Kharwa M, Goodell J, Saavedra-Pena R, Wing A, Li G, Medici N, Robert M, Varshney R, Rudolph M, Gorelick F, Wysolmerski J, Canals D, Haley J, Rodeheffer M, Muzumdar M. Diet-induced phospholipid remodeling dictates ferroptosis sensitivity and tumorigenesis in the pancreas. Cancer Discovery 2026 PMID: 42053430, DOI: 10.1158/2159-8290.cd-25-0734.
Peer-Reviewed Original Research
This study investigates how dietary fat composition influences pancreatic cancer, showing that monounsaturated fats promote tumor growth while polyunsaturated fats reduce risk by enhancing ferroptosis sensitivity.
Full Summary
PI3K Regulates Wild-type RAS Signaling to Confer Resistance to KRAS Inhibition.
Ge X, Singh J, Li W, Markham C, Ruiz C, Stites E, Bhattacharyya M, Liu Y, Muzumdar M. PI3K Regulates Wild-type RAS Signaling to Confer Resistance to KRAS Inhibition. Cancer Research 2026 PMID: 42095550, DOI: 10.1158/0008-5472.can-25-3625.
Peer-Reviewed Original Research
This study investigates how PI3K enables pancreatic cancer cells to resist KRAS inhibitors by activating wild-type RAS signaling, suggesting combined PI3K-KRAS targeting as a therapeutic strategy.
Full Summary
Tracing the evolution of single-cell 3D genomes in Kras-driven cancers
Liu M, Jin S, Agabiti S, Jensen T, Yang T, Radda J, Ruiz C, Baldissera G, Rajaei M, Li F, Townsend J, Muzumdar M, Wang S. Tracing the evolution of single-cell 3D genomes in Kras-driven cancers. Nature Genetics 2025, 57: 3075-3087. PMID: 40825871, PMCID: PMC12695640, DOI: 10.1038/s41588-025-02297-w.
Peer-Reviewed Original Research
This study investigates 3D genome changes in Kras-driven cancers, identifying structural bottlenecks in early progression and potential diagnostic and therapeutic biomarkers.
Full Summary

2026

Baseline cellular state dictates the molecular impact of KRAS mutant variants in pancreatic cancer cells.
Quiñones-Avilés Y, Salovska B, Markham CS, Di Y, Turk BE, Liu Y, Muzumdar MD. Baseline cellular state dictates the molecular impact of KRAS mutant variants in pancreatic cancer cells. BioRxiv 2026 PMID: 41959224, DOI: 10.64898/2026.03.10.710185.
Peer-Reviewed Original Research
Beta cell-derived cholecystokinin drives obesity-associated pancreatic adenocarcinoma development
Garcia CC, Venkat A, McQuaid DC, Agabiti SS, Tong A, Mathew B, Cardone RL, Starble R, Ruiz CF, Zheng C, Sogunro A, Jacox JB, Loh KH, Kibbey RG, Krishnaswamy S, Muzumdar MD. Beta cell-derived cholecystokinin drives obesity-associated pancreatic adenocarcinoma development. Nature Communications 2026 DOI: 10.1038/s41467-026-69821-2.
Peer-Reviewed Original Research
This study investigates how beta cell-derived cholecystokinin drives obesity-associated pancreatic cancer development, showing that targeting endocrine signaling could prevent tumor progression in obesity-related contexts.
Full Summary

2025

2024

2023

Oligomeric organization of membrane proteins from native membranes at nanoscale spatial and single-molecule resolution
Walker G, Brown C, Ge X, Kumar S, Muzumdar M, Gupta K, Bhattacharyya M. Oligomeric organization of membrane proteins from native membranes at nanoscale spatial and single-molecule resolution. Nature Nanotechnology 2023, 19: 85-94. PMID: 38012273, PMCID: PMC10981947, DOI: 10.1038/s41565-023-01547-4.
Peer-Reviewed Original Research
Concepts
The Effects of Heat Stress and Calorie Restriction on Impaired Memory Retention in the Terrestrial Slug Deroceras reticulatum (Müller, 1744)
Link, C. D., Blair, A. C., & Peters, B. J. (2023). The Effects of Heat Stress and Calorie Restriction on Impaired Memory Retention in the Terrestrial Slug Deroceras reticulatum (Müller, 1744). American Malacological Bulletin, 40(1), 41-48.
Peer-Reviewed Original Research In Press
Dectin-3-targeted antifungal liposomes efficiently bind and kill diverse fungal pathogens.
Choudhury QJ, Ambati S, Link CD, Lin X, Lewis ZA, Meagher RB. Dectin-3-targeted antifungal liposomes efficiently bind and kill diverse fungal pathogens. Mol Microbiol 2023, 120: 723-739. PMID: 37800599, DOI: 10.1111/mmi.15174.
Peer-Reviewed Original Research In Press
Decoding the obesity–cancer connection: lessons from preclinical models of pancreatic adenocarcinoma
Ruiz C, Garcia C, Jacox J, Lawres L, Muzumdar M. Decoding the obesity–cancer connection: lessons from preclinical models of pancreatic adenocarcinoma. Life Science Alliance 2023, 6: e202302228. PMID: 37648285, PMCID: PMC10474221, DOI: 10.26508/lsa.202302228.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
MeSH Keywords and Concepts
Physical Restraints in Advanced Illness #462
McQuaid D, Roberts A, Lescott S, Prsic E. Physical Restraints in Advanced Illness #462. Journal Of Palliative Medicine 2023, 26: 1150-1152. DOI: 10.1089/jpm.2023.0174.
Peer-Reviewed Original Research
Abemaciclib is effective in palbociclib-resistant hormone receptor-positive metastatic breast cancers
Navarro-Yepes J, Kettner N, Rao X, Bishop C, Bui T, Wingate H, Raghavendra A, Wang Y, Wang J, Sahin A, Meric-Bernstam F, Hunt K, Damodaran S, Tripathy D, Keyomarsi K. Abemaciclib is effective in palbociclib-resistant hormone receptor-positive metastatic breast cancers. Cancer Research 2023, 83: 3264-3283. PMID: 37384539, PMCID: PMC10592446, DOI: 10.1158/0008-5472.can-23-0705.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Erratum. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Diabetes 2023;72:433-448.
Mastracci T, Apte M, Amundadottir L, Alvarsson A, Artandi S, Bellin M, Bernal-Mizrachi E, Caicedo A, Campbell-Thompson M, Cruz-Monserrate Z, Ouaamari A, Gaulton K, Geisz A, Goodarzi M, Hara M, Hull-Meichle R, Kleger A, Klein A, Kopp J, Kulkarni R, Muzumdar M, Naren A, Oakes S, Olesen S, Phelps E, Powers A, Stabler C, Tirkes T, Whitcomb D, Yadav D, Yong J, Zaghloul N, Pandol S, Sander M. Erratum. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Diabetes 2023;72:433-448. Diabetes 2023, 72: 1173. PMID: 37116182, PMCID: PMC10382644, DOI: 10.2337/db23-er08.
Commentaries, Editorials and Letters
Concepts
Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings
Mastracci T, Apte M, Amundadottir L, Alvarsson A, Artandi S, Bellin M, Bernal-Mizrachi E, Caicedo A, Campbell-Thompson M, Cruz-Monserrate Z, El Ouaamari A, Gaulton K, Geisz A, Goodarzi M, Hara M, Hull-Meichle R, Kleger A, Klein A, Kopp J, Kulkarni R, Muzumdar M, Naren A, Oakes S, Olesen S, Phelps E, Powers A, Stabler C, Tirkes T, Whitcomb D, Yadav D, Yong J, Zaghloul N, Pandol S, Sander M. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Diabetes 2023, 72: 433-448. PMID: 36940317, PMCID: PMC10033248, DOI: 10.2337/db22-0942.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
MeSH Keywords and Concepts

2022

2021

5‐Fluorouracil efficacy requires anti‐tumor immunity triggered by cancer‐cell‐intrinsic STING
Tian J, Zhang D, Kurbatov V, Wang Q, Wang Y, Fang D, Wu L, Bosenberg M, Muzumdar MD, Khan S, Lu Q, Yan Q, Lu J. 5‐Fluorouracil efficacy requires anti‐tumor immunity triggered by cancer‐cell‐intrinsic STING. The EMBO Journal 2021, 40: embj2020106065. PMID: 33615517, PMCID: PMC8013832, DOI: 10.15252/embj.2020106065.
Peer-Reviewed Original Research
MeSH Keywords and Concepts

2020

2019

Identification of DHODH as a therapeutic target in small cell lung cancer
Li L, Ng SR, Colón CI, Drapkin BJ, Hsu PP, Li Z, Nabel CS, Lewis CA, Romero R, Mercer KL, Bhutkar A, Phat S, Myers DT, Muzumdar MD, Westcott PMK, Beytagh MC, Farago AF, Vander Heiden MG, Dyson NJ, Jacks T. Identification of DHODH as a therapeutic target in small cell lung cancer. Science Translational Medicine 2019, 11: eaaw7852. PMID: 31694929, PMCID: PMC7401885, DOI: 10.1126/scitranslmed.aaw7852.
Peer-Reviewed Original Research
MeSH Keywords and Concepts

Publications

Featured Publications

Beta cell-derived cholecystokinin drives obesity-associated pancreatic adenocarcinoma development

Diet-induced phospholipid remodeling dictates ferroptosis sensitivity and tumorigenesis in the pancreas.

PI3K Regulates Wild-type RAS Signaling to Confer Resistance to KRAS Inhibition.

Tracing the evolution of single-cell 3D genomes in Kras-driven cancers

2026

Baseline cellular state dictates the molecular impact of KRAS mutant variants in pancreatic cancer cells.

Beta cell-derived cholecystokinin drives obesity-associated pancreatic adenocarcinoma development

2025

Direct genetic transformation bypasses tumor-associated DNA methylation alterations

The Student Physician–Patient–AI Relationship

2024

Keep It Moving: Physical Activity in the Prevention of Obesity-Driven Pancreatic Cancer.

Perioperative Modified FOLFIRINOX for Resectable Pancreatic Cancer

2023

Oligomeric organization of membrane proteins from native membranes at nanoscale spatial and single-molecule resolution

The Effects of Heat Stress and Calorie Restriction on Impaired Memory Retention in the Terrestrial Slug Deroceras reticulatum (Müller, 1744)

Dectin-3-targeted antifungal liposomes efficiently bind and kill diverse fungal pathogens.

Decoding the obesity–cancer connection: lessons from preclinical models of pancreatic adenocarcinoma

Physical Restraints in Advanced Illness #462

Abemaciclib is effective in palbociclib-resistant hormone receptor-positive metastatic breast cancers

Erratum. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Diabetes 2023;72:433-448.

Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings

2022

Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases

IRF8 as a Novel Marker to Differentiate Between CD30-Positive Large Cell Lymphomas

Global assessment of IRF8 as a novel cancer biomarker

2021

5‐Fluorouracil efficacy requires anti‐tumor immunity triggered by cancer‐cell‐intrinsic STING

2020

Cryptic Cachexia

Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma

2019

Identification of DHODH as a therapeutic target in small cell lung cancer