Faye Rogers, PhD
Associate Professor of Therapeutic RadiologyDownloadHi-Res Photo
Cards
Appointments
Therapeutic Radiology
Primary
Additional Titles
Associate Cancer Center Director, Diversity, Equity, and Inclusion
Vice Chair for Diversity, Equity and Inclusion, Therapeutic Radiology
Associate Director, Yale MD-PhD Program
Director, Yale BioMed Amgen Scholars Program
Contact Info
Therapeutic Radiology
PO Box 208040
New Haven, CT 06520-8040
United States
Appointments
Therapeutic Radiology
Primary
Additional Titles
Associate Cancer Center Director, Diversity, Equity, and Inclusion
Vice Chair for Diversity, Equity and Inclusion, Therapeutic Radiology
Associate Director, Yale MD-PhD Program
Director, Yale BioMed Amgen Scholars Program
Contact Info
Therapeutic Radiology
PO Box 208040
New Haven, CT 06520-8040
United States
Appointments
Therapeutic Radiology
Primary
Additional Titles
Associate Cancer Center Director, Diversity, Equity, and Inclusion
Vice Chair for Diversity, Equity and Inclusion, Therapeutic Radiology
Associate Director, Yale MD-PhD Program
Director, Yale BioMed Amgen Scholars Program
Contact Info
Therapeutic Radiology
PO Box 208040
New Haven, CT 06520-8040
United States
About
Titles
Associate Professor of Therapeutic Radiology
Associate Cancer Center Director, Diversity, Equity, and Inclusion; Vice Chair for Diversity, Equity and Inclusion, Therapeutic Radiology; Associate Director, Yale MD-PhD Program; Director, Yale BioMed Amgen Scholars Program
Appointments
Therapeutic Radiology
Associate Professor on TermPrimary
Other Departments & Organizations
- BioMed Amgen Scholars Program
- MD-PhD Program
- Molecular Medicine, Pharmacology, and Physiology
- Program in Translational Biomedicine (PTB)
- Radiobiology
- Radiobiology and Genome Integrity
- Therapeutic Radiology
- Yale Cancer Center
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Ventures
- YCC Diversity, Equity, and Inclusion
- YSM Office of Diversity, Equity and Inclusion
Education & Training
- PhD
- University of Maryland at Baltimore (1998)
- BS
- Andrews University (1992)
- Postdoctoral Fellow
- Yale School of Medicine
Research
Overview
Medical Research Interests
Apoptosis; Biochemistry; Breast Neoplasms; DNA Repair; Drug Design; Genomic Instability; Nucleic Acids; Radiation Oncology
Research at a Glance
Yale Co-Authors
Frequent collaborators of Faye Rogers's published research.
Publications Timeline
A big-picture view of Faye Rogers's research output by year.
Research Interests
Research topics Faye Rogers is interested in exploring.
Peter M. Glazer, MD, PhD
Leonard Milstone, MD
Adam Krysztofiak, PhD
Diane Krause, MD, PhD
Franziska Bleichert, PhD
Pradeep Uchil, PhD
18Publications
475Citations
DNA Repair
Apoptosis
Genomic Instability
Nucleic Acids
Publications
2024
Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition
Rackear M, Quijano E, Ianniello Z, Colón-Ríos D, Krysztofiak A, Abdullah R, Liu Y, Rogers F, Ludwig D, Dwivedi R, Bleichert F, Glazer P. Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition. Oncotarget 2024, 15: 699-713. PMID: 39352803, PMCID: PMC11444335, DOI: 10.18632/oncotarget.28651.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsTumor targetingMonoclonal antibody therapyTumor-specific targetingCell uptakeNucleic acid bindingCell surface antigensAntibody therapyHuman variantsClinical successCell-penetrating antibodiesAcid bindingSystemic administrationSurface antigensTumorRAD51 inhibitionAntibody platformMechanism of cell penetrationBind RAD51AntibodiesFull-lengthSpecific targetsCell penetrationDisease targetsCellsAutoantibodies
2016
Triplex structures induce DNA double strand breaks via replication fork collapse in NER deficient cells
Tiwari M, Adaku N, Peart N, Rogers FA. Triplex structures induce DNA double strand breaks via replication fork collapse in NER deficient cells. Nucleic Acids Research 2016, 44: 7742-7754. PMID: 27298253, PMCID: PMC5027492, DOI: 10.1093/nar/gkw515.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDouble-strand breaksReplication fork collapseFork collapseGenomic instabilityReplication-associated double-strand breaksDNA replication fork progressionNucleotide excision repair proteinsTriplex structureRobust DNA damage responseDNA double-strand breaksReplication fork progressionReplication fork stabilityStrand breaksReplication fork integrityXPC-deficient cellsDNA damage responseMirror repeat sequencesExcision repair proteinsMore DSBsNER-deficient cellsDamage recognition proteinsGenomic integrityDual phosphorylationFork stabilityFork integrityImaging Functional Nucleic Acid Delivery to Skin
Kaspar RL, Hickerson RP, González-González E, Flores MA, Speaker TP, Rogers FA, Milstone LM, Contag CH. Imaging Functional Nucleic Acid Delivery to Skin. Methods In Molecular Biology 2016, 1372: 1-24. PMID: 26530911, DOI: 10.1007/978-1-4939-3148-4_1.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsNucleic acid deliveryNucleic acid-based therapiesAcid deliveryAcid-based therapiesFunctional deliveryFunctional nucleic acid deliveryTherapeutic nucleic acidsNucleic acidsOptical imaging technologiesReal-time monitoringTriplex nucleic acidsInteraction of lightMonogenic skin diseasesLight-tissue interactionsGene editingGene silencingOptical imagingNoninvasive imaging technologyTopical deliveryTime monitoringImaging technologyReporter geneLayered structureGeneral strategyEnzymatic reactions
2014
Improved bioactivity of G-rich triplex-forming oligonucleotides containing modified guanine bases
Rogers FA, Lloyd JA, Tiwari MK. Improved bioactivity of G-rich triplex-forming oligonucleotides containing modified guanine bases. Artificial DNA PNA & XNA 2014, 5: e27792. PMID: 25483840, PMCID: PMC4014521, DOI: 10.4161/adna.27792.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMobility gel shift assaysDNA double-strand breaksTarget sequenceGel shift assaysDouble-strand breaksGene-targeted mutagenesisActivation of apoptosisG-quadruplex formationGenomic modificationsDNA repairShift assaysReporter geneMolecular mechanismsPolypurine sequenceStrand breaksTriplex technologyTarget siteMutagenesisTriplex structureGenesGuanine baseTriplex formationGuanine basesSequenceAG30
2013
Triplex-induced DNA damage response.
Rogers FA, Tiwari MK. Triplex-induced DNA damage response. The Yale Journal Of Biology And Medicine 2013, 86: 471-8. PMID: 24348211, PMCID: PMC3848101.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsDNA damage responseGenomic integrityDamage responseCellular pathwaysCellular DNA damage responseDNA damageAppropriate cellular responsesPro-apoptotic factorsCell cycle arrestDNA repairDNA strand breaksCellular responsesCycle arrestDamage sitesStrand breaksPathwayApoptosisHelical structureComplex seriesCentral roleTriplex formationXPDPhosphorylationΓH2AXDNAXPD-dependent activation of apoptosis in response to triplex-induced DNA damage
Tiwari M, Rogers FA. XPD-dependent activation of apoptosis in response to triplex-induced DNA damage. Nucleic Acids Research 2013, 41: 8979-8994. PMID: 23913414, PMCID: PMC3799437, DOI: 10.1093/nar/gkt670.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDouble-strand breaksStrand breaksGenomic integrityPro-apoptotic pathwaysHuman genomeTyrosine 142DNA repairDNA sequencesGenomic instabilityDNA strand breaksNoncanonical structuresCancer initiationDNA damageDamage sitesΓH2AX fociHelical distortionApoptosisTriplex structureCentral rolePathwayXPDGenomeTriplexesPhosphorylationΓH2AX
2012
Local Delivery of Gene-Modifying Triplex-Forming Molecules to the Epidermis
Rogers FA, Hu RH, Milstone LM. Local Delivery of Gene-Modifying Triplex-Forming Molecules to the Epidermis. Journal Of Investigative Dermatology 2012, 133: 685-691. PMID: 23014335, PMCID: PMC3532560, DOI: 10.1038/jid.2012.351.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsIntradermal deliveryHairless miceTransgenic miceBasal keratinocytesMethod of deliveryNuclei of keratinocytesIntraperitoneal administrationSitu gene correctionBack skinLocal deliveryMiceDisease-causing genesEpidermal keratinocytesKeratinocytesLocal administrationAdministrationDeliverySkinEpidermisDays
2011
Targeted Disruption of the CCR5 Gene in Human Hematopoietic Stem Cells Stimulated by Peptide Nucleic Acids
Schleifman EB, Bindra R, Leif J, del Campo J, Rogers FA, Uchil P, Kutsch O, Shultz LD, Kumar P, Greiner DL, Glazer PM. Targeted Disruption of the CCR5 Gene in Human Hematopoietic Stem Cells Stimulated by Peptide Nucleic Acids. Cell Chemical Biology 2011, 18: 1189-1198. PMID: 21944757, PMCID: PMC3183429, DOI: 10.1016/j.chembiol.2011.07.010.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsHematopoietic stem cellsHIV-1CCR5 geneHIV-1-infected individualsHIV-1 infectionGene modificationHIV-1 entryCCR5-Delta32 mutationImmune system functionStem cellsCCR5 knockoutMonths posttransplantationChemokine receptorsHuman hematopoietic stem cellsTherapeutic strategiesSubsequent engraftmentGenome modificationProtein levelsHuman cellsTargeted disruptionCCR5Peptide nucleic acidInfectionNucleic acidsCellsTargeted Gene Modification of Hematopoietic Progenitor Cells in Mice Following Systemic Administration of a PNA-peptide Conjugate
Rogers FA, Lin SS, Hegan DC, Krause DS, Glazer PM. Targeted Gene Modification of Hematopoietic Progenitor Cells in Mice Following Systemic Administration of a PNA-peptide Conjugate. Molecular Therapy 2011, 20: 109-118. PMID: 21829173, PMCID: PMC3255600, DOI: 10.1038/mt.2011.163.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsGene modificationGene therapyHematopoietic stem cell gene therapyStem cell gene therapyGenomic modificationsVivo gene therapyCell gene therapyTargeted gene modificationVivo gene modificationHematopoietic progenitor cellsPeptide nucleic acidSystemic administrationBone marrowGene-targeting strategiesProgenitor cellsPrimary recipient miceStem cell mobilizationEx vivo manipulationSickle cell anemiaLymphoid cell lineagesDonor miceRecipient miceHematologic disordersInvasive alternativeCell mobilizationXPD‐Dependent induction of apoptosis in cells with DNA containing triple helical repeats
Rogers F, Kaushik M. XPD‐Dependent induction of apoptosis in cells with DNA containing triple helical repeats. The FASEB Journal 2011, 25: 310.3-310.3. DOI: 10.1096/fasebj.25.1_supplement.310.3.Peer-Reviewed Original ResearchConceptsDNA repairH-DNAAltered helical structureNucleotide excision repair pathwayExcision repair pathwayTriple helical repeatsGenomic integrityPro-apoptotic pathwaysHuman genomeInduction of mutationsDNA sequencesRepair pathwaysHelical repeatBase pairsDNA damageIntricate balanceHelical distortionRepair synthesisTriplex structureApoptosisHelical structureCentral roleTriplex formationPathwayInduction
Academic Achievements & Community Involvement
honor Leadership in Diversity, Equity & Inclusion Award
Yale School of Medicine AwardYale Cancer CenterDetails03/24/2022United Stateshonor Translational Science Research Prize
Yale School of Medicine AwardYale Cancer CenterDetails03/24/2022United Stateshonor Kingsley Fellowship in Medical Research
UnknownDetailsUnited Stateshonor Carl Storm Underrepresented Minority Fellowship
UnknownDetailsUnited Stateshonor NCI Research Supplement to Promote Diversity in Health–Related Research
UnknownDetailsUnited States
News & Links
News
- August 16, 2024
Biomedical Summer Undergraduate Research Fellowship Symposium 2024
- July 16, 2024
Amgen Scholars North American Symposium 2024
- June 05, 2024
Welcome to the 2024 Yale BioMed Amgen, ACS, BP-Endure, and Summer Undergraduate Research Scholars
- November 15, 2023
Building Bridges: DICE-Driven Exchange Connects Navajo Technical University Students with Yale School of Medicine
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Contacts
Email
Academic Office Number
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Mailing Address
Therapeutic Radiology
PO Box 208040
New Haven, CT 06520-8040
United States
Locations
Hunter Building
Academic Office
15 York Street, Ste 213B
New Haven, CT 06510
Appointments
203.737.3658Fax
203.785.6309