Selected Publications*

(*contributed equally)

Zhou H, Kalayasiri R, Sun Y, Nuñez YZ, Deng HW, Chen XD, Justice AC, Kranzler HR, Chang S, Lu L, Shi J, Sanichwankul K, Mutirangura A, Malison RT, Gelernter J. Genome-wide Meta-analysis of Alcohol Use Disorder in East Asian. Neuropsychopharmacology 2022 Jan 29. doi: 10.1038/s41386-022-01265-w. Epub ahead of print.

Kranzler HR, Zhou H, Kember RL. Identifying and Reducing Bias in Genome-Wide Association Studies of Alcohol-Related Traits. American Journal of Psychiatry 2022 Jan;179(1):14-16. doi: 10.1176/appi.ajp.2021.21111107.

Hatoum AS, Johnson EC, Colbert SMC, Polimanti R, Zhou H, Walters RK, Gelernter J, Edenberg HJ, Bogdan R, Agrawal A. The addiction risk factor: A unitary genetic vulnerability characterizes substance use disorders and their associations with common correlates. Neuropsychopharmacology 2021 Nov 8. doi: 10.1038/s41386-021-01209-w.

Karlsson Linnér R, Mallard TT, Barr PB, Sanchez-Roige S, Madole JW, Driver MN, Poore HE, de Vlaming R, Grotzinger AD, Tielbeek JT, Johnson EC, Liu M, Rosenthal SB, Ideker T, Zhou H, Kember RL, Pasman JA, Verweij KJH, Liu DJ, Vrieze S, COGA Collaborators, Kranzler HR, Gelernter J, Harris KM, Tucker-Drob EM, Waldman I, Palmer AA, Harden KP, Koellinger PD, Dick DM. Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction. Nature Neuroscience 2021 Aug 26. doi: 10.1038/s41593-021-00908-3.

Levey DF, Stein MB, Wendt F, Pathak G, Zhou H, Aslan M, Quaden R, Harrington KM, Nuñez YZ, Overstreet C, Radhakrishnan K, Sanacora G, McIntosh AM, Shi J, Shringarpure SS, 23andMe Research Team, Million Veteran Program, Concato J, Polimanti R, Gelernter J. Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions. Nature Neuroscience 2021 May 27. doi: 10.1038/s41593-021-00860-2.

Dao C, Zhou H, Small A, Gordon KS, Li B, Kember RL, Ye Y, Gelernter J, Xu K, Kranzler HR*, Zhao H*, Justice AC*. The Impact of Removing Former Drinkers from Genome-wide Association Studies of AUDIT-C. Addiction 2021 Apr 16. doi: 10.1111/add.15511.

Johnson EC, Kapoor M, Hatoum AS, Zhou H, Polimanti R, Wendt FR, Walters RK, Lai D, Kember RL, Hartz S, Meyers JL, Peterson RE, Ripke S, Bigdeli TB, Fanous AH, Pato CN, Pato MT, Goate AM, Kranzler HR, O'Donovan MC, Walters JTR, Gelernter J, Edenberg HJ, Agrawal A. Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder. Psychological Medicine 2021 Jul 7:1-9. doi: 10.1017/S003329172100266X.

Zhou H, Rentsch CT, Cheng Z, Kember RL, Nuñez YZ, Tate JP, Dao C, Xu K, Polimanti R, Farrer LA, Justice AC, Kranzler HR, Gelernter J, for the VA Million Veteran Program. Association of OPRM1 functional coding variant with opioid use disorder: A genome-wide association study. JAMA Psychiatry 2020, 77(10):1072–80.

Zhou H, Sealock JM, Sanchez-Roige S, Clarke TK, Levey DF, Cheng Z, Li B, Polimanti R, Kember RL, Smith RV, Thygesen JH, Morgan MY, Atkinson SR, Thursz MR, Nyegaard M, Mattheisen M, Børglum AD, Johnson EC, Justice AC, Palmer AA, McQuillin A, Davis LK, Edenberg HJ, Agrawal A, Kranzler HR, Gelernter J. Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits. Nature Neuroscience 2020, 23(7):809-818.

Xu K, Li B, McGinnis KA, Vickers-Smith R, Dao C, Sun N, Kember RL, Zhou H, Becker WC, Gelernter J, Kranzler HR, Zhao H, Justice AC; VA Million Veteran Program. Genome-wide association study of smoking trajectory and meta-analysis of smoking status in 842,000 individuals. Nature Communications 2020, 11(1):5302.

Cao H, Zhou H, Cannon TD. Functional connectome-wide associations of schizophrenia polygenic risk. Molecular Psychiatry 2020, doi: 10.1038/s41380-020-0699-3.

Levey DF, Gelernter J, Polimanti R, Zhou H, Cheng Z, Aslan M, Quaden R, Concato J, Radhakrishnan K, Bryois J, Sullivan PF, Million Veteran Program, Stein MB. Reproducible genetic risk loci for anxiety: Results from ∼200,000 participants in the Million Veteran Program. American Journal of Psychiatry 2020, 177(3):223-232.

Kranzler HR*, Zhou H*, Kember RL*, Smith RV, Justice AC, Damrauer S, Tsao PS, Klarin D, Baras A, Reid J, Overton J, Rader DJ, Cheng Z, Tate JP, Becker WC, Concato J, Xu K, Polimanti R, Zhao H, Gelernter J. Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. Nature Communications 2019, 10(1):1499.

Zhou H, Cheng Z, Bass N, Farrer LA, Krystal JH, Kranzler HR, Gelernter J. Genome-wide association study identifies glutamate ionotropic receptor GRIA4 as a risk gene for comorbid nicotine dependence and major depression. Translational Psychiatry 2018, 8(1):208.

Cheng Z, Zhou H, Sherva R, Farrer LA, Kranzler HR, Gelernter J. Genome-wide association study identifies a regulatory variant of RGMA associated with opioid dependence in European Americans. Biological Psychiatry 2018, 84(10):762-770.

Montalvo-Ortiz JL, Zhou H, D’Andrea I, Maroteaux L, Lori A, Smith A, Ressler K, Nuñez Y, Farrer LA, Zhao H, Kranzler HR, Gelernter J. Translational studies support a role for serotonin 2B receptors in aggression-related cannabis response. Molecular Psychiatry 2018, 23(12):2277-2286.

Gelernter J, Zhou H, Nuñez YZ, Mutirangura A, Malison RT, Kalayasiri R. Genomewide association study of alcohol dependence and related traits in a Thai population. Alcoholism: Clinical and Experimental Research 2018, 42(5):861-868.

Zhou H, Polimanti R, Yang BZ, Wang Q, Han S, Sherva R, Nuñez YZ, Zhao H, Farrer LA, Kranzler HR, Gelernter J. Genetic risk variants associated with comorbid alcohol dependence and major depression. JAMA Psychiatry 2017, 74(12):1234-1241.

Andersen AM, Pietrzak RH, Kranzler HR, Ma L, Zhou H, Liu X, Kramer J, Kuperman S, Edenberg HJ, Nurnberger JI Jr, Rice JP, Tischfield JA, Goate A, Foroud TM, Meyers JL, Porjesz B, Dick DM, Hesselbrock V, Boerwinkle E, Southwick SM, Krystal JH, Weissman MM, Levinson DF, Potash JB, Gelernter J, Han S. Polygenic scores for major depressive disorder and risk of alcohol dependence. JAMA Psychiatry 2017, 74(11):1153-1160.

Qiao L, Yang Y, Fu P, Hu S, Zhou H, Tan J, Lu Y, Lou H, Lu D, Wu S, Guo J, Peng S, Jin L, Guan Y, Wang S, Xu S, Tang K. Genome-wide variants of Eurasian facial shape differentiation and a prospective model of DNA based face prediction. Journal of Genetics and Genomics 2018, 45(8):419-432.

* Contributed equally

Qian W, Zhou H, Tang K. Recent coselection in human populations revealed by protein-protein interaction network. Genome Biology and Evolution 2014, 7(1):136-53.

Valverde G*, Zhou H*, Lippold S, de Filippo C, Tang K, López Herráez D, Li J, Stoneking M. A novel candidate region for genetic adaptation to high altitude in Andean populations. PLoS One 2015, 10(5):e0125444.

Guo J, Tan J, Yang Y, Zhou H, Hu S, Hashan A, Bahaxar N, Xu S, Weaver TD, Jin L, Stoneking M, Tang K. Variation and signatures of selection on the human face. Journal of Human Evolution 2014, 75:143-52.

Peng S, Tan J, Hu S, Zhou H, Guo J, Jin L, Tang K. Detecting genetic association of common human facial morphological variation using high density 3D image registration. PLoS Computational Biology 2013, 9(12):e1003375.

Li J, Zhang L, Zhou H, Stoneking M, Tang K. Global patterns of genetic diversity and signals of natural selection for human ADME genes. Human Molecular Genetics 2011, 20(3):528-40.