2015
FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders
Mariani J, Coppola G, Zhang P, Abyzov A, Provini L, Tomasini L, Amenduni M, Szekely A, Palejev D, Wilson M, Gerstein M, Grigorenko EL, Chawarska K, Pelphrey KA, Howe JR, Vaccarino FM. FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders. Cell 2015, 162: 375-390. PMID: 26186191, PMCID: PMC4519016, DOI: 10.1016/j.cell.2015.06.034.Peer-Reviewed Original ResearchMeSH KeywordsChild Development Disorders, PervasiveFemaleForkhead Transcription FactorsGene Expression ProfilingHumansInduced Pluripotent Stem CellsMaleMegalencephalyModels, BiologicalNerve Tissue ProteinsNeurogenesisNeuronsOrganoidsTelencephalonConceptsInduced pluripotent stem cellsGene network analysisGene network modulesUpregulation of genesTranscription factor Foxg1Accelerated cell cyclePluripotent stem cellsRNA interferenceGenetic basisSynaptic assemblyCell cycleBrain developmentNeuron fateNeuron differentiationNeuronal differentiationGenomic mutationsHuman brain developmentIdiopathic autism spectrum disorderAltered expressionStem cellsCell proliferationFOXG1ASD pathophysiologyNetwork modulesNeural cultures
2014
18-Month Predictors of Later Outcomes in Younger Siblings of Children With Autism Spectrum Disorder: A Baby Siblings Research Consortium Study
Chawarska K, Shic F, Macari S, Campbell DJ, Brian J, Landa R, Hutman T, Nelson CA, Ozonoff S, Tager-Flusberg H, Young GS, Zwaigenbaum L, Cohen IL, Charman T, Messinger DS, Klin A, Johnson S, Bryson S. 18-Month Predictors of Later Outcomes in Younger Siblings of Children With Autism Spectrum Disorder: A Baby Siblings Research Consortium Study. Journal Of The American Academy Of Child & Adolescent Psychiatry 2014, 53: 1317-1327.e1. PMID: 25457930, PMCID: PMC4254798, DOI: 10.1016/j.jaac.2014.09.015.Peer-Reviewed Original ResearchMeSH KeywordsChild Development Disorders, PervasiveChild, PreschoolFemaleGenetic Predisposition to DiseaseHumansInfantMaleRiskSiblingsConceptsPoor eye contactHigh riskEarly diagnostic considerationAutism spectrum disorderAge 3 yearsEye contactBaby Siblings Research Consortium StudyClinical featuresDiagnostic considerationsSpectrum disorderSpecific treatmentYounger siblingsSymptom profilesAutism Diagnostic Observation ScheduleConsortium studyMonthsDiagnostic outcomesRegression tree analysisOutcomesLater OutcomesChildrenDevelopmental outcomesHigh functioningSiblingsBehavioral profileScreening for Autism Spectrum Disorders in 12-Month-Old High-Risk Siblings by Parental Report
Rowberry J, Macari S, Chen G, Campbell D, Leventhal JM, Weitzman C, Chawarska K. Screening for Autism Spectrum Disorders in 12-Month-Old High-Risk Siblings by Parental Report. Journal Of Autism And Developmental Disorders 2014, 45: 221-229. PMID: 25149178, PMCID: PMC4289092, DOI: 10.1007/s10803-014-2211-x.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesChild Development Disorders, PervasiveChild, PreschoolCommunication DisordersEarly DiagnosisFemaleHumansInfantMaleParentsPlay and PlaythingsSiblingsConceptsAutism spectrum disorderParental reportsSpectrum disorderDevelopmental outcomesHigh-risk siblingsFirst Year InventoryVocal imitationRepetitive behaviorsSocial communicationGreater impairmentClinician ratingsYounger siblingsScreening instrumentPreliminary findingsASD casesImportant implicationsDisordersSiblingsImitationParentsRatingsImpairmentInventoryChildrenCommunication
2013
Speech Disturbs Face Scanning in 6-Month-Old Infants Who Develop Autism Spectrum Disorder
Shic F, Macari S, Chawarska K. Speech Disturbs Face Scanning in 6-Month-Old Infants Who Develop Autism Spectrum Disorder. Biological Psychiatry 2013, 75: 231-237. PMID: 23954107, PMCID: PMC3864607, DOI: 10.1016/j.biopsych.2013.07.009.Peer-Reviewed Original ResearchMeSH KeywordsChild Development Disorders, PervasiveChild, PreschoolDevelopmental DisabilitiesEye MovementsFaceFemaleHumansInfantLongitudinal StudiesMalePhotic StimulationSpeechVisual PerceptionConceptsAutism spectrum disorderSpectrum disorderComplex social scenesAttention of infantsCritical developmental pointPresence of speechPositive affectASD outcomeGaze patternsSocial scenesSocial targetsDevelopmental pointInner featuresSocial worldOlder infantsAtypical behaviorScanning patternsSpontaneous deploymentsFaceMonths of ageAttentionDisordersAffectClinical outcomesComprehensive assessmentGaze Response to Dyadic Bids at 2 Years Related to Outcomes at 3 Years in Autism Spectrum Disorders: A Subtyping Analysis
Campbell DJ, Shic F, Macari S, Chawarska K. Gaze Response to Dyadic Bids at 2 Years Related to Outcomes at 3 Years in Autism Spectrum Disorders: A Subtyping Analysis. Journal Of Autism And Developmental Disorders 2013, 44: 431-442. PMID: 23877749, PMCID: PMC3900601, DOI: 10.1007/s10803-013-1885-9.Peer-Reviewed Original ResearchMeSH KeywordsAttentionAutistic DisorderChild Development Disorders, PervasiveChild, PreschoolCuesEye MovementsFaceFemaleHumansInfantMaleConceptsAutism spectrum disorderSpectrum disorderChild-directed speechVisual responsesDirect gazeAdaptive functioningSocial scenesSpeaker's mouthHigh functioningBetter attentionCuesToddlersFunctioningLimited attentionEarly predictorAttentionDisordersSpeechSceneGazeYears of ageLanguageEngagementOutcomesMeaningful approachDecreased Spontaneous Attention to Social Scenes in 6-Month-Old Infants Later Diagnosed with Autism Spectrum Disorders
Chawarska K, Macari S, Shic F. Decreased Spontaneous Attention to Social Scenes in 6-Month-Old Infants Later Diagnosed with Autism Spectrum Disorders. Biological Psychiatry 2013, 74: 195-203. PMID: 23313640, PMCID: PMC3646074, DOI: 10.1016/j.biopsych.2012.11.022.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSocial scenesSpectrum disorderSocial brain networkEye-tracking taskAttentional biasSocial cognitionSocial overturesSpontaneous attentionAtypical developmentEnhanced attentionBrain networksSocial interaction patternsMonitoring skillsOlder infantsVisual responsesProdromal symptomsDiminished abilityInteraction patternsLimited attentionDisordersFirst yearAttentionSceneCognition
2012
Pivotal Response Treatment for Infants At-Risk for Autism Spectrum Disorders: A Pilot Study
Steiner AM, Gengoux GW, Klin A, Chawarska K. Pivotal Response Treatment for Infants At-Risk for Autism Spectrum Disorders: A Pilot Study. Journal Of Autism And Developmental Disorders 2012, 43: 91-102. PMID: 22573001, PMCID: PMC3571709, DOI: 10.1007/s10803-012-1542-8.Peer-Reviewed Original ResearchMeSH KeywordsBehavior TherapyChild Development Disorders, PervasiveCommunicationCuesHumansInfantMaleParentsPilot ProjectsRisk FactorsTreatment OutcomeConceptsPivotal Response TreatmentEfficacious interventionsResponse treatmentInfantsPRT procedurePilot studyInfant's frequencyYoung childrenRiskPreschool childrenAutism spectrum disorderPreliminary supportFunctional communicationSpectrum disorderTreatmentChildrenCurrent studyMultiple baseline designAutismDevelopmental adaptationsFidelity of implementationParent training modelPredicting Developmental Status from 12 to 24 Months in Infants at Risk for Autism Spectrum Disorder: A Preliminary Report
Macari SL, Campbell D, Gengoux GW, Saulnier CA, Klin AJ, Chawarska K. Predicting Developmental Status from 12 to 24 Months in Infants at Risk for Autism Spectrum Disorder: A Preliminary Report. Journal Of Autism And Developmental Disorders 2012, 42: 2636-2647. PMID: 22484794, PMCID: PMC3565427, DOI: 10.1007/s10803-012-1521-0.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsChild DevelopmentChild Development Disorders, PervasiveChild, PreschoolFemaleHumansInfantMalePredictive Value of TestsProspective StudiesRisk Factors
2011
Adaptive Behavior in Toddlers Under Two with Autism Spectrum Disorders
Paul R, Loomis R, Chawarska K. Adaptive Behavior in Toddlers Under Two with Autism Spectrum Disorders. Journal Of Autism And Developmental Disorders 2011, 44: 264-270. PMID: 21573835, DOI: 10.1007/s10803-011-1279-9.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAlgorithmsCase-Control StudiesChild Development Disorders, PervasiveCognitionCommunicationDevelopmental DisabilitiesFemaleHumansInfantMaleConceptsAutism spectrum disorderSpectrum disorderVineland Adaptive Behavior ScalesAdaptive Behavior ScalesNonverbal developmentNonverbal abilityDevelopmental delayAutistic symptomsReceptive communicationBehavior ScaleAdaptive behaviorCommunication scoresAge 2Algorithm scoresToddlersClinical implicationsAreas of differenceCognitionDaily livingDisordersDD pairsScoresVinelandPeersCorrelation analysisEarly-Emerging Social Adaptive Skills in Toddlers with Autism Spectrum Disorders: An Item Analysis
Ventola P, Saulnier CA, Steinberg E, Chawarska K, Klin A. Early-Emerging Social Adaptive Skills in Toddlers with Autism Spectrum Disorders: An Item Analysis. Journal Of Autism And Developmental Disorders 2011, 44: 283-293. PMID: 21567256, PMCID: PMC7311046, DOI: 10.1007/s10803-011-1278-x.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalChild Development Disorders, PervasiveChild, PreschoolDevelopmental DisabilitiesDiagnosis, DifferentialFemaleHumansInfantMaleSocial BehaviorPhonology and vocal behavior in toddlers with autism spectrum disorders
Schoen E, Paul R, Chawarska K. Phonology and vocal behavior in toddlers with autism spectrum disorders. Autism Research 2011, 4: 177-188. PMID: 21308998, PMCID: PMC3110574, DOI: 10.1002/aur.183.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSpectrum disorderAge-matched toddlersLanguage-matched peersLanguage-matched controlsSpeech-like vocalizationsNonspeech vocalizationsTypical developmentSpeech samplesLanguage environmentPlay sessionsVocal developmentAtypical vocalizationsLanguage modelLanguage levelVocal productionToddlersVocal behaviorVocalization productionVocalizationsSound productionDisordersPhonologyPeersControl group
2010
Brief Report: Face-Specific Recognition Deficits in Young Children with Autism Spectrum Disorders
Bradshaw J, Shic F, Chawarska K. Brief Report: Face-Specific Recognition Deficits in Young Children with Autism Spectrum Disorders. Journal Of Autism And Developmental Disorders 2010, 41: 1429-1435. PMID: 21373955, PMCID: PMC4871156, DOI: 10.1007/s10803-010-1150-4.Peer-Reviewed Original ResearchMeSH KeywordsChild Development Disorders, PervasiveChild, PreschoolFaceFemaleHumansMaleRecognition, PsychologyVisual PerceptionConceptsAutism spectrum disorderNonsocial stimuliSpectrum disorderYoung childrenRecognition of facesFace recognitionRecognition deficitsTD controlsNovel objectsSpecific impairmentComparison paradigmSimple objectsChildrenStimuliRecognitionEyetrackingDisordersObjectsDeficitsImpairmentParadigmFaceEvidenceFindingsAbilityLimited activity monitoring in toddlers with autism spectrum disorder
Shic F, Bradshaw J, Klin A, Scassellati B, Chawarska K. Limited activity monitoring in toddlers with autism spectrum disorder. Brain Research 2010, 1380: 246-254. PMID: 21129365, PMCID: PMC3050079, DOI: 10.1016/j.brainres.2010.11.074.Peer-Reviewed Original ResearchMeSH KeywordsAttentionChild Development Disorders, PervasiveFemaleHumansInfantMaleSocial BehaviorSocial Behavior DisordersConceptsAutism spectrum disorderTypical developmentSpectrum disorderAdult–child play interactionsGreater autism severityAutism severityObservational learningDevelopmental delayPlay interactionsCognitive deficitsDevelopmental progressionPeople's headsToddlersSocial activitiesFuture avenuesLess attentionBackground objectsAutismDisordersDeficitsLearningAttentionPeopleObjectsContextOut of the mouths of babes: vocal production in infant siblings of children with ASD
Paul R, Fuerst Y, Ramsay G, Chawarska K, Klin A. Out of the mouths of babes: vocal production in infant siblings of children with ASD. Journal Of Child Psychology And Psychiatry 2010, 52: 588-598. PMID: 21039489, PMCID: PMC3078949, DOI: 10.1111/j.1469-7610.2010.02332.x.Peer-Reviewed Original ResearchMeSH KeywordsChild Development Disorders, PervasiveChild, PreschoolCross-Sectional StudiesFemaleHumansInfantInfant BehaviorLanguage DevelopmentMaleProspective StudiesRisk FactorsSiblingsSpeechSpeech AcousticsSpeech Production MeasurementConceptsAutism spectrum disorderInfant siblingsVocal behaviorVocal productionNon-speech vocalizationsInfant vocal behaviorEarly vocal behavioursHigh riskAutistic symptomsLanguage developmentSpectrum disorderMouths of BabesCross-sectional designConsonant inventoryLarge prospective studiesCanonical syllablesVocalization samplesStandard clinical assessmentYounger siblingsProspective studyProvisional diagnosisClinical assessmentRisk groupsFamily historyGeneral population
2009
A prospective study of toddlers with ASD: short‐term diagnostic and cognitive outcomes
Chawarska K, Klin A, Paul R, Macari S, Volkmar F. A prospective study of toddlers with ASD: short‐term diagnostic and cognitive outcomes. Journal Of Child Psychology And Psychiatry 2009, 50: 1235-1245. PMID: 19594835, PMCID: PMC4878113, DOI: 10.1111/j.1469-7610.2009.02101.x.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderPDD-NOSASD diagnosisCognitive outcomesCommunication skillsSocial-communicative skillsNon-ASD disordersNon-ASD groupDiagnosis of autismNonverbal communication skillsNumber of toddlersSpectrum disorderAutism diagnosisSkill profilesToddlersDiagnostic presentationDisability symptomsSkillsEnhances accuracyAutismDiagnostic classificationDisordersPrediction of outcomeSeverity of symptomsSecond yearLooking But Not Seeing: Atypical Visual Scanning and Recognition of Faces in 2 and 4-Year-Old Children with Autism Spectrum Disorder
Chawarska K, Shic F. Looking But Not Seeing: Atypical Visual Scanning and Recognition of Faces in 2 and 4-Year-Old Children with Autism Spectrum Disorder. Journal Of Autism And Developmental Disorders 2009, 39: 1663. PMID: 19590943, PMCID: PMC4878114, DOI: 10.1007/s10803-009-0803-7.Peer-Reviewed Original ResearchMeSH KeywordsAttentionChild Development Disorders, PervasiveChild, PreschoolEye MovementsFaceFemaleHumansLongitudinal StudiesMalePattern Recognition, VisualPhotic StimulationRecognition, Psychology