2014
Fgfr1 Inactivation in the Mouse Telencephalon Results in Impaired Maturation of Interneurons Expressing Parvalbumin
Smith KM, Maragnoli ME, Phull PM, Tran KM, Choubey L, Vaccarino FM. Fgfr1 Inactivation in the Mouse Telencephalon Results in Impaired Maturation of Interneurons Expressing Parvalbumin. PLOS ONE 2014, 9: e103696. PMID: 25116473, PMCID: PMC4130531, DOI: 10.1371/journal.pone.0103696.Peer-Reviewed Original ResearchConceptsGanglionic eminenceSoma sizeCortical interneuronsAstrocytes of miceCortex of adultCortical GABAergic neuronsParvalbumin-positive cortical interneuronsRadial glial cellsSmaller soma sizeMedial ganglionic eminenceFibroblast growth factorDeficient astrocytesLocomotor hyperactivityGABAergic cellsGABAergic neuronsInterneuron maturationGlial cellsCortical astrocytesPostnatal periodAdult CNSPostnatal brainInterneuron markersInterneuronsImmunopositive interneuronsAstrocytes
2004
Chronic neonatal hypoxia leads to long term decreases in the volume and cell number of the rat cerebral cortex
Schwartz ML, Vaccarino F, Chacon M, Yan WL, Ment LR, Stewart WB. Chronic neonatal hypoxia leads to long term decreases in the volume and cell number of the rat cerebral cortex. Seminars In Perinatology 2004, 28: 379-388. PMID: 15693394, DOI: 10.1053/j.semperi.2004.10.009.Peer-Reviewed Original ResearchConceptsDays of hypoxiaPreterm birth resultsNeuronal sizeBirth resultsHypoxic exposureCell numberChronic neonatal hypoxiaChronic sublethal hypoxiaNeonatal rodent modelPerinatal period altersRat cerebral cortexNeuronal cell numberBcl-2Glial cell numbersNormoxic environmentPostnatal day 3Cortical cell numberSignificant neurodevelopmental disabilitiesWestern blot analysisPreterm birthNeonatal hypoxiaNormoxic exposureCerebral cortexChronic hypoxiaControl pups
2000
Basic Fibroblast Growth Factor (Fgf2) Is Necessary for Cell Proliferation and Neurogenesis in the Developing Cerebral Cortex
Raballo R, Rhee J, Lyn-Cook R, Leckman J, Schwartz M, Vaccarino F. Basic Fibroblast Growth Factor (Fgf2) Is Necessary for Cell Proliferation and Neurogenesis in the Developing Cerebral Cortex. Journal Of Neuroscience 2000, 20: 5012-5023. PMID: 10864959, PMCID: PMC6772267, DOI: 10.1523/jneurosci.20-13-05012.2000.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCell DivisionCerebral CortexChoroid PlexusEmbryonic and Fetal DevelopmentFibroblast Growth Factor 2Gene Expression Regulation, DevelopmentalGerm-Line MutationGestational AgeMiceMice, KnockoutProsencephalonReceptor Protein-Tyrosine KinasesReceptor, Fibroblast Growth Factor, Type 1Receptors, Fibroblast Growth FactorTelencephalonConceptsFgf2 knockout micePseudostratified ventricular epitheliumKnockout miceCerebral cortexCortical neuronsFrontal cerebral cortexDeep cortical layersBasic fibroblast growth factorEnd of neurogenesisCortical neuron numberNeuronal progenitor cellsNull mutant miceBasic fibroblast growth factor (bFGF) geneFibroblast growth factorDegree of apoptosisLarge neuronsBasal gangliaCortical layersFgf2 knockoutGrowth factor geneMutant miceVentricular epitheliumGermline mutationsNeuron numberNeurogenesis
1999
Progressive impairment of developing neuroendocrine cell lineages in the hypothalamus of mice lacking the Orthopedia gene
Acampora D, Postiglione M, Avantaggiato V, Di Bonito M, Vaccarino F, Michaud J, Simeone A. Progressive impairment of developing neuroendocrine cell lineages in the hypothalamus of mice lacking the Orthopedia gene. Genes & Development 1999, 13: 2787-2800. PMID: 10557207, PMCID: PMC317121, DOI: 10.1101/gad.13.21.2787.Peer-Reviewed Original ResearchConceptsCorticotropin-releasing hormoneAnterior periventricularProgressive impairmentArginine vasopressinHypothalamus of miceTerminal differentiationNeuroendocrine cell lineagesCell lineagesNeuronal cell lineagesMagnocellular neuronsNeuroendocrine hypothalamusAbnormal cell migrationParaventricularCell proliferationHypothalamusCell migrationMiceBRN2 expressionNeuronsImpairmentOxytocinPeriventricularDifferentiation
1998
Development of the Cerebral Cortex: VII. Growth Factors: II
VACCARINO F, LOMBROSO P, Lombroso P. Development of the Cerebral Cortex: VII. Growth Factors: II. Journal Of The American Academy Of Child & Adolescent Psychiatry 1998, 37: 789-790. PMID: 9666636, DOI: 10.1097/00004583-199807000-00020.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements