2023
Test-Retest Reliability of Functional Connectivity in Adolescents With Depression
Camp C, Noble S, Scheinost D, Stringaris A, Nielson D. Test-Retest Reliability of Functional Connectivity in Adolescents With Depression. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2023, 9: 21-29. PMID: 37734478, PMCID: PMC10843837, DOI: 10.1016/j.bpsc.2023.09.002.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBrainBrain MappingDepressionDepressive Disorder, MajorFemaleHumansReproducibility of ResultsConceptsMajor depressive disorderIntraclass correlation coefficientTest-retest reliabilityPsychiatric illnessFunctional connectivityMean intraclass correlation coefficientFunctional magnetic resonance imagingMagnetic resonance imagingAverage intraclass correlation coefficientEffect sizeDepressive disorderLongitudinal cohortHealthy individualsMultivariate analysisResonance imagingSymptom severityReproducible biomarkersBrain-behavior associationsGroup differencesDepressionHealthy samplesCorrelation coefficientIllnessAdolescentsBiomarker identificationFunctional brain networks reflect spatial and temporal autocorrelation
Shinn M, Hu A, Turner L, Noble S, Preller K, Ji J, Moujaes F, Achard S, Scheinost D, Constable R, Krystal J, Vollenweider F, Lee D, Anticevic A, Bullmore E, Murray J. Functional brain networks reflect spatial and temporal autocorrelation. Nature Neuroscience 2023, 26: 867-878. PMID: 37095399, DOI: 10.1038/s41593-023-01299-3.Peer-Reviewed Original Research
2022
Hypoconnectivity between anterior insula and amygdala associates with future vulnerabilities in social development in a neurodiverse sample of neonates
Scheinost D, Chang J, Lacadie C, Brennan-Wydra E, Foster R, Boxberger A, Macari S, Vernetti A, Constable RT, Ment LR, Chawarska K. Hypoconnectivity between anterior insula and amygdala associates with future vulnerabilities in social development in a neurodiverse sample of neonates. Scientific Reports 2022, 12: 16230. PMID: 36171268, PMCID: PMC9517994, DOI: 10.1038/s41598-022-20617-6.Peer-Reviewed Original ResearchConceptsFirst Year InventoryAnterior insulaFunctional connectivityMaternal mental health factorsLeft anterior insulaState functional connectivityMental health factorsSubsample of participantsPostmenstrual ageSalience networkFamily historySocial domainsNeural circuitryAutismSocial behaviorBrain imagingHigher likelihoodInsulaSocial developmentHypoconnectivityExploratory analysisThird trimesterFuture onsetHealth factorsRisk scoreArousal impacts distributed hubs modulating the integration of brain functional connectivity
Lee K, Horien C, O’Connor D, Garand-Sheridan B, Tokoglu F, Scheinost D, Lake EMR, Constable RT. Arousal impacts distributed hubs modulating the integration of brain functional connectivity. NeuroImage 2022, 258: 119364. PMID: 35690257, PMCID: PMC9341222, DOI: 10.1016/j.neuroimage.2022.119364.Peer-Reviewed Original ResearchMultimodal neuroimaging of metabotropic glutamate 5 receptors and functional connectivity in alcohol use disorder
Smart K, Worhunsky PD, Scheinost D, Angarita GA, Esterlis I, Carson RE, Krystal JH, O'Malley SS, Cosgrove KP, Hillmer AT. Multimodal neuroimaging of metabotropic glutamate 5 receptors and functional connectivity in alcohol use disorder. Alcohol Clinical And Experimental Research 2022, 46: 770-782. PMID: 35342968, PMCID: PMC9117461, DOI: 10.1111/acer.14816.Peer-Reviewed Original ResearchConceptsMetabotropic glutamate 5 receptorsDefault mode networkFunctional magnetic resonance imagingReceptor availabilityPositron emission tomographyAUD groupFunctional connectivityReceptor positron emission tomographyResting-state functional magnetic resonance imagingNetwork-level functional connectivityBrain connectivityWeeks of abstinenceGlobal functional connectivityAlcohol use disorderMagnetic resonance imagingFMRI outcomesHealthy controlsSupervised abstinencePET resultsUse disordersSynaptic plasticityResonance imagingBrain regionsEmission tomographyOrbitofrontal cortexLarge-scale differences in functional organization of left- and right-handed individuals using whole-brain, data-driven analysis of connectivity
Tejavibulya L, Peterson H, Greene A, Gao S, Rolison M, Noble S, Scheinost D. Large-scale differences in functional organization of left- and right-handed individuals using whole-brain, data-driven analysis of connectivity. NeuroImage 2022, 252: 119040. PMID: 35272202, PMCID: PMC9013515, DOI: 10.1016/j.neuroimage.2022.119040.Peer-Reviewed Original ResearchConceptsHanded individualsFunctional connectivityLanguage areasWhole-brain functional connectivityRight-handed individualsFunctional organizationWhole-brain levelIndividual differencesHandedness differencesHandedness effectsFunctional connectomeBrain levelsSomatosensory cortexNetworks of interestWhole brainSex differencesBrainConnectomeIndividualsData-driven analysisConnectivityDistinct patternsLateralizationDifferencesSimilar amountsNeurofeedback-guided kinesthetic motor imagery training in Parkinson’s disease: Randomized trial
Tinaz S, Kamel S, Aravala SS, Elfil M, Bayoumi A, Patel A, Scheinost D, Sinha R, Hampson M. Neurofeedback-guided kinesthetic motor imagery training in Parkinson’s disease: Randomized trial. NeuroImage Clinical 2022, 34: 102980. PMID: 35247729, PMCID: PMC8897714, DOI: 10.1016/j.nicl.2022.102980.Peer-Reviewed Original ResearchConceptsKinesthetic motor imageryMotor function scoresMild Parkinson's diseaseParkinson's diseaseFunctional connectivityFunction scoresMI trainingSecondary clinical outcomesClinical outcome measuresRandomized clinical trialsWhole-brain functional connectivityPost-training changeFunctional connectivity strengthMotor imageryMotor imagery trainingDorsomedial frontal cortexDistinct neural circuitsClinical outcomesImaging outcomesSubjective improvementClinical trialsMotor functionMotor examFrontal cortexOutcome measures
2021
Functional Connectivity for the Language Network in the Developing Brain: 30 Weeks of Gestation to 30 Months of Age
Scheinost D, Chang J, Lacadie C, Brennan-Wydra E, Constable RT, Chawarska K, Ment LR. Functional Connectivity for the Language Network in the Developing Brain: 30 Weeks of Gestation to 30 Months of Age. Cerebral Cortex 2021, 32: 3289-3301. PMID: 34875024, PMCID: PMC9340393, DOI: 10.1093/cercor/bhab415.Peer-Reviewed Original ResearchMeSH KeywordsBrainBrain MappingCross-Sectional StudiesFemaleHumansInfant, NewbornLanguageMagnetic Resonance ImagingPregnancyConceptsWeeks of gestationFirst postnatal monthMonths of agePostnatal monthFunctional connectivityWernicke's areaWeeks postmenstrual ageLanguage networkResting-state fMRI dataPostmenstrual ageFetal onsetInterhemispheric connectionsIntrahemispheric connectionsPrimary analysisOlder infantsNeurobehavioral disordersSecondary analysisGestationCross-sectional dataMonthsBrocaUnique participantsWeeksSignificant increaseFunctional connectionsA graph theory‐based whole brain approach to assess mood state differences in adolescents and young adults with bipolar disorder
Goldman DA, Sankar A, Colic L, Villa L, Kim JA, Pittman B, Constable RT, Scheinost D, Blumberg HP. A graph theory‐based whole brain approach to assess mood state differences in adolescents and young adults with bipolar disorder. Bipolar Disorders 2021, 24: 412-423. PMID: 34665907, PMCID: PMC9016085, DOI: 10.1111/bdi.13144.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBipolar DisorderBrainBrain MappingHumansMagnetic Resonance ImagingPrefrontal CortexYoung AdultConceptsLenticular nucleusFunctional connectivityPrefrontal cortexMood statesYoung adultsLimited brain regionsAcute mood statesRight lenticular nucleusBipolar I disorderDorsal prefrontal cortexPrevious neuroimaging studiesWhole-brain approachTemporal functional connectivityFunctional magnetic resonanceLeft prefrontal cortexBrain dysfunctionContralateral homologuesHealthy controlsI disordersDepression scoresICD increasesRight cerebellumBipolar disorderEarly interventionBrain regions
2020
Simultaneous cortex-wide fluorescence Ca2+ imaging and whole-brain fMRI
Lake EMR, Ge X, Shen X, Herman P, Hyder F, Cardin JA, Higley MJ, Scheinost D, Papademetris X, Crair MC, Constable RT. Simultaneous cortex-wide fluorescence Ca2+ imaging and whole-brain fMRI. Nature Methods 2020, 17: 1262-1271. PMID: 33139894, PMCID: PMC7704940, DOI: 10.1038/s41592-020-00984-6.Peer-Reviewed Original ResearchConceptsOptical measurementsBrain functionTransgenic murine modelFunctional magnetic resonance imagingMagnetic resonance imagingFluorescent measuresWhole-brain fMRIMurine modelResonance imagingFluorescence Ca2Human brain functionConnectivity strengthBOLD signalBrain activityWidefieldLow frequencyImagingModalitiesTransfer functionMeasurementsCortexFunctional brain connectivity in ex utero premature infants compared to in utero fetuses
De Asis-Cruz J, Kapse K, Basu SK, Said M, Scheinost D, Murnick J, Chang T, du Plessis A, Limperopoulos C. Functional brain connectivity in ex utero premature infants compared to in utero fetuses. NeuroImage 2020, 219: 117043. PMID: 32534962, PMCID: PMC7493786, DOI: 10.1016/j.neuroimage.2020.117043.Peer-Reviewed Original ResearchConceptsPremature infantsHealthy fetusesBrain connectivityStructural brain injuryBlood oxygenation level-dependent (BOLD) signalBrain structural changesStress-related areasNormal brain MRIState functional MRIFunctional connectivity strengthFunctional brain connectivityLevel-dependent signalMedial temporal lobeNetwork-based statisticsSeed-based correlation analysisUtero fetusesBasal gangliaBrain injuryTerm ageBrain MRITemporal lobeExposure altersInfantsRegion of interestFunctional MRI
2019
Differential Resting State Connectivity Responses to Glycemic State in Type 1 Diabetes
Parikh L, Seo D, Lacadie C, Belfort-Deaguiar R, Groskreutz D, Hamza M, Dai F, Scheinost D, Sinha R, Constable R, Sherwin R, Hwang JJ. Differential Resting State Connectivity Responses to Glycemic State in Type 1 Diabetes. The Journal Of Clinical Endocrinology & Metabolism 2019, 105: dgz004. PMID: 31511876, PMCID: PMC6936965, DOI: 10.1210/clinem/dgz004.Peer-Reviewed Original ResearchConceptsState functional connectivityHealthy controlsDefault mode networkType 1 diabetes mellitusFunctional connectivityImpact of T1DMAcademic medical centerAngular gyrus connectivityBlood oxygenation levelState connectivity patternsFunctional connectivity analysisHyperinsulinemic euglycemicHypoglycemic unawarenessHypoglycemia unawarenessDiabetes mellitusHypoglycemic clampHypoglycemia awarenessFunctional outcomeMild hypoglycemiaGlycemic stateObservational studyMedical CenterT1DMHC volunteersType 1A decade of test-retest reliability of functional connectivity: A systematic review and meta-analysis
Noble S, Scheinost D, Constable RT. A decade of test-retest reliability of functional connectivity: A systematic review and meta-analysis. NeuroImage 2019, 203: 116157. PMID: 31494250, PMCID: PMC6907736, DOI: 10.1016/j.neuroimage.2019.116157.Peer-Reviewed Original ResearchConceptsIntraclass correlation coefficientTest-retest reliabilityFunctional connectivitySystematic reviewShort test-retest intervalsTest-retest reliability studyIndividual edgesNarrative summaryTest-retest intervalSearch of ScopusMeta-analytic estimatesCortical edgeRandom effectsQualitative reviewNeuroscience toolsReviewActive recordingReview of factorsExpense of validitySubject dataStudyRegions and Connections: Complementary Approaches to Characterize Brain Organization and Function
Horien C, Greene AS, Constable RT, Scheinost D. Regions and Connections: Complementary Approaches to Characterize Brain Organization and Function. The Neuroscientist 2019, 26: 117-133. PMID: 31304866, PMCID: PMC7079335, DOI: 10.1177/1073858419860115.Peer-Reviewed Original Research
2018
Amygdala functional connectivity is associated with social impairments in preterm born young adults
Johns CB, Lacadie C, Vohr B, Ment LR, Scheinost D. Amygdala functional connectivity is associated with social impairments in preterm born young adults. NeuroImage Clinical 2018, 21: 101626. PMID: 30545688, PMCID: PMC6413301, DOI: 10.1016/j.nicl.2018.101626.Peer-Reviewed Original ResearchConceptsVineland Adaptive Behavior ScalesYouth Self-ReportAmygdala functional connectivitySocial impairmentChild Behavior ChecklistFunctional connectivityAmygdala connectivityPreterm participantsSocial functioningSocial functioning correlatesSocial functioning deficitsResting-state functional magnetic resonanceFunctional magnetic resonancePreterm-born adolescentsAdaptive Behavior ScalesAge 16Term-born peersEmotional developmentPreterm birth experienceParent reportDevelopmental trajectoriesRisk of depressionLate adolescentsBehavior ChecklistSelf-Report
2017
An exemplar-based approach to individualized parcellation reveals the need for sex specific functional networks
Salehi M, Karbasi A, Shen X, Scheinost D, Constable RT. An exemplar-based approach to individualized parcellation reveals the need for sex specific functional networks. NeuroImage 2017, 170: 54-67. PMID: 28882628, PMCID: PMC5905726, DOI: 10.1016/j.neuroimage.2017.08.068.Peer-Reviewed Original ResearchConceptsIndividualized parcellationParcellation techniqueFunctional networksCross-validated predictive modelSpecific functional networksCerebral cortexPatient subgroupsFunctional connectivity dataFunctional organizationBrainParcellation schemesClinical applicationParcellation approachParcellationSexSubgroupsConnectivity dataIndividualized studyNetwork organizationIndividualsAmple evidencePatientsCortexCan brain state be manipulated to emphasize individual differences in functional connectivity?
Finn ES, Scheinost D, Finn DM, Shen X, Papademetris X, Constable RT. Can brain state be manipulated to emphasize individual differences in functional connectivity? NeuroImage 2017, 160: 140-151. PMID: 28373122, PMCID: PMC8808247, DOI: 10.1016/j.neuroimage.2017.03.064.Peer-Reviewed Original ResearchConceptsIndividual differencesFunctional connectivityBrain statesIndividual differences researchBrain functional organizationHuman Connectome ProjectDifferences researchBrain activityConnectome ProjectSubject variabilityNetworks of interestBehavioral phenotypesCertain tasksFunctional organizationDefault stateNeutral backdropOutline questionsFuture studiesConnectivityTask
2016
Multisite reliability of MR-based functional connectivity
Noble S, Scheinost D, Finn ES, Shen X, Papademetris X, McEwen SC, Bearden CE, Addington J, Goodyear B, Cadenhead KS, Mirzakhanian H, Cornblatt BA, Olvet DM, Mathalon DH, McGlashan TH, Perkins DO, Belger A, Seidman LJ, Thermenos H, Tsuang MT, van Erp TGM, Walker EF, Hamann S, Woods SW, Cannon TD, Constable RT. Multisite reliability of MR-based functional connectivity. NeuroImage 2016, 146: 959-970. PMID: 27746386, PMCID: PMC5322153, DOI: 10.1016/j.neuroimage.2016.10.020.Peer-Reviewed Original ResearchConceptsNorth American Prodrome Longitudinal StudyRight motor cortexIntrinsic connectivity distributionPosterior cingulate cortexFunctional connectivity studiesFunctional connectivity measurementsMultisite studyVoxel-wise connectivityConnectivity studiesConnectivity measuresSeed-based connectivityConnectivity analysisMotor cortexHealthy cohortCingulate cortexScan durationSingle-subject levelFcMRI dataFunctional connectivityConnectivity measurementsClinical populationsLittle dataLongitudinal studyMultisite reliabilityScanner manufacturersNeural Correlates of Success and Failure Signals During Neurofeedback Learning
Radua J, Stoica T, Scheinost D, Pittenger C, Hampson M. Neural Correlates of Success and Failure Signals During Neurofeedback Learning. Neuroscience 2016, 378: 11-21. PMID: 27063101, PMCID: PMC5537049, DOI: 10.1016/j.neuroscience.2016.04.003.Peer-Reviewed Original ResearchConceptsNeurofeedback signalFeedback learningMedial prefrontal/anterior cingulate cortexFeedback-driven learningPrecuneus/posterior cingulateClear adaptive valueDefault mode networkLevel-dependent responsesAnterior cingulate cortexOperant conditioning paradigmReduction of anxietyNeurofeedback learningNeural correlatesSignals of failureNeural processesNeurofeedback interventionConditioning paradigmNeurofeedback experimentsMode networkOrbitofrontal cortexCingulate cortexPosterior cingulateFunctional runsAbstract representationLearningFunctional magnetic resonance connectivity studies in infants born preterm: suggestions of proximate and long‐lasting changes in language organization
Kwon SH, Scheinost D, Vohr B, Lacadie C, Schneider K, Dai F, Sze G, Constable RT, Ment LR. Functional magnetic resonance connectivity studies in infants born preterm: suggestions of proximate and long‐lasting changes in language organization. Developmental Medicine & Child Neurology 2016, 58: 28-34. PMID: 27027605, PMCID: PMC6426123, DOI: 10.1111/dmcn.13043.Peer-Reviewed Original Research