2025
Neural Variability and Cognitive Control in Individuals With Opioid Use Disorder
Ye J, Mehta S, Peterson H, Ibrahim A, Saeed G, Linsky S, Kreinin I, Tsang S, Nwanaji-Enwerem U, Raso A, Arora J, Tokoglu F, Yip S, Hahn C, Lacadie C, Greene A, Constable R, Barry D, Redeker N, Yaggi H, Scheinost D. Neural Variability and Cognitive Control in Individuals With Opioid Use Disorder. JAMA Network Open 2025, 8: e2455165. PMID: 39821393, PMCID: PMC11742521, DOI: 10.1001/jamanetworkopen.2024.55165.Peer-Reviewed Original ResearchConceptsDecreased cognitive controlCognitive controlOpioid use disorderCueing paradigmResting-stateHC participantsUse disorderBrain statesBrain dynamicsHealthy controlsNeural mechanismsCognitive processesNeural variabilityFMRIBehavioral implicationsImpaired abilityBrainAccuracy scoresMagnetic resonance imagingDynamic alterationsParticipantsCase-control studyDisordersParadigmImpacts millions
2022
A generalizable connectome-based marker of in-scan sustained attention in neurodiverse youth
Horien C, Greene A, Shen X, Fortes D, Brennan-Wydra E, Banarjee C, Foster R, Donthireddy V, Butler M, Powell K, Vernetti A, Mandino F, O'Connor D, Lake E, McPartland J, Volkmar F, Chun M, Chawarska K, Rosenberg M, Scheinost D, Constable R. A generalizable connectome-based marker of in-scan sustained attention in neurodiverse youth. Cerebral Cortex 2022, 33: 6320-6334. PMID: 36573438, PMCID: PMC10183743, DOI: 10.1093/cercor/bhac506.Peer-Reviewed Original ResearchConceptsAttention taskAttentional stateConnectome-based predictive modelingNeurodiverse conditionsSustained attention taskAttention network modelSample of youthNeurotypical participantsSustained attentionBrain correlatesNeurobiological correlatesAttention networkIndividual participantsSeparate samplesYouthParticipantsHead motionTaskCorrelatesAttentionAutismConfoundsNetwork modelGeneralizesHealthcare settings
2020
Low-motion fMRI data can be obtained in pediatric participants undergoing a 60-minute scan protocol
Horien C, Fontenelle S, Joseph K, Powell N, Nutor C, Fortes D, Butler M, Powell K, Macris D, Lee K, Greene AS, McPartland JC, Volkmar FR, Scheinost D, Chawarska K, Constable RT. Low-motion fMRI data can be obtained in pediatric participants undergoing a 60-minute scan protocol. Scientific Reports 2020, 10: 21855. PMID: 33318557, PMCID: PMC7736342, DOI: 10.1038/s41598-020-78885-z.Peer-Reviewed Original ResearchConceptsPediatric participantsMRI protocolMagnetic resonance imaging (MRI) scansFunctional magnetic resonance imaging (fMRI) scansShorter MRI protocolsScan protocolResonance imaging scansImaging scansMRI sessionsFMRI connectivity analysisFMRI dataFMRI findingsSignificant confoundScansReplication groupConnectivity analysisAutism spectrum disorderMock scanSpectrum disorderParticipantsHead motionProtocol
2014
Cerebral Lateralization is Protective in the Very Prematurely Born
Scheinost D, Lacadie C, Vohr BR, Schneider KC, Papademetris X, Constable RT, Ment LR. Cerebral Lateralization is Protective in the Very Prematurely Born. Cerebral Cortex 2014, 25: 1858-1866. PMID: 24451659, PMCID: PMC4459290, DOI: 10.1093/cercor/bht430.Peer-Reviewed Original ResearchConceptsVery preterm participantsPreterm participantsCerebral lateralizationFunctional connectivityPreterm birth altersSevere brain injuryPreterm brainBrain injuryBirth altersTemporal lobeTerm controlsVoxel-based measureDevelopmental delayRight hemisphere lateralizationTerm participantsLateralizationYoung adulthoodSignificant decreaseCerebral asymmetryFurther studiesHemisphere lateralizationLanguage scoresBrainParticipantsAlterations