Multimodal Functional and Structural Neuroimaging
Our lab uses optimized data collection procedures provided by Human Connectome Project. Specifically, we use accelerated echo planar imaging (EPI) pulse sequences based on the multi-band (MB) approach (Finberg et al., 2010). This effectively allows us to acquire whole-brain functional data at ~2mm isotropic voxels with 700msec volumetric acquisition time (about 3x faster than standard BOLD neuroimaging) (see figure on the right panels A-B). Our analyses approaches closely follow the HCP approaches advocating minimal preprocessing and neurobiologically grounded analyses that respect the geometry of cortical and sub-cortical structures for each individual brain (Glasser et al., 2013).
Anticevic, A., Dierker, D., Gillespie, S.K., Repovs, G., Van Essen, D.C., Csernansky, J.G., & Barch, D.M. (2008). Comparing surface-based and volume-based analyses of functional neuroimaging data in patients with schizophrenia. Neuroimage. 41(3):835-48. [Link]
Glasser, M.F., Sotiropoulos, S.N., Wilson, A.J., Coalson, T.S., Fischl, B., Andersson, J.L., Xu, J., Jbabdi, S., Webster, M., Polimeni, J.R., Van Essen, D.C., Jenkinson, M. (2013). The minimal preprocessing pipelines for the Human Connectome Project. Neuroimage 80: 105-124. [Link]
Note: Data were provided [in part] by the Human Connectome Project, WU-Minn Consortium (Principal Investigators: David Van Essen and Kamil Ugurbil; 1U54MH091657) funded by the 16 NIH Institutes and Centers that support the NIH Blueprint for Neuroscience Research; and by the McDonnell Center for Systems Neuroscience at Washington University.