Yale/NIDA Neuroproteomics Center Project Investigators

The Yale/NIDA Neuroproteomics Center brings 27 exceptionally strong research programs in proteomics, signal transduction, and drug addiction from 10 institutions across the country together with the Keck Foundation Biotechnology Resource Laboratory at Yale University. The resulting collaboration creates a unique virtual and synergistic environment that fosters the development of innovative approaches for using cutting edge MS/proteomics and related technologies to quantitatively analyze neuronal signaling processes and to identify the adaptive changes in these processes that occur in response to exposure to drugs of abuse. The Center’s theme, “Proteomics of Altered Signaling in Addiction”, follows from the premise that drugs of abuse usurp normal regulation of intracellular signaling processes in brain reward centers that in turn alters gene expression, protein translation, and post-translational modifications of proteins. Repeated exposure to drugs of abuse results in stable alterations in these signaling systems that are critical for the changes in brain chemistry and development of the structure of the addicted brain. The Center’s research is focused on four inter-related scientific areas:

1. pre- and post-synaptic signaling
2. transcriptional and translational control
3. neurotransmitter and ion channel function
4. how altered synaptic plasticity and structural changes mediate altered behavior in the addicted brain

Included among our Center’s research programs are studies of the molecular actions of psychostimulants such as cocaine and methamphetamine, as well as nicotine, opiates, cannabinoids, and benzodiazepines. Comparative analysis of proteome profiling data sets from studies with different drugs may help identify common molecular targets.