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Nucleic Acid Isolation and Assessment


Keck Microarray Shared Resource (KMSR) offers DNA/RNA isolation services for a large variety of sample types, including saliva, blood, fresh/frozen or FFPE tissue, and cultured cells, using the following instruments.

  • PerkinElmer Chemagic 360
  • Promega HSM System
  • KingFisher Apex System

Proper quantitation and size analysis of RNA and DNA samples prior to downstream processing provides useful insight into sample quality, purity, and integrity which can help ensure high quality data and improved reproducibility. KMSR provides nucleic acid assessment services to quantify and determine purity and size of RNA and DNA. The quality assessment (QA) service is supported with a variety of measurement instruments, including several UV spectrophotometers, a plate reader, a fluorimeter and state-of-the-art Bioanalyzer systems including the Agilent 2100 and TapeStation 4200.

Sample Submission

  • Before submitting samples to the KMSR core laboratory, please contact for project specifications. The KMSR team is available to share their experience on working with multiple sample types and provide guidance on the specifics of optimal sample preparation for your study.
    • Please do not deliver or ship samples without first contacting KMSR staff to set-up a delivery time.
  • Complete the service request form and submit request for KMSR services through KMSR online sample submission and tracking system: KMSR PPMS. After service order received and approved by the core staff, prepare samples and deliver/ship to the core lab as described below.
    • Nucleic Acid Isolation and Assessment Service Request Form
  • Samples can be dropped off at our campus locations:
    • Tuesday and Thursday: 300 George St., (Room 2127)
    • Monday, Wednesday, and Friday: 300 Cedar St. (TAC), (Room S352),
    • Samples are picked up at 8 AM.
    • Please complete the sample submission form and place a hard copy in a Ziploc bag along with your samples.
  • Shipping information
    • *Please send the tracking information to
    • Yale Center for Genome Analysis
      Keck Microarray Shared Resource
      ATTN: Guilin Wang/Evelyn Ng
      830 West Campus Dr.
      West Haven, CT 06516

Service Fees

Services Yale Fee Non-Yale Fee
DNA Extraction-Tissue/Buccal Swab/Blood/Saliva $33 $46
DNA Extraction-FFPE $50 $72
HWM DNA Extraction-Cells $65 $94
RNA Isolation-Tissue/Blood/Cell $43 $61
RNA Isolation-FFPE $54 $78