Harold W. Jockers Professor of Medicine, Deputy Dean for Academic Affairs
- Faculty
- Immunity, Innate
- Lyme Disease
- Rheumatology
- Tick-Borne Diseases
- Lyme Neuroborreliosis
Individual variations in immune status determine responses to infection and contribute to disease severity and outcome. These variations contribute to susceptibility to autoimmune diseases and may contribute to clinical expression and response to therapy. To define immune signatures that are associated with specific clinical manifestations of diseases, we profile multiple aspects of cell functions, using primary cells of well-defined patient cohorts. We have developed reproducible methods for primary cells and small sample sizes to identify cell types, responses to treatment, and functional mechanisms. Our overall goal is to delineate predictive immune signatures important for understanding diverse states of disease such as mild vs severe disease, isolated organ involvement vs systemic disease, remission vs flare, young vs old.
Harold W. Jockers Professor of Medicine, Deputy Dean for Academic Affairs
Waldemar Von Zedtwitz Professor of Medicine (Rheumatology) and Professor of Pathology and of Epidemiology (Microbial Diseases); Chief, Rheumatology, Allergy, & Immunology; Rheumatologist in Chief, Rheumatology; Affiliated Faculty, Yale Institute for Global Health
Professor; Director of Allergy & Immunology, Internal Medicine
Professor of Medicine and Professor of Epidemiology (Microbial Diseases); Director, Yale CyTOF Facility, Present; Associate Dean for Scientific Affairs, Dept Clinical: Internal Medicine
ImageStream
-which combines quantitative flow cytometry with simultaneous high-resolution digital imaging https://medicine.yale.edu/labmed/cellsorter/instrumentation/amnis.aspx
Genetic Polymorphisms
-Flow Cytometry https://medicine.yale.edu/labmed/cellsorter/
Immune cell phenotyping methods
-CyTOF allows detection of ~ 40 labels in a sample and high-dimensional functional data from multiple cell lineages simultaneously https://medicine.yale.edu/intmed/rheumat/cytof/index.aspx
Transcriptomics
-(Microarray, Nanostring) http://keck.med.yale.edu/genomic/