Phillip Joseph, MD
Assistant ProfessorCards
About
Research
Publications
2024
The metabolic and physiologic impairments underlying long COVID associated exercise intolerance
Leitner B, Joseph P, Quast A, Ramirez M, Heerdt P, Villalobos J, Singh I. The metabolic and physiologic impairments underlying long COVID associated exercise intolerance. Pulmonary Circulation 2024, 14: e70009. PMID: 39544193, PMCID: PMC11560803, DOI: 10.1002/pul2.70009.Peer-Reviewed Original ResearchPeak VO2Long COVID patientsCOVID patientsReduced peak VOSeverity of SARS-CoV-2 infectionSystemic oxygen extractionSARS-CoV-2 infectionLong COVIDArterial blood samplesQuantitative metabolomicsPeak VOVenous lactateCardiac outputImpaired mitochondrial ATP productionMild infectionExercise capacityPatientsMitochondrial ATP productionExercise intoleranceArteriovenous gradientBlood samplesOxygen extractionDependent mannerMetabolomicsPhysiological impairmentRight Ventricular Pressure Waveform Analysis—Clinical Relevance and Future Directions
Heerdt P, Kheyfets V, Oakland H, Joseph P, Singh I. Right Ventricular Pressure Waveform Analysis—Clinical Relevance and Future Directions. Journal Of Cardiothoracic And Vascular Anesthesia 2024, 38: 2433-2445. PMID: 39025682, PMCID: PMC11580041, DOI: 10.1053/j.jvca.2024.06.022.Peer-Reviewed Original ResearchRight ventricular pressureRight ventricular functionVentricular pressureVentricular functionMeasuring right ventricular pressureMeasurements of right ventricular pressurePeak right ventricular pressurePulmonary artery pressureEvaluate cardiac functionPulmonary arteryStroke volume measurementsRight atriumCardiac functionDiastolic fillingSurgical patientsArterial pressureClinical valueDemonstrating utilityVolume measurementsMeasurements of pressurePressure waveformAccurate surrogateContinuous measurement of pressurePhysiological factorsEchocardiographyThree-dimensional (3D) Right Ventricular Surface Strain Computed From 3D Echocardiography Correlates With RVEF and Reveals Differences in Deformation Based on Severity of Pulmonary Arterial Hypertension Symptoms
Oakland H, Bellumkonda L, Sugeng L, Joseph P, Izzi D, Zalik F, McCabe S, Raza A, Amendola R, Heerdt P, Singh I, Hunter K. Three-dimensional (3D) Right Ventricular Surface Strain Computed From 3D Echocardiography Correlates With RVEF and Reveals Differences in Deformation Based on Severity of Pulmonary Arterial Hypertension Symptoms. 2024, a7381-a7381. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a7381.Peer-Reviewed Original ResearchDuct Effects on Acoustic Source Radiation
Baddour B, Joseph P, McAlpine A, Leung R. Duct Effects on Acoustic Source Radiation. AIAA Journal 2024, 62: 1037-1051. DOI: 10.2514/1.j063444.Peer-Reviewed Original ResearchAn Investigation into the Physical Mechanisms of Leak Noise Propagation in Buried Plastic Water Pipes: A Wave Dynamic Stiffness Approach
Scussel O, Brennan M, Muggleton J, de Almeida F, Joseph P, Gao Y. An Investigation into the Physical Mechanisms of Leak Noise Propagation in Buried Plastic Water Pipes: A Wave Dynamic Stiffness Approach. Acoustics 2024, 6: 157-176. DOI: 10.3390/acoustics6010009.Peer-Reviewed Original ResearchOn the balance between the tonal and broadband noise of isolated propellers
Akiwate D, Joseph P, Parry A, Paruchuri C. On the balance between the tonal and broadband noise of isolated propellers. International Journal Of Aeroacoustics 2024, 23: 122-153. DOI: 10.1177/1475472x231225631.Peer-Reviewed Original Research
2023
Differential cardiopulmonary haemodynamic phenotypes in PASC-related exercise intolerance
Kahn P, Joseph P, Heerdt P, Singh I. Differential cardiopulmonary haemodynamic phenotypes in PASC-related exercise intolerance. ERJ Open Research 2023, 10: 00714-2023. PMID: 38348243, PMCID: PMC10860209, DOI: 10.1183/23120541.00714-2023.Peer-Reviewed Original ResearchInvasive cardiopulmonary exercise testingRight heart catheterizationPASC patientsExertional intoleranceCardiac outputPulmonary artery wedge pressurePeak VO 2Supranormal cardiac outputPeak exercise capacityCardiopulmonary exercise testingMaximal voluntary ventilationPost-acute sequelaeBody mass indexSystemic oxygen extractionMild acute illnessSARS-CoV-2Exercise hemodynamicsHFpEF patientsHFpEF phenotypeHeart catheterizationWedge pressureAcute illnessExercise capacityExercise testingHemodynamic abnormalitiesAnalysis of phase data from ground vibration measurements above a leaking plastic water pipe
Scussel O, Brennan M, Iwanaga M, Almeida F, Karimi M, Muggleton J, Joseph P, Rustighi E. Analysis of phase data from ground vibration measurements above a leaking plastic water pipe. Journal Of Sound And Vibration 2023, 564: 117873. DOI: 10.1016/j.jsv.2023.117873.Peer-Reviewed Original ResearchAn experimental investigation on the effect of in-flow distortions of propeller noise
Petricelli F, Chaitanya P, Palleja-Cabre S, Meloni S, Joseph P, Karimian A, Palani S, Camussi R. An experimental investigation on the effect of in-flow distortions of propeller noise. Applied Acoustics 2023, 214: 109682. DOI: 10.1016/j.apacoust.2023.109682.Peer-Reviewed Original ResearchPost-Acute Sequelae of SARS-CoV-2 More Than Deconditioning
Joseph P, Singh I. Post-Acute Sequelae of SARS-CoV-2 More Than Deconditioning. Chest 2023, 164: 583-584. PMID: 37689472, DOI: 10.1016/j.chest.2023.03.014.Peer-Reviewed Original Research
Clinical Trials
Current Trials
A Study of Sotatercept for the Treatment of Cpc-PH Due to HFpEF (MK-7962-007/A011-16) (CADENCE)
HIC ID2000032349RolePrincipal InvestigatorPrimary Completion Date08/31/2023Recruiting ParticipantsGenderBothAge18 years - 85 years
Clinical Care
Overview
Clinical Specialties
Pulmonary Hypertension; Pulmonary Critical Care
Fact Sheets
Pulmonary Hypertension
Learn More on Yale MedicineAcute Respiratory Distress Syndrome (ARDS)
Learn More on Yale MedicinePediatric Respiratory Failure
Learn More on Yale MedicineCOVID-19
Learn More on Yale Medicine
Board Certifications
Critical Care Medicine (Internal Medicine)
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2019
Pulmonary Disease
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2018
Internal Medicine
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2015
Yale Medicine News
News
News
- April 02, 2024
Yale Department of Internal Medicine Promotions and Appointments (April 2024)
- February 05, 2024Source: Yale Medicine
How Surgery Can Fix CTEPH, a Rare Type of Pulmonary Hypertension
- June 07, 2023
D’Ambrosio Awarded Outstanding Educator Award by Association of Pulmonary and Critical Care Medicine Program Directors
- April 27, 2023
Study Uncovers Reduced Exercise Tolerance and Other Changes in Long COVID
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