Martin Schwartz

Bio Profile

Martin Schwartz, PhD

Robert W. Berliner Professor of Medicine (Cardiology) and Professor of Biomedical Engineering and of Cell Biology

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Schwartz Lab

The main research topics in my laboratory are integrin signaling and mechanotransduction in vascular biology, with emphasis on topics that are relevant to human disease. We use a variety of biophysical and cell biological tools as well as animal models in these studies.


Bidone TC, Polley A, Jin J, Driscoll T, Iwamoto DV, Calderwood DA, Schwartz MA, Voth GA: Coarse-Grained Simulation of Full-Length Integrin Activation. Biophys J. 2019 Mar 19; 2019 Feb 22. PMID: 30851876

Min E, Schwartz MA: Translocating transcription factors in fluid shear stress-mediated vascular remodeling and disease. Exp Cell Res. 2019 Mar 1; 2019 Jan 8. PMID: 30633880

Lay AJ, Coleman PR, Formaz-Preston A, Ting KK, Roediger B, Weninger W, Schwartz MA, Vadas MA, Gamble JR: ARHGAP18: A Flow-Responsive Gene That Regulates Endothelial Cell Alignment and Protects Against Atherosclerosis. J Am Heart Assoc. 2019 Jan 22. PMID: 30630384

Herrera J, Forster C, Pengo T, Montero A, Swift J, Schwartz MA, Henke CA, Bitterman PB: Registration of the extracellular matrix components constituting the fibroblastic focus in idiopathic pulmonary fibrosis. JCI Insight. 2019 Jan 10; 2019 Jan 10. PMID: 30626754

Rosowski KA, Boltyanskiy R, Xiang Y, Van den Dries K, Schwartz MA, Dufresne ER: Vinculin and the mechanical response of adherent fibroblasts to matrix deformation. Sci Rep. 2018 Dec 19; 2018 Dec 19. PMID: 30568231

Goult BT, Yan J, Schwartz MA: Talin as a mechanosensitive signaling hub. J Cell Biol. 2018 Nov 5; 2018 Sep 25. PMID: 30254032

Kumar A, Anderson KL, Swift MF, Hanein D, Volkmann N, Schwartz MA: Local Tension on Talin in Focal Adhesions Correlates with F-Actin Alignment at the Nanometer Scale. Biophys J. 2018 Oct 16; 2018 Sep 10. PMID: 30274833

Di Modugno F, Spada S, Palermo B, Visca P, Iapicca P, Di Carlo A, Antoniani B, Sperduti I, Di Benedetto A, Terrenato I, Mottolese M, Gandolfi F, Facciolo F, Chen EI, Schwartz MA, Santoni A, Bissell MJ, Nisticò P: hMENA isoforms impact NSCLC patient outcome through fibronectin/β1 integrin axis. Oncogene. 2018 Oct; 2018 Jun 15. PMID: 29907768

Liao X, Shen Y, Zhang R, Sugi K, Vasudevan NT, Alaiti MA, Sweet DR, Zhou L, Qing Y, Gerson SL, Fu C, Wynshaw-Boris A, Hu R, Schwartz MA, Fujioka H, Richardson B, Cameron MJ, Hayashi H, Stamler JS, Jain MK: Distinct roles of resident and nonresident macrophages in nonischemic cardiomyopathy. Proc Natl Acad Sci U S A. 2018 May 15; 2018 Apr 30. PMID: 29712858

Schwartz MA, Vestweber D, Simons M: A unifying concept in vascular health and disease. Science. 2018 Apr 20. PMID: 29674582

Fang JS, Coon BG, Gillis N, Chen Z, Qiu J, Chittenden TW, Burt JM, Schwartz MA, Hirschi KK: Addendum: Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification. Nat Commun. 2018 Feb 14; 2018 Feb 14. PMID: 29445140

Budatha M, Zhang J, Zhuang ZW, Yun S, Dahlman JE, Anderson DG, Schwartz MA: Inhibiting Integrin α5 Cytoplasmic Domain Signaling Reduces Atherosclerosis and Promotes Arteriogenesis. J Am Heart Assoc. 2018 Jan 30; 2018 Jan 30. PMID: 29382667

Fang JS, Coon BG, Gillis N, Chen Z, Qiu J, Chittenden TW, Burt JM, Schwartz MA, Hirschi KK: Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification. Nat Commun. 2017 Dec 15; 2017 Dec 15. PMID: 29247167

Lagendijk AK, Gomez GA, Baek S, Hesselson D, Hughes WE, Paterson S, Conway DE, Belting HG, Affolter M, Smith KA, Schwartz MA, Yap AS, Hogan BM: Live imaging molecular changes in junctional tension upon VE-cadherin in zebrafish. Nat Commun. 2017 Nov 10; 2017 Nov 10. PMID: 29123087

Conway DE, Coon BG, Budatha M, Arsenovic PT, Orsenigo F, Wessel F, Zhang J, Zhuang Z, Dejana E, Vestweber D, Schwartz MA: VE-Cadherin Phosphorylation Regulates Endothelial Fluid Shear Stress Responses through the Polarity Protein LGN. Curr Biol. 2017 Sep 11. PMID: 28898639

Conway DE, Coon BG, Budatha M, Arsenovic PT, Orsenigo F, Wessel F, Zhang J, Zhuang Z, Dejana E, Vestweber D, Schwartz MA: VE-Cadherin Phosphorylation Regulates Endothelial Fluid Shear Stress Responses through the Polarity Protein LGN. Curr Biol. 2017 Jul 24; 2017 Jul 14. PMID: 28712573

Bosco DB, Roycik MD, Jin Y, Schwartz MA, Lively TJ, Zorio DA, Sang QA: A new synthetic matrix metalloproteinase inhibitor reduces human mesenchymal stem cell adipogenesis. PLoS One. 2017; 2017 Feb 24. PMID: 28234995

Wang Y, Baeyens N, Corti F, Tanaka K, Fang JS, Zhang J, Jin Y, Coon B, Hirschi KK, Schwartz MA, Simons M: Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic development. Development. 2016 Dec 1; 2016 Oct 27. PMID: 27789626

Yun S, Budatha M, Dahlman JE, Coon BG, Cameron RT, Langer R, Anderson DG, Baillie G, Schwartz MA: Interaction between integrin α5 and PDE4D regulates endothelial inflammatory signalling. Nat Cell Biol. 2016 Oct; 2016 Sep 5. PMID: 27595237

Baeyens N, Larrivée B, Ola R, Hayward-Piatkowskyi B, Dubrac A, Huang B, Ross TD, Coon BG, Min E, Tsarfati M, Tong H, Eichmann A, Schwartz MA: Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia. J Cell Biol. 2016 Sep 26; 2016 Sep 19. PMID: 27646277

Ahmed M, Sottnik JL, Dancik GM, Sahu D, Hansel DE, Theodorescu D, Schwartz MA: An Osteopontin/CD44 Axis in RhoGDI2-Mediated Metastasis Suppression. Cancer Cell. 2016 Sep 12; 2016 Sep 1. PMID: 27593345

Balestrini JL, Gard AL, Gerhold KA, Wilcox EC, Liu A, Schwan J, Le AV, Baevova P, Dimitrievska S, Zhao L, Sundaram S, Sun H, Rittié L, Dyal R, Broekelmann TJ, Mecham RP, Schwartz MA, Niklason LE, White ES: Comparative biology of decellularized lung matrix: Implications of species mismatch in regenerative medicine. Biomaterials. 2016 Sep; 2016 Jun 16. PMID: 27344365

Gerhold KA, Schwartz MA: Ion Channels in Endothelial Responses to Fluid Shear Stress. Physiology (Bethesda). 2016 Sep. PMID: 27511462

Kumar A, Ouyang M, Van den Dries K, McGhee EJ, Tanaka K, Anderson MD, Groisman A, Goult BT, Anderson KI, Schwartz MA: Correction: Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity. J Cell Biol. 2016 Jul 18. PMID: 27432899

Kumar A, Ouyang M, Van den Dries K, McGhee EJ, Tanaka K, Anderson MD, Groisman A, Goult BT, Anderson KI, Schwartz MA: Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity. J Cell Biol. 2016 May 9. PMID: 27161398

Brenner MD, Zhou R, Conway DE, Lanzano L, Gratton E, Schwartz MA, Ha T: Spider Silk Peptide Is a Compact, Linear Nanospring Ideal for Intracellular Tension Sensing. Nano Lett. 2016 Mar 9; 2016 Feb 3. PMID: 26824190

Baeyens N, Bandyopadhyay C, Coon BG, Yun S, Schwartz MA: Endothelial fluid shear stress sensing in vascular health and disease. J Clin Invest. 2016 Mar 1; 2016 Mar 1. PMID: 26928035

Dubrac A, Genet G, Ola R, Zhang F, Pibouin-Fragner L, Han J, Zhang J, Thomas JL, Chedotal A, Schwartz MA, Eichmann A: Targeting NCK-Mediated Endothelial Cell Front-Rear Polarity Inhibits Neovascularization. Circulation. 2016 Jan 26; 2015 Dec 9. PMID: 26659946

Baeyens N, Schwartz MA: Biomechanics of vascular mechanosensation and remodeling. Mol Biol Cell. 2016 Jan 1. PMID: 26715421

Chen PY, Qin L, Baeyens N, Li G, Afolabi T, Budatha M, Tellides G, Schwartz MA, Simons M: Endothelial-to-mesenchymal transition drives atherosclerosis progression. J Clin Invest. 2015 Oct 26; 2015 Oct 26. PMID: 26517696

Schwartz MA: The importance of indifference in scientific research. J Cell Sci. 2015 Aug 1; 2015 Jul 1. PMID: 26136366

Daneshjou N, Sieracki N, van Nieuw Amerongen GP, Conway DE, Schwartz MA, Komarova YA, Malik AB: Rac1 functions as a reversible tension modulator to stabilize VE-cadherin trans-interaction. J Cell Biol. 2015 Apr 13; 2015 Apr 6. PMID: 25847538

Humphrey JD, Schwartz MA, Tellides G, Milewicz DM: Role of mechanotransduction in vascular biology: focus on thoracic aortic aneurysms and dissections. Circ Res. 2015 Apr 10. PMID: 25858068

Coon BG, Baeyens N, Han J, Budatha M, Ross TD, Fang JS, Yun S, Thomas JL, Schwartz MA: Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complex. J Cell Biol. 2015 Mar 30; 2015 Mar 23. PMID: 25800053

Tornavaca O, Chia M, Dufton N, Almagro LO, Conway DE, Randi AM, Schwartz MA, Matter K, Balda MS: ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation. J Cell Biol. 2015 Mar 16; 2015 Mar 9. PMID: 25753039

Baeyens N, Nicoli S, Coon BG, Ross TD, Van den Dries K, Han J, Lauridsen HM, Mejean CO, Eichmann A, Thomas JL, Humphrey JD, Schwartz MA: Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point. Elife. 2015 Feb 2; 2015 Feb 2. PMID: 25643397

Daneshjou N, Sieracki N, van Nieuw Amerongen GP, Conway DE, Schwartz MA, Komarova YA, Malik AB: Rac1 functions as a reversible tension modulator to stabilize VE-cadherin trans-interaction. J Cell Biol. 2015 Jan 5. PMID: 25559184

Mohamied Y, Rowland EM, Bailey EL, Sherwin SJ, Schwartz MA, Weinberg PD: Change of direction in the biomechanics of atherosclerosis. Ann Biomed Eng. 2015 Jan; 2014 Aug 20. PMID: 25138165

Conway DE, Schwartz MA: Mechanotransduction of shear stress occurs through changes in VE-cadherin and PECAM-1 tension: implications for cell migration. Cell Adh Migr. 2015; 2014 Oct 3. PMID: 25482618

Andarawewa KL, Moissoglu K, Sup Lee C, Ando Y, Yu M, Debnath P, Shannon JD, Sirinivasan S, Conaway MR, Weber MJ, Schwartz MA: Integrin adjunct therapy for melanoma. Pigment Cell Melanoma Res. 2015 Jan; 2014 Nov 3. PMID: 25264294

Baeyens N, Mulligan-Kehoe MJ, Corti F, Simon DD, Ross TD, Rhodes JM, Wang TZ, Mejean CO, Simons M, Humphrey J, Schwartz MA: Syndecan 4 is required for endothelial alignment in flow and atheroprotective signaling. Proc Natl Acad Sci U S A. 2014 Dec 2; 2014 Nov 17. PMID: 25404299

Humphrey JD, Dufresne ER, Schwartz MA: Mechanotransduction and extracellular matrix homeostasis. Nat Rev Mol Cell Biol. 2014 Dec; 2014 Oct 22. PMID: 25355505

Yan C, Liu D, Li L, Wempe MF, Guin S, Khanna M, Meier J, Hoffman B, Owens C, Wysoczynski CL, Nitz MD, Knabe WE, Ahmed M, Brautigan DL, Paschal BM, Schwartz MA, Jones DN, Ross D, Meroueh SO, Theodorescu D: Discovery and characterization of small molecules that target the GTPase Ral. Nature. 2014 Nov 20; 2014 Sep 14. PMID: 25219851

Morrison AR, Yarovinsky TO, Young BD, Moraes F, Ross TD, Ceneri N, Zhang J, Zhuang ZW, Sinusas AJ, Pardi R, Schwartz MA, Simons M, Bender JR: Chemokine-coupled β2 integrin-induced macrophage Rac2-Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis. J Exp Med. 2014 Sep 22; 2014 Sep 1. PMID: 25180062

Leerberg JM, Gomez GA, Verma S, Moussa EJ, Wu SK, Priya R, Hoffman BD, Grashoff C, Schwartz MA, Yap AS: Tension-sensitive actin assembly supports contractility at the epithelial zonula adherens. Curr Biol. 2014 Aug 4; 2014 Jul 24. PMID: 25065757

Humphrey JD, Milewicz DM, Tellides G, Schwartz MA: Cell biology. Dysfunctional mechanosensing in aneurysms. Science. 2014 May 2. PMID: 24786066

Conway DE, Schwartz MA: Flow-dependent cellular mechanotransduction in atherosclerosis. J Cell Sci. 2013 Nov 15; 2013 Nov 4. PMID: 24190880

Ross TD, Coon BG, Yun S, Baeyens N, Tanaka K, Ouyang M, Schwartz MA: Integrins in mechanotransduction. Curr Opin Cell Biol. 2013 Oct; 2013 Jun 21. PMID: 23797029

Dufresne ER, Schwartz MA: Cell migration: Towards the void. Nat Mater. 2013 Sep. PMID: 23966050

Jin Y, Roycik MD, Bosco DB, Cao Q, Constantino MH, Schwartz MA, Sang QX: Matrix metalloproteinase inhibitors based on the 3-mercaptopyrrolidine core. J Med Chem. 2013 Jun 13; 2013 May 16. PMID: 23631440

Conway DE, Breckenridge MT, Hinde E, Gratton E, Chen CS, Schwartz MA: Fluid shear stress on endothelial cells modulates mechanical tension across VE-cadherin and PECAM-1. Curr Biol. 2013 Jun 3; 2013 May 16. PMID: 23684974

Schwartz MA, Chen CS: Cell biology. Deconstructing dimensionality. Science. 2013 Jan 25. PMID: 23349278

Ouyang M, Lu S, Kim T, Chen CE, Seong J, Leckband DE, Wang F, Reynolds AB, Schwartz MA, Wang Y: N-cadherin regulates spatially polarized signals through distinct p120ctn and β-catenin-dependent signalling pathways. Nat Commun. 2013. PMID: 23481397

Tirziu D, Jaba IM, Yu P, Larrivée B, Coon BG, Cristofaro B, Zhuang ZW, Lanahan AA, Schwartz MA, Eichmann A, Simons M: Endothelial nuclear factor-κB-dependent regulation of arteriogenesis and branching. Circulation. 2012 Nov 27; 2012 Oct 22. PMID: 23091063

Simons M, Schwartz MA: Profilin phosphorylation as a VEGFR effector in angiogenesis. Nat Cell Biol. 2012 Oct. PMID: 23033049

Batra N, Burra S, Siller-Jackson AJ, Gu S, Xia X, Weber GF, DeSimone D, Bonewald LF, Lafer EM, Sprague E, Schwartz MA, Jiang JX: Mechanical stress-activated integrin α5β1 induces opening of connexin 43 hemichannels. Proc Natl Acad Sci U S A. 2012 Feb 28; 2012 Feb 13. PMID: 22331870

Schwartz MA, Simons M: Lymphatics thrive on stress: mechanical force in lymphatic development. EMBO J. 2012 Feb 15; 2012 Feb 15. PMID: 22334045

Conway D, Schwartz MA: Lessons from the endothelial junctional mechanosensory complex. F1000 Biol Rep. 2012; 2012 Jan 3. PMID: 22238515

Norambuena A, Schwartz MA: Effects of integrin-mediated cell adhesion on plasma membrane lipid raft components and signaling. Mol Biol Cell. 2011 Sep; 2011 Jul 27. PMID: 21795400

Hoffman BD, Grashoff C, Schwartz MA: Dynamic molecular processes mediate cellular mechanotransduction. Nature. 2011 Jul 20; 2011 Jul 20. PMID: 21776077

Goguen BN, Hoffman BD, Sellers JR, Schwartz MA, Imperiali B: Light-triggered myosin activation for probing dynamic cellular processes. Angew Chem Int Ed Engl. 2011 Jun 14; 2011 May 3. PMID: 21542072

Min D, Chen M, Zheng L, Jin Y, Schwartz MA, Sang QX, Yang W: Enhancing QM/MM molecular dynamics sampling in explicit environments via an orthogonal-space-random-walk-based strategy. J Phys Chem B. 2011 Apr 14; 2011 Mar 21. PMID: 21417256

Thomas S, Overdevest JB, Nitz MD, Williams PD, Owens CR, Sanchez-Carbayo M, Frierson HF, Schwartz MA, Theodorescu D: Src and caveolin-1 reciprocally regulate metastasis via a common downstream signaling pathway in bladder cancer. Cancer Res. 2011 Feb 1; 2010 Dec 10. PMID: 21148751

Shin ME, He Y, Li D, Na S, Chowdhury F, Poh YC, Collin O, Su P, de Lanerolle P, Schwartz MA, Wang N, Wang F: Spatiotemporal organization, regulation, and functions of tractions during neutrophil chemotaxis. Blood. 2010 Oct 28; 2010 Jul 8. PMID: 20616216

Parsons JT, Horwitz AR, Schwartz MA: Cell adhesion: integrating cytoskeletal dynamics and cellular tension. Nat Rev Mol Cell Biol. 2010 Sep. PMID: 20729930

Grashoff C, Hoffman BD, Brenner MD, Zhou R, Parsons M, Yang MT, McLean MA, Sligar SG, Chen CS, Ha T, Schwartz MA: Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics. Nature. 2010 Jul 8. PMID: 20613844

Feaver RE, Gelfand BD, Wang C, Schwartz MA, Blackman BR: Atheroprone hemodynamics regulate fibronectin deposition to create positive feedback that sustains endothelial inflammation. Circ Res. 2010 Jun 11; 2010 Apr 8. PMID: 20378855

Schwartz MA: Remembrance of dead cells past: discovering that the extracellular matrix is a cell survival factor. Mol Biol Cell. 2010 Feb 15. PMID: 20150528

Elfenbein A, Rhodes JM, Meller J, Schwartz MA, Matsuda M, Simons M: Suppression of RhoG activity is mediated by a syndecan 4-synectin-RhoGDI1 complex and is reversed by PKCalpha in a Rac1 activation pathway. J Cell Biol. 2009 Jul 13; 2009 Jul 6. PMID: 19581409

Wu Y, Moissoglu K, Wang H, Wang X, Frierson HF, Schwartz MA, Theodorescu D: Src phosphorylation of RhoGDI2 regulates its metastasis suppressor function. Proc Natl Acad Sci U S A. 2009 Apr 7; 2009 Mar 25. PMID: 19321744

Moissoglu K, McRoberts KS, Meier JA, Theodorescu D, Schwartz MA: Rho GDP dissociation inhibitor 2 suppresses metastasis via unconventional regulation of RhoGTPases. Cancer Res. 2009 Apr 1; 2009 Mar 10. PMID: 19276387

Dzamba BJ, Jakab KR, Marsden M, Schwartz MA, DeSimone DW: Cadherin adhesion, tissue tension, and noncanonical Wnt signaling regulate fibronectin matrix organization. Dev Cell. 2009 Mar. PMID: 19289087

Schwartz MA: Cell biology. The force is with us. Science. 2009 Jan 30. PMID: 19179515

Sebbagh M, Santoni MJ, Hall B, Borg JP, Schwartz MA: Regulation of LKB1/STRAD localization and function by E-cadherin. Curr Biol. 2009 Jan 13; 2008 Dec 24. PMID: 19110428

Hahn C, Schwartz MA: Mechanotransduction in vascular physiology and atherogenesis. Nat Rev Mol Cell Biol. 2009 Jan. PMID: 19197332

Hahn C, Schwartz MA: The role of cellular adaptation to mechanical forces in atherosclerosis. Arterioscler Thromb Vasc Biol. 2008 Dec; 2008 Sep 11. PMID: 18787190

Harry BL, Sanders JM, Feaver RE, Lansey M, Deem TL, Zarbock A, Bruce AC, Pryor AW, Gelfand BD, Blackman BR, Schwartz MA, Ley K: Endothelial cell PECAM-1 promotes atherosclerotic lesions in areas of disturbed flow in ApoE-deficient mice. Arterioscler Thromb Vasc Biol. 2008 Nov; 2008 Aug 7. PMID: 18688018

Schwartz MA, McRoberts K, Coyner M, Andarawewa KL, Frierson HF Jr, Sanders JM, Swenson S, Markland F, Conaway MR, Theodorescu D: Integrin agonists as adjuvants in chemotherapy for melanoma. Clin Cancer Res. 2008 Oct 1. PMID: 18829498

Schwartz MA, DeSimone DW: Cell adhesion receptors in mechanotransduction. Curr Opin Cell Biol. 2008 Oct; 2008 Jun 24. PMID: 18583124

Schwartz MA: The importance of stupidity in scientific research. J Cell Sci. 2008 Jun 1. PMID: 18492790

Hall B, McLean MA, Davis K, Casanova JE, Sligar SG, Schwartz MA: A fluorescence resonance energy transfer activation sensor for Arf6. Anal Biochem. 2008 Mar 15; 2007 Dec 3. PMID: 18162163

Meller N, Westbrook MJ, Shannon JD, Guda C, Schwartz MA: Function of the N-terminus of zizimin1: autoinhibition and membrane targeting. Biochem J. 2008 Jan 15. PMID: 17935486

Reutershan J, Stockton R, Zarbock A, Sullivan GW, Chang D, Scott D, Schwartz MA, Ley K: Blocking p21-activated kinase reduces lipopolysaccharide-induced acute lung injury by preventing polymorphonuclear leukocyte infiltration. Am J Respir Crit Care Med. 2007 May 15; 2007 Feb 22. PMID: 17322107

Del Pozo MA, Schwartz MA: Rac, membrane heterogeneity, caveolin and regulation of growth by integrins. Trends Cell Biol. 2007 May; 2007 Mar 23. PMID: 17363257

Orr AW, Ginsberg MH, Shattil SJ, Deckmyn H, Schwartz MA: Matrix-specific suppression of integrin activation in shear stress signaling. Mol Biol Cell. 2006 Nov; 2006 Aug 23. PMID: 16928957

Gaus K, Le Lay S, Balasubramanian N, Schwartz MA: Integrin-mediated adhesion regulates membrane order. J Cell Biol. 2006 Aug 28. PMID: 16943184

Schwartz MA, Horwitz AR: Integrating adhesion, protrusion, and contraction during cell migration. Cell. 2006 Jun 30. PMID: 16814706

Moissoglu K, Slepchenko BM, Meller N, Horwitz AF, Schwartz MA: In vivo dynamics of Rac-membrane interactions. Mol Biol Cell. 2006 Jun; 2006 Apr 5. PMID: 16597700

Sang QX, Jin Y, Newcomer RG, Monroe SC, Fang X, Hurst DR, Lee S, Cao Q, Schwartz MA: Matrix metalloproteinase inhibitors as prospective agents for the prevention and treatment of cardiovascular and neoplastic diseases. Curr Top Med Chem. 2006. PMID: 16611144

Orr AW, Helmke BP, Blackman BR, Schwartz MA: Mechanisms of mechanotransduction. Dev Cell. 2006 Jan. PMID: 16399074

Hurst DR, Schwartz MA, Jin Y, Ghaffari MA, Kozarekar P, Cao J, Sang QX: Inhibition of enzyme activity of and cell-mediated substrate cleavage by membrane type 1 matrix metalloproteinase by newly developed mercaptosulphide inhibitors. Biochem J. 2005 Dec 15. PMID: 16026329

Bolick DT, Orr AW, Whetzel A, Srinivasan S, Hatley ME, Schwartz MA, Hedrick CC: 12/15-lipoxygenase regulates intercellular adhesion molecule-1 expression and monocyte adhesion to endothelium through activation of RhoA and nuclear factor-kappaB. Arterioscler Thromb Vasc Biol. 2005 Nov; 2005 Sep 15. PMID: 16166569

de Rooij J, Kerstens A, Danuser G, Schwartz MA, Waterman-Storer CM: Integrin-dependent actomyosin contraction regulates epithelial cell scattering. J Cell Biol. 2005 Oct 10. PMID: 16216928

del Pozo MA, Balasubramanian N, Alderson NB, Kiosses WB, Grande-García A, Anderson RG, Schwartz MA: Phospho-caveolin-1 mediates integrin-regulated membrane domain internalization. Nat Cell Biol. 2005 Sep; 2005 Aug 21. PMID: 16113676

Nishikimi A, Meller N, Uekawa N, Isobe K, Schwartz MA, Maruyama M: Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes. FEBS Lett. 2005 Feb 14; 2005 Jan 13. PMID: 15710388

Tzima E, Reader JS, Irani-Tehrani M, Ewalt KL, Schwartz MA, Schimmel P: VE-cadherin links tRNA synthetase cytokine to anti-angiogenic function. J Biol Chem. 2005 Jan 28; 2004 Dec 3. PMID: 15579907

Titus B, Schwartz MA, Theodorescu D: Rho proteins in cell migration and metastasis. Crit Rev Eukaryot Gene Expr. 2005. PMID: 16022631

Helmke BP, Schwartz MA: Putting the squeeze on mechanotransduction. Dev Cell. 2004 Jun. PMID: 15177022

Shiu YT, Li S, Marganski WA, Usami S, Schwartz MA, Wang YL, Dembo M, Chien S: Rho mediates the shear-enhancement of endothelial cell migration and traction force generation. Biophys J. 2004 Apr. PMID: 15041692

del Pozo MA, Alderson NB, Kiosses WB, Chiang HH, Anderson RG, Schwartz MA: Integrins regulate Rac targeting by internalization of membrane domains. Science. 2004 Feb 6. PMID: 14764880

Hurst DR, Schwartz MA, Ghaffari MA, Jin Y, Tschesche H, Fields GB, Sang QX: Catalytic- and ecto-domains of membrane type 1-matrix metalloproteinase have similar inhibition profiles but distinct endopeptidase activities. Biochem J. 2004 Feb 1. PMID: 14533979

Park HI, Jin Y, Hurst DR, Monroe CA, Lee S, Schwartz MA, Sang QX: The intermediate S1' pocket of the endometase/matrilysin-2 active site revealed by enzyme inhibition kinetic studies, protein sequence analyses, and homology modeling. J Biol Chem. 2003 Dec 19; 2003 Oct 7. PMID: 14532275

Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR: Cell migration: integrating signals from front to back. Science. 2003 Dec 5. PMID: 14657486

Hood JD, Frausto R, Kiosses WB, Schwartz MA, Cheresh DA: Differential alphav integrin-mediated Ras-ERK signaling during two pathways of angiogenesis. J Cell Biol. 2003 Sep 1. PMID: 12952943

Lin T, Zeng L, Liu Y, DeFea K, Schwartz MA, Chien S, Shyy JY: Rho-ROCK-LIMK-cofilin pathway regulates shear stress activation of sterol regulatory element binding proteins. Circ Res. 2003 Jun 27; 2003 May 29. PMID: 12775580

del Pozo MA, Schwartz MA, Hu J, Kiosses WB, Altman A, Villalba M: Guanine exchange-dependent and -independent effects of Vav1 on integrin-induced T cell spreading. J Immunol. 2003 Jan 1. PMID: 12496381

Meller N, Irani-Tehrani M, Kiosses WB, Del Pozo MA, Schwartz MA: Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins. Nat Cell Biol. 2002 Sep. PMID: 12172552

Liu S, Kiosses WB, Rose DM, Slepak M, Salgia R, Griffin JD, Turner CE, Schwartz MA, Ginsberg MH: A fragment of paxillin binds the alpha 4 integrin cytoplasmic domain (tail) and selectively inhibits alpha 4-mediated cell migration. J Biol Chem. 2002 Jun 7; 2002 Mar 27. PMID: 11919182

Schwartz MA, Ginsberg MH: Networks and crosstalk: integrin signalling spreads. Nat Cell Biol. 2002 Apr. PMID: 11944032

Blaber SI, Scarisbrick IA, Bernett MJ, Dhanarajan P, Seavy MA, Jin Y, Schwartz MA, Rodriguez M, Blaber M: Enzymatic properties of rat myelencephalon-specific protease. Biochemistry. 2002 Jan 29. PMID: 11802715

Schwartz MA: Matrix and meaning. Methods Cell Biol. 2002. PMID: 12070989