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Women’s Health Research at Yale Funds Projects on Obesity and Ovarian Aging, Diabetes, Cancers, and Autoimmunity
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Aging Reshapes the Ovary Long Before Reproductive Function Ends
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Meet Yogita Verma, Senior Manager of Research Center Operations, Cardiovascular Medicine
Yale Cardiovascular Research Center (YCVRC)
Yale Cardiovascular Research Center (YCVRC)
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The Yale Cardiovascular Research Center (YCVRC) is dedicated to improving cardiovascular health through innovative research. Our scientists are advancing the frontiers of knowledge in the physiology and diseases of the cardiovascular system, with studies spanning fundamental molecular mechanisms, human genetics, and translational breakthroughs.
The YCVRC is home to 19 laboratories and a community of more than 120 researchers and staff. Our faculty hold primary appointments in the Section of Cardiovascular Medicine at Yale School of Medicine and include physician-scientists and scientists whose work supports the Section's research, education, and clinical missions. We are dedicated to providing an outstanding training environment for the next generation of cardiovascular researchers.
The YCVRC is a unique scientific community built on a culture of collaboration. Our collaborative and collegial culture is reflected physically in our open laboratories and shared cutting-edge scientific infrastructure, as well as in our foundational research-in-progress forums where faculty and trainees benefit from the broad expertise of our investigative community and form vital collaborations. Our researchers include experts in cardiac, vascular, and stem cell biology, physiology, molecular biology, genetics, metabolism, immunology, imaging, computational biology, and cardiovascular medicine. This environment, along with our participation in the Yale Vascular Biology and Therapeutics program and integration with our Cardiovascular Medicine physicians, provides a powerful environment for discovery.
Research Highlights
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PRC2 Drives Vascular Inflammation and Atherosclerosis
- Science Advances | August 2026
Metabolism Controls Artery-Hardening Cell Behavior
This study shows that the enzyme PDK4 controls smooth muscle cell behavior in atherosclerosis, with its suppression reducing plaque development in mice. - Journal of Cardiovascular Magnetic Resonance | May 2026
CMR Predicts Outcomes in Immune Checkpoint Inhibitor Myocarditis
This study investigates how serial cardiovascular magnetic resonance imaging helps predict adverse cardiovascular events in immune checkpoint inhibitor myocarditis, highlighting its potential for improved patient risk stratification and outcomes. - Nature Cardiovascular Research | January 2026
Sphingosine Kinase 1 Drives Arterial Disease in Elastin Loss
This study shows that the enzyme SPHK1 drives excess arterial smooth muscle cell growth when elastin—a key structural protein—is deficient. - Nature Communications | October 2025
Stem Cells Enhance Skin Repair via ECM-Driven Junctions
This study investigates how basal epidermal stem cells regulate skin healing by forming extracellular matrix-specific junctions that enhance periderm injury repair.