Cardiovascular Medicine Research
The Section of Cardiovascular Medicine had another very productive and successful academic year. FY 2015 research activities were supported by $ 23 M in funding, including twenty-six R01s, four R21s, two P01s (PPGs), four U01s, five K and VA Career Development awards, two T32 grants, 1 DOD grant, $2M VA Merit Review grants, as well as other federal awards. Non-federal and foundation funding includes awards from the American Heart Association, the American Diabetes Association, the American Lung Association, the Connecticut Stem Cell Foundation, the Connecticut Biomedical Research Fund, the Sackler Foundation for Arts and Sciences, the CARIPLO Foundation and numerous industry-sponsored clinical trials.
The broad research efforts of CV Medicine are divided into five separate (and often interactive) domains: (1) the Yale Cardiovascular Research Center (YCVRC), (2) the Center for Outcomes Research (CORE), (3) Clinical Studies, including the Yale Cardiovascular Research Group (YCVRG), (4) the Yale Translational Imaging Center (YTRIC), and (5) VA Connecticut Healthcare System Cardiology Research Group
Started 1995 and directed by Harlan Krumholz, MD, Harold H. Hines, Jr. Professor of Medicine, CORE has been a pioneer in the field of outcomes research and health care policy. The 56 investigators and staff members of the Center are engaged in a broad spectrum of activities from analysis of Medicare data sets to clinical trials and clinical database management. CORE also is the home to NHLBI-funded Center for Cardiovascular Outcomes Research.
Founded in 2010, YCVRC houses the Section’s basic cardiovascular research program. The Center’s 14 primary investigators and 81 students and post-doctoral trainees conduct research in vascular, developmental and myocardial biology as well as genetics, stem cells and metabolism. The Center has extensive research facilities including state of the art zebrafish facility, confocal microscopy core facilities, and mouse physiology and surgery core laboratories. YCVRC houses NHLBI-supported PPG focused an arteriogenesis and Foundation Leducq-sponsored Trans-Atlantic Research program on arteriogenesis and metabolism. Postdoctoral training in the Center is supported by an NHLBI-funded T32 program in vascular biology.
Founded in 2010 and directed by Albert Sinusas, MD, Professor of Medicine and Diagnostic Radiology, Y-TRIC was established to facilitate translational animal research. The facility centralizes small and large animal housing and surgery with state-of-the-art imaging resources. The core resources include; an integrated surgical and fluoroscopy suite, radiochemistry laboratory, a unique hybrid SPECT/64-slice CT scanner, a microSPECT/CT imaging suite, in vitro and in vivo microCT scanners, 3D ultrasound imaging systems, a state-of-the-art mouse echo core laboratory, and 3D graphics workstations. The center focuses on imaging probe and technology development and multimodality anatomic, physiological, and molecular imaging, and image registration and quantification. The training in the Center is supported by an NHLBI-funded T32 program in multimodality molecular and translational cardiovascular imaging. Y-TRIC staff also facilitate multimodality animal imaging at the Yale Magnetic Resonance Research Center (MRRC) and Yale PET Center.
Founded in 2010 and directed by Alexandra Lansky, MD, Professor of Medicine, YCVRG focuses on conduct of clinical trials at Yale and internationally. The Center provides core lab services that include angiographic, echo, CT and ECG core laboratories, trial management and data analyses services. Over 30 investigators and staff at the Center are currently involved in 30 trials at Yale and 25 national and international clinical trials.