Mei Xue Dong, MD, PhD
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Rheumatology
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Assistant Professor of Medicine (Rheumatology, Allergy & Immunology)
Biography
Dr. Dong received medical degree from Wuhan University School of Medicine before pursuing PhD study at the University of Connecticut Health Center. Her PhD work focused on chemoattractant signaling in leukocyte activation at the sites of infection and inflammation including arteriosclerosis. For post-doctoral work, she joined Dr. Craft’s laboratory while completing rheumatology fellowship in Yale. Since then, she starts growing the Yale lupus patient registry and biorepository. She is an active clinical faculty, enjoying caring for rheumatology patients and clinical teaching of medical trainees. Her current research focuses on the risk factors and prevention of cardiovascular disease in rheumatic disorders, especially patients with lupus
Appointments
Rheumatology
Assistant ProfessorPrimary
Other Departments & Organizations
Education & Training
- Fellowship
- Yale Medicine (2018)
- Residency
- Saint Mary's Hospital (2015)
- Postdoctoral Fellow
- Yale University School of Medicine (2012)
- PhD
- University of Connecticut Health Center (2007)
- MD
- Wuhan University School of Medicine (1996)
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Mei Xue Dong's published research.
Publications Timeline
A big-picture view of Mei Xue Dong's research output by year.
Joseph Craft, MD
Wenzhi Song
8Publications
925Citations
Publications
2021
Type I Interferon–Activated STAT4 Regulation of Follicular Helper T Cell–Dependent Cytokine and Immunoglobulin Production in Lupus
Dong X, Antao OQ, Song W, Sanchez GM, Zembrzuski K, Koumpouras F, Lemenze A, Craft J, Weinstein JS. Type I Interferon–Activated STAT4 Regulation of Follicular Helper T Cell–Dependent Cytokine and Immunoglobulin Production in Lupus. Arthritis & Rheumatology 2021, 73: 478-489. PMID: 33512094, PMCID: PMC7914134, DOI: 10.1002/art.41532.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAdultAnimalsAntibody FormationAutoantibodiesB-LymphocytesCase-Control StudiesCytokinesDisease Models, AnimalFemaleHumansImmunoglobulinsInterferon Type IInterferon-gammaInterleukinsLupus Erythematosus, SystemicMaleMice, Inbred MRL lprMiddle AgedRNA-SeqSTAT4 Transcription FactorT Follicular Helper CellsConceptsSystemic lupus erythematosusTfh-like cellsTfh cellsIL-21Human lupusDisease activityCytokine productionSTAT4 activationImmunoglobulin productionPathogenic B cell responsesCourse of lupusClinical disease activityT cell secretionLupus-prone miceHealthy control subjectsCourse of diseaseB cell responsesCytokine interleukin-21Potential therapeutic targetType I IFNB cell maturationSLE patientsPathogenic cytokinesLupus erythematosusInterleukin-21
2008
Lack of a significant role of P-Rex1, a major regulator of macrophage Rac1 activation and chemotaxis, in atherogenesis
Wang Z, Dong X, Li Z, Smith JD, Wu D. Lack of a significant role of P-Rex1, a major regulator of macrophage Rac1 activation and chemotaxis, in atherogenesis. Prostaglandins And Other Lipid Mediators 2008, 87: 9-13. PMID: 18502673, PMCID: PMC3644862, DOI: 10.1016/j.prostaglandins.2008.04.001.Peer-Reviewed Original ResearchCitations
2007
Phospholipase C β3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice
Wang Z, Liu B, Wang P, Dong X, Fernandez-Hernando C, Li Z, Hla T, Li Z, Claffey K, Smith JD, Wu D. Phospholipase C β3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice. Journal Of Clinical Investigation 2007, 118: 195-204. PMID: 18079968, PMCID: PMC2129238, DOI: 10.1172/jci33139.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsPLC-beta3PLC-betaPKC-dependent upregulationMacrophage survivalPLC isoformsNovel roleBcl-xLMultiple inducersSubsequent differentiationApoptotic inductionAtherosclerotic plaquesMacrophage apoptosisApoE-deficient mouse modelPLC activityPLC-beta2Murine macrophagesAtherosclerotic lesion sizeReduction of atherosclerosisPotential targetLipid-laden macrophagesTreatment of atherosclerosisBeta3Key membersMacrophage functionApoptosisSignaling requirements for translocation of P-Rex1, a key Rac2 exchange factor involved in chemoattractant-stimulated human neutrophil function
Zhao T, Nalbant P, Hoshino M, Dong X, Wu D, Bokoch GM. Signaling requirements for translocation of P-Rex1, a key Rac2 exchange factor involved in chemoattractant-stimulated human neutrophil function. Journal Of Leukocyte Biology 2007, 81: 1127-1136. PMID: 17227822, DOI: 10.1189/jlb.0406251.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsProtein kinase AEndogenous P-Rex1P-Rex1Exchange factorBetagamma subunitsCAMP-dependent protein kinase ACell adhesionG protein betagamma subunitsHeterotrimeric G proteinsActivation of PKARac-specific guanineG protein-coupled receptorsProtein betagamma subunitsNeutrophil chemoattractant receptorsProtein-coupled receptorsTyrosine kinase activityDependent RacExtracellular stimuliSpatial regulationKinase AKinase activityF-actinG proteinsImportant regulatorRac2 activation
2006
Characterization and Application of a New Optical Probe for Membrane Lipid Domains
Jin L, Millard AC, Wuskell JP, Dong X, Wu D, Clark HA, Loew LM. Characterization and Application of a New Optical Probe for Membrane Lipid Domains. Biophysical Journal 2006, 90: 2563-2575. PMID: 16415047, PMCID: PMC1403187, DOI: 10.1529/biophysj.105.072884.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsEmission spectraStrong second harmonic generation (SHG) signalNew optical probeSecond harmonic generation signalNonlinear optical microscopyHarmonic generation signalLiquid-disordered phasesLarge unilamellar lipid vesiclesOptical propertiesOptical probeGeneration signalSensitive probeBlue shiftOptical microscopyGiant unilamellar vesiclesLiquid-ordered stateDye moleculesUnilamellar lipid vesiclesLiquid-disordered domainsLipid domainsMolecular packingSpectraLipid membranesRed fluorescencePhase separationMethods for Studying Neutrophil Chemotaxis
Dong X, Wu D. Methods for Studying Neutrophil Chemotaxis. Methods In Enzymology 2006, 406: 605-613. PMID: 16472691, DOI: 10.1016/s0076-6879(06)06047-2.Peer-Reviewed Original ResearchCitations
2005
P-Rex1 Is a Primary Rac2 Guanine Nucleotide Exchange Factor in Mouse Neutrophils
Dong X, Mo Z, Bokoch G, Guo C, Li Z, Wu D. P-Rex1 Is a Primary Rac2 Guanine Nucleotide Exchange Factor in Mouse Neutrophils. Current Biology 2005, 15: 1874-1879. PMID: 16243036, DOI: 10.1016/j.cub.2005.09.014.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsMeSH KeywordsActinsAnimalsCaseinsCell LineChemotaxisCloning, MolecularEnzyme ActivationGene TargetingGuanine Nucleotide Exchange FactorsHumansImmunoprecipitationMiceMice, KnockoutNeuropeptidesNeutrophilsN-Formylmethionine Leucyl-PhenylalanineProtein TransportRac GTP-Binding ProteinsRac1 GTP-Binding ProteinSuperoxidesConceptsP-Rex1Exchange factorGuanine nucleotide exchange factorsNucleotide exchange factorsRegulation of RacF-actin formationMouse neutrophilsSmall GTPasesRho familyRac activityApparent high affinityRac activatorActin formationRac1 activationRac2 activationCdc42Mouse linesRacRac2RhoAMigration rateRegulationHigh affinityLeukocyte chemoattractantsGTPasesRegulation of PTEN by Rho small GTPases
Li Z, Dong X, Wang Z, Liu W, Deng N, Ding Y, Tang L, Hla T, Zeng R, Li L, Wu D. Regulation of PTEN by Rho small GTPases. Nature Cell Biology 2005, 7: 399-404. PMID: 15793569, DOI: 10.1038/ncb1236.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAnimalsCdc42 GTP-Binding ProteinChemotaxisDictyosteliumHumansIntracellular Signaling Peptides and ProteinsLeukocytesMiceModels, BiologicalNeutrophilsPhosphoric Monoester HydrolasesProtein Serine-Threonine KinasesProtein TransportPTEN PhosphohydrolaseRhoA GTP-Binding ProteinRho-Associated KinasesTumor Suppressor ProteinsConceptsRegulation of PTENIntracellular localizationEmbryonic kidney cellsSmall GTPaseDownstream effectorsPhospholipid phosphatase activityRho small GTPasesRegulation of chemotaxisKidney cellsHuman embryonic kidney cellsSmall GTPasesRho familyPhosphoinositide substratesKey residuesActive RhoAPhosphatase activityPTENRhoAGTPaseRegulationHuman tumorsCellsDiverse rangeGTPasesCdc42
Clinical Trials
Current Trials
Yale Rheumatology Program Patient Registry and Bio-Repository
HIC ID2000026608REGRoleSub InvestigatorPrimary Completion Date06/01/2030Recruiting ParticipantsGenderBothAge18 years - 99 yearsYale Lupus and Connective Tissue Disease Bio-Repository / Yale Rheumatology Bio-Repository
HIC ID1602017276REGRoleSub InvestigatorPrimary Completion Date06/30/2036Recruiting ParticipantsGenderBothAge18+ years
Clinical Care
Overview
Mei Xue Dong, MD, PhD, received her medical degree from Wuhan University School of Medicine before pursuing PhD study at the University of Connecticut Health Center. Her PhD work focused on chemoattractant signaling in leukocyte activation at the sites of infection and inflammation, including arteriosclerosis. For post-doctoral work, she joined Dr. Craft’s laboratory while completing her rheumatology fellowship at Yale. Since then, she started growing the Yale lupus patient registry and biorepository.
Dr. Dong is an active clinical faculty member who enjoys caring for rheumatology patients and the clinical teaching of medical trainees. Her current research focuses on the risk factors and prevention of cardiovascular disease in rheumatic disorders, especially in patients with lupus.
Clinical Specialties
Rheumatology
Fact Sheets
Diagnosing Lupus Nephritis
Learn More on Yale MedicineLupus
Learn More on Yale MedicineThumb Arthritis
Learn More on Yale MedicineJuvenile Idiopathic Arthritis
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Board Certifications
Rheumatology
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2017
Internal Medicine
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2015
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Yale Rheumatology, Allergy & Immunology
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The Anlyan Center
300 Cedar Street, Fl 4th floor, Ste TAC, Rm S-411
New Haven, CT 06519
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