2017
Race-dependent association of sulfidogenic bacteria with colorectal cancer
Yazici C, Wolf PG, Kim H, Cross TL, Vermillion K, Carroll T, Augustus GJ, Mutlu E, Tussing-Humphreys L, Braunschweig C, Xicola RM, Jung B, Llor X, Ellis NA, Gaskins HR. Race-dependent association of sulfidogenic bacteria with colorectal cancer. Gut 2017, 66: 1983. PMID: 28153960, PMCID: PMC5575988, DOI: 10.1136/gutjnl-2016-313321.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedBlack or African AmericanCase-Control StudiesChicagoColonColorectal NeoplasmsDietDietary FatsDietary ProteinsFemaleHealth Status DisparitiesHumansIntestinal MucosaMaleMiddle AgedProspective StudiesReal-Time Polymerase Chain ReactionRisk FactorsSulfur-Reducing BacteriaWhite PeopleConceptsNon-Hispanic whitesEnvironmental risk factorsRisk factorsAA casesCRC casesColonic mucosaCRC developmentDisease statusAfrican AmericansCRC risk factorsUninvolved colonic mucosaColorectal cancer incidencePotential environmental risk factorsTumor-free controlsMultiple dietary componentsRace-dependent associationsEffect of dietColonic biopsiesColorectal cancerDaily servingsHealthy mucosaCancer incidenceDietary intakeProinflammatory pathwaysDiet high
2014
IGFBP3 Methylation Is a Novel Diagnostic and Predictive Biomarker in Colorectal Cancer
Perez-Carbonell L, Balaguer F, Toiyama Y, Egoavil C, Rojas E, Guarinos C, Andreu M, Llor X, Castells A, Jover R, Boland CR, Goel A. IGFBP3 Methylation Is a Novel Diagnostic and Predictive Biomarker in Colorectal Cancer. PLOS ONE 2014, 9: e104285. PMID: 25127039, PMCID: PMC4134211, DOI: 10.1371/journal.pone.0104285.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsBiomarkers, TumorColorectal NeoplasmsCpG IslandsDNA MethylationFemaleHumansInsulin-Like Growth Factor Binding Protein 3Intestinal MucosaMaleMicrosatellite InstabilityMicrosatellite RepeatsMiddle AgedMutationNeoplasm StagingPrognosisPromoter Regions, GeneticProto-Oncogene Proteins B-rafTreatment OutcomeConceptsCRC patientsColorectal cancerPredictive biomarkersStage IICRC cohortPoor disease-free survivalDisease-free survivalIndependent risk factorPopulation-based cohortPotential clinical significancePromising diagnostic biomarkerFree survivalRisk factorsColonic tumorsCRC-specific genesClinical significanceNormal mucosaCancer-related genesPatientsDiagnostic biomarkersTumor tissueBiomarkersCohortCancerHuman cancers
2011
Colorectal Cancers with Microsatellite Instability Display Unique miRNA Profiles
Balaguer F, Moreira L, Lozano JJ, Link A, Ramirez G, Shen Y, Cuatrecasas M, Arnold M, Meltzer SJ, Syngal S, Stoffel E, Jover R, Llor X, Castells A, Boland CR, Gironella M, Goel A. Colorectal Cancers with Microsatellite Instability Display Unique miRNA Profiles. Clinical Cancer Research 2011, 17: 6239-6249. PMID: 21844009, PMCID: PMC3186834, DOI: 10.1158/1078-0432.ccr-11-1424.Peer-Reviewed Original ResearchConceptsColorectal cancerTypes of MSIMicrosatellite instabilityMiRNA expression profilesUnique miRNA profileCRC tissuesNormal colonic mucosa tissuesSporadic MSI tumorsColonic mucosa tissuesMSS colorectal cancerLynch syndrome tumorsNormal colonic mucosaSporadic microsatellite instabilityMiRNA profilesMSI-positive samplesNormal colonic tissueUnique miRNA expression profilesExpression profilesQuantitative reverse transcriptase PCRReverse transcriptase-PCRDistinct miRNA expression profilesColonic mucosaLynch syndromeColonic tissueColorectal carcinogenesis
2008
Aberrant Crypt Focus Size Predicts Distal Polyp Histopathology
Kim J, Ng J, Arozulllah A, Ewing R, Llor X, Carroll RE, Benya RV. Aberrant Crypt Focus Size Predicts Distal Polyp Histopathology. Cancer Epidemiology Biomarkers & Prevention 2008, 17: 1155-1162. PMID: 18483337, DOI: 10.1158/1055-9965.epi-07-2731.Peer-Reviewed Original ResearchConceptsAberrant crypt fociSmall aberrant crypt fociHyperplastic polypsDistal adenomasColorectal cancerOdds ratioLarge aberrant crypt fociRoutine colorectal cancerCancer chemoprevention studiesDistal hyperplastic polypsAfrican AmericansACF prevalenceACF sizePatient ageACF numberChemoprevention studiesCrypt fociSurrogate markerHistopathologic lesionsUnselected populationPatientsTissue planesAdenomasPolypsHistopathology