Digestive Diseases Publications

Clara Abraham, MD

Interleukin-23 p19 and Interleukin-12 p40, Head-to-Head, against Gut Inflammation.Abraham C. N Engl J Med. 2024 Jul 18. PMID: 39018537.
Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans: report of an expert meeting.Sun J, Ince MN, Abraham C, Barrett T, Brenner LA, Cong Y, Dashti R, Dudeja PK, Elliott D, Griffith TS, Heeger PS, Hoisington A, Irani K, Kim TK, Kapur N, Leventhal J, Mohamadzadeh M, Mutlu E, Newberry R, Peled JU, Rubinstein I, Sengsayadeth S, Tan CS, Tan XD, Tkaczyk E, Wertheim J, Zhang ZJ. Gut Microbes. 2023 Dec; 2023 Oct 16. PMID: 37842912.
ScRNA-seq defines dynamic T-cell subsets in longitudinal colon and peripheral blood samples in immune checkpoint inhibitor-induced colitis.Mann JE, Lucca L, Austin MR, Merkin RD, Robert ME, Al Bawardy B, Raddassi K, Aizenbud L, Joshi NS, Hafler DA, Abraham C, Herold KC, Kluger HM. J Immunother Cancer. 2023 Aug. PMID: 37586769.
IL-12 and IL-23 pathway inhibition in inflammatory bowel disease.Verstockt B, Salas A, Sands BE, Abraham C, Leibovitzh H, Neurath MF, Vande Casteele N. Nat Rev Gastroenterol Hepatol. 2023 Jul; 2023 Apr 17. PMID: 37069321.
Pattern Recognition Receptor Signaling and Cytokine Networks in Microbial Defenses and Regulation of Intestinal Barriers: Implications for Inflammatory Bowel Disease.Abraham C, Abreu MT, Turner JR. Gastroenterology. 2022 May; 2022 Feb 9. PMID: 35149024.
The Tight Junction Protein ZO-1 Is Dispensable for Barrier Function but Critical for Effective Mucosal Repair.Kuo WT, Zuo L, Odenwald MA, Madha S, Singh G, Gurniak CB, Abraham C, Turner JR. Gastroenterology. 2021 Dec; 2021 Aug 31. PMID: 34478742.
Ubiquitination of ATF6 by disease-associated RNF186 promotes the innate receptor-induced unfolded protein response.Ranjan K, Hedl M, Sinha S, Zhang X, Abraham C. J Clin Invest. 2021 Sep 1. PMID: 34623328.
The E3 ubiquitin ligase RNF186 and RNF186 risk variants regulate innate receptor-induced outcomes.Ranjan K, Hedl M, Abraham C. Proc Natl Acad Sci U S A. 2021 Aug 10. PMID: 34353900.
TNFSF15 Promotes Antimicrobial Pathways in Human Macrophages and These Are Modulated by TNFSF15 Disease-Risk Variants.Sun R, Hedl M, Abraham C. Cell Mol Gastroenterol Hepatol. 2021; 2020 Aug 19. PMID: 32827707.
Myeloid Cell Expression of LACC1 Is Required for Bacterial Clearance and Control of Intestinal Inflammation.Kang JW, Yan J, Ranjan K, Zhang X, Turner JR, Abraham C. Gastroenterology. 2020 Sep; 2020 Jul 18. PMID: 32693188.
Disease Risk-Associated Genetic Variants in STAT1 and STAT4 Function in a Complementary Manner to Increase Pattern-Recognition Receptor-Induced Outcomes in Human Macrophages.Hedl M, Sun R, Abraham C. J Immunol. 2020 Sep 1; 2020 Jul 13. PMID: 32661180.
Myeloid Cell-Intrinsic IRF5 Promotes T Cell Responses through Multiple Distinct Checkpoints In Vivo, and IRF5 Immune-Mediated Disease Risk Variants Modulate These Myeloid Cell Functions.Yan J, Hedl M, Abraham C. J Immunol. 2020 Aug 15; 2020 Jul 20. PMID: 32690658.
T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation.Yan J, Pandey SP, Barnes BJ, Turner JR, Abraham C. Cell Rep. 2020 Jun 30. PMID: 32610123.
IL23 induces IL23R recycling and amplifies innate receptor-induced signalling and cytokines in human macrophages, and the IBD-protective IL23R R381Q variant modulates these outcomes.Sun R, Hedl M, Abraham C. Gut. 2020 Feb; 2019 May 16. PMID: 31097538.
IL23 Promotes Antimicrobial Pathways in Human Macrophages, Which Are Reduced With the IBD-Protective IL23R R381Q Variant.Sun R, Abraham C. Cell Mol Gastroenterol Hepatol. 2020; 2020 May 29. PMID: 32474165.
LACC1 Required for NOD2-Induced, ER Stress-Mediated Innate Immune Outcomes in Human Macrophages and LACC1 Risk Variants Modulate These Outcomes.Huang C, Hedl M, Ranjan K, Abraham C. Cell Rep. 2019 Dec 24. PMID: 31875558.
STAT3 and STAT5 Signaling Thresholds Determine Distinct Regulation for Innate Receptor-Induced Inflammatory Cytokines, and STAT3/STAT5 Disease Variants Modulate These Outcomes.Hedl M, Sun R, Huang C, Abraham C. J Immunol. 2019 Dec 15; 2019 Nov 15. PMID: 31732533.
Prioritizing Crohn's disease genes by integrating association signals with gene expression implicates monocyte subsets.Gettler K, Giri M, Kenigsberg E, Martin J, Chuang LS, Hsu NY, Denson LA, Hyams JS, Griffiths A, Noe JD, Crandall WV, Mack DR, Kellermayer R, Abraham C, Hoffman G, Kugathasan S, Cho JH. Genes Immun. 2019 Sep; 2019 Jan 29. PMID: 30692607.
Correction to: Reducing IRF5 expression attenuates colitis in mice, but impairs the clearance of intestinal pathogens.Pandey SP, Yan J, Turner JR, Abraham C. Mucosal Immunol. 2019 Jul. PMID: 31182816.
Reducing IRF5 expression attenuates colitis in mice, but impairs the clearance of intestinal pathogens.Pandey SP, Yan J, Turner JR, Abraham C. Mucosal Immunol. 2019 Jul; 2019 May 3. PMID: 31053739.
Twist1 and Twist2 Induce Human Macrophage Memory upon Chronic Innate Receptor Treatment by HDAC-Mediated Deacetylation of Cytokine Promoters.Sun R, Hedl M, Abraham C. J Immunol. 2019 Jun 1; 2019 Apr 26. PMID: 31028123.
Challenges in IBD Research: Precision Medicine.Denson LA, Curran M, McGovern DPB, Koltun WA, Duerr RH, Kim SC, Sartor RB, Sylvester FA, Abraham C, de Zoeten EF, Siegel CA, Burns RM, Dobes AM, Shtraizent N, Honig G, Heller CA, Hurtado-Lorenzo A, Cho JH. Inflamm Bowel Dis. 2019 May 16. PMID: 31095701.
IRF5 Is Required for Bacterial Clearance in Human M1-Polarized Macrophages, and IRF5 Immune-Mediated Disease Risk Variants Modulate This Outcome.Hedl M, Yan J, Witt H, Abraham C. J Immunol. 2019 Feb 1; 2018 Dec 28. PMID: 30593537.
INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling.Luong P, Hedl M, Yan J, Zuo T, Fu TM, Jiang X, Thiagarajah JR, Hansen SH, Lesser CF, Wu H, Abraham C, Lencer WI. Elife. 2018 Oct 25; 2018 Oct 25. PMID: 30355448.
Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells.Zhu S, Ding S, Wang P, Wei Z, Pan W, Palm NW, Yang Y, Yu H, Li HB, Wang G, Lei X, de Zoete MR, Zhao J, Zheng Y, Chen H, Zhao Y, Jurado KA, Feng N, Shan L, Kluger Y, Lu J, Abraham C, Fikrig E, Greenberg HB, Flavell RA. Nature. 2017 Jun 29; 2017 Jun 21. PMID: 28636595.
E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP.Bist P, Cheong WS, Ng A, Dikshit N, Kim BH, Pulloor NK, Khameneh HJ, Hedl M, Shenoy AR, Balamuralidhar V, Malik NBA, Hong M, Neutzner A, Chin KC, Kobayashi KS, Bertoletti A, Mortellaro A, Abraham C, MacMicking JD, Xavier RJ, Sukumaran B. Nat Commun. 2017 Jun 28; 2017 Jun 28. PMID: 28656966.
Human LACC1 increases innate receptor-induced responses and a LACC1 disease-risk variant modulates these outcomes.Lahiri A, Hedl M, Yan J, Abraham C. Nat Commun. 2017 Jun 8; 2017 Jun 8. PMID: 28593945.
ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation.Schumacher MA, Hedl M, Abraham C, Bernard JK, Lozano PR, Hsieh JJ, Almohazey D, Bucar EB, Punit S, Dempsey PJ, Frey MR. Cell Death Dis. 2017 Feb 23; 2017 Feb 23. PMID: 28230865.
Lessons Learned From Trials Targeting Cytokine Pathways in Patients With Inflammatory Bowel Diseases.Abraham C, Dulai PS, Vermeire S, Sandborn WJ. Gastroenterology. 2017 Feb; 2016 Oct 22. PMID: 27780712.
JAK2 Disease-Risk Variants Are Gain of Function and JAK Signaling Threshold Determines Innate Receptor-Induced Proinflammatory Cytokine Secretion in Macrophages.Hedl M, Proctor DD, Abraham C. J Immunol. 2016 Nov 1; 2016 Sep 23. PMID: 27664279.
A TPL2 (MAP3K8) disease-risk polymorphism increases TPL2 expression thereby leading to increased pattern recognition receptor-initiated caspase-1 and caspase-8 activation, signalling and cytokine secretion.Hedl M, Abraham C. Gut. 2016 Nov; 2015 Jul 27. PMID: 26215868.
A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF.Chuang LS, Villaverde N, Hui KY, Mortha A, Rahman A, Levine AP, Haritunians T, Evelyn Ng SM, Zhang W, Hsu NY, Facey JA, Luong T, Fernandez-Hernandez H, Li D, Rivas M, Schiff ER, Gusev A, Schumm LP, Bowen BM, Sharma Y, Ning K, Remark R, Gnjatic S, Legnani P, George J, Sands BE, Stempak JM, Datta LW, Lipka S, Katz S, Cheifetz AS, Barzilai N, Pontikos N, Abraham C, Dubinsky MJ, Targan S, Taylor K, Rotter JI, Scherl EJ, Desnick RJ, Abreu MT, Zhao H, Atzmon G, Pe'er I, Kugathasan S, Hakonarson H, McCauley JL, Lencz T, Darvasi A, Plagnol V, Silverberg MS, Muise AM, Brant SR, Daly MJ, Segal AW, Duerr RH, Merad M, McGovern DP, Peter I, Cho JH. Gastroenterology. 2016 Oct; 2016 Jul 1. PMID: 27377463.
IRF5 and IRF5 Disease-Risk Variants Increase Glycolysis and Human M1 Macrophage Polarization by Regulating Proximal Signaling and Akt2 Activation.Hedl M, Yan J, Abraham C. Cell Rep. 2016 Aug 30; 2016 Aug 18. PMID: 27545875.
MTMR3 risk allele enhances innate receptor-induced signaling and cytokines by decreasing autophagy and increasing caspase-1 activation.Lahiri A, Hedl M, Abraham C. Proc Natl Acad Sci U S A. 2015 Aug 18; 2015 Aug 3. PMID: 26240347.
Twist1 and Twist2 Contribute to Cytokine Downregulation following Chronic NOD2 Stimulation of Human Macrophages through the Coordinated Regulation of Transcriptional Repressors and Activators.Zheng S, Hedl M, Abraham C. J Immunol. 2015 Jul 1; 2015 May 27. PMID: 26019273.
T cell-extrinsic CD18 attenuates antigen-dependent CD4+ T cell activation in vivo.Wu X, Lahiri A, Sarin R, Abraham C. J Immunol. 2015 May 1; 2015 Mar 23. PMID: 25801431.
TAM receptor-dependent regulation of SOCS3 and MAPKs contributes to proinflammatory cytokine downregulation following chronic NOD2 stimulation of human macrophages.Zheng S, Hedl M, Abraham C. J Immunol. 2015 Feb 15; 2015 Jan 7. PMID: 25567680.
Activation of pattern recognition receptors up-regulates metallothioneins, thereby increasing intracellular accumulation of zinc, autophagy, and bacterial clearance by macrophages.Lahiri A, Abraham C. Gastroenterology. 2014 Oct; 2014 Jun 21. PMID: 24960189.
A TNFSF15 disease-risk polymorphism increases pattern-recognition receptor-induced signaling through caspase-8-induced IL-1.Hedl M, Abraham C. Proc Natl Acad Sci U S A. 2014 Sep 16; 2014 Sep 2. PMID: 25197060.
The IL18RAP region disease polymorphism decreases IL-18RAP/IL-18R1/IL-1R1 expression and signaling through innate receptor-initiated pathways.Hedl M, Zheng S, Abraham C. J Immunol. 2014 Jun 15; 2014 May 19. PMID: 24842757.
Pattern recognition receptor signaling in human dendritic cells is enhanced by ICOS ligand and modulated by the Crohn's disease ICOSLG risk allele.Hedl M, Lahiri A, Ning K, Cho JH, Abraham C. Immunity. 2014 May 15. PMID: 24837102.
NOD2 regulates CXCR3-dependent CD8+ T cell accumulation in intestinal tissues with acute injury.Wu X, Lahiri A, Haines GK 3rd, Flavell RA, Abraham C. J Immunol. 2014 Apr 1; 2014 Mar 3. PMID: 24591373.
NF-κB1 inhibits NOD2-induced cytokine secretion through ATF3-dependent mechanisms.Zheng S, Abraham C. Mol Cell Biol. 2013 Dec; 2013 Oct 7. PMID: 24100018.
The influence of depression on quality of life in patients with inflammatory bowel disease.Zhang CK, Hewett J, Hemming J, Grant T, Zhao H, Abraham C, Oikonomou I, Kanakia M, Cho JH, Proctor DD. Inflamm Bowel Dis. 2013 Jul. PMID: 23669400.
NLRP1 and NLRP3 inflammasomes are essential for distinct outcomes of decreased cytokines but enhanced bacterial killing upon chronic Nod2 stimulation.Hedl M, Abraham C. Am J Physiol Gastrointest Liver Physiol. 2013 Mar 15; 2013 Jan 3. PMID: 23287275.
Age and CD161 expression contribute to inter-individual variation in interleukin-23 response in CD8+ memory human T cells.Shen H, Zhang W, Abraham C, Cho JH. PLoS One. 2013; 2013 Mar 1. PMID: 23469228.
Nod2-induced autocrine interleukin-1 alters signaling by ERK and p38 to differentially regulate secretion of inflammatory cytokines.Hedl M, Abraham C. Gastroenterology. 2012 Dec; 2012 Sep 8. PMID: 22967725.
IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine.Huber S, Gagliani N, Zenewicz LA, Huber FJ, Bosurgi L, Hu B, Hedl M, Zhang W, O'Connor W Jr, Murphy AJ, Valenzuela DM, Yancopoulos GD, Booth CJ, Cho JH, Ouyang W, Abraham C, Flavell RA. Nature. 2012 Nov 8; 2012 Oct 17. PMID: 23075849.
CD18 is required for optimal lymphopenia-induced proliferation of mouse T cells.Sarin R, Abraham C. Am J Physiol Gastrointest Liver Physiol. 2012 Oct; 2012 Jul 19. PMID: 22821945.
IRF5 risk polymorphisms contribute to interindividual variance in pattern recognition receptor-mediated cytokine secretion in human monocyte-derived cells.Hedl M, Abraham C. J Immunol. 2012 Jun 1; 2012 Apr 27. PMID: 22544929.
Effector CD4+ T cell expression signatures and immune-mediated disease associated genes.Zhang W, Ferguson J, Ng SM, Hui K, Goh G, Lin A, Esplugues E, Flavell RA, Abraham C, Zhao H, Cho JH. PLoS One. 2012; 2012 Jun 8. PMID: 22715389.
The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans.Menard L, Saadoun D, Isnardi I, Ng YS, Meyers G, Massad C, Price C, Abraham C, Motaghedi R, Buckner JH, Gregersen PK, Meffre E. J Clin Invest. 2011 Sep; 2011 Aug 1. PMID: 21804190.
Distinct roles for Nod2 protein and autocrine interleukin-1beta in muramyl dipeptide-induced mitogen-activated protein kinase activation and cytokine secretion in human macrophages.Hedl M, Abraham C. J Biol Chem. 2011 Jul 29; 2011 Jun 9. PMID: 21659536.
Inflammatory disease protective R381Q IL23 receptor polymorphism results in decreased primary CD4+ and CD8+ human T-cell functional responses.Sarin R, Wu X, Abraham C. Proc Natl Acad Sci U S A. 2011 Jun 7; 2011 May 23. PMID: 21606346.
Interactions between the host innate immune system and microbes in inflammatory bowel disease.Abraham C, Medzhitov R. Gastroenterology. 2011 May. PMID: 21530739.
Secretory mediators regulate Nod2-induced tolerance in human macrophages.Hedl M, Abraham C. Gastroenterology. 2011 Jan; 2010 Sep 18. PMID: 20854823.
Development of a nanoparticulate formulation of retinoic acid that suppresses Th17 cells and upregulates regulatory T cells.Capurso NA, Look M, Jeanbart L, Nowyhed H, Abraham C, Craft J, Fahmy TM. Self Nonself. 2010 Oct. PMID: 21487509.
Unraveling the genetics of autoimmunity.Zenewicz LA, Abraham C, Flavell RA, Cho JH. Cell. 2010 Mar 19. PMID: 20303870.
Inflammatory bowel disease.Abraham C, Cho JH. N Engl J Med. 2009 Nov 19. PMID: 19923578.
Interleukin-23/Th17 pathways and inflammatory bowel disease.Abraham C, Cho J. Inflamm Bowel Dis. 2009 Jul. PMID: 19253307.
IL-23 and autoimmunity: new insights into the pathogenesis of inflammatory bowel disease.Abraham C, Cho JH. Annu Rev Med. 2009. PMID: 18976050.
A case of indometacin-induced acute hepatitis developing into chronic autoimmune hepatitis.Abraham C, Hart J, Locke SM, Baker AL. Nat Clin Pract Gastroenterol Hepatol. 2008 Mar; 2008 Jan 29. PMID: 18227818.
Inflammatory bowel disease genetics: Nod2.Cho JH, Abraham C. Annu Rev Med. 2007. PMID: 16987083.

Harry Aslanian, MD

Coexistent Eosinophilic Esophagitis and Dysplastic Barrett's Esophagus With Rapid Eosinophilic Infiltration of Neosquamous Mucosa After Radiofrequency Ablation.Ameyaw PA, Parsons D, Mahmoud A, Marie R, Nagar A, Aslanian HR. ACG Case Rep J. 2024 Sep; 2024 Aug 29. PMID: 39221230.
Penile Prosthetic Pump Reservoir Mimicking a Cecal Subepithelial Mass.Ameyaw PA, Aslanian HR. ACG Case Rep J. 2024 Jul; 2024 Jul 12. PMID: 39006051.
EUS-guided Gastroenterostomy: A Multicenter International Study Comparing Benign and Malignant Diseases.Kahaleh M, Tyberg A, Sameera S, Sarkar A, Shahid HM, Abdelqader A, Gjeorgjievski M, Gaidhane M, Muniraj T, Jamidar PA, Aslanian HR, Abraham M, Lajin M, Kedia P, Nieto J, Parsa N, Andalib I, Bashir M, Kowalski TE, Loren DE, Kumar A, Schlachterman A, Chiang A, Holmes I, Mendoza Ladd AH, Oleas R, Zolotarevsky E, Robles-Medranda C, Barthet M. J Clin Gastroenterol. 2024 Jul 1; 2024 Jul 1. PMID: 37646532.
Clinical predictive value of renalase in post-ERCP pancreatitis.Muniraj T, Desir G, Gorelick FS, Guo X, Ciarleglio MM, Deng Y, Jamidar PA, Farrell J, Aslanian HR, Laine L. Gastrointest Endosc. 2024 May; 2023 Dec 14. PMID: 38103747.
Endoscopic Ultrasound in Cancer Staging.Aslanian HR, Muniraj T, Nagar A, Parsons D. Gastrointest Endosc Clin N Am. 2024 Jan; 2023 Sep 27. PMID: 37973230.
Endoscopic Removal of Ingested Wire Bristle from the Pancreas.Lerner BA, Aslanian HR, Muniraj T. Clin Gastroenterol Hepatol. 2022 Apr; 2021 Feb 17. PMID: 33609785.
Evaluation of socioeconomic and healthcare disparities on same admission cholecystectomy after endoscopic retrograde cholangiopancreatography among patients with acute gallstone pancreatitis.Chouairi F, McCarty TR, Hathorn KE, Sharma P, Aslanian HR, Jamidar PA, Thompson CC, Muniraj T. Surg Endosc. 2022 Jan; 2021 Jan 22. PMID: 33481109.
Gallbladder Cryoablation: Other Endoscopic Options for High-Risk Patients with Cholecystitis.Jones J, Aslanian HR, Muniraj T. Am J Med. 2021 Nov. PMID: 34799010.
Factors associated with complete clip closure after endoscopic mucosal resection of large colorectal polyps.Ortiz O, Rex DK, Grimm IS, Moyer MT, Hasan MK, Pleskow D, Elmunzer BJ, Khashab MA, Sanaei O, Al-Kawas FH, Gordon SR, Mathew A, Levenick JM, Aslanian HR, Antaki F, von Renteln D, Crockett SD, Rastogi A, Gill JA, Law R, Wallace MB, Elias PA, MacKenzie TA, Pohl H, Pellisé M. Endoscopy. 2021 Nov; 2021 Apr 20. PMID: 33291159.
Education and gastroenterology fellow knowledge about endoscopic mucosal resection of colon adenomas: a survey-based study.Garg S, Inamdar S, Tharian B, Muniraj T, Aslanian HR. Endosc Int Open. 2021 Aug; 2021 Jul 16. PMID: 34447869.
Resection of pancreatic cystic neoplasms in recurrent acute pancreatitis prevents recurrent pancreatitis but does not identify more malignancies.Muniraj T, Aslanian HR, Laine L, Jamidar PA, Farrell JF, Mitchell KA, Salem RR. World J Gastroenterol. 2021 Apr 21. PMID: 33958848.
Enhanced EUS imaging (with videos).Krishnan K, Bhutani MS, Aslanian HR, Melson J, Navaneethan U, Pannala R, Parsi MA, Schulman AR, Sethi A, Sullivan S, Trikudanathan G, Trindade AJ, Watson RR, Maple JT, Lichtenstein DR. Gastrointest Endosc. 2021 Feb; 2020 Oct 28. PMID: 33129492.
Endoscopic ultrasound-guided fine needle aspiration cytology diagnosis of upper gastrointestinal tract mesenchymal tumors: Impact of rapid onsite evaluation and correlation with histopathologic follow-up.Gilani SM, Muniraj T, Aslanian HR, Cai G. Diagn Cytopathol. 2021 Feb; 2020 Oct 2. PMID: 33006819.
Musculoskeletal Pain Symptoms and Injuries Among Endoscopists Who Perform ERCP.Campbell EV 3rd, Muniraj T, Aslanian HR, Laine L, Jamidar P. Dig Dis Sci. 2021 Jan; 2020 Mar 6. PMID: 32144599.
Endoscopic management of gastric outlet obstruction of remnant stomach in a patient with Roux-en-Y gastric bypass.Kesar V, Magulick J, Kesar V, Muniraj T, Aslanian HR. VideoGIE. 2020 Nov; 2020 Aug 20. PMID: 33204916.
Intestinal metaplasia around the gastroesophageal junction is frequently associated with antral reactive gastropathy: implications for carcinoma at the gastroesophageal junction.Vyas M, Celli R, Singh M, Patel N, Aslanian HR, Boffa D, Deng Y, Ciarleglio MM, Laine L, Jain D. Hum Pathol. 2020 Nov; 2020 Sep 14. PMID: 32941964.
The Reply.Lam R, Jamidar PA, Aslanian HR, Muniraj T. Am J Med. 2020 Oct. PMID: 33004185.
Esophageal stent-assisted biliary access.Campbell EV 3rd, Magulick J, Aslanian HR, Jamidar P. Gastrointest Endosc. 2020 Oct; 2020 May 1. PMID: 32360903.
Fitz-Hugh-Curtis Syndrome Presenting as Acute Abdomen.Lam R, Jamidar PA, Aslanian HR, Muniraj T. Am J Med. 2020 Oct; 2020 Apr 9. PMID: 32277885.
Endoscopic Ultrasound-Guided, Percutaneous, and Transjugular Liver Biopsy: A Comparative Systematic Review and Meta-Analysis.McCarty TR, Bazarbashi AN, Njei B, Ryou M, Aslanian HR, Muniraj T. Clin Endosc. 2020 Sep; 2020 Sep 29. PMID: 33027584.
The New Virtual Reality: Advanced Endoscopy Education in the COVID-19 Era.Siddiqui UD, Aslanian HR. Dig Dis Sci. 2020 Jul. PMID: 32504351.
AGA Clinical Practice Update on Pancreas Cancer Screening in High-Risk Individuals: Expert Review.Aslanian HR, Lee JH, Canto MI. Gastroenterology. 2020 Jul; 2020 May 19. PMID: 32416142.
Endoscopic ultrasound-guided fine needle aspiration of accessory spleen: Cytomorphologic features and diagnostic considerations.Gilani SM, Muniraj T, Farrell JJ, Aslanian HR, Cai G. Diagn Cytopathol. 2020 Jul; 2020 Apr 21. PMID: 32315514.
Effects of Blended (Yellow) vs Forced Coagulation (Blue) Currents on Adverse Events, Complete Resection, or Polyp Recurrence After Polypectomy in a Large Randomized Trial.Pohl H, Grimm IS, Moyer MT, Hasan MK, Pleskow D, Elmunzer BJ, Khashab MA, Sanaei O, Al-Kawas FH, Gordon SR, Mathew A, Levenick JM, Aslanian HR, Antaki F, von Renteln D, Crockett SD, Rastogi A, Gill JA, Law RJ, Elias PA, Pellise M, Mackenzie TA, Rex DK. Gastroenterology. 2020 Jul; 2020 Mar 12. PMID: 32173478.
Endoscopic rectal variceal ligation.Campbell EV 3rd, Aslanian HR, Muniraj T. VideoGIE. 2020 Jun; 2020 Jun 3. PMID: 32529163.
Endoscopic ultrasound (EUS) and the management of pancreatic cancer.Yousaf MN, Chaudhary FS, Ehsan A, Suarez AL, Muniraj T, Jamidar P, Aslanian HR, Farrell JJ. BMJ Open Gastroenterol. 2020 May. PMID: 32414753.
Fine needle aspiration cytology of peripancreatic myelolipoma.Huang Q, Parmer C, Muniraj T, Aslanian HR, Cai G. Diagn Cytopathol. 2020 May; 2020 Mar 9. PMID: 32150351.
Endoscopic Resection of a Giant Duodenal Lipoma.Gnanapandithan K, Aslanian HR, Jamidar PA, Muniraj T. ACG Case Rep J. 2020 Mar; 2020 Mar 17. PMID: 32337302.
Comparative effectiveness of pharmacologic and endoscopic interventions for prevention of post-ERCP pancreatitis: a network meta-analysis.Njei B, McCarty TR, Muniraj T, Sharma P, Jamidar PA, Aslanian HR, Varadarajulu S, Navaneethan U. Endosc Int Open. 2020 Jan; 2020 Jan 8. PMID: 31921982.
Combined versus single use 20 G fine-needle biopsy and 25 G fine-needle aspiration for endoscopic ultrasound-guided tissue sampling of solid gastrointestinal lesions.van Riet PA, Giorgio Arcidiacono P, Petrone M, Quoc Nguyen N, Kitano M, Chang K, Larghi A, Iglesias-Garcia J, Giovannini M, van der Merwe S, Santo E, Baldaque-Silva F, Bucobo JC, Bruno MJ, Aslanian HR, Cahen DL, Farrell J. Endoscopy. 2020 Jan; 2019 Jul 22. PMID: 31330556.
Clip Closure Prevents Bleeding After Endoscopic Resection of Large Colon Polyps in a Randomized Trial.Pohl H, Grimm IS, Moyer MT, Hasan MK, Pleskow D, Elmunzer BJ, Khashab MA, Sanaei O, Al-Kawas FH, Gordon SR, Mathew A, Levenick JM, Aslanian HR, Antaki F, von Renteln D, Crockett SD, Rastogi A, Gill JA, Law RJ, Elias PA, Pellise M, Wallace MB, Mackenzie TA, Rex DK. Gastroenterology. 2019 Oct; 2019 Mar 15. PMID: 30885778.
Novel Methylated DNA Markers Discriminate Advanced Neoplasia in Pancreatic Cysts: Marker Discovery, Tissue Validation, and Cyst Fluid Testing.Majumder S, Taylor WR, Yab TC, Berger CK, Dukek BA, Cao X, Foote PH, Wu CW, Mahoney DW, Aslanian HR, Fernández-Del Castillo C, Doyle LA, Farrell JJ, Fisher WE, Lee LS, Lee YN, Park W, Rodrigues C, Gould Rothberg BE, Salem RR, Simeone DM, Urs S, Van Buren G, Smyrk TC, Allawi HT, Lidgard GP, Raimondo M, Chari ST, Kendrick ML, Kisiel JB, Topazian MD, Ahlquist DA. Am J Gastroenterol. 2019 Sep. PMID: 31306149.
Advances in the diagnosis and surveillance of Barrett's esophagus (with videos).Trindade AJ, Navaneethan U, Aslanian HR, Bhutani MS, Krishnan K, Lichtenstein DR, Melson J, Pannala R, Parsi MA, Schulman AR, Sethi A, Trikudanathan G, Watson RR, Maple JT. Gastrointest Endosc. 2019 Sep; 2019 May 18. PMID: 31113535.
ASGE guideline for endoscopic full-thickness resection and submucosal tunnel endoscopic resection.Aslanian HR, Sethi A, Bhutani MS, Goodman AJ, Krishnan K, Lichtenstein DR, Melson J, Navaneethan U, Pannala R, Parsi MA, Schulman AR, Sullivan SA, Thosani N, Trikudanathan G, Trindade AJ, Watson RR, Maple JT. VideoGIE. 2019 Aug; 2019 Jun 29. PMID: 31388606.
Devices for endoscopic hemostasis of nonvariceal GI bleeding (with videos).Parsi MA, Schulman AR, Aslanian HR, Bhutani MS, Krishnan K, Lichtenstein DR, Melson J, Navaneethan U, Pannala R, Sethi A, Trikudanathan G, Trindade AJ, Watson RR, Maple JT. VideoGIE. 2019 Jul; 2019 Jun 27. PMID: 31334417.
Endoscopic simulators.Goodman AJ, Melson J, Aslanian HR, Bhutani MS, Krishnan K, Lichtenstein DR, Navaneethan U, Pannala R, Parsi MA, Schulman AR, Sethi A, Sullivan SA, Thosani N, Trikudanathan G, Trindade AJ, Watson RR, Maple JT. Gastrointest Endosc. 2019 Jul; 2019 May 20. PMID: 31122746.
Perforation of the duodenum 2 weeks after lumen-apposing metal stent placement for malignant pyloric stricture.Muniraj T, Salem R, Olave-Martinez M, Suarez A, Aslanian HR. Gastrointest Endosc. 2019 May; 2019 Jan 10. PMID: 30639540.
Endoscopic Ultrasound for the Diagnosis and Staging of Liver Tumors.Lange A, Muniraj T, Aslanian HR. Gastrointest Endosc Clin N Am. 2019 Apr. PMID: 30846157.
Barrett's esophagus: A comprehensive review for the internist.Klavan H, Russell MB, Macklin J, Lee E, Aslanian HR, Muniraj T. Dis Mon. 2018 Nov; 2018 Jun 5. PMID: 29880269.
Long-Term Follow-Up of Low-Risk Branch Duct IPMNs of the Pancreas: Watch for Main Pancreatic Duct Dilatation, and for How Long?Muniraj T, Aslanian HR. Clin Transl Gastroenterol. 2018 Oct 24; 2018 Oct 24. PMID: 30353003.
Safety and rate of delayed adverse events with lumen-apposing metal stents (LAMS) for pancreatic fluid collections: a multicenter study.Yang D, Perbtani YB, Mramba LK, Kerdsirichairat T, Prabhu A, Manvar A, Ho S, Pannu D, Keswani RN, Strand DS, Wang AY, Quintero E, Buscaglia JM, Muniraj T, Aslanian HR, Draganov PV, Siddiqui AS. Endosc Int Open. 2018 Oct; 2018 Oct 8. PMID: 30302385.
Cannabis Use Is Associated With Increased Risk of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis: Analysis of the US Nationwide Inpatient Sample Database, 2004-2014.Njei B, Sharma P, McCarty TR, Singh M, Haque L, Aslanian HR, Jamidar P, Muniraj T. Pancreas. 2018 Oct. PMID: 30134357.
Endoscopic management of pancreatic duct disruption with large mediastinal pseudocyst.Ortiz V, Yousaf MN, Muniraj T, Jamidar P, Aslanian HR. VideoGIE. 2018 May; 2018 Mar 16. PMID: 29917026.
EUS diagnosis of cystic pancreatic neuroendocrine tumors.Li-Geng T, Cai G, Aslanian HR. VideoGIE. 2018 Mar; 2018 Feb 28. PMID: 29916484.
Endoscopic submucosal dissection for resection of submucosal tumors of the colon and rectum: Within reach, or the edge of tomorrow?Sahakian AB, Aslanian HR. Gastrointest Endosc. 2018 Feb. PMID: 29406933.
EUS evaluation of liver lesions.Yousaf MN, Cai G, Aslanian HR. VideoGIE. 2018 Jan; 2017 Nov 11. PMID: 29905169.
Endoscopic diagnosis of paraesophageal hernia with gastric volvulus.Yousaf MN, Duffy AJ, Aslanian HR. VideoGIE. 2017 Nov; 2017 Oct 12. PMID: 30027133.
New Developments in Endoscopic Ultrasound Tissue Acquisition.Muniraj T, Aslanian HR. Gastrointest Endosc Clin N Am. 2017 Oct. PMID: 28918800.
Primary Care Physicians Could Play a Role in Improving Colonoscopy Quality Measures.Langberg KM, Solad Y, Ciarleglio M, Sukumar N, Teslya P, Chowdhury MM, Aslanian HR. Dig Dis Sci. 2017 May; 2017 Mar 27. PMID: 28349232.
Clinical utility of rapid on-site cytopathology.Oza VM, Cai G, Aslanian HR. Gastrointest Endosc. 2017 Jan; 2016 Aug 22. PMID: 27562939.
Endoscopic Management of Pancreatic Fluid Collections.Muniraj T, Jamidar PA, Nealon WH, Aslanian HR. J Clin Gastroenterol. 2017 Jan. PMID: 27548730.
Endoscopic Management of Esophagopleural Fistula.McCarty TR, Bakhit M, Aslanian HR, Rustagi T. J Clin Gastroenterol. 2016 Nov/Dec. PMID: 27552330.
EUS Needle Identification Comparison and Evaluation study (with videos).Tang SJ, Vilmann AS, Saftoiu A, Wang W, Streba CT, Fink PP, Griswold M, Wu R, Dietrich CF, Jenssen C, Hocke M, Kantowski M, Pohl J, Fockens P, Annema JT, van der Heijden EH, Havre RF, Pham KD, Kunda R, Deprez PH, Mariana J, Vazquez-Sequeiros E, Larghi A, Buscarini E, Fusaroli P, Lahav M, Puri R, Garg PK, Sharma M, Maluf-Filho F, Sahai A, Brugge WR, Lee LS, Aslanian HR, Wang AY, Shami VM, Markowitz A, Siddiqui AA, Mishra G, Scheiman JM, Isenberg G, Siddiqui UD, Shah RJ, Buxbaum J, Watson RR, Willingham FF, Bhutani MS, Levy MJ, Harris C, Wallace MB, Nolsøe CP, Lorentzen T, Bang N, Sørensen SM, Gilja OH, D'Onofrio M, Piscaglia F, Gritzmann N, Radzina M, Sparchez ZA, Sidhu PS, Freeman S, McCowan TC, de Araujo CR Jr, Patel A, Ali MA, Campbell G, Chen E, Vilmann P. Gastrointest Endosc. 2016 Sep; 2016 Feb 10. PMID: 26873530.
Confocal laser endomicroscopy features of sessile serrated adenomas/polyps.Parikh ND, Gibson J, Nagar A, Ahmed AA, Aslanian HR. United European Gastroenterol J. 2016 Aug; 2015 Dec 15. PMID: 27536371.
Awash in a Multitude of Pancreas Cysts: Can We Stop Looking?Muniraj T, Aslanian HR. Clin Gastroenterol Hepatol. 2016 Jun; 2016 Feb 4. PMID: 26851707.
Digital chromoendoscopy utilization in clinical practice: A survey of gastroenterologists in Connecticut.Langberg KM, Parikh ND, Deng Y, Ciarlegio M, Laine L, Aslanian HR. World J Gastrointest Pharmacol Ther. 2016 May 6. PMID: 27158543.
Can a Computerized Simulator Assess Skill Level and Improvement in Performance of ERCP?Sahakian AB, Laine L, Jamidar PA, Siddiqui UD, Duffy A, Ciarleglio MM, Deng Y, Nagar A, Aslanian HR. Dig Dis Sci. 2016 Mar; 2015 Nov 14. PMID: 26572779.
Endoscopic ultrasound-guided fine-needle aspiration diagnosis of secondary tumors involving the pancreas: An institution's experience.Alomari AK, Ustun B, Aslanian HR, Ge X, Chhieng D, Cai G. Cytojournal. 2016; 2016 Jan 28. PMID: 26955395.
Endoscopic Treatment of Gastrointestinal Perforations, Leaks, and Fistulae.Rustagi T, McCarty TR, Aslanian HR. J Clin Gastroenterol. 2015 Nov-Dec. PMID: 26325190.
Treatment of Refractory Gastrointestinal Strictures With Mitomycin C: A Systematic Review.Rustagi T, Aslanian HR, Laine L. J Clin Gastroenterol. 2015 Nov-Dec. PMID: 25626632.
Endoscopic ultrasound-guided fine-needle aspiration biopsy of autoimmune pancreatitis: diagnostic clues and pitfalls.Cai G, Bernstein J, Aslanian HR, Hui P, Chhieng D. J Am Soc Cytopathol. 2015 Jul-Aug; 2015 Jan 21. PMID: 31051756.
Is Advanced Endoscopy Training Worth it?Aslanian HR, Ahmed AM, Jamidar PA. Clin Gastroenterol Hepatol. 2015 Jul. PMID: 26091939.
Variation in Aptitude of Trainees in Endoscopic Ultrasonography, Based on Cumulative Sum Analysis.Wani S, Hall M, Keswani RN, Aslanian HR, Casey B, Burbridge R, Chak A, Chen AM, Cote G, Edmundowicz SA, Faulx AL, Hollander TG, Lee LS, Mullady D, Murad F, Muthusamy VR, Pfau PR, Scheiman JM, Tokar J, Wagh MS, Watson R, Early D. Clin Gastroenterol Hepatol. 2015 Jul; 2014 Nov 14. PMID: 25460557.
A double-blind, randomized, sham-controlled trial of the effect of a radiation-attenuating drape on radiation exposure to endoscopy staff during ERCP.Muniraj T, Aslanian HR, Laine L, Farrell J, Ciarleglio MM, Deng Y, Ho H, Jamidar PA. Am J Gastroenterol. 2015 May; 2015 Mar 31. PMID: 25823765.
Endoscopic strangulation techniques for treatment of upper GI mucosal and submucosal lesions.Rustagi T, Aslanian HR. Gastrointest Endosc. 2015 Apr; 2014 Jul 12. PMID: 25028275.
Influence of colonoscopy quality measures on patients' colonoscopist selection.Solad Y, Wang C, Laine L, Deng Y, Schwartz H, Ciarleglio MM, Aslanian HR. Am J Gastroenterol. 2015 Feb; 2014 Jul 29. PMID: 25070055.
Cold snare polypectomy for large sessile colonic polyps: a single-center experience.Muniraj T, Sahakian A, Ciarleglio MM, Deng Y, Aslanian HR. Gastroenterol Res Pract. 2015; 2015 Mar 23. PMID: 25878658.
Endoscopic management of biliary leaks after laparoscopic cholecystectomy.Rustagi T, Aslanian HR. J Clin Gastroenterol. 2014 Sep. PMID: 24296422.
Endoscopic ultrasound-guided fine-needle aspiration diagnosis of Merkel cell carcinoma metastatic to the pancreas.Bernstein J, Adeniran AJ, Cai G, Theoharis CG, Ustun B, Beckman D, Aslanian HR, Harigopal M. Diagn Cytopathol. 2014 Mar; 2012 Jun 25. PMID: 22730170.
The utility of esophagogastroduodenoscopy before endoscopic ultrasonography in patients undergoing endoscopic ultrasonography for pancreatico-biliary and mediastinal indications.Sahakian AB, Aslanian HR, Mehra M, Rossi F, Laine L, Sanchez M, Ciarleglio MM, Adimoolam V, Siddiqui UD. J Clin Gastroenterol. 2013 Nov-Dec. PMID: 23632349.
Emphysematous Cholecystitis Resulting in Secondary Biliary Cirrhosis: A Rare Complication of Endoscopic Retrograde Cholangiopancreatography.Bari K, Aslanian HR, Pollak J, Reiner E, Salem RR, Taddei TH, Emre SH, Jamidar PA. ACG Case Rep J. 2013 Oct; 2013 Oct 8. PMID: 26157820.
Endosonographic and cyst fluid characteristics of cystic pancreatic neuroendocrine tumours: a multicentre case series.Ho HC, Eloubeidi MA, Siddiqui UD, Brugge WR, Rossi F, Bounds BW, Aslanian HR. Dig Liver Dis. 2013 Sep; 2013 Apr 9. PMID: 23582348.
Performance of endoscopic ultrasound-guided fine needle aspiration in diagnosing pancreatic neuroendocrine tumors.Bernstein J, Ustun B, Alomari A, Bao F, Aslanian HR, Siddiqui U, Chhieng D, Cai G. Cytojournal. 2013; 2013 May 29. PMID: 23858320.
Nurse observation during colonoscopy increases polyp detection: a randomized prospective study.Aslanian HR, Shieh FK, Chan FW, Ciarleglio MM, Deng Y, Rogart JN, Jamidar PA, Siddiqui UD. Am J Gastroenterol. 2013 Feb. PMID: 23381064.
Pancreatic neuroendocrine tumors.Muniraj T, Vignesh S, Shetty S, Thiruvengadam S, Aslanian HR. Dis Mon. 2013 Jan. PMID: 23312533.
Hypertriglyceridemia independent propofol-induced pancreatitis.Muniraj T, Aslanian HR. JOP. 2012 Jul 10; 2012 Jul 10. PMID: 22797405.
Endoscopic ultrasound identifies synchronous pancreas cystic lesions not seen on initial cross-sectional imaging.Adimoolam V, Sanchez MJ, Siddiqui UD, Yu S, Dzuira JD, Padda MS, Aslanian HR. Pancreas. 2011 Oct. PMID: 21705942.
Endoscopic ultrasound and endoscopic retrograde cholangiopancreatography for obstructing pancreas head masses: combined or separate procedures?Aslanian HR, Estrada JD, Rossi F, Dziura J, Jamidar PA, Siddiqui UD. J Clin Gastroenterol. 2011 Sep. PMID: 21301359.
Patient preferences after endoscopic ultrasound with fine needle aspiration (EUS-FNA) diagnosis of pancreas cancer: rapid communication valued over long-term relationships.Siddiqui UD, Rossi F, Padda MS, Rosenthal LS, Aslanian HR. Pancreas. 2011 Jul. PMID: 21602735.
Littoral cell angioma of the spleen diagnosed by endoscopic ultrasound-guided fine-needle aspiration biopsy.Nagarajan P, Cai G, Padda MS, Selbst M, Kowalski D, Proctor DD, Chhieng D, Aslanian HR, Harigopal M. Diagn Cytopathol. 2011 May. PMID: 21488173.
Endoscopic ultrasound and gastric lesions.Nagler AK, Aslanian HR, Siddiqui UD. J Clin Gastroenterol. 2011 Mar. PMID: 21278579.
Narrow band imaging to detect residual or recurrent neoplastic tissue during surveillance endoscopy.Rogart JN, Aslanian HR, Siddiqui UD. Dig Dis Sci. 2011 Feb; 2010 Jun 9. PMID: 20532981.
Gastric perforations associated with the use of crack cocaine.Chander B, Aslanian HR. Gastroenterol Hepatol (N Y). 2010 Nov. PMID: 21437024.
EUS-guided FNA of solid pancreatic masses: a prospective, randomized trial comparing 22-gauge and 25-gauge needles.Siddiqui UD, Rossi F, Rosenthal LS, Padda MS, Murali-Dharan V, Aslanian HR. Gastrointest Endosc. 2009 Dec; 2009 Jul 28. PMID: 19640524.
Young female with pancreatic mass.Padda MS, Aslanian HR, Theoharis C. Gastroenterology. 2009 Sep; 2009 Jul 29. PMID: 19646403.
Massive hemobilia after transjugular liver biopsy treated endoscopically and angiographically.Rogart JN, Aslanian HR. Clin Gastroenterol Hepatol. 2008 Dec. PMID: 19081523.
Altered DNA mismatch repair expression in synchronous and metachronous colorectal cancers.Aslanian HR, Burgart LJ, Harrington JJ, Mahoney DW, Zinsmeister AR, Thibodeau SN, Ahlquist DA. Clin Gastroenterol Hepatol. 2008 Dec; 2008 Jul 17. PMID: 18639494.
Screening colonoscopy and fecal occult blood testing practice patterns: a population-based survey of gastroenterologists.Rossi F, Sosa JA, Aslanian HR. J Clin Gastroenterol. 2008 Nov-Dec. PMID: 18936643.
Fellow involvement may increase adenoma detection rates during colonoscopy.Rogart JN, Siddiqui UD, Jamidar PA, Aslanian HR. Am J Gastroenterol. 2008 Nov; 2008 Aug 27. PMID: 18759826.

David Assis, MD

Pathophysiology of Cystic Fibrosis Liver Disease.Kasper VL, Assis DN. Pediatr Pulmonol. 2024 Sep. PMID: 39105342.
PPAR-Mediated Bile Acid Glucuronidation: Therapeutic Targets for the Treatment of Cholestatic Liver Diseases.Gallucci GM, Hayes CM, Boyer JL, Barbier O, Assis DN, Ghonem NS. Cells. 2024 Aug 1; 2024 Aug 1. PMID: 39120326.
Cystic fibrosis screening, evaluation, and management of hepatobiliary disease consensus recommendations.Sellers ZM, Assis DN, Paranjape SM, Sathe M, Bodewes F, Bowen M, Cipolli M, Debray D, Green N, Hughan KS, Hunt WR, Leey J, Ling SC, Morelli G, Peckham D, Pettit RS, Philbrick A, Stoll J, Vavrina K, Allen S, Goodwin T, Hempstead SE, Narkewicz MR. Hepatology. 2024 May 1; 2023 Oct 26. PMID: 37934656.
Autoimmune hepatitis: Brighton Collaboration case definition and guidelines for data collection, analysis, and presentation of immunisation safety data.Kochhar S, Assis DN, Mack C, Izurieta HS, Muratori L, Munoz A, Nordenberg D, Gidudu JF, Blau EF, Vierling JM. Vaccine. 2024 Mar 7; 2024 Feb 16. PMID: 38368225.
Advancing Second-Line Treatment for Primary Biliary Cholangitis.Assis DN. N Engl J Med. 2024 Feb 29; 2024 Feb 21. PMID: 38381658.
African American race does not confer an increased risk of clinical events in patients with primary sclerosing cholangitis.Yazdanfar M, Zepeda J, Dean R, Wu J, Levy C, Goldberg D, Lammert C, Prenner S, Reddy KR, Pratt D, Forman L, Assis DN, Lytvyak E, Montano-Loza AJ, Gordon SC, Carey EJ, Ahn J, Schlansky B, Korzenik J, Karagozian R, Hameed B, Chandna S, Yu L, Bowlus CL. Hepatol Commun. 2024 Feb 1; 2024 Jan 29. PMID: 38285883.
Advancing diagnosis and management of liver disease in adults through exome sequencing.Zheng M, Hakim A, Konkwo C, Deaton AM, Ward LD, Silveira MG, Assis DN, Liapakis A, Jaffe A, Jiang ZG, Curry MP, Lai M, Cho MH, Dykas D, Bale A, Mistry PK, Vilarinho S. EBioMedicine. 2023 Sep; 2023 Aug 9. PMID: 37566928.
Recent Advances in the Management of Primary Sclerosing Cholangitis.Assis DN, Bowlus CL. Clin Gastroenterol Hepatol. 2023 Jul; 2023 Apr 19. PMID: 37084929.
Research gaps and opportunities in autoimmune hepatitis-Results of the international autoimmune hepatitis group research workshop 2022.Snijders RJALM, Assis DN, Oo YH, Sebode M, Taubert R, Willemse J, Tomsin B, Lohse AW, Drenth JPH, Gevers TJG. Liver Int. 2023 Jul; 2023 Apr 10. PMID: 37035872.
Reply: Insurance should cover vancomycin for primary sclerosing cholangitis.Bowlus CL, Arrivé L, Bergquist A, Deneau M, Forman L, Ilyas SI, Lunsford KE, Martinez M, Sapisochin G, Shroff R, Tabibian JH, Assis DN. Hepatology. 2023 Jun 1; 2023 Jan 26. PMID: 36695291.
Reply: Living donor liver transplantation for people with PSC.Forman LM, Sapisochin G, Assis DN, Arrivé L, Bergquist A, Bowlus CL, Deneau M, Ilyas SI, Lunsford KE, Martinez M, Shroff R, Tabibian JH. Hepatology. 2023 May 1; 2023 Jan 3. PMID: 36732294.
Outcomes of immunomodulator and advanced therapies for primary sclerosing cholangitis-associated inflammatory bowel disease.Sayed A, Assis DN, Silveira MG, Deng Y, Ciarleglio M, Gaidos JKJ, Proctor DD, Al-Bawardy B. Eur J Gastroenterol Hepatol. 2023 Mar 1; 2023 Jan 17. PMID: 36708297.
Unique DUOX2(+)ACE2(+) small cholangiocytes are pathogenic targets for primary biliary cholangitis.Li X, Li Y, Xiao J, Wang H, Guo Y, Mao X, Shi P, Hou Y, Zhang X, Zhao N, Zheng M, He Y, Ding J, Tan Y, Liao M, Li L, Peng Y, Li X, Pan Q, Xie Q, Li Q, Li J, Li Y, Chen Z, Huang Y, Assis DN, Cai SY, Boyer JL, Huang X, Tang CE, Liu X, Peng S, Chai J. Nat Commun. 2023 Feb 9; 2023 Feb 9. PMID: 36759512.
AASLD practice guidance on primary sclerosing cholangitis and cholangiocarcinoma.Bowlus CL, Arrivé L, Bergquist A, Deneau M, Forman L, Ilyas SI, Lunsford KE, Martinez M, Sapisochin G, Shroff R, Tabibian JH, Assis DN. Hepatology. 2023 Feb 1; 2022 Oct 20. PMID: 36083140.
Update in Advancing the Gastrointestinal Frontier in Cystic Fibrosis.Vélez C, Freedman SD, Assis DN. Clin Chest Med. 2022 Dec. PMID: 36344078.
Fenofibrate Downregulates NF-κB Signaling to Inhibit Pro-inflammatory Cytokine Secretion in Human THP-1 Macrophages and During Primary Biliary Cholangitis.Gallucci GM, Alsuwayt B, Auclair AM, Boyer JL, Assis DN, Ghonem NS. Inflammation. 2022 Dec; 2022 Jul 15. PMID: 35838934.
Mindfulness-based stress reduction may decrease stress, disease activity, and inflammatory cytokine levels in patients with autoimmune hepatitis.Alrabadi LS, Dutton A, Rabiee A, Roberts SJ, Deng Y, Cusack L, Silveira MG, Ciarleglio M, Bucala R, Sinha R, Boyer JL, Assis DN. JHEP Rep. 2022 May; 2022 Feb 18. PMID: 35434588.
Adjunct Fenofibrate Up-regulates Bile Acid Glucuronidation and Improves Treatment Response For Patients With Cholestasis.Gallucci GM, Trottier J, Hemme C, Assis DN, Boyer JL, Barbier O, Ghonem NS. Hepatol Commun. 2021 Dec; 2021 Aug 27. PMID: 34558841.
Defining Primary Sclerosing Cholangitis: Results From an International Primary Sclerosing Cholangitis Study Group Consensus Process.Ponsioen CY, Assis DN, Boberg KM, Bowlus CL, Deneau M, Thorburn D, Aabakken L, Färkkilä M, Petersen B, Rupp C, Hübscher SG. Gastroenterology. 2021 Dec; 2021 Aug 10. PMID: 34384749.
Outcome of COVID-19 in Patients With Autoimmune Hepatitis: An International Multicenter Study.Efe C, Dhanasekaran R, Lammert C, Ebik B, Higuera-de la Tijera F, Aloman C, Rıza Calışkan A, Peralta M, Gerussi A, Massoumi H, Catana AM, Torgutalp M, Purnak T, Rigamonti C, Gomez Aldana AJ, Khakoo N, Kacmaz H, Nazal L, Frager S, Demir N, Irak K, Ellik ZM, Balaban Y, Atay K, Eren F, Cristoferi L, Batıbay E, Urzua Á, Snijders R, Kıyıcı M, Akyıldız M, Ekin N, Carr RM, Harputluoğlu M, Hatemi I, Mendizabal M, Silva M, Idilman R, Silveira M, Drenth JPH, Assis DN, Björnsson E, Boyer JL, Invernizzi P, Levy C, Schiano TD, Ridruejo E, Wahlin S. Hepatology. 2021 Jun. PMID: 33713486.
Role of Biliary Organoids in Cholestasis Research and Regenerative Medicine.Soroka CJ, Roberts SJ, Boyer JL, Assis DN. Semin Liver Dis. 2021 May; 2021 May 6. PMID: 33957696.
Treatment of Metastatic Extramammary Paget Disease with Combination Ipilimumab and Nivolumab: A Case Report.Guercio BJ, Iyer G, Kidwai WZ, Lacouture ME, Ghafoor S, Rossi AM, Assis DN, Chen YB, Busam KJ, Janjigian YY, Jhaveri K, Feldman DR, Capozzi A, Figueroa V, Bajorin DF, Rosenberg JE, Hollmann TJ, Funt SA. Case Rep Oncol. 2021 Jan-Apr; 2021 Mar 12. PMID: 33790764.
Fenofibrate Improves Liver Function and Reduces the Toxicity of the Bile Acid Pool in Patients With Primary Biliary Cholangitis and Primary Sclerosing Cholangitis Who Are Partial Responders to Ursodiol.Ghonem NS, Auclair AM, Hemme CL, Gallucci GM, de la Rosa Rodriguez R, Boyer JL, Assis DN. Clin Pharmacol Ther. 2020 Dec; 2020 Jul 17. PMID: 32480421.
A Systematic Review of Patient-Reported Outcomes in Primary Biliary Cholangitis and Primary Sclerosing Cholangitis.Kim HP, Lieber SR, Rogers ME, Moon AM, Loiselle M, Walker J, Assis DN, Safer R, Gomel R, Evon DM. Hepatol Commun. 2020 Oct; 2020 Aug 1. PMID: 33024919.
Immunosuppressive Treatment Regimens in Autoimmune Hepatitis: Systematic Reviews and Meta-Analyses Supporting American Association for the Study of Liver Diseases Guidelines.Vierling JM, Kerkar N, Czaja AJ, Mack CL, Adams D, Assis DN, Manns MP, Mayo MJ, Nayfeh T, Majzoub AMM, Alzuabi MA, Ding J, Haffar S, Murad MH, Alsawas M. Hepatology. 2020 Aug. PMID: 32500593.
Diagnosis and Management of Autoimmune Hepatitis in Adults and Children: 2019 Practice Guidance and Guidelines From the American Association for the Study of Liver Diseases.Mack CL, Adams D, Assis DN, Kerkar N, Manns MP, Mayo MJ, Vierling JM, Alsawas M, Murad MH, Czaja AJ. Hepatology. 2020 Aug; 2020 May 12. PMID: 31863477.
Immunopathogenesis of Autoimmune Hepatitis.Assis DN. Clin Liver Dis (Hoboken). 2020 Mar; 2020 Apr 4. PMID: 32257125.
Machine Learning in a Complex Disease: PREsTo Improves the Prognostication of Primary Sclerosing Cholangitis.Shung DL, Assis DN. Hepatology. 2020 Jan. PMID: 31850533.
Effects of Vedolizumab in Patients With Primary Sclerosing Cholangitis and Inflammatory Bowel Diseases.Lynch KD, Chapman RW, Keshav S, Montano-Loza AJ, Mason AL, Kremer AE, Vetter M, de Krijger M, Ponsioen CY, Trivedi P, Hirschfield G, Schramm C, Liu CH, Bowlus CL, Estes DJ, Pratt D, Hedin C, Bergquist A, de Vries AC, van der Woude CJ, Yu L, Assis DN, Boyer J, Ytting H, Hallibasic E, Trauner M, Marschall HU, Daretti LM, Marzioni M, Yimam KK, Perin N, Floreani A, Beretta-Piccoli BT, Rogers JK, Levy C. Clin Gastroenterol Hepatol. 2020 Jan; 2019 May 14. PMID: 31100458.
The Contribution of B Cells in Autoimmune Liver Diseases.Taylor SA, Assis DN, Mack CL. Semin Liver Dis. 2019 Nov; 2019 Jun 21. PMID: 31226726.
Bile-Derived Organoids From Patients With Primary Sclerosing Cholangitis Recapitulate Their Inflammatory Immune Profile.Soroka CJ, Assis DN, Alrabadi LS, Roberts S, Cusack L, Jaffe AB, Boyer JL. Hepatology. 2019 Sep; 2019 Mar 13. PMID: 30561836.
Clinical utility of genomic analysis in adults with idiopathic liver disease.Hakim A, Zhang X, DeLisle A, Oral EA, Dykas D, Drzewiecki K, Assis DN, Silveira M, Batisti J, Jain D, Bale A, Mistry PK, Vilarinho S. J Hepatol. 2019 Jun; 2019 Apr 15. PMID: 31000363.
Patient-Derived Organoids from Human Bile: An In Vitro Method to Study Cholangiopathies.Soroka CJ, Assis DN, Boyer JL. Methods Mol Biol. 2019. PMID: 31016667.
Histologic features of autoimmune hepatitis: a critical appraisal.Gurung A, Assis DN, McCarty TR, Mitchell KA, Boyer JL, Jain D. Hum Pathol. 2018 Dec; 2018 Jul 21. PMID: 30041025.
Chronic Complications of Cholestasis: Evaluation and Management.Assis DN. Clin Liver Dis. 2018 Aug; 2018 May 28. PMID: 30259851.
Gallbladder and bile duct disease in Cystic Fibrosis.Assis DN, Debray D. J Cyst Fibros. 2017 Nov. PMID: 28986023.
Combination Therapy of All-Trans Retinoic Acid With Ursodeoxycholic Acid in Patients With Primary Sclerosing Cholangitis: A Human Pilot Study.Assis DN, Abdelghany O, Cai SY, Gossard AA, Eaton JE, Keach JC, Deng Y, Setchell KD, Ciarleglio M, Lindor KD, Boyer JL. J Clin Gastroenterol. 2017 Feb. PMID: 27428727.
A Macrophage Migration Inhibitory Factor Polymorphism Is Associated with Autoimmune Hepatitis Severity in US and Japanese Patients.Assis DN, Takahashi H, Leng L, Zeniya M, Boyer JL, Bucala R. Dig Dis Sci. 2016 Dec; 2016 Oct 1. PMID: 27696094.
Gastrointestinal Disorders in Cystic Fibrosis.Assis DN, Freedman SD. Clin Chest Med. 2016 Mar; 2015 Dec 24. PMID: 26857772.
Fibrates and cholestasis.Ghonem NS, Assis DN, Boyer JL. Hepatology. 2015 Aug; 2015 Mar 23. PMID: 25678132.
Editorial: environmental risk factors for PSC with and without IBD--the story unfolds.Assis DN, Levy C. Aliment Pharmacol Ther. 2015 Jun. PMID: 25939466.
The role of macrophage migration inhibitory factor in autoimmune liver disease.Assis DN, Leng L, Du X, Zhang CK, Grieb G, Merk M, Garcia AB, McCrann C, Chapiro J, Meinhardt A, Mizue Y, Nikolic-Paterson DJ, Bernhagen J, Kaplan MM, Zhao H, Boyer JL, Bucala R. Hepatology. 2014 Feb; 2013 Dec 20. PMID: 23913513.
New pharmacotherapy for hepatitis C.Assis DN, Lim JK. Clin Pharmacol Ther. 2012 Sep; 2012 Aug 1. PMID: 22850602.
Successful treatment of a bleeding umbilical varix by percutaneous umbilical vein embolization with sclerotherapy.Assis DN, Pollak J, Schilsky ML, Emre S. J Clin Gastroenterol. 2012 Feb. PMID: 21897280.
Testing and management of thrombocytopenia and coagulopathy in the pre- and postliver transplant patient.Assis DN, Schilsky ML. Minerva Gastroenterol Dietol. 2010 Sep. PMID: 21037549.

James Lorenzen Boyer, MD, FACEP

PPAR-Mediated Bile Acid Glucuronidation: Therapeutic Targets for the Treatment of Cholestatic Liver Diseases.Gallucci GM, Hayes CM, Boyer JL, Barbier O, Assis DN, Ghonem NS. Cells. 2024 Aug 1; 2024 Aug 1. PMID: 39120326.
Hepatic GDP-fucose transporter SLC35C1 attenuates cholestatic liver injury and inflammation by inducing CEACAM1 N153 fucosylation.Zhang L, Xie P, Li M, Zhang X, Fei S, Zhao N, Li L, Xie Q, Xu Z, Tang W, Zhu G, Zhu Z, Xu Z, Li J, Zhang C, Boyer JL, Chen W, Cai SY, Pan Q, Chai J. Hepatology. 2024 Jul 10; 2024 Jul 10. PMID: 38985995.
Human vascularized bile duct-on-a chip: a multi-cellular micro-physiological system for studying cholestatic liver disease.Du Y, de Jong IEM, Gupta K, Waisbourd-Zinman O, Har-Zahav A, Soroka CJ, Boyer JL, Llewellyn J, Liu C, Naji A, Polacheck WJ, Wells RG. Biofabrication. 2023 Oct 20; 2023 Oct 20. PMID: 37820623.
Runt-related transcription factor-1 ameliorates bile acid-induced hepatic inflammation in cholestasis through JAK/STAT3 signaling.Zhang L, Pan Q, Zhang L, Xia H, Liao J, Zhang X, Zhao N, Xie Q, Liao M, Tan Y, Li Q, Zhu J, Li L, Fan S, Li J, Zhang C, Cai SY, Boyer JL, Chai J. Hepatology. 2023 Jun 1; 2023 Jan 3. PMID: 36647589.
Unique DUOX2(+)ACE2(+) small cholangiocytes are pathogenic targets for primary biliary cholangitis.Li X, Li Y, Xiao J, Wang H, Guo Y, Mao X, Shi P, Hou Y, Zhang X, Zhao N, Zheng M, He Y, Ding J, Tan Y, Liao M, Li L, Peng Y, Li X, Pan Q, Xie Q, Li Q, Li J, Li Y, Chen Z, Huang Y, Assis DN, Cai SY, Boyer JL, Huang X, Tang CE, Liu X, Peng S, Chai J. Nat Commun. 2023 Feb 9; 2023 Feb 9. PMID: 36759512.
Bile Acid Induced Inflammation and the Role of β-Catenin.Boyer JL. Cell Mol Gastroenterol Hepatol. 2023; 2023 Sep 7. PMID: 37690462.
Organic Anion Transporting Polypeptide (OATP) 1B3 is a Significant Transporter for Hepatic Uptake of Conjugated Bile Acids in Humans.Pan Q, Zhu G, Xu Z, Zhu J, Ouyang J, Tong Y, Zhao N, Zhang X, Cheng Y, Zhang L, Tan Y, Li J, Zhang C, Chen W, Cai SY, Boyer JL, Chai J. Cell Mol Gastroenterol Hepatol. 2023; 2023 May 3. PMID: 37146714.
Fenofibrate Downregulates NF-κB Signaling to Inhibit Pro-inflammatory Cytokine Secretion in Human THP-1 Macrophages and During Primary Biliary Cholangitis.Gallucci GM, Alsuwayt B, Auclair AM, Boyer JL, Assis DN, Ghonem NS. Inflammation. 2022 Dec; 2022 Jul 15. PMID: 35838934.
SEMA7AR148W mutation promotes lipid accumulation and NAFLD progression via increased localization on the hepatocyte surface.Zhao N, Zhang X, Ding J, Pan Q, Zheng MH, Liu WY, Luo G, Qu J, Li M, Li L, Cheng Y, Peng Y, Xie Q, Wei Q, Li Q, Zou L, Ouyang X, Cai SY, Boyer JL, Chai J. JCI Insight. 2022 Aug 8; 2022 Aug 8. PMID: 35938531.
Mindfulness-based stress reduction may decrease stress, disease activity, and inflammatory cytokine levels in patients with autoimmune hepatitis.Alrabadi LS, Dutton A, Rabiee A, Roberts SJ, Deng Y, Cusack L, Silveira MG, Ciarleglio M, Bucala R, Sinha R, Boyer JL, Assis DN. JHEP Rep. 2022 May; 2022 Feb 18. PMID: 35434588.
Effects of immunosuppressive drugs on COVID-19 severity in patients with autoimmune hepatitis.Efe C, Lammert C, Taşçılar K, Dhanasekaran R, Ebik B, Higuera-de la Tijera F, Calışkan AR, Peralta M, Gerussi A, Massoumi H, Catana AM, Purnak T, Rigamonti C, Aldana AJG, Khakoo N, Nazal L, Frager S, Demir N, Irak K, Melekoğlu-Ellik Z, Kacmaz H, Balaban Y, Atay K, Eren F, Alvares-da-Silva MR, Cristoferi L, Urzua Á, Eşkazan T, Magro B, Snijders R, Barutçu S, Lytvyak E, Zazueta GM, Demirezer-Bolat A, Aydın M, Heurgue-Berlot A, De Martin E, Ekin N, Yıldırım S, Yavuz A, Bıyık M, Narro GC, Kıyıcı M, Akyıldız M, Kahramanoğlu-Aksoy E, Vincent M, Carr RM, Günşar F, Reyes EC, Harputluoğlu M, Aloman C, Gatselis NK, Üstündağ Y, Brahm J, Vargas NCE, Güzelbulut F, Garcia SR, Aguirre J, Anders M, Ratusnu N, Hatemi I, Mendizabal M, Floreani A, Fagiuoli S, Silva M, Idilman R, Satapathy SK, Silveira M, Drenth JPH, Dalekos GN, N Assis D, Björnsson E, Boyer JL, Yoshida EM, Invernizzi P, Levy C, Montano-Loza AJ, Schiano TD, Ridruejo E, Wahlin S. Liver Int. 2022 Mar; 2021 Dec 13. PMID: 34846800.
Adjunct Fenofibrate Up-regulates Bile Acid Glucuronidation and Improves Treatment Response For Patients With Cholestasis.Gallucci GM, Trottier J, Hemme C, Assis DN, Boyer JL, Barbier O, Ghonem NS. Hepatol Commun. 2021 Dec; 2021 Aug 27. PMID: 34558841.
A homozygous R148W mutation in Semaphorin 7A causes progressive familial intrahepatic cholestasis.Pan Q, Luo G, Qu J, Chen S, Zhang X, Zhao N, Ding J, Yang H, Li M, Li L, Cheng Y, Li X, Xie Q, Li Q, Zhou X, Zou H, Fan S, Zou L, Liu W, Deng G, Cai SY, Boyer JL, Chai J. EMBO Mol Med. 2021 Nov 8; 2021 Sep 29. PMID: 34585848.
Bile formation and secretion: An update.Boyer JL, Soroka CJ. J Hepatol. 2021 Jul; 2021 Feb 20. PMID: 33617926.
Outcome of COVID-19 in Patients With Autoimmune Hepatitis: An International Multicenter Study.Efe C, Dhanasekaran R, Lammert C, Ebik B, Higuera-de la Tijera F, Aloman C, Rıza Calışkan A, Peralta M, Gerussi A, Massoumi H, Catana AM, Torgutalp M, Purnak T, Rigamonti C, Gomez Aldana AJ, Khakoo N, Kacmaz H, Nazal L, Frager S, Demir N, Irak K, Ellik ZM, Balaban Y, Atay K, Eren F, Cristoferi L, Batıbay E, Urzua Á, Snijders R, Kıyıcı M, Akyıldız M, Ekin N, Carr RM, Harputluoğlu M, Hatemi I, Mendizabal M, Silva M, Idilman R, Silveira M, Drenth JPH, Assis DN, Björnsson E, Boyer JL, Invernizzi P, Levy C, Schiano TD, Ridruejo E, Wahlin S. Hepatology. 2021 Jun. PMID: 33713486.
Role of Biliary Organoids in Cholestasis Research and Regenerative Medicine.Soroka CJ, Roberts SJ, Boyer JL, Assis DN. Semin Liver Dis. 2021 May; 2021 May 6. PMID: 33957696.
The role of the retinoid receptor, RAR/RXR heterodimer, in liver physiology.Li B, Cai SY, Boyer JL. Biochim Biophys Acta Mol Basis Dis. 2021 May 1; 2021 Jan 24. PMID: 33497820.
The role of bile acids in cholestatic liver injury.Cai SY, Boyer JL. Ann Transl Med. 2021 Apr. PMID: 33987435.
Hepatic NFAT signaling regulates the expression of inflammatory cytokines in cholestasis.Cai SY, Yu D, Soroka CJ, Wang J, Boyer JL. J Hepatol. 2021 Mar; 2020 Oct 9. PMID: 33039404.
Fenofibrate Improves Liver Function and Reduces the Toxicity of the Bile Acid Pool in Patients With Primary Biliary Cholangitis and Primary Sclerosing Cholangitis Who Are Partial Responders to Ursodiol.Ghonem NS, Auclair AM, Hemme CL, Gallucci GM, de la Rosa Rodriguez R, Boyer JL, Assis DN. Clin Pharmacol Ther. 2020 Dec; 2020 Jul 17. PMID: 32480421.
Organic Solute Transporter Alpha Deficiency: A Disorder With Cholestasis, Liver Fibrosis, and Congenital Diarrhea.Gao E, Cheema H, Waheed N, Mushtaq I, Erden N, Nelson-Williams C, Jain D, Soroka CJ, Boyer JL, Khalil Y, Clayton PT, Mistry PK, Lifton RP, Vilarinho S. Hepatology. 2020 May. PMID: 31863603.
A Positive Feedback Loop of TET3 and TGF-β1 Promotes Liver Fibrosis.Xu Y, Sun X, Zhang R, Cao T, Cai SY, Boyer JL, Zhang X, Li D, Huang Y. Cell Rep. 2020 Feb 4. PMID: 32023451.
Inflammasome Is Activated in the Liver of Cholestatic Patients and Aggravates Hepatic Injury in Bile Duct-Ligated Mouse.Cai SY, Ge M, Mennone A, Hoque R, Ouyang X, Boyer JL. Cell Mol Gastroenterol Hepatol. 2020; 2019 Dec 27. PMID: 31887435.
Bile acid metabolism and T cell responses in cholangiopathy: Not one-way traffic.Shetty S, Boyer JL. J Hepatol. 2019 Oct; 2019 Aug 22. PMID: 31447221.
Bile-Derived Organoids From Patients With Primary Sclerosing Cholangitis Recapitulate Their Inflammatory Immune Profile.Soroka CJ, Assis DN, Alrabadi LS, Roberts S, Cusack L, Jaffe AB, Boyer JL. Hepatology. 2019 Sep; 2019 Mar 13. PMID: 30561836.
Bile Infarcts: New Insights Into the Pathogenesis of Obstructive Cholestasis.Cai SY, Boyer JL. Hepatology. 2019 Feb; 2019 Jan 16. PMID: 30251326.
Liver Complications Following Treatment of Hematologic Malignancy With Anti-CD22-Calicheamicin (Inotuzumab Ozogamicin).McDonald GB, Freston JW, Boyer JL, DeLeve LD. Hepatology. 2019 Feb; 2019 Jan 18. PMID: 30120894.
Patient-Derived Organoids from Human Bile: An In Vitro Method to Study Cholangiopathies.Soroka CJ, Assis DN, Boyer JL. Methods Mol Biol. 2019. PMID: 31016667.
Histologic features of autoimmune hepatitis: a critical appraisal.Gurung A, Assis DN, McCarty TR, Mitchell KA, Boyer JL, Jain D. Hum Pathol. 2018 Dec; 2018 Jul 21. PMID: 30041025.
H19 Is Expressed in Hybrid Hepatocyte Nuclear Factor 4α(+) Periportal Hepatocytes but Not Cytokeratin 19(+) Cholangiocytes in Cholestatic Livers.Jiang Y, Huang Y, Cai S, Song Y, Boyer JL, Zhang K, Gao L, Zhao J, Huang W, Liang G, Liangpunsakul S, Wang L. Hepatol Commun. 2018 Nov; 2018 Sep 24. PMID: 30411082.
Solute Carrier Organic Anion Transporter Family Member 3A1 Is a Bile Acid Efflux Transporter in Cholestasis.Pan Q, Zhang X, Zhang L, Cheng Y, Zhao N, Li F, Zhou X, Chen S, Li J, Xu S, Huang D, Chen Y, Li L, Wang H, Chen W, Cai SY, Boyer JL, Chai J. Gastroenterology. 2018 Nov; 2018 Jul 29. PMID: 30063921.
Cenicriviroc, a cytokine receptor antagonist, potentiates all-trans retinoic acid in reducing liver injury in cholestatic rodents.Yu D, Cai SY, Mennone A, Vig P, Boyer JL. Liver Int. 2018 Jun; 2018 Feb 13. PMID: 29356312.
Primary Sclerosing Cholangitis Is Not Rare Among Blacks in a Multicenter North American Consortium.Goldberg DS, Levy C, Yimam K, Gordon SC, Forman L, Verna E, Yu L, Rahimi R, Schwarz K, Eksteen B, Pratt D, Boyer JL, Assis D, Bowlus C. Clin Gastroenterol Hepatol. 2018 Apr; 2017 Nov 2. PMID: 29102704.
OSTα-OSTβ Guards the Ileal Enterocyte From the Accumulation of Toxic Levels of Bile Acids.Boyer JL. Cell Mol Gastroenterol Hepatol. 2018; 2018 Feb 10. PMID: 29713669.
Maintaining a Vibrant and Productive Laboratory as a Senior Investigator.Boyer JL. Cell Mol Gastroenterol Hepatol. 2017 Sep; 2017 Jun 7. PMID: 28840184.
Mechanisms of bile acid mediated inflammation in the liver.Li M, Cai SY, Boyer JL. Mol Aspects Med. 2017 Aug; 2017 Jul 1. PMID: 28606651.
Na(+)-taurocholate cotransporting polypeptide (NTCP/SLC10A1) ortholog in the marine skate Leucoraja erinacea is not a physiological bile salt transporter.Yu D, Zhang H, Lionarons DA, Boyer JL, Cai SY. Am J Physiol Regul Integr Comp Physiol. 2017 Apr 1; 2017 Jan 11. PMID: 28077388.
Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response.Cai SY, Ouyang X, Chen Y, Soroka CJ, Wang J, Mennone A, Wang Y, Mehal WZ, Jain D, Boyer JL. JCI Insight. 2017 Mar 9; 2017 Mar 9. PMID: 28289714.
Combination Therapy of All-Trans Retinoic Acid With Ursodeoxycholic Acid in Patients With Primary Sclerosing Cholangitis: A Human Pilot Study.Assis DN, Abdelghany O, Cai SY, Gossard AA, Eaton JE, Keach JC, Deng Y, Setchell KD, Ciarleglio M, Lindor KD, Boyer JL. J Clin Gastroenterol. 2017 Feb. PMID: 27428727.
Studies on the mechanisms of bile acid initiated hepatic inflammation in cholestatic liver injury.Cai SY, Boyer JL. Inflamm Cell Signal. 2017; 2017 Jun 19. PMID: 28804737.
The Role of Inflammation in the Mechanisms of Bile Acid-Induced Liver Damage.Cai SY, Boyer JL. Dig Dis. 2017; 2017 Mar 1. PMID: 28249287.
CFTR-associated ligand is a negative regulator of Mrp2 expression.Li M, Soroka CJ, Harry K, Boyer JL. Am J Physiol Cell Physiol. 2017 Jan 1; 2016 Nov 9. PMID: 27834195.
Treatment of chronic cholestasis: What we know and what we will know?Boyer JL. Clin Liver Dis (Hoboken). 2016 Dec; 2016 Dec 30. PMID: 31041082.
A Macrophage Migration Inhibitory Factor Polymorphism Is Associated with Autoimmune Hepatitis Severity in US and Japanese Patients.Assis DN, Takahashi H, Leng L, Zeniya M, Boyer JL, Bucala R. Dig Dis Sci. 2016 Dec; 2016 Oct 1. PMID: 27696094.
Sirtuin 1 activation alleviates cholestatic liver injury in a cholic acid-fed mouse model of cholestasis.Kulkarni SR, Soroka CJ, Hagey LR, Boyer JL. Hepatology. 2016 Dec; 2016 Oct 28. PMID: 27639250.
A Novel Di-Leucine Motif at the N-Terminus of Human Organic Solute Transporter Beta Is Essential for Protein Association and Membrane Localization.Xu S, Soroka CJ, Sun AQ, Backos DS, Mennone A, Suchy FJ, Boyer JL. PLoS One. 2016; 2016 Jun 28. PMID: 27351185.
Canalicular membrane MRP2/ABCC2 internalization is determined by Ezrin Thr567 phosphorylation in human obstructive cholestasis.Chai J, Cai SY, Liu X, Lian W, Chen S, Zhang L, Feng X, Cheng Y, He X, He Y, Chen L, Wang R, Wang H, Boyer JL, Chen W. J Hepatol. 2015 Dec; 2015 Jul 23. PMID: 26212029.
Na(+) /H(+) exchanger regulatory factor 1 knockout mice have an attenuated hepatic inflammatory response and are protected from cholestatic liver injury.Li M, Mennone A, Soroka CJ, Hagey LR, Ouyang X, Weinman EJ, Boyer JL. Hepatology. 2015 Oct; 2015 Aug 22. PMID: 26108984.
Fibrates and cholestasis.Ghonem NS, Assis DN, Boyer JL. Hepatology. 2015 Aug; 2015 Mar 23. PMID: 25678132.
The origins of hepatobiliary and gastrointestinal physiology.Boyer JL. Hepatology. 2015 May; 2015 Mar 18. PMID: 25677183.
A Novel Small-Molecule Inhibitor Targeting CREB-CBP Complex Possesses Anti-Cancer Effects along with Cell Cycle Regulation, Autophagy Suppression and Endoplasmic Reticulum Stress.Lee JW, Park HS, Park SA, Ryu SH, Meng W, Jürgensmeier JM, Kurie JM, Hong WK, Boyer JL, Herbst RS, Koo JS. PLoS One. 2015; 2015 Apr 21. PMID: 25897662.
Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats.Perry RJ, Zhang D, Zhang XM, Boyer JL, Shulman GI. Science. 2015 Mar 13; 2015 Feb 26. PMID: 25721504.
The hepatobiliary paracellular pathway: a paradigm revisited.Boyer JL. Gastroenterology. 2014 Nov; 2014 Sep 26. PMID: 25263297.
A RAS renaissance: emerging targeted therapies for KRAS-mutated non-small cell lung cancer.Vasan N, Boyer JL, Herbst RS. Clin Cancer Res. 2014 Aug 1; 2014 Jun 3. PMID: 24893629.
Biosynthesis and trafficking of the bile salt export pump, BSEP: therapeutic implications of BSEP mutations.Soroka CJ, Boyer JL. Mol Aspects Med. 2014 Jun; 2013 May 15. PMID: 23685087.
Altered expression and function of canalicular transporters during early development of cholestatic liver injury in Abcb4-deficient mice.Cai SY, Mennone A, Soroka CJ, Boyer JL. Am J Physiol Gastrointest Liver Physiol. 2014 Apr 15; 2014 Jan 30. PMID: 24481602.
Glucocerebrosidase 2 gene deletion rescues type 1 Gaucher disease.Mistry PK, Liu J, Sun L, Chuang WL, Yuen T, Yang R, Lu P, Zhang K, Li J, Keutzer J, Stachnik A, Mennone A, Boyer JL, Jain D, Brady RO, New MI, Zaidi M. Proc Natl Acad Sci U S A. 2014 Apr 1; 2014 Mar 17. PMID: 24639522.
All-trans-retinoic acid improves cholestasis in α-naphthylisothiocyanate-treated rats and Mdr2-/- mice.Cai SY, Mennone A, Soroka CJ, Boyer JL. J Pharmacol Exp Ther. 2014 Apr; 2014 Feb 3. PMID: 24492652.
Peroxisome proliferator-activated receptor α activates human multidrug resistance transporter 3/ATP-binding cassette protein subfamily B4 transcription and increases rat biliary phosphatidylcholine secretion.Ghonem NS, Ananthanarayanan M, Soroka CJ, Boyer JL. Hepatology. 2014 Mar; 2014 Jan 27. PMID: 24122873.
The role of macrophage migration inhibitory factor in autoimmune liver disease.Assis DN, Leng L, Du X, Zhang CK, Grieb G, Merk M, Garcia AB, McCrann C, Chapiro J, Meinhardt A, Mizue Y, Nikolic-Paterson DJ, Bernhagen J, Kaplan MM, Zhao H, Boyer JL, Bucala R. Hepatology. 2014 Feb; 2013 Dec 20. PMID: 23913513.
"Quitting smoking will benefit your health": the evolution of clinician messaging to encourage tobacco cessation.Toll BA, Rojewski AM, Duncan LR, Latimer-Cheung AE, Fucito LM, Boyer JL, O'Malley SS, Salovey P, Herbst RS. Clin Cancer Res. 2014 Jan 15; 2014 Jan 16. PMID: 24436474.
Deleterious effect of oltipraz on extrahepatic cholestasis in bile duct-ligated mice.Weerachayaphorn J, Luo Y, Mennone A, Soroka CJ, Harry K, Boyer JL. J Hepatol. 2014 Jan; 2013 Aug 23. PMID: 23978715.
Bile formation and secretion.Boyer JL. Compr Physiol. 2013 Jul. PMID: 23897680.
Adult sea lamprey tolerates biliary atresia by altering bile salt composition and renal excretion.Cai SY, Lionarons DA, Hagey L, Soroka CJ, Mennone A, Boyer JL. Hepatology. 2013 Jun. PMID: 23175353.
A step towards treating KRAS-mutant NSCLC.Goldberg SB, Schlessinger J, Boyer JL, Herbst RS. Lancet Oncol. 2013 Jan; 2012 Nov 28. PMID: 23200176.
Evolution of substrate specificity for the bile salt transporter ASBT (SLC10A2).Lionarons DA, Boyer JL, Cai SY. J Lipid Res. 2012 Aug; 2012 Jun 5. PMID: 22669917.
A C-terminal tyrosine-based motif in the bile salt export pump directs clathrin-dependent endocytosis.Lam P, Xu S, Soroka CJ, Boyer JL. Hepatology. 2012 Jun; 2012 Apr 25. PMID: 22161577.
Nuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestine.Weerachayaphorn J, Mennone A, Soroka CJ, Harry K, Hagey LR, Kensler TW, Boyer JL. Am J Physiol Gastrointest Liver Physiol. 2012 May 1; 2012 Feb 16. PMID: 22345550.
Targeting vascular endothelial growth factor in patients with squamous cell lung cancer.Koo PJ, Morgensztern D, Boyer JL, Herbst RS. J Clin Oncol. 2012 Apr 1; 2012 Feb 21. PMID: 22355057.
Ostα depletion protects liver from oral bile acid load.Soroka CJ, Velazquez H, Mennone A, Ballatori N, Boyer JL. Am J Physiol Gastrointest Liver Physiol. 2011 Sep; 2011 Jun 30. PMID: 21719738.
Combination of retinoic acid and ursodeoxycholic acid attenuates liver injury in bile duct-ligated rats and human hepatic cells.He H, Mennone A, Boyer JL, Cai SY. Hepatology. 2011 Feb; 2010 Dec 10. PMID: 21274875.
Small-duct sclerosing cholangitis associated with Schistosoma mansoni.McCrann CH, Boyer JL. Hepatology. 2011 Feb; 2010 Sep 29. PMID: 20882579.
Psychological stress is associated with relapse in type 1 autoimmune hepatitis.Srivastava S, Boyer JL. Liver Int. 2010 Nov; 2010 Sep 16. PMID: 20849437.
Role of breast cancer resistance protein in the adaptive response to cholestasis.Mennone A, Soroka CJ, Harry KM, Boyer JL. Drug Metab Dispos. 2010 Oct; 2010 Jul 2. PMID: 20601550.
Retinoic acid represses CYP7A1 expression in human hepatocytes and HepG2 cells by FXR/RXR-dependent and independent mechanisms.Cai SY, He H, Nguyen T, Mennone A, Boyer JL. J Lipid Res. 2010 Aug; 2010 Mar 25. PMID: 20338915.
Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression.Xu S, Weerachayaphorn J, Cai SY, Soroka CJ, Boyer JL. Am J Physiol Gastrointest Liver Physiol. 2010 Jul; 2010 Apr 15. PMID: 20395535.
NHERF-1 binds to Mrp2 and regulates hepatic Mrp2 expression and function.Li M, Wang W, Soroka CJ, Mennone A, Harry K, Weinman EJ, Boyer JL. J Biol Chem. 2010 Jun 18; 2010 Apr 19. PMID: 20404332.
Organic solute transporter, OSTalpha-OSTbeta: its role in bile acid transport and cholestasis.Soroka CJ, Ballatori N, Boyer JL. Semin Liver Dis. 2010 May; 2010 Apr 26. PMID: 20422499.
The bile salt export pump: clinical and experimental aspects of genetic and acquired cholestatic liver disease.Lam P, Soroka CJ, Boyer JL. Semin Liver Dis. 2010 May; 2010 Apr 26. PMID: 20422495.
Cholestasis: genetic and acquired.Boyer JL. Semin Liver Dis. 2010 May; 2010 Apr 26. PMID: 20422493.
Mouse organic solute transporter alpha deficiency enhances renal excretion of bile acids and attenuates cholestasis.Soroka CJ, Mennone A, Hagey LR, Ballatori N, Boyer JL. Hepatology. 2010 Jan. PMID: 19902485.
Nuclear factor erythroid 2-related factor 2 is a positive regulator of human bile salt export pump expression.Weerachayaphorn J, Cai SY, Soroka CJ, Boyer JL. Hepatology. 2009 Nov. PMID: 19821532.
It's all about bile.Boyer JL. Hepatology. 2009 Mar. PMID: 19242972.
ATP8B1 deficiency disrupts the bile canalicular membrane bilayer structure in hepatocytes, but FXR expression and activity are maintained.Cai SY, Gautam S, Nguyen T, Soroka CJ, Rahner C, Boyer JL. Gastroenterology. 2009 Mar; 2008 Nov 1. PMID: 19027009.
Degradation of the bile salt export pump at endoplasmic reticulum in progressive familial intrahepatic cholestasis type II.Wang L, Dong H, Soroka CJ, Wei N, Boyer JL, Hochstrasser M. Hepatology. 2008 Nov. PMID: 18798335.
N-Glycosylation of the alpha subunit does not influence trafficking or functional activity of the human organic solute transporter alpha/beta.Soroka CJ, Xu S, Mennone A, Lam P, Boyer JL. BMC Cell Biol. 2008 Oct 10; 2008 Oct 10. PMID: 18847488.
Bile canalicular secretion - tales from Vienna and Yale.Boyer JL. Wien Med Wochenschr. 2008. PMID: 18998067.
Levels of plasma membrane expression in progressive and benign mutations of the bile salt export pump (Bsep/Abcb11) correlate with severity of cholestatic diseases.Lam P, Pearson CL, Soroka CJ, Xu S, Mennone A, Boyer JL. Am J Physiol Cell Physiol. 2007 Nov; 2007 Sep 13. PMID: 17855769.
The farnesoid X receptor FXRalpha/NR1H4 acquired ligand specificity for bile salts late in vertebrate evolution.Cai SY, Xiong L, Wray CG, Ballatori N, Boyer JL. Am J Physiol Regul Integr Comp Physiol. 2007 Sep; 2007 Jun 13. PMID: 17567710.
Nuclear receptors RXRalpha:RARalpha are repressors for human MRP3 expression.Chen W, Cai SY, Xu S, Denson LA, Soroka CJ, Boyer JL. Am J Physiol Gastrointest Liver Physiol. 2007 May; 2007 Feb 1. PMID: 17272513.
New perspectives for the treatment of cholestasis: lessons from basic science applied clinically.Boyer JL. J Hepatol. 2007 Mar; 2006 Dec 18. PMID: 17223219.
Radixin is required to maintain apical canalicular membrane structure and function in rat hepatocytes.Wang W, Soroka CJ, Mennone A, Rahner C, Harry K, Pypaert M, Boyer JL. Gastroenterology. 2006 Sep. PMID: 16952556.
FXR: a target for cholestatic syndromes?Cai SY, Boyer JL. Expert Opin Ther Targets. 2006 Jun. PMID: 16706681.
Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents.Boyer JL, Trauner M, Mennone A, Soroka CJ, Cai SY, Moustafa T, Zollner G, Lee JY, Ballatori N. Am J Physiol Gastrointest Liver Physiol. 2006 Jun; 2006 Jan 19. PMID: 16423920.
Mrp4-/- mice have an impaired cytoprotective response in obstructive cholestasis.Mennone A, Soroka CJ, Cai SY, Harry K, Adachi M, Hagey L, Schuetz JD, Boyer JL. Hepatology. 2006 May. PMID: 16628672.
A comparison of gene expression in mouse liver and kidney in obstructive cholestasis utilizing high-density oligonucleotide microarray technology.Denk GU, Cai SY, Chen WS, Lin A, Soroka CJ, Boyer JL. World J Gastroenterol. 2006 Apr 28. PMID: 16688799.
Rat hepatocyte engraftment in severe combined immunodeficient x beige mice using mouse-specific anti-fas antibody.Wilson JH, Paturzo FX, Johnson LK, Carreiro MP, Hixson DC, Mennone A, Boyer JL, Pober JS, Harding MJ. Xenotransplantation. 2006 Jan. PMID: 16497212.
Nuclear receptor ligands: rational and effective therapy for chronic cholestatic liver disease?Boyer JL. Gastroenterology. 2005 Aug. PMID: 16083726.
Liver biopsy: evolving role in the new millennium.Sheela H, Seela S, Caldwell C, Boyer JL, Jain D. J Clin Gastroenterol. 2005 Aug. PMID: 16000929.
Autoimmune hepatitis type 1: safety and efficacy of prolonged medical therapy.Seela S, Sheela H, Boyer JL. Liver Int. 2005 Aug. PMID: 15998423.

Shi-Ying Cai, DSc

Integrative multiomic analysis identifies distinct molecular subtypes of NAFLD in a Chinese population.Ding J, Liu H, Zhang X, Zhao N, Peng Y, Shi J, Chen J, Chi X, Li L, Zhang M, Liu WY, Zhang L, Ouyang J, Yuan Q, Liao M, Tan Y, Li M, Xu Z, Tang W, Xie C, Li Y, Pan Q, Xu Y, Cai SY, Byrne CD, Targher G, Ouyang X, Zhang L, Jiang Z, Zheng MH, Sun F, Chai J. Sci Transl Med. 2024 Nov 6; 2024 Nov 6. PMID: 39504356.
Hepatic GDP-fucose transporter SLC35C1 attenuates cholestatic liver injury and inflammation by inducing CEACAM1 N153 fucosylation.Zhang L, Xie P, Li M, Zhang X, Fei S, Zhao N, Li L, Xie Q, Xu Z, Tang W, Zhu G, Zhu Z, Xu Z, Li J, Zhang C, Boyer JL, Chen W, Cai SY, Pan Q, Chai J. Hepatology. 2024 Jul 10; 2024 Jul 10. PMID: 38985995.
Runt-related transcription factor-1 ameliorates bile acid-induced hepatic inflammation in cholestasis through JAK/STAT3 signaling.Zhang L, Pan Q, Zhang L, Xia H, Liao J, Zhang X, Zhao N, Xie Q, Liao M, Tan Y, Li Q, Zhu J, Li L, Fan S, Li J, Zhang C, Cai SY, Boyer JL, Chai J. Hepatology. 2023 Jun 1; 2023 Jan 3. PMID: 36647589.
Unique DUOX2(+)ACE2(+) small cholangiocytes are pathogenic targets for primary biliary cholangitis.Li X, Li Y, Xiao J, Wang H, Guo Y, Mao X, Shi P, Hou Y, Zhang X, Zhao N, Zheng M, He Y, Ding J, Tan Y, Liao M, Li L, Peng Y, Li X, Pan Q, Xie Q, Li Q, Li J, Li Y, Chen Z, Huang Y, Assis DN, Cai SY, Boyer JL, Huang X, Tang CE, Liu X, Peng S, Chai J. Nat Commun. 2023 Feb 9; 2023 Feb 9. PMID: 36759512.
Hepatic TNFRSF12A promotes bile acid-induced hepatocyte pyroptosis through NFκB/Caspase-1/GSDMD signaling in cholestasis.Liao M, Liao J, Qu J, Shi P, Cheng Y, Pan Q, Zhao N, Zhang X, Zhang L, Tan Y, Li Q, Zhu JF, Li J, Zhang C, Cai SY, Chai J. Cell Death Discov. 2023 Jan 23; 2023 Jan 23. PMID: 36690641.
Organic Anion Transporting Polypeptide (OATP) 1B3 is a Significant Transporter for Hepatic Uptake of Conjugated Bile Acids in Humans.Pan Q, Zhu G, Xu Z, Zhu J, Ouyang J, Tong Y, Zhao N, Zhang X, Cheng Y, Zhang L, Tan Y, Li J, Zhang C, Chen W, Cai SY, Boyer JL, Chai J. Cell Mol Gastroenterol Hepatol. 2023; 2023 May 3. PMID: 37146714.
SEMA7AR148W mutation promotes lipid accumulation and NAFLD progression via increased localization on the hepatocyte surface.Zhao N, Zhang X, Ding J, Pan Q, Zheng MH, Liu WY, Luo G, Qu J, Li M, Li L, Cheng Y, Peng Y, Xie Q, Wei Q, Li Q, Zou L, Ouyang X, Cai SY, Boyer JL, Chai J. JCI Insight. 2022 Aug 8; 2022 Aug 8. PMID: 35938531.
A homozygous R148W mutation in Semaphorin 7A causes progressive familial intrahepatic cholestasis.Pan Q, Luo G, Qu J, Chen S, Zhang X, Zhao N, Ding J, Yang H, Li M, Li L, Cheng Y, Li X, Xie Q, Li Q, Zhou X, Zou H, Fan S, Zou L, Liu W, Deng G, Cai SY, Boyer JL, Chai J. EMBO Mol Med. 2021 Nov 8; 2021 Sep 29. PMID: 34585848.
The role of the retinoid receptor, RAR/RXR heterodimer, in liver physiology.Li B, Cai SY, Boyer JL. Biochim Biophys Acta Mol Basis Dis. 2021 May 1; 2021 Jan 24. PMID: 33497820.
The role of bile acids in cholestatic liver injury.Cai SY, Boyer JL. Ann Transl Med. 2021 Apr. PMID: 33987435.
Hepatic NFAT signaling regulates the expression of inflammatory cytokines in cholestasis.Cai SY, Yu D, Soroka CJ, Wang J, Boyer JL. J Hepatol. 2021 Mar; 2020 Oct 9. PMID: 33039404.
A Positive Feedback Loop of TET3 and TGF-β1 Promotes Liver Fibrosis.Xu Y, Sun X, Zhang R, Cao T, Cai SY, Boyer JL, Zhang X, Li D, Huang Y. Cell Rep. 2020 Feb 4. PMID: 32023451.
Inflammasome Is Activated in the Liver of Cholestatic Patients and Aggravates Hepatic Injury in Bile Duct-Ligated Mouse.Cai SY, Ge M, Mennone A, Hoque R, Ouyang X, Boyer JL. Cell Mol Gastroenterol Hepatol. 2020; 2019 Dec 27. PMID: 31887435.
A novel ASBT inhibitor, IMB17-15, repressed nonalcoholic fatty liver disease development in high-fat diet-fed Syrian golden hamsters.Ge MX, Niu WX, Ren JF, Cai SY, Yu DK, Liu HT, Zhang N, Zhang YX, Wang YC, Shao RG, Wang JX, He HW. Acta Pharmacol Sin. 2019 Jul; 2018 Dec 20. PMID: 30573812.
Bile Infarcts: New Insights Into the Pathogenesis of Obstructive Cholestasis.Cai SY, Boyer JL. Hepatology. 2019 Feb; 2019 Jan 16. PMID: 30251326.
Solute Carrier Organic Anion Transporter Family Member 3A1 Is a Bile Acid Efflux Transporter in Cholestasis.Pan Q, Zhang X, Zhang L, Cheng Y, Zhao N, Li F, Zhou X, Chen S, Li J, Xu S, Huang D, Chen Y, Li L, Wang H, Chen W, Cai SY, Boyer JL, Chai J. Gastroenterology. 2018 Nov; 2018 Jul 29. PMID: 30063921.
Cenicriviroc, a cytokine receptor antagonist, potentiates all-trans retinoic acid in reducing liver injury in cholestatic rodents.Yu D, Cai SY, Mennone A, Vig P, Boyer JL. Liver Int. 2018 Jun; 2018 Feb 13. PMID: 29356312.
Elevated hepatic expression of H19 long noncoding RNA contributes to diabetic hyperglycemia.Zhang N, Geng T, Wang Z, Zhang R, Cao T, Camporez JP, Cai SY, Liu Y, Dandolo L, Shulman GI, Carmichael GG, Taylor HS, Huang Y. JCI Insight. 2018 May 17; 2018 May 17. PMID: 29769440.
Digoxin Suppresses Pyruvate Kinase M2-Promoted HIF-1α Transactivation in Steatohepatitis.Ouyang X, Han SN, Zhang JY, Dioletis E, Nemeth BT, Pacher P, Feng D, Bataller R, Cabezas J, Stärkel P, Caballeria J, Pongratz RL, Cai SY, Schnabl B, Hoque R, Chen Y, Yang WH, Garcia-Martinez I, Wang FS, Gao B, Torok NJ, Kibbey RG, Mehal WZ. Cell Metab. 2018 Feb 6. PMID: 29414684.
Mechanisms of bile acid mediated inflammation in the liver.Li M, Cai SY, Boyer JL. Mol Aspects Med. 2017 Aug; 2017 Jul 1. PMID: 28606651.
Na(+)-taurocholate cotransporting polypeptide (NTCP/SLC10A1) ortholog in the marine skate Leucoraja erinacea is not a physiological bile salt transporter.Yu D, Zhang H, Lionarons DA, Boyer JL, Cai SY. Am J Physiol Regul Integr Comp Physiol. 2017 Apr 1; 2017 Jan 11. PMID: 28077388.
Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response.Cai SY, Ouyang X, Chen Y, Soroka CJ, Wang J, Mennone A, Wang Y, Mehal WZ, Jain D, Boyer JL. JCI Insight. 2017 Mar 9; 2017 Mar 9. PMID: 28289714.
Combination Therapy of All-Trans Retinoic Acid With Ursodeoxycholic Acid in Patients With Primary Sclerosing Cholangitis: A Human Pilot Study.Assis DN, Abdelghany O, Cai SY, Gossard AA, Eaton JE, Keach JC, Deng Y, Setchell KD, Ciarleglio M, Lindor KD, Boyer JL. J Clin Gastroenterol. 2017 Feb. PMID: 27428727.
Studies on the mechanisms of bile acid initiated hepatic inflammation in cholestatic liver injury.Cai SY, Boyer JL. Inflamm Cell Signal. 2017; 2017 Jun 19. PMID: 28804737.
The Role of Inflammation in the Mechanisms of Bile Acid-Induced Liver Damage.Cai SY, Boyer JL. Dig Dis. 2017; 2017 Mar 1. PMID: 28249287.
Canalicular membrane MRP2/ABCC2 internalization is determined by Ezrin Thr567 phosphorylation in human obstructive cholestasis.Chai J, Cai SY, Liu X, Lian W, Chen S, Zhang L, Feng X, Cheng Y, He X, He Y, Chen L, Wang R, Wang H, Boyer JL, Chen W. J Hepatol. 2015 Dec; 2015 Jul 23. PMID: 26212029.
The anti-fibrotic effects of epigallocatechin-3-gallate in bile duct-ligated cholestatic rats and human hepatic stellate LX-2 cells are mediated by the PI3K/Akt/Smad pathway.Yu DK, Zhang CX, Zhao SS, Zhang SH, Zhang H, Cai SY, Shao RG, He HW. Acta Pharmacol Sin. 2015 Apr; 2015 Mar 16. PMID: 25832428.
Altered expression and function of canalicular transporters during early development of cholestatic liver injury in Abcb4-deficient mice.Cai SY, Mennone A, Soroka CJ, Boyer JL. Am J Physiol Gastrointest Liver Physiol. 2014 Apr 15; 2014 Jan 30. PMID: 24481602.
All-trans-retinoic acid improves cholestasis in α-naphthylisothiocyanate-treated rats and Mdr2-/- mice.Cai SY, Mennone A, Soroka CJ, Boyer JL. J Pharmacol Exp Ther. 2014 Apr; 2014 Feb 3. PMID: 24492652.
Adult sea lamprey tolerates biliary atresia by altering bile salt composition and renal excretion.Cai SY, Lionarons DA, Hagey L, Soroka CJ, Mennone A, Boyer JL. Hepatology. 2013 Jun. PMID: 23175353.
Evolution of substrate specificity for the bile salt transporter ASBT (SLC10A2).Lionarons DA, Boyer JL, Cai SY. J Lipid Res. 2012 Aug; 2012 Jun 5. PMID: 22669917.
Combination of retinoic acid and ursodeoxycholic acid attenuates liver injury in bile duct-ligated rats and human hepatic cells.He H, Mennone A, Boyer JL, Cai SY. Hepatology. 2011 Feb; 2010 Dec 10. PMID: 21274875.
Retinoic acid represses CYP7A1 expression in human hepatocytes and HepG2 cells by FXR/RXR-dependent and independent mechanisms.Cai SY, He H, Nguyen T, Mennone A, Boyer JL. J Lipid Res. 2010 Aug; 2010 Mar 25. PMID: 20338915.
Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression.Xu S, Weerachayaphorn J, Cai SY, Soroka CJ, Boyer JL. Am J Physiol Gastrointest Liver Physiol. 2010 Jul; 2010 Apr 15. PMID: 20395535.
Nuclear factor erythroid 2-related factor 2 is a positive regulator of human bile salt export pump expression.Weerachayaphorn J, Cai SY, Soroka CJ, Boyer JL. Hepatology. 2009 Nov. PMID: 19821532.
ATP8B1 deficiency disrupts the bile canalicular membrane bilayer structure in hepatocytes, but FXR expression and activity are maintained.Cai SY, Gautam S, Nguyen T, Soroka CJ, Rahner C, Boyer JL. Gastroenterology. 2009 Mar; 2008 Nov 1. PMID: 19027009.
The farnesoid X receptor FXRalpha/NR1H4 acquired ligand specificity for bile salts late in vertebrate evolution.Cai SY, Xiong L, Wray CG, Ballatori N, Boyer JL. Am J Physiol Regul Integr Comp Physiol. 2007 Sep; 2007 Jun 13. PMID: 17567710.
Nuclear receptors RXRalpha:RARalpha are repressors for human MRP3 expression.Chen W, Cai SY, Xu S, Denson LA, Soroka CJ, Boyer JL. Am J Physiol Gastrointest Liver Physiol. 2007 May; 2007 Feb 1. PMID: 17272513.
FXR: a target for cholestatic syndromes?Cai SY, Boyer JL. Expert Opin Ther Targets. 2006 Jun. PMID: 16706681.
Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents.Boyer JL, Trauner M, Mennone A, Soroka CJ, Cai SY, Moustafa T, Zollner G, Lee JY, Ballatori N. Am J Physiol Gastrointest Liver Physiol. 2006 Jun; 2006 Jan 19. PMID: 16423920.
Mrp4-/- mice have an impaired cytoprotective response in obstructive cholestasis.Mennone A, Soroka CJ, Cai SY, Harry K, Adachi M, Hagey L, Schuetz JD, Boyer JL. Hepatology. 2006 May. PMID: 16628672.
A comparison of gene expression in mouse liver and kidney in obstructive cholestasis utilizing high-density oligonucleotide microarray technology.Denk GU, Cai SY, Chen WS, Lin A, Soroka CJ, Boyer JL. World J Gastroenterol. 2006 Apr 28. PMID: 16688799.
Molecular characterization of a multidrug resistance-associated protein, Mrp2, from the little skate.Cai SY, Soroka CJ, Ballatori N, Boyer JL. Am J Physiol Regul Integr Comp Physiol. 2003 Jan; 2002 Oct 3. PMID: 12388433.
An evolutionarily ancient Oatp: insights into conserved functional domains of these proteins.Cai SY, Wang W, Soroka CJ, Ballatori N, Boyer JL. Am J Physiol Gastrointest Liver Physiol. 2002 Apr. PMID: 11897630.
Bile salt export pump is highly conserved during vertebrate evolution and its expression is inhibited by PFIC type II mutations.Cai SY, Wang L, Ballatori N, Boyer JL. Am J Physiol Gastrointest Liver Physiol. 2001 Aug. PMID: 11447010.
A primitive ATP receptor from the little skate Raja erinacea.Dranoff JA, O'Neill AF, Franco AM, Cai SY, Connolly GC, Ballatori N, Boyer JL, Nathanson MH. J Biol Chem. 2000 Sep 29. PMID: 10900200.
A mutant deubiquitinating enzyme (Ubp-M) associates with mitotic chromosomes and blocks cell division.Cai SY, Babbitt RW, Marchesi VT. Proc Natl Acad Sci U S A. 1999 Mar 16. PMID: 10077596.

Chuhan Chung, MD

A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation.Vujkovic M, Ramdas S, Lorenz KM, Guo X, Darlay R, Cordell HJ, He J, Gindin Y, Chung C, Myers RP, Schneider CV, Park J, Lee KM, Serper M, Carr RM, Kaplan DE, Haas ME, MacLean MT, Witschey WR, Zhu X, Tcheandjieu C, Kember RL, Kranzler HR, Verma A, Giri A, Klarin DM, Sun YV, Huang J, Huffman JE, Creasy KT, Hand NJ, Liu CT, Long MT, Yao J, Budoff M, Tan J, Li X, Lin HJ, Chen YI, Taylor KD, Chang RK, Krauss RM, Vilarinho S, Brancale J, Nielsen JB, Locke AE, Jones MB, Verweij N, Baras A, Reddy KR, Neuschwander-Tetri BA, Schwimmer JB, Sanyal AJ, Chalasani N, Ryan KA, Mitchell BD, Gill D, Wells AD, Manduchi E, Saiman Y, Mahmud N, Miller DR, Reaven PD, Phillips LS, Muralidhar S, DuVall SL, Lee JS, Assimes TL, Pyarajan S, Cho K, Edwards TL, Damrauer SM, Wilson PW, Gaziano JM, O'Donnell CJ, Khera AV, Grant SFA, Brown CD, Tsao PS, Saleheen D, Lotta LA, Bastarache L, Anstee QM, Daly AK, Meigs JB, Rotter JI, Lynch JA, Rader DJ, Voight BF, Chang KM. Nat Genet. 2022 Jun; 2022 Jun 2. PMID: 35654975.
An endoplasmic reticulum protein, Nogo-B, facilitates alcoholic liver disease through regulation of kupffer cell polarization.Park JK, Shao M, Kim MY, Baik SK, Cho MY, Utsumi T, Satoh A, Ouyang X, Chung C, Iwakiri Y. Hepatology. 2017 May; 2017 Mar 22. PMID: 28090670.
Pigment Epithelium-derived Factor (PEDF) Blocks Wnt3a Protein-induced Autophagy in Pancreatic Intraepithelial Neoplasms.Gong J, Belinsky G, Sagheer U, Zhang X, Grippo PJ, Chung C. J Biol Chem. 2016 Oct 14; 2016 Aug 24. PMID: 27557659.
The liver throws the skeleton a bone (resorption factor).Chung C, Insogna KL. Hepatology. 2016 Sep; 2016 Jul 25. PMID: 27312397.
Pigment epithelium-derived factor restoration increases bone mass and improves bone plasticity in a model of osteogenesis imperfecta type VI via Wnt3a blockade.Belinsky GS, Sreekumar B, Andrejecsk JW, Saltzman WM, Gong J, Herzog RI, Lin S, Horsley V, Carpenter TO, Chung C. FASEB J. 2016 Aug; 2016 Apr 28. PMID: 27127101.
Pigment epithelium-derived factor (PEDF) normalizes matrix defects in iPSCs derived from Osteogenesis imperfecta Type VI.Belinsky GS, Ward L, Chung C. Rare Dis. 2016; 2016 Jul 19. PMID: 27579219.
Targeting αv Integrins in Pancreatic Fibrosis: Progress in Resolving the Scar.Chung C, Gorelick FS. Cell Mol Gastroenterol Hepatol. 2016 Jul; 2016 May 24. PMID: 28090563.
PEDF inhibits pancreatic tumorigenesis by attenuating the fibro-inflammatory reaction.Principe DR, DeCant B, Diaz AM, Mangan RJ, Hwang R, Lowy A, Shetuni BB, Sreekumar BK, Chung C, Bentrem DJ, Munshi HG, Jung B, Grippo PJ, Bishehsari F. Oncotarget. 2016 May 10. PMID: 27058416.
Pigment Epithelium-Derived Factor (PEDF) is a Determinant of Stem Cell Fate: Lessons from an Ultra-Rare Disease.Sagheer U, Gong J, Chung C. J Dev Biol. 2015 Dec; 2015 Nov 20. PMID: 27239449.
Pigment Epithelium-Derived Factor (PEDF) Inhibits Wnt/β-catenin Signaling in the Liver.Protiva P, Gong J, Sreekumar B, Torres R, Zhang X, Belinsky GS, Cornwell M, Crawford SE, Iwakiri Y, Chung C. Cell Mol Gastroenterol Hepatol. 2015 Sep 1; 2015 Jul 4. PMID: 26473164.
Polarization of the vacuolar adenosine triphosphatase delineates a transition to high-grade pancreatic intraepithelial neoplasm lesions.Sreekumar BK, Belinsky GS, Einwachter H, Rhim AD, Schmid R, Chung C. Pancreas. 2014 Nov. PMID: 25072283.
Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling.Gattu AK, Birkenfeld AL, Iwakiri Y, Jay S, Saltzman M, Doll J, Protiva P, Samuel VT, Crawford SE, Chung C. Endocrinology. 2014 Apr; 2014 Jan 23. PMID: 24456163.
Determination of mesenchymal stem cell fate by pigment epithelium-derived factor (PEDF) results in increased adiposity and reduced bone mineral content.Gattu AK, Swenson ES, Iwakiri Y, Samuel VT, Troiano N, Berry R, Church CD, Rodeheffer MS, Carpenter TO, Chung C. FASEB J. 2013 Nov; 2013 Jul 25. PMID: 23887690.
The lymphatic vascular system in liver diseases: its role in ascites formation.Chung C, Iwakiri Y. Clin Mol Hepatol. 2013 Jun; 2013 Jun 27. PMID: 23837133.
Absence of Nogo-B (reticulon 4B) facilitates hepatic stellate cell apoptosis and diminishes hepatic fibrosis in mice.Tashiro K, Satoh A, Utsumi T, Chung C, Iwakiri Y. Am J Pathol. 2013 Mar; 2013 Jan 9. PMID: 23313137.
Activated hepatic stellate cells: negative regulators of hepatocyte proliferation in liver diseases.Chung C, Iwakiri Y. Hepatology. 2012 Jul. PMID: 22876366.
The vacuolar-ATPase modulates matrix metalloproteinase isoforms in human pancreatic cancer.Chung C, Mader CC, Schmitz JC, Atladottir J, Fitchev P, Cornwell ML, Koleske AJ, Crawford SE, Gorelick F. Lab Invest. 2011 May; 2011 Feb 21. PMID: 21339745.
Reticulon 4B (Nogo-B) is a novel regulator of hepatic fibrosis.Zhang D, Utsumi T, Huang HC, Gao L, Sangwung P, Chung C, Shibao K, Okamoto K, Yamaguchi K, Groszmann RJ, Jozsef L, Hao Z, Sessa WC, Iwakiri Y. Hepatology. 2011 Apr. PMID: 21480333.
Ethanol exposure depletes hepatic pigment epithelium-derived factor, a novel lipid regulator.Chung C, Shugrue C, Nagar A, Doll JA, Cornwell M, Gattu A, Kolodecik T, Pandol SJ, Gorelick F. Gastroenterology. 2009 Jan; 2008 Oct 7. PMID: 18996124.
Anti-angiogenic pigment epithelium-derived factor regulates hepatocyte triglyceride content through adipose triglyceride lipase (ATGL).Chung C, Doll JA, Gattu AK, Shugrue C, Cornwell M, Fitchev P, Crawford SE. J Hepatol. 2008 Mar; 2007 Dec 26. PMID: 18191271.
Pigment epithelium-derived factor is an angiogenesis and lipid regulator that activates peroxisome proliferator-activated receptor alpha.Chung C, Doll JA, Stellmach VM, Gonzales J, Surapureddi S, Cornwell M, Reddy JK, Crawford SE. Adv Exp Med Biol. 2008. PMID: 18497086.

Luca Fabris, MD, PhD

Machine learning application to histology for the study of cholangiopathies (BiliQML): A chance to put liver biopsy back to its former glory?Venturin C, Fabris L. Am J Physiol Gastrointest Liver Physiol. 2024 Dec 1; 2024 Oct 8. PMID: 39378378.
Liver-related aspects of valoctocogene roxaparvovec gene therapy for hemophilia A: expert guidance for clinical practice.La Mura V, Cardinale V, De Cristofaro R, De Santis A, Di Minno G, Fabris L, Marra F, Morisco F, Peyvandi F, Pompili M, Santoro C, Zanon E, Castaman G. Blood Adv. 2024 Nov 26. PMID: 39226466.
Procoagulant phenotype of virus-infected pericytes is associated with portal thrombosis and intrapulmonary vascular dilations in fatal COVID-19.Cadamuro M, Lasagni A, Radu CM, Calistri A, Pilan M, Valle C, Bonaffini PA, Vitiello A, Toffanin S, Venturin C, Friòn-Herrera Y, Sironi S, Alessio MG, Previtali G, Seghezzi M, Gianatti A, Strazzabosco M, Strain AJ, Campello E, Spiezia L, Palù G, Frigo AC, Tosoni A, Nebuloni M, Parolin C, Sonzogni A, Simioni P, Fabris L. J Hepatol. 2024 Nov; 2024 Jun 20. PMID: 38908437.
Comparing Survival of Perihilar Cholangiocarcinoma After R1 Resection Versus Palliative Chemotherapy for Unresected Localized Disease.van Keulen AM, Buettner S, Olthof PB, Klümpen HJ, Erdmann JI, Izquierdo-Sanchez L, Banales JM, Goeppert B, Roessler S, Zieniewicz K, Lamarca A, Valle JW, La Casta A, Hoogwater FJH, Donadon M, Scheiter A, Marzioni M, Adeva J, Kiudeliene E, Fernández JMU, Vidili G, Mocan T, Fabris L, Krawczyk M, Folseraas T, Dopazo C, Detry O, Voiosu T, Scripcariu V, Biancaniello F, Braconi C, Macias RIR, Groot Koerkamp B. Ann Surg Oncol. 2024 Oct; 2024 Jun 19. PMID: 38896226.
Comparative performance of methylation DNA markers, brushing cytology, and FISH in diagnosing malignant biliary strictures.Banales JM, Lapitz A, Fabris L. Hepatology. 2024 Aug 8; 2024 Aug 8. PMID: 39116342.
Mast cells and histamine in cholangiocarcinoma: exploring overlooked avenues for enhanced patient management.Fabris L, Pol J. Gut. 2024 Jul 11; 2024 Jul 11. PMID: 38631898.
Sex and Gender in Ageing and Longevity: Highlights From an International Course.Candore G, Accardi G, Aiello A, Baggio G, Bellini T, Calabrese V, Carreca AP, Carreca I, Masucci A, Cattaneo M, Dato S, Di Bona D, Fabris L, Gambino C, Di Lorenzo G, Franceschi C, Ligotti ME, Manfrinato MC, Puca AA, Tamburello M, Vassallo R, Caruso C. Transl Med UniSa. 2024; 2024 Feb 27. PMID: 38560614.
FXR agonists INT-787 and OCA increase RECK and inhibit liver steatosis and inflammation in diet-induced ob/ob mouse model of NASH.Di Pasqua LG, Cagna M, Palladini G, Croce AC, Cadamuro M, Fabris L, Perlini S, Adorini L, Ferrigno A, Vairetti M. Liver Int. 2024 Jan; 2023 Oct 30. PMID: 37904642.
A TGFβ-ECM-integrin signaling axis drives structural reconfiguration of the bile duct to promote polycystic liver disease.Waddell SH, Yao Y, Olaizola P, Walker A, Jarman EJ, Gournopanos K, Gradinaru A, Christodoulou E, Gautier P, Boerrigter MM, Cadamuro M, Fabris L, Drenth JP, Kendall TJ, Banales JM, Khamseh A, Mill P, Boulter L. Sci Transl Med. 2023 Sep 13; 2023 Sep 13. PMID: 37703354.
Criteria for preclinical models of cholangiocarcinoma: scientific and medical relevance.Calvisi DF, Boulter L, Vaquero J, Saborowski A, Fabris L, Rodrigues PM, Coulouarn C, Castro RE, Segatto O, Raggi C, van der Laan LJW, Carpino G, Goeppert B, Roessler S, Kendall TJ, Evert M, Gonzalez-Sanchez E, Valle JW, Vogel A, Bridgewater J, Borad MJ, Gores GJ, Roberts LR, Marin JJG, Andersen JB, Alvaro D, Forner A, Banales JM, Cardinale V, Macias RIR, Vicent S, Chen X, Braconi C, Verstegen MMA, Fouassier L. Nat Rev Gastroenterol Hepatol. 2023 Jul; 2023 Feb 8. PMID: 36755084.
Intrahepatic Cholangiocarcinoma Developing in Patients with Metabolic Syndrome Is Characterized by Osteopontin Overexpression in the Tumor Stroma.Cadamuro M, Sarcognato S, Camerotto R, Girardi N, Lasagni A, Zanus G, Cillo U, Gringeri E, Morana G, Strazzabosco M, Campello E, Simioni P, Guido M, Fabris L. Int J Mol Sci. 2023 Mar 1; 2023 Mar 1. PMID: 36902188.
The Landscape of HNF1B Deficiency: A Syndrome Not Yet Fully Explored.Gambella A, Kalantari S, Cadamuro M, Quaglia M, Delvecchio M, Fabris L, Pinon M. Cells. 2023 Jan 13; 2023 Jan 13. PMID: 36672242.
Rational development of combination therapies for biliary tract cancers.Harding JJ, Khalil DN, Fabris L, Abou-Alfa GK. J Hepatol. 2023 Jan; 2022 Sep 20. PMID: 36150578.
New case of syncytial giant-cell variant of hepatocellular carcinoma in a pediatric patient with HNF1B deficiency: does it fit with the syndrome?Pinon M, Gambella A, Giugliano L, Chiadò C, Kalantari S, Bracciamà V, Deaglio S, Tinti D, Peruzzi L, Cotti R, Catalano S, Cadamuro M, Fabris L, Calvo PL, Romagnoli R. BMJ Open Gastroenterol. 2022 Dec. PMID: 36572455.
Targeting NAE1-mediated protein hyper-NEDDylation halts cholangiocarcinogenesis and impacts on tumor-stroma crosstalk in experimental models.Olaizola P, Lee-Law PY, Fernandez-Barrena MG, Alvarez L, Cadamuro M, Azkargorta M, O'Rourke CJ, Caballero-Camino FJ, Olaizola I, Macias RIR, Marin JJG, Serrano-Maciá M, Martinez-Chantar ML, Avila MA, Aspichueta P, Calvisi DF, Evert M, Fabris L, Castro RE, Elortza F, Andersen JB, Bujanda L, Rodrigues PM, Perugorria MJ, Banales JM. J Hepatol. 2022 Jul; 2022 Feb 23. PMID: 35217064.
Translational Value of Tumor-Associated Lymphangiogenesis in Cholangiocarcinoma.Cadamuro M, Romanzi A, Guido M, Sarcognato S, Cillo U, Gringeri E, Zanus G, Strazzabosco M, Simioni P, Villa E, Fabris L. J Pers Med. 2022 Jun 30; 2022 Jun 30. PMID: 35887583.
Dysregulation of the Scribble/YAP/β-catenin axis sustains the fibroinflammatory response in a PKHD1(-/-) mouse model of congenital hepatic fibrosis.Fabris L, Milani C, Fiorotto R, Mariotti V, Kaffe E, Seller B, Sonzogni A, Strazzabosco M, Cadamuro M. FASEB J. 2022 Jun. PMID: 35593740.
Cholangiocarcinoma landscape in Europe: Diagnostic, prognostic and therapeutic insights from the ENSCCA Registry.Izquierdo-Sanchez L, Lamarca A, La Casta A, Buettner S, Utpatel K, Klümpen HJ, Adeva J, Vogel A, Lleo A, Fabris L, Ponz-Sarvise M, Brustia R, Cardinale V, Braconi C, Vidili G, Jamieson NB, Macias RI, Jonas JP, Marzioni M, Hołówko W, Folseraas T, Kupčinskas J, Sparchez Z, Krawczyk M, Krupa Ł, Scripcariu V, Grazi GL, Landa-Magdalena A, Ijzermans JN, Evert K, Erdmann JI, López-López F, Saborowski A, Scheiter A, Santos-Laso A, Carpino G, Andersen JB, Marin JJ, Alvaro D, Bujanda L, Forner A, Valle JW, Koerkamp BG, Banales JM. J Hepatol. 2022 May; 2022 Feb 12. PMID: 35167909.
The Neglected Role of Bile Duct Epithelial Cells in NASH.Cadamuro M, Lasagni A, Sarcognato S, Guido M, Fabris R, Strazzabosco M, Strain AJ, Simioni P, Villa E, Fabris L. Semin Liver Dis. 2022 Feb; 2021 Nov 18. PMID: 34794182.
Mechanisms of Pharmacoresistance in Hepatocellular Carcinoma: New Drugs but Old Problems.Marin JJG, Romero MR, Herraez E, Asensio M, Ortiz-Rivero S, Sanchez-Martin A, Fabris L, Briz O. Semin Liver Dis. 2022 Feb; 2021 Sep 20. PMID: 34544160.
Tumor microenvironment and immunology of cholangiocarcinoma.Cadamuro M, Fabris L, Zhang X, Strazzabosco M. Hepatoma Res. 2022; 2022 Mar 10. PMID: 39301518.
New insights on the role of vascular endothelial growth factor in biliary pathophysiology.Mariotti V, Fiorotto R, Cadamuro M, Fabris L, Strazzabosco M. JHEP Rep. 2021 Jun; 2021 Feb 4. PMID: 34151244.
Fibrocystic liver disease: novel concepts and translational perspectives.Lasagni A, Cadamuro M, Morana G, Fabris L, Strazzabosco M. Transl Gastroenterol Hepatol. 2021; 2021 Apr 5. PMID: 33824930.
Rare and undiagnosed liver diseases: challenges and opportunities.Fabris L, Strazzabosco M. Transl Gastroenterol Hepatol. 2021; 2021 Apr 5. PMID: 33824922.
Targeted therapies for extrahepatic cholangiocarcinoma: preclinical and clinical development and prospects for the clinic.Cadamuro M, Lasagni A, Lamarca A, Fouassier L, Guido M, Sarcognato S, Gringeri E, Cillo U, Strazzabosco M, Marin JJ, Banales JM, Fabris L. Expert Opin Investig Drugs. 2021 Apr; 2021 Feb 23. PMID: 33622120.
Illuminate TWEAK/Fn14 pathway in intrahepatic cholangiocarcinoma: Another brick in the wall of tumor niche.Fabris L, Cadamuro M, Fouassier L. J Hepatol. 2021 Apr; 2021 Feb 12. PMID: 33583626.
The Tumor Microenvironment in Cholangiocarcinoma Progression.Fabris L, Sato K, Alpini G, Strazzabosco M. Hepatology. 2021 Jan; 2020 Nov 6. PMID: 32500550.
Intrahepatic cholangiocarcinoma: A single-cell resolution unraveling the complexity of the tumor microenvironment.Fabris L, Andersen JB, Fouassier L. J Hepatol. 2020 Nov; 2020 Sep 6. PMID: 32900521.
Health related quality of life in chronic liver diseases.Cortesi PA, Conti S, Scalone L, Jaffe A, Ciaccio A, Okolicsanyi S, Rota M, Fabris L, Colledan M, Fagiuoli S, Belli LS, Cesana G, Strazzabosco M, Mantovani LG. Liver Int. 2020 Nov. PMID: 32851764.
Obeticholic acid reduces biliary and hepatic matrix metalloproteinases activity in rat hepatic ischemia/reperfusion injury.Ferrigno A, Palladini G, Di Pasqua LG, Berardo C, Richelmi P, Cadamuro M, Fabris L, Perlini S, Adorini L, Vairetti M. PLoS One. 2020; 2020 Sep 10. PMID: 32911524.
Cholangiocarcinoma 2020: the next horizon in mechanisms and management.Banales JM, Marin JJG, Lamarca A, Rodrigues PM, Khan SA, Roberts LR, Cardinale V, Carpino G, Andersen JB, Braconi C, Calvisi DF, Perugorria MJ, Fabris L, Boulter L, Macias RIR, Gaudio E, Alvaro D, Gradilone SA, Strazzabosco M, Marzioni M, Coulouarn C, Fouassier L, Raggi C, Invernizzi P, Mertens JC, Moncsek A, Ilyas SI, Heimbach J, Koerkamp BG, Bruix J, Forner A, Bridgewater J, Valle JW, Gores GJ. Nat Rev Gastroenterol Hepatol. 2020 Sep; 2020 Jun 30. PMID: 32606456.
Liver Matrix in Benign and Malignant Biliary Tract Disease.Fabris L, Cadamuro M, Cagnin S, Strazzabosco M, Gores GJ. Semin Liver Dis. 2020 Aug; 2020 Mar 11. PMID: 32162285.
HCV infection and the risk of head and neck cancer: A meta-analysis.Borsetto D, Fussey J, Fabris L, Bandolin L, Gaudioso P, Phillips V, Polesel J, Boscolo-Rizzo P. Oral Oncol. 2020 Jun 26; 2020 Jun 26. PMID: 32599500.
The Emerging Role of Macrophages in Chronic Cholangiopathies Featuring Biliary Fibrosis: An Attractive Therapeutic Target for Orphan Diseases.Cadamuro M, Girardi N, Gores GJ, Strazzabosco M, Fabris L. Front Med (Lausanne). 2020; 2020 Apr 21. PMID: 32373615.
Modulation of the Tryptophan Hydroxylase 1/Monoamine Oxidase-A/5-Hydroxytryptamine/5-Hydroxytryptamine Receptor 2A/2B/2C Axis Regulates Biliary Proliferation and Liver Fibrosis During Cholestasis.Kyritsi K, Chen L, O'Brien A, Francis H, Hein TW, Venter J, Wu N, Ceci L, Zhou T, Zawieja D, Gashev AA, Meng F, Invernizzi P, Fabris L, Wu C, Skill NJ, Saxena R, Liangpunsakul S, Alpini G, Glaser SS. Hepatology. 2020 Mar; 2019 Oct 18. PMID: 31344280.
Clinical outcome indicators in chronic hepatitis B and C: A primer for value-based medicine in hepatology.Strazzabosco M, Cortesi PA, Conti S, Okolicsanyi S, Rota M, Ciaccio A, Cozzolino P, Fornari C, Gemma M, Scalone L, Cesana G, Fabris L, Colledan M, Fagiuoli S, Ideo G, Zavaglia C, Perricone G, Munari LM, Mantovani LG, Belli LS. Liver Int. 2020 Jan; 2019 Nov 12. PMID: 31654608.
Secretin/secretin receptor signaling mediates biliary damage and liver fibrosis in early-stage primary biliary cholangitis.Kennedy L, Francis H, Invernizzi P, Venter J, Wu N, Carbone M, Gershwin ME, Bernuzzi F, Franchitto A, Alvaro D, Marzioni M, Onori P, Gaudio E, Sybenga A, Fabris L, Meng F, Glaser S, Alpini G. FASEB J. 2019 Sep; 2019 Jun 28. PMID: 31251081.
Cell Interactions in Biliary Diseases: Clues from Pathophysiology and Repair Mechanisms to Foster Early Assessment.Fabris L, Spirli C, Mertens J. Int J Mol Sci. 2019 Aug 14; 2019 Aug 14. PMID: 31416247.
Pathobiology of inherited biliary diseases: a roadmap to understand acquired liver diseases.Fabris L, Fiorotto R, Spirli C, Cadamuro M, Mariotti V, Perugorria MJ, Banales JM, Strazzabosco M. Nat Rev Gastroenterol Hepatol. 2019 Aug. PMID: 31165788.
Pinealectomy or light exposure exacerbates biliary damage and liver fibrosis in cholestatic rats through decreased melatonin synthesis.Chen L, Zhou T, Wu N, O'Brien A, Venter J, Ceci L, Kyritsi K, Onori P, Gaudio E, Sybenga A, Xie L, Wu C, Fabris L, Invernizzi P, Zawieja D, Liangpunsakul S, Meng F, Francis H, Alpini G, Huang Q, Glaser S. Biochim Biophys Acta Mol Basis Dis. 2019 Jun 1; 2019 Mar 16. PMID: 30890428.
Incretin-based treatment in type 2 diabetes mellitus and risk of cholangiocarcinoma: Is it only adverse drug effect?Barbato GM, Cadamuro M, Fabris L. Clin Res Hepatol Gastroenterol. 2019 Jun; 2019 Mar 1. PMID: 30833185.
The tumour microenvironment and immune milieu of cholangiocarcinoma.Fabris L, Perugorria MJ, Mertens J, Björkström NK, Cramer T, Lleo A, Solinas A, Sänger H, Lukacs-Kornek V, Moncsek A, Siebenhüner A, Strazzabosco M. Liver Int. 2019 May. PMID: 30907492.
Animal models of cholestasis: An update on inflammatory cholangiopathies.Mariotti V, Cadamuro M, Spirli C, Fiorotto R, Strazzabosco M, Fabris L. Biochim Biophys Acta Mol Basis Dis. 2019 May 1; 2018 Aug 11. PMID: 30398152.
Liver diseases in the dish: iPSC and organoids as a new approach to modeling liver diseases.Fiorotto R, Amenduni M, Mariotti V, Fabris L, Spirli C, Strazzabosco M. Biochim Biophys Acta Mol Basis Dis. 2019 May 1; 2018 Sep 5. PMID: 30264693.
Animal models for cystic fibrosis liver disease (CFLD).Fiorotto R, Amenduni M, Mariotti V, Cadamuro M, Fabris L, Spirli C, Strazzabosco M. Biochim Biophys Acta Mol Basis Dis. 2019 May 1; 2018 Jul 30. PMID: 30071276.
Platelet-derived growth factor-D enables liver myofibroblasts to promote tumor lymphangiogenesis in cholangiocarcinoma.Cadamuro M, Brivio S, Mertens J, Vismara M, Moncsek A, Milani C, Fingas C, Cristina Malerba M, Nardo G, Dall'Olmo L, Milani E, Mariotti V, Stecca T, Massani M, Spirli C, Fiorotto R, Indraccolo S, Strazzabosco M, Fabris L. J Hepatol. 2019 Apr; 2018 Dec 14. PMID: 30553841.
Animal models of cholangiocarcinoma: What they teach us about the human disease.Cadamuro M, Brivio S, Stecca T, Kaffe E, Mariotti V, Milani C, Fiorotto R, Spirli C, Strazzabosco M, Fabris L. Clin Res Hepatol Gastroenterol. 2018 Oct; 2018 May 9. PMID: 29753731.
Precision medicine in cholangiocarcinoma.Pellino A, Loupakis F, Cadamuro M, Dadduzio V, Fassan M, Guido M, Cillo U, Indraccolo S, Fabris L. Transl Gastroenterol Hepatol. 2018; 2018 Jul 12. PMID: 30148225.
β-Catenin and interleukin-1β-dependent chemokine (C-X-C motif) ligand 10 production drives progression of disease in a mouse model of congenital hepatic fibrosis.Kaffe E, Fiorotto R, Pellegrino F, Mariotti V, Amenduni M, Cadamuro M, Fabris L, Strazzabosco M, Spirli C. Hepatology. 2018 May; 2018 Mar 25. PMID: 29140564.
Optimising the clinical strategy for autoimmune liver diseases: Principles of value-based medicine.Carbone M, Cristoferi L, Cortesi PA, Rota M, Ciaccio A, Okolicsanyi S, Gemma M, Scalone L, Cesana G, Fabris L, Colledan M, Fagiuoli S, Ideo G, Belli LS, Munari LM, Mantovani L, Strazzabosco M. Biochim Biophys Acta Mol Basis Dis. 2018 Apr; 2017 Aug 24. PMID: 28844954.
The deleterious interplay between tumor epithelia and stroma in cholangiocarcinoma.Cadamuro M, Stecca T, Brivio S, Mariotti V, Fiorotto R, Spirli C, Strazzabosco M, Fabris L. Biochim Biophys Acta Mol Basis Dis. 2018 Apr; 2017 Jul 27. PMID: 28757170.
Pathophysiologic implications of innate immunity and autoinflammation in the biliary epithelium.Strazzabosco M, Fiorotto R, Cadamuro M, Spirli C, Mariotti V, Kaffe E, Scirpo R, Fabris L. Biochim Biophys Acta Mol Basis Dis. 2018 Apr; 2017 Jul 25. PMID: 28754453.
Animal models of biliary injury and altered bile acid metabolism.Mariotti V, Strazzabosco M, Fabris L, Calvisi DF. Biochim Biophys Acta Mol Basis Dis. 2018 Apr; 2017 Jul 11. PMID: 28709963.
Src kinase inhibition reduces inflammatory and cytoskeletal changes in ΔF508 human cholangiocytes and improves cystic fibrosis transmembrane conductance regulator correctors efficacy.Fiorotto R, Amenduni M, Mariotti V, Fabris L, Spirli C, Strazzabosco M. Hepatology. 2018 Mar; 2018 Jan 26. PMID: 28836688.
Emerging concepts in biliary repair and fibrosis.Fabris L, Spirli C, Cadamuro M, Fiorotto R, Strazzabosco M. Am J Physiol Gastrointest Liver Physiol. 2017 Aug 1; 2017 May 19. PMID: 28526690.
Adenylyl cyclase 5 links changes in calcium homeostasis to cAMP-dependent cyst growth in polycystic liver disease.Spirli C, Mariotti V, Villani A, Fabris L, Fiorotto R, Strazzabosco M. J Hepatol. 2017 Mar; 2016 Nov 5. PMID: 27826057.
Autocrine and Paracrine Mechanisms Promoting Chemoresistance in Cholangiocarcinoma.Cadamuro M, Brivio S, Spirli C, Joplin RE, Strazzabosco M, Fabris L. Int J Mol Sci. 2017 Jan 13; 2017 Jan 13. PMID: 28098760.
Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma.Cadamuro M, Spagnuolo G, Sambado L, Indraccolo S, Nardo G, Rosato A, Brivio S, Caslini C, Stecca T, Massani M, Bassi N, Novelli E, Spirli C, Fabris L, Strazzabosco M. Cancer Res. 2016 Aug 15; 2016 Jun 21. PMID: 27328733.
Macrophage recruitment by fibrocystin-defective biliary epithelial cells promotes portal fibrosis in congenital hepatic fibrosis.Locatelli L, Cadamuro M, Spirlì C, Fiorotto R, Lecchi S, Morell CM, Popov Y, Scirpo R, De Matteis M, Amenduni M, Pietrobattista A, Torre G, Schuppan D, Fabris L, Strazzabosco M. Hepatology. 2016 Mar; 2016 Jan 16. PMID: 26645994.
Revisiting Epithelial-to-Mesenchymal Transition in Liver Fibrosis: Clues for a Better Understanding of the "Reactive" Biliary Epithelial Phenotype.Fabris L, Brivio S, Cadamuro M, Strazzabosco M. Stem Cells Int. 2016; 2016 Jan 6. PMID: 26880950.
Epithelial-to-Mesenchymal Transition and Cancer Invasiveness: What Can We Learn from Cholangiocarcinoma?Brivio S, Cadamuro M, Fabris L, Strazzabosco M. J Clin Med. 2015 Dec 19; 2015 Dec 19. PMID: 26703747.
Posttranslational regulation of polycystin-2 protein expression as a novel mechanism of cholangiocyte reaction and repair from biliary damage.Spirli C, Villani A, Mariotti V, Fabris L, Fiorotto R, Strazzabosco M. Hepatology. 2015 Dec; 2015 Oct 10. PMID: 26313562.
Leukemia inhibitory factor protects cholangiocarcinoma cells from drug-induced apoptosis via a PI3K/AKT-dependent Mcl-1 activation.Morton SD, Cadamuro M, Brivio S, Vismara M, Stecca T, Massani M, Bassi N, Furlanetto A, Joplin RE, Floreani A, Fabris L, Strazzabosco M. Oncotarget. 2015 Sep 22. PMID: 26296968.
Osteopontin: a new player in regulating hepatic ductular reaction and hepatic progenitor cell responses during chronic liver injury.Strazzabosco M, Fabris L, Albano E. Gut. 2014 Nov; 2014 Jul 23. PMID: 25056656.
Neural cell adhesion molecule and polysialic acid in ductular reaction: the puzzle is far from completed, but the picture is becoming more clear.Strazzabosco M, Fabris L. Hepatology. 2014 Nov; 2014 Oct 1. PMID: 24995463.
Protein kinase A-dependent pSer(675) -β-catenin, a novel signaling defect in a mouse model of congenital hepatic fibrosis.Spirli C, Locatelli L, Morell CM, Fiorotto R, Morton SD, Cadamuro M, Fabris L, Strazzabosco M. Hepatology. 2013 Nov; 2013 Sep 30. PMID: 23744610.
Unveiling the role of tumor reactive stroma in cholangiocarcinoma: an opportunity for new therapeutic strategies.Cadamuro M, Morton SD, Strazzabosco M, Fabris L. Transl Gastrointest Cancer. 2013 Jul. PMID: 28989865.
Notch signaling regulates tubular morphogenesis during repair from biliary damage in mice.Fiorotto R, Raizner A, Morell CM, Torsello B, Scirpo R, Fabris L, Spirli C, Strazzabosco M. J Hepatol. 2013 Jul; 2013 Mar 7. PMID: 23500150.
The balance between Notch/Wnt signaling regulates progenitor cells' commitment during liver repair: mystery solved?Strazzabosco M, Fabris L. J Hepatol. 2013 Jan; 2012 Aug 15. PMID: 22902547.
Cyclic AMP/PKA-dependent paradoxical activation of Raf/MEK/ERK signaling in polycystin-2 defective mice treated with sorafenib.Spirli C, Morell CM, Locatelli L, Okolicsanyi S, Ferrero C, Kim AK, Fabris L, Fiorotto R, Strazzabosco M. Hepatology. 2012 Dec; 2012 Aug 27. PMID: 22653837.
Development of the bile ducts: essentials for the clinical hepatologist.Strazzabosco M, Fabris L. J Hepatol. 2012 May; 2012 Jan 13. PMID: 22245898.
Altered store operated calcium entry increases cyclic 3',5'-adenosine monophosphate production and extracellular signal-regulated kinases 1 and 2 phosphorylation in polycystin-2-defective cholangiocytes.Spirli C, Locatelli L, Fiorotto R, Morell CM, Fabris L, Pozzan T, Strazzabosco M. Hepatology. 2012 Mar. PMID: 21987453.
Loss of CFTR affects biliary epithelium innate immunity and causes TLR4-NF-κB-mediated inflammatory response in mice.Fiorotto R, Scirpo R, Trauner M, Fabris L, Hoque R, Spirli C, Strazzabosco M. Gastroenterology. 2011 Oct; 2011 Jun 26. PMID: 21712022.
Mammalian target of rapamycin regulates vascular endothelial growth factor-dependent liver cyst growth in polycystin-2-defective mice.Spirli C, Okolicsanyi S, Fiorotto R, Fabris L, Cadamuro M, Lecchi S, Tian X, Somlo S, Strazzabosco M. Hepatology. 2010 May. PMID: 20131403.
ERK1/2-dependent vascular endothelial growth factor signaling sustains cyst growth in polycystin-2 defective mice.Spirli C, Okolicsanyi S, Fiorotto R, Fabris L, Cadamuro M, Lecchi S, Tian X, Somlo S, Strazzabosco M. Gastroenterology. 2010 Jan; 2009 Sep 18. PMID: 19766642.
Functional anatomy of normal bile ducts.Strazzabosco M, Fabris L. Anat Rec (Hoboken). 2008 Jun. PMID: 18484611.
Ursodeoxycholic acid stimulates cholangiocyte fluid secretion in mice via CFTR-dependent ATP secretion.Fiorotto R, Spirlì C, Fabris L, Cadamuro M, Okolicsanyi L, Strazzabosco M. Gastroenterology. 2007 Nov; 2007 Sep 2. PMID: 17983806.

James J Farrell, MBChB

Risk of Pancreatitis After Endoscopic Ultrasound-Guided Fine-Needle Aspiration of Pancreatic Cystic Lesions: A Systematic Review and Meta-Analysis.Magahis PT, Chhoda A, Berzin TM, Farrell JJ, Wright DN, Rizvi A, Hanscom M, Carr-Locke DL, Sampath K, Sharaiha RZ, Mahadev S. Am J Gastroenterol. 2024 Nov 1; 2024 Jul 5. PMID: 38976379.
Pancreatic Cysts.Gonda TA, Cahen DL, Farrell JJ. N Engl J Med. 2024 Sep 5. PMID: 39231345.
Disparities in race, ethnicity, sex, and age inclusion in pancreatic cancer screening studies: a systematic review and meta-analysis.Silva-Santisteban A, Hernandez Woodbine MJ, Noriega MA, Rabinowitz LG, Grimshaw A, Farrell JJ, Chhoda A, Sawhney MS. Gastrointest Endosc. 2024 Jul; 2024 Mar 1. PMID: 38432492.
The Pancreatic Cancer Early Detection (PRECEDE) Study is a Global Effort to Drive Early Detection: Baseline Imaging Findings in High-Risk Individuals.Zogopoulos G, Haimi I, Sanoba SA, Everett JN, Wang Y, Katona BW, Farrell JJ, Grossberg AJ, Paiella S, Klute KA, Bi Y, Wallace MB, Kwon RS, Stoffel EM, Wadlow RC, Sussman DA, Merchant NB, Permuth JB, Golan T, Raitses-Gurevich M, Lowy AM, Liau J, Jeter JM, Lindberg JM, Chung DC, Earl J, Brentnall TA, Schrader KA, Kaul V, Huang C, Chandarana H, Smerdon C, Graff JJ, Kastrinos F, Kupfer SS, Lucas AL, Sears RC, Brand RE, Parmigiani G, Simeone DM. J Natl Compr Canc Netw. 2024 Apr. PMID: 38626807.
Precision Medicine for Pancreas Cancer Treatment: A Multidisciplinary Challenge or Opportunity?Farrell JJ, Robert ME, Lacy J. Clin Gastroenterol Hepatol. 2023 Oct; 2023 Jan 12. PMID: 36640803.
Surveillance of Pancreatic Cystic Neoplasms.Chhoda A, Schmidt J, Farrell JJ. Gastrointest Endosc Clin N Am. 2023 Jul; 2023 Apr 24. PMID: 37245939.
A Rare Cause of Gastrointestinal Bleeding After Pancreaticoduodenectomy.Block PD, Farrell JJ, Li DK. Gastroenterology. 2023 Jul; 2022 Dec 30. PMID: 36592728.
Racial, Ethnic, and Sex-based Disparities among High-risk Individuals Undergoing Pancreatic Cancer Surveillance.Katona BW, Klute K, Brand RE, Everett JN, Farrell JJ, Hawthorne K, Kaul V, Kupfer SS, Paiella S, Simeone DM, Sussman DA, Zogopoulos G, Lucas AL, Kastrinos F. Cancer Prev Res (Phila). 2023 Jun 1. PMID: 37259800.
Benefit of Extended Surveillance of Low-Risk Pancreatic Cysts After 5-Year Stability: A Systematic Review and Meta-Analysis.Chhoda A, Singh S, Sheth AH, Grimshaw AA, Gunderson CG, Sharma P, Kunstman JW, Sharma A, Ahuja N, Gonda TA, Farrell JJ. Clin Gastroenterol Hepatol. 2023 Jun; 2022 May 11. PMID: 35568304.
Utility of promoter hypermethylation in malignant risk stratification of intraductal papillary mucinous neoplasms.Chhoda A, Sharma A, Sailo B, Tang H, Ruzgar N, Tan WY, Ying L, Khatri R, Narayanan A, Mane S, De Kumar B, Wood LD, Iacobuzio-Donahue C, Wolfgang CL, Kunstman JW, Salem RR, Farrell JJ, Ahuja N. Clin Epigenetics. 2023 Feb 20; 2023 Feb 20. PMID: 36803844.
Reply to S. Raoof.Dbouk M, Katona BW, Brand RE, Chak A, Syngal S, Farrell JJ, Kastrinos F, Stoffel EM, Canto MI, Goggins M. J Clin Oncol. 2023 Feb 10; 2022 Oct 31. PMID: 36315911.
The Multicenter Cancer of Pancreas Screening Study: Impact on Stage and Survival.Dbouk M, Katona BW, Brand RE, Chak A, Syngal S, Farrell JJ, Kastrinos F, Stoffel EM, Blackford AL, Rustgi AK, Dudley B, Lee LS, Chhoda A, Kwon R, Ginsberg GG, Klein AP, Kamel I, Hruban RH, He J, Shin EJ, Lennon AM, Canto MI, Goggins M. J Clin Oncol. 2022 Oct 1; 2022 Jun 15. PMID: 35704792.
International external validation of a stratification tool to identify branch-duct intraductal papillary mucinous neoplasms at lowest risk of progression.Overbeek KA, van Leeuwen N, Tacelli M, Anwar MS, Yousaf MN, Chhoda A, Arcidiacono PG, Gonda TA, Wallace MB, Capurso G, Farrell JJ, Cahen DL, Bruno MJ. United European Gastroenterol J. 2022 Mar; 2022 Feb 24. PMID: 35199484.
Late-Stage Pancreatic Cancer Detected During High-Risk Individual Surveillance: A Systematic Review and Meta-Analysis.Chhoda A, Vodusek Z, Wattamwar K, Mukherjee E, Gunderson C, Grimshaw A, Sharma A, Ahuja N, Kastrinos F, Farrell JJ. Gastroenterology. 2022 Mar; 2021 Nov 20. PMID: 34813861.
Comorbidities Drive the Majority of Overall Mortality in Low-Risk Mucinous Pancreatic Cysts Under Surveillance.Chhoda A, Yousaf MN, Madhani K, Aslanian H, Jamidar PA, Suarez AL, Salem RR, Muniraj T, Kunstman JW, Farrell JJ. Clin Gastroenterol Hepatol. 2022 Mar; 2020 Dec 10. PMID: 33309984.
Methylation-based Cell-free DNA Signature for Early Detection of Pancreatic Cancer.Ying L, Sharma A, Chhoda A, Ruzgar N, Hasan N, Kwak R, Wolfgang CL, Wang TH, Kunstman JW, Salem RR, Wood LD, Iacobuzio-Donahue C, Schneider EB, Farrell JJ, Ahuja N. Pancreas. 2021 Oct 1. PMID: 34860810.
Screening for Pancreatic Ductal Adenocarcinoma: Are We Asking the Impossible?-Letter.Katona BW, Brand RE, Canto MI, Chak A, Farrell JJ, Kastrinos F, Rustgi AK, Stoffel EM, Syngal S, Goggins M. Cancer Prev Res (Phila). 2021 Oct. PMID: 34607877.
COVID-19 related pancreatic cancer surveillance disruptions amongst high-risk individuals.Katona BW, Mahmud N, Dbouk M, Ahmad N, Chhoda A, Dudley B, Hayat U, Kwon RS, Lee LS, Rustgi AK, Ukaegbu C, Vasquez L, Volk S, Brand RE, Canto MI, Chak A, Farrell JJ, Kastrinos F, Stoffel EM, Syngal S, Goggins M. Pancreatology. 2021 Apr 20; 2021 Apr 20. PMID: 33926820.
Gastrointestinal mucosal damage in patients with COVID-19 undergoing endoscopy: an international multicentre study.Vanella G, Capurso G, Burti C, Fanti L, Ricciardiello L, Souza Lino A, Boskoski I, Bronswijk M, Tyberg A, Krishna Kumar Nair G, Angeletti S, Mauro A, Zingone F, Oppong KW, de la Iglesia-Garcia D, Pouillon L, Papanikolaou IS, Fracasso P, Ciceri F, Rovere-Querini P, Tomba C, Viale E, Eusebi LH, Riccioni ME, van der Merwe S, Shahid H, Sarkar A, Yoo JWG, Dilaghi E, Speight RA, Azzolini F, Buttitta F, Porcari S, Petrone MC, Iglesias-Garcia J, Savarino EV, Di Sabatino A, Di Giulio E, Farrell JJ, Kahaleh M, Roelandt P, Costamagna G, Artifon ELA, Bazzoli F, Testoni PA, Greco S, Arcidiacono PG. BMJ Open Gastroenterol. 2021 Feb. PMID: 33627313.
Relationship between papilla-related variables and post endoscopic retrograde cholangiopancreatography pancreatitis: A multicenter, prospective study.Wang X, Zhao J, Wang L, Ning B, Zeng W, Tao Q, Ren G, Liang S, Luo H, Wang B, Farrell JJ, Pan Y, Guo X, Wu K. J Gastroenterol Hepatol. 2020 Dec; 2020 Jun 29. PMID: 32511794.
Learning curve of double-guidewire technique by trainees during hands-on endoscopic retrograde cholangiopancreatography training.Wang X, Ren G, Xi Y, Luo H, Liang S, Wang B, Tao Q, Luo B, Qin Q, Farrell JJ, Guo X, Wu K, Pan Y. J Gastroenterol Hepatol. 2020 Dec; 2020 Jun 23. PMID: 32473040.
Reviews on Current Liquid Biopsy for Detection and Management of Pancreatic Cancers.Kaczor-Urbanowicz KE, Cheng J, King JC, Sedarat A, Pandol SJ, Farrell JJ, Wong DTW, Kim Y. Pancreas. 2020 Oct. PMID: 33003085.
Endoscopic ultrasound-guided fine needle aspiration of accessory spleen: Cytomorphologic features and diagnostic considerations.Gilani SM, Muniraj T, Farrell JJ, Aslanian HR, Cai G. Diagn Cytopathol. 2020 Jul; 2020 Apr 21. PMID: 32315514.
Endoscopic ultrasound (EUS) and the management of pancreatic cancer.Yousaf MN, Chaudhary FS, Ehsan A, Suarez AL, Muniraj T, Jamidar P, Aslanian HR, Farrell JJ. BMJ Open Gastroenterol. 2020 May. PMID: 32414753.
Does Pancreatic Cyst Stability Justify Stopping Intraductal Papillary Mucinous Neoplasm Surveillance?Farrell JJ. Gastroenterology. 2020 Jan; 2019 Nov 15. PMID: 31738923.
Novel Methylated DNA Markers Discriminate Advanced Neoplasia in Pancreatic Cysts: Marker Discovery, Tissue Validation, and Cyst Fluid Testing.Majumder S, Taylor WR, Yab TC, Berger CK, Dukek BA, Cao X, Foote PH, Wu CW, Mahoney DW, Aslanian HR, Fernández-Del Castillo C, Doyle LA, Farrell JJ, Fisher WE, Lee LS, Lee YN, Park W, Rodrigues C, Gould Rothberg BE, Salem RR, Simeone DM, Urs S, Van Buren G, Smyrk TC, Allawi HT, Lidgard GP, Raimondo M, Chari ST, Kendrick ML, Kisiel JB, Topazian MD, Ahlquist DA. Am J Gastroenterol. 2019 Sep. PMID: 31306149.
Overview and comparison of guidelines for management of pancreatic cystic neoplasms.Hasan A, Visrodia K, Farrell JJ, Gonda TA. World J Gastroenterol. 2019 Aug 21. PMID: 31496620.
Incidence of pancreatitis with the use of immune checkpoint inhibitors (ICI) in advanced cancers: A systematic review and meta-analysis.George J, Bajaj D, Sankaramangalam K, Yoo JW, Joshi NS, Gettinger S, Price C, Farrell JJ. Pancreatology. 2019 Jun; 2019 May 2. PMID: 31076344.
Pancreatic Cancer Prediction Through an Artificial Neural Network.Muhammad W, Hart GR, Nartowt B, Farrell JJ, Johung K, Liang Y, Deng J. Front Artif Intell. 2019; 2019 May 3. PMID: 33733091.
Impact of endoscopic ultrasound on diagnosis and management of presumed mucinous neoplasms when done for pancreatic cyst morphology change on non-invasive surveillance imaging.Madhani K, Yousaf M, Aamar A, Ooka K, Muniraj T, Aslanian H, Salem R, Farrell JJ. Endosc Int Open. 2019 Apr; 2019 Mar 15. PMID: 30931368.
Incremental value of DNA analysis in pancreatic cysts stratified by clinical risk factors.Farrell JJ, Al-Haddad MA, Jackson SA, Gonda TA. Gastrointest Endosc. 2019 Apr; 2018 Nov 14. PMID: 30447214.
Current Approaches to Pancreatic Cancer Screening.Chhoda A, Lu L, Clerkin BM, Risch H, Farrell JJ. Am J Pathol. 2019 Jan. PMID: 30558719.
Management of Autoimmune Pancreatitis.Madhani K, Farrell JJ. Gastrointest Endosc Clin N Am. 2018 Oct; 2018 Aug 1. PMID: 30241640.
Intraductal papillary mucinous neoplasm to pancreas ductal adenocarcinoma sequence and pancreas cancer screening.Farrell JJ. Endosc Ultrasound. 2018 Sep-Oct. PMID: 30323160.
A variant Sp1 (R218Q) transcription factor might enhance HbF expression in β(0) -thalassaemia homozygotes.Jiang Z, Luo HY, Farrell JJ, Zhang Z, Schulz VP, Albarawi D, Steinberg MH, Al-Allawi NAS, Gallagher PG, Forget BG, Chui DHK. Br J Haematol. 2018 Mar; 2017 Feb 27. PMID: 28240767.
Cryoablation of a duodenal adenoma with intramucosal carcinoma.Ooka K, Celli R, Farrell JJ. VideoGIE. 2017 Sep; 2017 May 20. PMID: 29905297.
Comparison of the diagnostic accuracy of three current guidelines for the evaluation of asymptomatic pancreatic cystic neoplasms.Xu MM, Yin S, Siddiqui AA, Salem RR, Schrope B, Sethi A, Poneros JM, Gress FG, Genkinger JM, Do C, Brooks CA, Chabot JA, Kluger MD, Kowalski T, Loren DE, Aslanian H, Farrell JJ, Gonda TA. Medicine (Baltimore). 2017 Sep. PMID: 28858107.
Surveillance and Outcomes of Nonresected Presumed Branch-Duct Intraductal Papillary Mucinous Neoplasms: A Meta-analysis.Ooka K, Rustagi T, Evans A, Farrell JJ. Pancreas. 2017 Aug. PMID: 28697134.
Editorial: Stopping Pancreatic Cyst Surveillance?Farrell JJ. Am J Gastroenterol. 2017 Jul. PMID: 28725064.
Pancreatic Cysts and Guidelines.Farrell JJ. Dig Dis Sci. 2017 Jul; 2017 May 20. PMID: 28528374.
Response to Del Chiaro et al.Farrell JJ. Am J Gastroenterol. 2017 May. PMID: 28469214.
Precision Medicine and Pancreatic Cancer: A Gemcitabine Pathway Approach.Farrell JJ, Moughan J, Wong JL, Regine WF, Schaefer P, Benson AB 3rd, Macdonald JS, Liu X, Yen Y, Lai R, Zheng Z, Bepler G, Guha C, Elsaleh H. Pancreas. 2016 Nov. PMID: 27748721.
Poking the Pancreas: When to Needle that Incidental Cyst.Farrell JJ. Am J Gastroenterol. 2016 Oct; 2016 Sep 13. PMID: 27619834.
Autoimmune Pancreatitis: An Update on Diagnosis and Management.Madhani K, Farrell JJ. Gastroenterol Clin North Am. 2016 Mar. PMID: 26895679.
The genetic basis of asymptomatic codon 8 frame-shift (HBB:c25_26delAA) β(0) -thalassaemia homozygotes.Jiang Z, Luo HY, Huang S, Farrell JJ, Davis L, Théberge R, Benson KA, Riolueang S, Viprakasit V, Al-Allawi NA, Ünal S, Gümrük F, Akar N, Başak AN, Osorio L, Badens C, Pissard S, Joly P, Campbell AD, Gallagher PG, Steinberg MH, Forget BG, Chui DH. Br J Haematol. 2016 Mar; 2016 Jan 13. PMID: 26771086.
Linear-array EUS improves detection of pancreatic lesions in high-risk individuals: a randomized tandem study.Shin EJ, Topazian M, Goggins MG, Syngal S, Saltzman JR, Lee JH, Farrell JJ, Canto MI. Gastrointest Endosc. 2015 Nov; 2015 Apr 27. PMID: 25930097.
Prevalence, Diagnosis and Management of Pancreatic Cystic Neoplasms: Current Status and Future Directions.Farrell JJ. Gut Liver. 2015 Sep 23. PMID: 26343068.
Endoscopic diagnosis and treatment of pancreatic neuroendocrine tumors.Rustagi T, Farrell JJ. J Clin Gastroenterol. 2014 Nov-Dec. PMID: 24828360.
Endoscopically acquired pancreatic cyst fluid microRNA 21 and 221 are associated with invasive cancer.Farrell JJ, Toste P, Wu N, Li L, Wong J, Malkhassian D, Tran LM, Wu X, Li X, Dawson D, Wu H, Donahue TR. Am J Gastroenterol. 2013 Aug; 2013 Jun 11. PMID: 23752880.
Pancreatic cystic neoplasms: management and unanswered questions.Farrell JJ, Fernández-del Castillo C. Gastroenterology. 2013 Jun. PMID: 23622140.

Romina Fiorotto, PhD

Prominent role of gut dysbiosis in the pathogenesis of cystic fibrosis-related liver disease in mice.Bertolini A, Nguyen M, Zehra SA, Taleb SA, Bauer-Pisani T, Palm N, Strazzabosco M, Fiorotto R. J Hepatol. 2024 Sep; 2024 Mar 28. PMID: 38554847.
Fibroblasts to hepatocytes: A nonstop flight into cell therapy for liver diseases?Gouon-Evans V, Fiorotto R. Hepatology. 2023 May 1; 2023 Apr 17. PMID: 35957526.
Cell-matrix interactions control biliary organoid polarity, architecture, and differentiation.Fiorotto R, Mariotti V, Taleb SA, Zehra SA, Nguyen M, Amenduni M, Strazzabosco M. Hepatol Commun. 2023 Apr 1; 2023 Mar 24. PMID: 36972396.
Molecular determinants of peri-apical targeting of inositol 1,4,5-trisphosphate receptor type 3 in cholangiocytes.Rodrigues MA, Gomes DA, Fiorotto R, Guerra MT, Weerachayaphorn J, Bo T, Sessa WC, Strazzabosco M, Nathanson MH. Hepatol Commun. 2022 Oct; 2022 Jul 19. PMID: 35852334.
Bile acids and their receptors: modulators and therapeutic targets in liver inflammation.Bertolini A, Fiorotto R, Strazzabosco M. Semin Immunopathol. 2022 Jul; 2022 Apr 12. PMID: 35415765.
Dysregulation of the Scribble/YAP/β-catenin axis sustains the fibroinflammatory response in a PKHD1(-/-) mouse model of congenital hepatic fibrosis.Fabris L, Milani C, Fiorotto R, Mariotti V, Kaffe E, Seller B, Sonzogni A, Strazzabosco M, Cadamuro M. FASEB J. 2022 Jun. PMID: 35593740.
New insights on the role of vascular endothelial growth factor in biliary pathophysiology.Mariotti V, Fiorotto R, Cadamuro M, Fabris L, Strazzabosco M. JHEP Rep. 2021 Jun; 2021 Feb 4. PMID: 34151244.
Novel approaches to liver disease diagnosis and modeling.Oliveira AG, Fiorotto R. Transl Gastroenterol Hepatol. 2021; 2021 Apr 5. PMID: 33824923.
IL-17A/F enable cholangiocytes to restrict T cell-driven experimental cholangitis by upregulating PD-L1 expression.Stein S, Henze L, Poch T, Carambia A, Krech T, Preti M, Schuran FA, Reich M, Keitel V, Fiorotto R, Strazzabosco M, Fischer L, Li J, Müller LM, Wagner J, Gagliani N, Herkel J, Schwinge D, Schramm C. J Hepatol. 2021 Apr; 2020 Nov 13. PMID: 33197512.
Abnormal Liver Function Tests in Patients With COVID-19: Relevance and Potential Pathogenesis.Bertolini A, van de Peppel IP, Bodewes FAJA, Moshage H, Fantin A, Farinati F, Fiorotto R, Jonker JW, Strazzabosco M, Verkade HJ, Peserico G. Hepatology. 2020 Nov; 2020 Oct 20. PMID: 32702162.
Recent Advances in Practical Methods for Liver Cell Biology: A Short Overview.Torres S, Abdullah Z, Brol MJ, Hellerbrand C, Fernandez M, Fiorotto R, Klein S, Königshofer P, Liedtke C, Lotersztajn S, Nevzorova YA, Schierwagen R, Reiberger T, Uschner FE, Tacke F, Weiskirchen R, Trebicka J. Int J Mol Sci. 2020 Mar 16; 2020 Mar 16. PMID: 32188134.
Pathobiology of inherited biliary diseases: a roadmap to understand acquired liver diseases.Fabris L, Fiorotto R, Spirli C, Cadamuro M, Mariotti V, Perugorria MJ, Banales JM, Strazzabosco M. Nat Rev Gastroenterol Hepatol. 2019 Aug. PMID: 31165788.
Animal models of cholestasis: An update on inflammatory cholangiopathies.Mariotti V, Cadamuro M, Spirli C, Fiorotto R, Strazzabosco M, Fabris L. Biochim Biophys Acta Mol Basis Dis. 2019 May 1; 2018 Aug 11. PMID: 30398152.
Liver diseases in the dish: iPSC and organoids as a new approach to modeling liver diseases.Fiorotto R, Amenduni M, Mariotti V, Fabris L, Spirli C, Strazzabosco M. Biochim Biophys Acta Mol Basis Dis. 2019 May 1; 2018 Sep 5. PMID: 30264693.
Animal models for cystic fibrosis liver disease (CFLD).Fiorotto R, Amenduni M, Mariotti V, Cadamuro M, Fabris L, Spirli C, Strazzabosco M. Biochim Biophys Acta Mol Basis Dis. 2019 May 1; 2018 Jul 30. PMID: 30071276.
Platelet-derived growth factor-D enables liver myofibroblasts to promote tumor lymphangiogenesis in cholangiocarcinoma.Cadamuro M, Brivio S, Mertens J, Vismara M, Moncsek A, Milani C, Fingas C, Cristina Malerba M, Nardo G, Dall'Olmo L, Milani E, Mariotti V, Stecca T, Massani M, Spirli C, Fiorotto R, Indraccolo S, Strazzabosco M, Fabris L. J Hepatol. 2019 Apr; 2018 Dec 14. PMID: 30553841.
Pathophysiology of Cystic Fibrosis Liver Disease: A Channelopathy Leading to Alterations in Innate Immunity and in Microbiota.Fiorotto R, Strazzabosco M. Cell Mol Gastroenterol Hepatol. 2019; 2019 May 7. PMID: 31075352.
Animal models of cholangiocarcinoma: What they teach us about the human disease.Cadamuro M, Brivio S, Stecca T, Kaffe E, Mariotti V, Milani C, Fiorotto R, Spirli C, Strazzabosco M, Fabris L. Clin Res Hepatol Gastroenterol. 2018 Oct; 2018 May 9. PMID: 29753731.
β-Catenin and interleukin-1β-dependent chemokine (C-X-C motif) ligand 10 production drives progression of disease in a mouse model of congenital hepatic fibrosis.Kaffe E, Fiorotto R, Pellegrino F, Mariotti V, Amenduni M, Cadamuro M, Fabris L, Strazzabosco M, Spirli C. Hepatology. 2018 May; 2018 Mar 25. PMID: 29140564.
The deleterious interplay between tumor epithelia and stroma in cholangiocarcinoma.Cadamuro M, Stecca T, Brivio S, Mariotti V, Fiorotto R, Spirli C, Strazzabosco M, Fabris L. Biochim Biophys Acta Mol Basis Dis. 2018 Apr; 2017 Jul 27. PMID: 28757170.
Pathophysiologic implications of innate immunity and autoinflammation in the biliary epithelium.Strazzabosco M, Fiorotto R, Cadamuro M, Spirli C, Mariotti V, Kaffe E, Scirpo R, Fabris L. Biochim Biophys Acta Mol Basis Dis. 2018 Apr; 2017 Jul 25. PMID: 28754453.
Src kinase inhibition reduces inflammatory and cytoskeletal changes in ΔF508 human cholangiocytes and improves cystic fibrosis transmembrane conductance regulator correctors efficacy.Fiorotto R, Amenduni M, Mariotti V, Fabris L, Spirli C, Strazzabosco M. Hepatology. 2018 Mar; 2018 Jan 26. PMID: 28836688.
Notch signaling and progenitor/ductular reaction in steatohepatitis.Morell CM, Fiorotto R, Meroni M, Raizner A, Torsello B, Cadamuro M, Spagnuolo G, Kaffe E, Sutti S, Albano E, Strazzabosco M. PLoS One. 2017; 2017 Nov 15. PMID: 29140985.
Emerging concepts in biliary repair and fibrosis.Fabris L, Spirli C, Cadamuro M, Fiorotto R, Strazzabosco M. Am J Physiol Gastrointest Liver Physiol. 2017 Aug 1; 2017 May 19. PMID: 28526690.
Adenylyl cyclase 5 links changes in calcium homeostasis to cAMP-dependent cyst growth in polycystic liver disease.Spirli C, Mariotti V, Villani A, Fabris L, Fiorotto R, Strazzabosco M. J Hepatol. 2017 Mar; 2016 Nov 5. PMID: 27826057.
The cystic fibrosis transmembrane conductance regulator controls biliary epithelial inflammation and permeability by regulating Src tyrosine kinase activity.Fiorotto R, Villani A, Kourtidis A, Scirpo R, Amenduni M, Geibel PJ, Cadamuro M, Spirli C, Anastasiadis PZ, Strazzabosco M. Hepatology. 2016 Dec; 2016 Oct 27. PMID: 27629435.
Cystic Fibrosis-Related Liver Diseases: New Paradigm for Treatment Based on Pathophysiology.Fiorotto R, Strazzabosco M. Clin Liver Dis (Hoboken). 2016 Nov; 2016 Nov 30. PMID: 31041076.
Macrophage recruitment by fibrocystin-defective biliary epithelial cells promotes portal fibrosis in congenital hepatic fibrosis.Locatelli L, Cadamuro M, Spirlì C, Fiorotto R, Lecchi S, Morell CM, Popov Y, Scirpo R, De Matteis M, Amenduni M, Pietrobattista A, Torre G, Schuppan D, Fabris L, Strazzabosco M. Hepatology. 2016 Mar; 2016 Jan 16. PMID: 26645994.
Posttranslational regulation of polycystin-2 protein expression as a novel mechanism of cholangiocyte reaction and repair from biliary damage.Spirli C, Villani A, Mariotti V, Fabris L, Fiorotto R, Strazzabosco M. Hepatology. 2015 Dec; 2015 Oct 10. PMID: 26313562.
Stimulation of nuclear receptor peroxisome proliferator-activated receptor-γ limits NF-κB-dependent inflammation in mouse cystic fibrosis biliary epithelium.Scirpo R, Fiorotto R, Villani A, Amenduni M, Spirli C, Strazzabosco M. Hepatology. 2015 Nov; 2015 Aug 28. PMID: 26199136.
Protein kinase A-dependent pSer(675) -β-catenin, a novel signaling defect in a mouse model of congenital hepatic fibrosis.Spirli C, Locatelli L, Morell CM, Fiorotto R, Morton SD, Cadamuro M, Fabris L, Strazzabosco M. Hepatology. 2013 Nov; 2013 Sep 30. PMID: 23744610.
Notch signaling regulates tubular morphogenesis during repair from biliary damage in mice.Fiorotto R, Raizner A, Morell CM, Torsello B, Scirpo R, Fabris L, Spirli C, Strazzabosco M. J Hepatol. 2013 Jul; 2013 Mar 7. PMID: 23500150.
Cyclic AMP/PKA-dependent paradoxical activation of Raf/MEK/ERK signaling in polycystin-2 defective mice treated with sorafenib.Spirli C, Morell CM, Locatelli L, Okolicsanyi S, Ferrero C, Kim AK, Fabris L, Fiorotto R, Strazzabosco M. Hepatology. 2012 Dec; 2012 Aug 27. PMID: 22653837.
Altered store operated calcium entry increases cyclic 3',5'-adenosine monophosphate production and extracellular signal-regulated kinases 1 and 2 phosphorylation in polycystin-2-defective cholangiocytes.Spirli C, Locatelli L, Fiorotto R, Morell CM, Fabris L, Pozzan T, Strazzabosco M. Hepatology. 2012 Mar. PMID: 21987453.
Loss of CFTR affects biliary epithelium innate immunity and causes TLR4-NF-κB-mediated inflammatory response in mice.Fiorotto R, Scirpo R, Trauner M, Fabris L, Hoque R, Spirli C, Strazzabosco M. Gastroenterology. 2011 Oct; 2011 Jun 26. PMID: 21712022.
Mammalian target of rapamycin regulates vascular endothelial growth factor-dependent liver cyst growth in polycystin-2-defective mice.Spirli C, Okolicsanyi S, Fiorotto R, Fabris L, Cadamuro M, Lecchi S, Tian X, Somlo S, Strazzabosco M. Hepatology. 2010 May. PMID: 20131403.
ERK1/2-dependent vascular endothelial growth factor signaling sustains cyst growth in polycystin-2 defective mice.Spirli C, Okolicsanyi S, Fiorotto R, Fabris L, Cadamuro M, Lecchi S, Tian X, Somlo S, Strazzabosco M. Gastroenterology. 2010 Jan; 2009 Sep 18. PMID: 19766642.
Differentially expressed adenylyl cyclase isoforms mediate secretory functions in cholangiocyte subpopulation.Strazzabosco M, Fiorotto R, Melero S, Glaser S, Francis H, Spirli C, Alpini G. Hepatology. 2009 Jul. PMID: 19444869.
Ursodeoxycholic acid stimulates cholangiocyte fluid secretion in mice via CFTR-dependent ATP secretion.Fiorotto R, Spirlì C, Fabris L, Cadamuro M, Okolicsanyi L, Strazzabosco M. Gastroenterology. 2007 Nov; 2007 Sep 2. PMID: 17983806.

Guadalupe Garcia-Tsao, MD

Comparative effectiveness of different corticosteroid regimens in severe alcohol-associated hepatitis.Islam AH, Díaz LA, Idalsoaga F, Guizzetti L, Mortuza R, Dunn W, Singal AK, Simonetto D, Ramirez-Cadiz C, Zhang W, Qian S, Cabezas J, Sarin SK, Maiwall R, Jalal PK, Higuera-De La Tijera F, Skladany L, Bystrianska N, Rincon D, Chacko KR, Ventura Cots M, Garcia-Tsao G, Abraldes JG, Kamath PS, Arrese M, Shah V, Bataller R, Arab JP. Hepatol Commun. 2024 Nov 1; 2024 Oct 24. PMID: 39445912.
An artificial intelligence-generated model predicts 90-day survival in alcohol-associated hepatitis: A global cohort study.Dunn W, Li Y, Singal AK, Simonetto DA, Díaz LA, Idalsoaga F, Ayares G, Arnold J, Ayala-Valverde M, Perez D, Gomez J, Escarate R, Fuentes-López E, Ramirez-Cadiz C, Morales-Arraez D, Zhang W, Qian S, Ahn JC, Buryska S, Mehta H, Dunn N, Waleed M, Stefanescu H, Bumbu A, Horhat A, Attar B, Agrawal R, Cabezas J, Echavaría V, Cuyàs B, Poca M, Soriano G, Sarin SK, Maiwall R, Jalal PK, Higuera-de-la-Tijera F, Kulkarni AV, Rao PN, Guerra-Salazar P, Skladaný L, Kubánek N, Prado V, Clemente-Sanchez A, Rincon D, Haider T, Chacko KR, Romero GA, Pollarsky FD, Restrepo JC, Toro LG, Yaquich P, Mendizabal M, Garrido ML, Marciano S, Dirchwolf M, Vargas V, Jiménez C, Hudson D, García-Tsao G, Ortiz G, Abraldes JG, Kamath PS, Arrese M, Shah VH, Bataller R, Arab JP. Hepatology. 2024 Nov 1; 2024 Apr 12. PMID: 38607809.
Viral antibody response predicts morbidity and mortality in alcohol-associated hepatitis.Hsu CL, Wang L, Maestri E, Jacob AR, Do WL, Mayo S, Bosques-Padilla F, Verna EC, Abraldes JG, Brown RS Jr, Vargas V, Altamirano J, Caballería J, Shawcross DL, Louvet A, Lucey MR, Mathurin P, Garcia-Tsao G, Stärkel P, Bataller R, Investigators A, Wang XW, Schnabl B. Hepatology. 2024 Sep 25; 2024 Sep 25. PMID: 39325984.
Relationship between updated MELD and prognosis in alcohol-associated hepatitis: Opportunities for more efficient trial design.Al-Karaghouli M, Ventura-Cots M, Wong YJ, Genesca J, Bosques F, Brown RS Jr, Mathurin P, Louvet A, Shawcross D, Vargas V, Verna EC, Schnabl B, Caballeria J, Shah VJ, Kamath PS, Lucey MR, Garcia-Tsao G, Bataller R, Abraldes JG. Hepatol Commun. 2024 Aug 1; 2024 Jul 31. PMID: 39082963.
Reply: On the use of nonselective beta blockers in cirrhosis.Garcia-Tsao G, Kaplan DE. Hepatology. 2024 Aug 1; 2024 Apr 16. PMID: 38626347.
Reply: Endoscopy for potential variceal bleeding within 12 hours-Not so fast!Garcia-Tsao G, Kaplan DE. Hepatology. 2024 Aug 1; 2024 Apr 12. PMID: 38607742.
Serum aryl hydrocarbon receptor activity is associated with survival in patients with alcohol-associated hepatitis.Yamazaki T, Kouno T, Hsu CL, Hartmann P, Mayo S, Zhang X, Stärkel P, Bosques-Padilla F, Verna EC, Abraldes JG, Brown RS Jr, Vargas V, Altamirano J, Caballería J, Shawcross DL, Louvet A, Lucey MR, Mathurin P, Garcia-Tsao G, Bataller R, Schnabl B. Hepatology. 2024 Aug 1; 2024 Feb 20. PMID: 38377466.
Faecal proteomics links neutrophil degranulation with mortality in patients with alcohol-associated hepatitis.Kreimeyer H, Gonzalez CG, Fondevila MF, Hsu CL, Hartmann P, Zhang X, Stärkel P, Bosques-Padilla F, Verna EC, Abraldes JG, Brown RS Jr, Vargas V, Altamirano J, Caballería J, Shawcross DL, Louvet A, Lucey MR, Mathurin P, Garcia-Tsao G, Bataller R, Investigators A, Gonzalez DJ, Schnabl B. Gut. 2024 Jul 20; 2024 Jul 20. PMID: 39033024.
Acute kidney injury in patients with cirrhosis: Acute Disease Quality Initiative (ADQI) and International Club of Ascites (ICA) joint multidisciplinary consensus meeting.Nadim MK, Kellum JA, Forni L, Francoz C, Asrani SK, Ostermann M, Allegretti AS, Neyra JA, Olson JC, Piano S, VanWagner LB, Verna EC, Akcan-Arikan A, Angeli P, Belcher JM, Biggins SW, Deep A, Garcia-Tsao G, Genyk YS, Gines P, Kamath PS, Kane-Gill SL, Kaushik M, Lumlertgul N, Macedo E, Maiwall R, Marciano S, Pichler RH, Ronco C, Tandon P, Velez JQ, Mehta RL, Durand F. J Hepatol. 2024 Jul; 2024 Mar 26. PMID: 38527522.
Management of acute variceal bleeding.Mohanty A, Garcia-Tsao G. Clin Liver Dis (Hoboken). 2024 Jan-Jun; 2024 Jun 28. PMID: 38952694.
AASLD Practice Guidance on risk stratification and management of portal hypertension and varices in cirrhosis.Kaplan DE, Ripoll C, Thiele M, Fortune BE, Simonetto DA, Garcia-Tsao G, Bosch J. Hepatology. 2024 May 1; 2023 Oct 23. PMID: 37870298.
Further decompensation in cirrhosis: Results of a large multicenter cohort study supporting Baveno VII statements.D'Amico G, Zipprich A, Villanueva C, Sordà JA, Morillas RM, Garcovich M, García Retortillo M, Martinez J, Calès P, D'Amico M, Dollinger M, García-Guix M, Gonzalez Ballerga E, Tsochatzis E, Cirera I, Albillos A, Roquin G, Pasta L, Colomo A, Daruich J, Canete N, Boursier J, Dallio M, Gasbarrini A, Iacobellis A, Gobbo G, Merli M, Federico A, Svegliati Baroni G, Pozzoni P, Addario L, Chessa L, Ridola L, Garcia-Tsao G. Hepatology. 2024 Apr 1; 2023 Nov 2. PMID: 37916970.
AGA Clinical Practice Update on the Use of Vasoactive Drugs and Intravenous Albumin in Cirrhosis: Expert Review.Garcia-Tsao G, Abraldes JG, Rich NE, Wong VW. Gastroenterology. 2024 Jan; 2023 Nov 18. PMID: 37978969.
The effect of endoscopic gastric plication on portosystemic pressure gradient in patients with nonalcoholic fatty liver disease and compensated advanced chronic liver disease.Jirapinyo P, Thompson CC, Garcia-Tsao G, Zucker SD, Ryou M. Endoscopy. 2024 Jan; 2023 Aug 2. PMID: 37532114.
AASLD Practice Guidance on the use of TIPS, variceal embolization, and retrograde transvenous obliteration in the management of variceal hemorrhage.Lee EW, Eghtesad B, Garcia-Tsao G, Haskal ZJ, Hernandez-Gea V, Jalaeian H, Kalva SP, Mohanty A, Thabut D, Abraldes JG. Hepatology. 2024 Jan 1; 2023 Jun 30. PMID: 37390489.
Liver Transplantation for Mahvash Disease, an Inborn Error of Metabolism.Mistry PK, Garcia-Tsao G. N Engl J Med. 2023 Nov 23. PMID: 37991861.
Controversies regarding albumin therapy in cirrhosis.Trebicka J, Garcia-Tsao G. Hepatology. 2023 Aug 7; 2023 Aug 7. PMID: 37540192.
MELD 3.0 adequately predicts mortality and renal replacement therapy requirements in patients with alcohol-associated hepatitis.Díaz LA, Fuentes-López E, Ayares G, Idalsoaga F, Arnold J, Valverde MA, Perez D, Gómez J, Escarate R, Villalón A, Ramírez CA, Hernandez-Tejero M, Zhang W, Qian S, Simonetto DA, Ahn JC, Buryska S, Dunn W, Mehta H, Agrawal R, Cabezas J, García-Carrera I, Cuyàs B, Poca M, Soriano G, Sarin SK, Maiwall R, Jalal PK, Abdulsada S, Higuera-de-la-Tijera F, Kulkarni AV, Rao PN, Salazar PG, Skladaný L, Bystrianska N, Clemente-Sanchez A, Villaseca-Gómez C, Haider T, Chacko KR, Romero GA, Pollarsky FD, Restrepo JC, Castro-Sanchez S, Toro LG, Yaquich P, Mendizabal M, Garrido ML, Marciano S, Dirchwolf M, Vargas V, Jiménez C, Louvet A, García-Tsao G, Roblero JP, Abraldes JG, Shah VH, Kamath PS, Arrese M, Singal AK, Bataller R, Arab JP. JHEP Rep. 2023 Aug; 2023 Mar 15. PMID: 37456675.
Update in the Treatment of the Complications of Cirrhosis.Abraldes JG, Caraceni P, Ghabril M, Garcia-Tsao G. Clin Gastroenterol Hepatol. 2023 Jul; 2023 Mar 25. PMID: 36972759.
Emerging concepts in the care of patients with cirrhosis and septic shock.Jimenez JV, Garcia-Tsao G, Saffo S. World J Hepatol. 2023 Apr 27. PMID: 37206653.
Medications for alcohol use disorder improve survival in patients with hazardous drinking and alcohol-associated cirrhosis.Rabiee A, Mahmud N, Falker C, Garcia-Tsao G, Taddei T, Kaplan DE. Hepatol Commun. 2023 Apr 1; 2023 Mar 24. PMID: 36972386.
Admission Serum Metabolites and Thyroxine Predict Advanced Hepatic Encephalopathy in a Multicenter Inpatient Cirrhosis Cohort.Bajaj JS, Tandon P, O'Leary JG, Reddy KR, Garcia-Tsao G, Thuluvath P, Lai JC, Subramanian RM, Vargas HE, Wong F, Fagan A, McGeorge S, Thacker LR, Kamath PS. Clin Gastroenterol Hepatol. 2023 Apr; 2022 Apr 15. PMID: 35436625.
Endovascular Assessment of Liver Hemodynamics in Patients with Cirrhosis Complicated by Portal Hypertension.Ferral H, Schepis F, Gaba RC, Garcia-Tsao G, Zanetto A, Perez-Campuzano V, Haskal ZJ, Garcia-Pagan JC. J Vasc Interv Radiol. 2023 Mar; 2022 Dec 11. PMID: 36516940.
Thromboelastography-Guided Therapy Enhances Patient Blood Management in Cirrhotic Patients: A Meta-analysis Based on Randomized Controlled Trials.Hartmann J, Dias JD, Pivalizza EG, Garcia-Tsao G. Semin Thromb Hemost. 2023 Mar; 2022 Sep 2. PMID: 36055266.
Acute Kidney Injury in Patients with Cirrhosis.Nadim MK, Garcia-Tsao G. N Engl J Med. 2023 Feb 23. PMID: 36812435.
Machine learning liver histology scores correlate with portal hypertension assessments in nonalcoholic steatohepatitis cirrhosis.Noureddin M, Goodman Z, Tai D, Chng ELK, Ren Y, Boudes P, Shlevin H, Garcia-Tsao G, Harrison SA, Chalasani NP. Aliment Pharmacol Ther. 2023 Feb; 2023 Jan 17. PMID: 36647687.
Noninvasive predictors of clinically significant portal hypertension in NASH cirrhosis: Validation of ANTICIPATE models and development of a lab-based model.Rabiee A, Deng Y, Ciarleglio M, Chan JL, Pons M, Genesca J, Garcia-Tsao G. Hepatol Commun. 2022 Dec; 2022 Oct 10. PMID: 36214066.
"Periprocedural management of abnormal coagulation parameters and thrombocytopenia in patients with cirrhosis: Guidance from the SSC of the ISTH": Comment from Hartmann et al.Hartmann J, Dias JD, Garcia-Tsao G, Pivalizza EG. J Thromb Haemost. 2022 Nov. PMID: 36271460.
Clinical, histological and molecular profiling of different stages of alcohol-related liver disease.Ventura-Cots M, Argemi J, Jones PD, Lackner C, El Hag M, Abraldes JG, Alvarado E, Clemente A, Ravi S, Alves A, Alboraie M, Altamirano J, Barace S, Bosques F, Brown R, Caballeria J, Cabezas J, Carvalhana S, Cortez-Pinto H, Costa A, Degré D, Fernandez-Carrillo C, Ganne-Carrie N, Garcia-Tsao G, Genesca J, Koskinas J, Lanthier N, Louvet A, Lozano JJ, Lucey MR, Masson S, Mathurin P, Mendez-Sanchez N, Miquel R, Moreno C, Mounajjed T, Odena G, Kim W, Sancho-Bru P, Warren Sands R, Szafranska J, Verset L, Schnabl B, Sempoux C, Shah V, Shawcross DL, Stauber RE, Straub BK, Verna E, Tiniakos D, Trépo E, Vargas V, Villanueva C, Woosley JT, Ziol M, Mueller S, Stärkel P, Bataller R. Gut. 2022 Sep; 2022 Jan 6. PMID: 34992134.
Early mechanical ventilation for grade IV hepatic encephalopathy is associated with increased mortality among patients with cirrhosis: an exploratory study.Saffo S, Garcia-Tsao G. Acute Crit Care. 2022 Aug; 2022 Aug 18. PMID: 35977889.
Reply to: 'Management of portal hypertension in patients treated with atezolizumab and bevacizumab for hepatocellular carcinoma'.de Franchis R, Bosch J, Garcia-Tsao G, Reiberger T, Ripoll C. J Hepatol. 2022 Aug; 2022 May 5. PMID: 35526788.
North American Practice-Based Recommendations for Transjugular Intrahepatic Portosystemic Shunts in Portal Hypertension.Boike JR, Thornburg BG, Asrani SK, Fallon MB, Fortune BE, Izzy MJ, Verna EC, Abraldes JG, Allegretti AS, Bajaj JS, Biggins SW, Darcy MD, Farr MA, Farsad K, Garcia-Tsao G, Hall SA, Jadlowiec CC, Krowka MJ, Laberge J, Lee EW, Mulligan DC, Nadim MK, Northup PG, Salem R, Shatzel JJ, Shaw CJ, Simonetto DA, Susman J, Kolli KP, VanWagner LB. Clin Gastroenterol Hepatol. 2022 Aug; 2021 Jul 15. PMID: 34274511.
Portal pressure reductions induced by nonselective beta-blockers improve outcomes and decrease mortality in patients with cirrhosis with and without ascites.Turco L, García-Tsao G. Clin Liver Dis (Hoboken). 2022 Jul; 2022 Jun 3. PMID: 35899241.
Corrigendum to 'Baveno VII - Renewing consensus in portal hypertension' [J Hepatol (2022) 959-974].de Franchis R, Bosch J, Garcia-Tsao G, Reiberger T, Ripoll C. J Hepatol. 2022 Jul; 2022 Apr 14. PMID: 35431106.
Reply.Saffo S, Garcia-Tsao G. Clin Gastroenterol Hepatol. 2022 Jul; 2021 Aug 28. PMID: 34464719.
Management of varices and variceal hemorrhage in liver cirrhosis: a recent update.Diaz-Soto MP, Garcia-Tsao G. Therap Adv Gastroenterol. 2022; 2022 Jun 20. PMID: 35757384.
Correction to: The MELD Score Is Superior to the Maddrey Discriminant Function Score to Predict Short-Term Mortality in Alcohol-Associated Hepatitis: A Global Study.Morales-Arráez D, Ventura-Cots M, Altamirano J, Abraldes JG, Cruz-Lemini M, Thursz MR, Atkinson SR, Sarin SK, Kim W, Chavez-Araujo R, Higuera-de la Tijera MF, Singal AK, Shah VH, Kamath PS, Duarte-Rojo A, Charles EA, Vargas V, Jager M, Rautou PE, Rincon D, Zamarripa F, Restrepo-Gutiérrez JC, Torre A, Lucey MR, Arab JP, Mathurin P, Louvet A, García-Tsao G, González JA, Verna EC, Brown RS Jr, Argemi J, Fernández-Carrillo C, Clemente A, Alvarado-Tapias E, Forrest E, Allison M, Bataller R. Am J Gastroenterol. 2022 May 1. PMID: 35501978.
Effect of rifaximin on infections, acute-on-chronic liver failure and mortality in alcoholic hepatitis: A pilot study (RIFA-AH).Jiménez C, Ventura-Cots M, Sala M, Calafat M, Garcia-Retortillo M, Cirera I, Cañete N, Soriano G, Poca M, Simón-Talero M, Altamirano J, Lucey M, Garcia-Tsao G, Brown RS Jr, Schwabe RF, Verna EC, Schnabl B, Bosques-Padilla F, Mathurin P, Caballería J, Louvet A, Shawcross DL, Abraldes JG, Genescà J, Bataller R, Vargas V. Liver Int. 2022 May; 2022 Mar 7. PMID: 35220659.
Terlipressin and the Treatment of Hepatorenal Syndrome: How the CONFIRM Trial Moves the Story Forward.Belcher JM, Parada XV, Simonetto DA, Juncos LA, Karakala N, Wadei HM, Sharma P, Regner KR, Nadim MK, Garcia-Tsao G, Velez JCQ, Parikh SM, Chung RT, Allegretti AS. Am J Kidney Dis. 2022 May; 2021 Oct 2. PMID: 34606933.
Changes in Ascitic Fluid Polymorphonuclear Cell Count After Antibiotics Are Associated With Mortality in Spontaneous Bacterial Peritonitis.Saffo S, To UK, Santoiemma PP, Laurito M, Haque L, Rabiee A, Verna EC, Angarone MP, Garcia-Tsao G. Clin Gastroenterol Hepatol. 2022 May; 2021 Jul 14. PMID: 34273564.
Baveno VII - Renewing consensus in portal hypertension.de Franchis R, Bosch J, Garcia-Tsao G, Reiberger T, Ripoll C. J Hepatol. 2022 Apr; 2021 Dec 30. PMID: 35120736.
Prognosis of hospitalized patients with cirrhosis and acute kidney disease.Wong F, Garcia-Tsao G, Reddy KR, O'Leary JG, Kamath PS, Tandon P, Lai JC, Vargas HE, Biggins SW, Fallon MB, Thuluvath PJ, Maliakkal BJ, Subramanian R, Thacker L, Bajaj JS. Liver Int. 2022 Apr; 2022 Jan 28. PMID: 35023264.
Nonselective Beta-Blockers in Portal Hypertension: Why, When, and How?Rabiee A, Garcia-Tsao G, Tapper EB. Clin Liver Dis (Hoboken). 2022 Mar; 2022 Mar 8. PMID: 35355838.
The MELD Score Is Superior to the Maddrey Discriminant Function Score to Predict Short-Term Mortality in Alcohol-Associated Hepatitis: A Global Study.Morales-Arráez D, Ventura-Cots M, Altamirano J, Abraldes JG, Cruz-Lemini M, Thursz MR, Atkinson SR, Sarin SK, Kim W, Chavez-Araujo R, Higuera-de la Tijera MF, Singal AK, Shah VH, Kamath PS, Duarte-Rojo A, Charles EA, Vargas V, Jager M, Rautou PE, Rincon D, Zamarripa F, Restrepo-Gutiérrez JC, Torre A, Lucey MR, Arab JP, Mathurin P, Louvet A, García-Tsao G, González JA, Verna EC, Brown RS Jr, Argemi J, Fernández-Carrillo C, Clemente A, Alvarado-Tapias E, Forrest E, Allison M, Bataller R. Am J Gastroenterol. 2022 Feb 1. PMID: 34962498.
Trajectory of Serum Bilirubin Predicts Spontaneous Recovery in a Real-World Cohort of Patients With Alcoholic Hepatitis.Parker R, Cabezas J, Altamirano J, Arab JP, Ventura-Cots M, Sinha A, Dhanda A, Arrese M, McCune CA, Rowe IA, Schnabl B, Mathurin P, Shawcross D, Abraldes JG, Lucey MR, Garcia-Tsao G, Verna E, Brown RS Jr, Bosques-Padilla F, Vargas V, Louvet A, Holt AP, Bataller R. Clin Gastroenterol Hepatol. 2022 Feb; 2021 Jan 28. PMID: 33516950.
Invasive Fungal Infections Are Underdiagnosed in Hospitalized Patients With Decompensated Cirrhosis: An Autopsy Study.Saffo S, Jain D, Sanchez H, Garcia-Tsao G. Gastro Hep Adv. 2022; 2022 Jun 2. PMID: 36160304.
Can We Rely on Changes in HVPG in Patients with Cirrhosis?Garcia-Tsao G. Hepatology. 2021 Dec; 2021 Oct 28. PMID: 34569630.
Identification of optimal therapeutic window for steroid use in severe alcohol-associated hepatitis: A worldwide study.Arab JP, Díaz LA, Baeza N, Idalsoaga F, Fuentes-López E, Arnold J, Ramírez CA, Morales-Arraez D, Ventura-Cots M, Alvarado-Tapias E, Zhang W, Clark V, Simonetto D, Ahn JC, Buryska S, Mehta TI, Stefanescu H, Horhat A, Bumbu A, Dunn W, Attar B, Agrawal R, Haque ZS, Majeed M, Cabezas J, García-Carrera I, Parker R, Cuyàs B, Poca M, Soriano G, Sarin SK, Maiwall R, Jalal PK, Abdulsada S, Higuera-de la Tijera MF, Kulkarni AV, Rao PN, Guerra Salazar P, Skladaný L, Bystrianska N, Prado V, Clemente-Sanchez A, Rincón D, Haider T, Chacko KR, Cairo F, de Sousa Coelho M, Romero GA, Pollarsky FD, Restrepo JC, Castro-Sanchez S, Toro LG, Yaquich P, Mendizabal M, Garrido ML, Narvaez A, Bessone F, Marcelo JS, Piombino D, Dirchwolf M, Arancibia JP, Altamirano J, Kim W, Araujo RC, Duarte-Rojo A, Vargas V, Rautou PE, Issoufaly T, Zamarripa F, Torre A, Lucey MR, Mathurin P, Louvet A, García-Tsao G, González JA, Verna E, Brown RS, Roblero JP, Abraldes JG, Arrese M, Shah VH, Kamath PS, Singal AK, Bataller R. J Hepatol. 2021 Nov; 2021 Jun 21. PMID: 34166722.
REPLY.Bajaj JS, Garcia-Tsao G, Kamath PS, O'Leary JG, Reddy KR, Wong F. Hepatology. 2021 Nov; 2021 Jul 2. PMID: 34110034.
Admission Urinary and Serum Metabolites Predict Renal Outcomes in Hospitalized Patients With Cirrhosis.Bajaj JS, Garcia-Tsao G, Reddy KR, O'Leary JG, Vargas HE, Lai JC, Kamath PS, Tandon P, Subramanian RM, Thuluvath P, Fagan A, Sehrawat T, de la Rosa Rodriguez R, Thacker LR, Wong F. Hepatology. 2021 Nov; 2021 Jul 8. PMID: 34002868.
A Historical Overview of Spontaneous Bacterial Peritonitis: From Rare to Resistant.Haque LY, Garcia-Tsao G. Clin Liver Dis (Hoboken). 2021 Oct; 2021 Oct 29. PMID: 34745584.
Nonalcoholic Steatohepatitis - Opportunities and Challenges.Garcia-Tsao G. N Engl J Med. 2021 Oct 21. PMID: 34670048.
Thick Fibrous Septa on Liver Biopsy Specimens Predict the Development of Decompensation in Patients With Compensated Cirrhosis.Jain D, Sreenivasan P, Inayat I, Deng Y, Ciarleglio MM, Garcia-Tsao G. Am J Clin Pathol. 2021 Oct 13. PMID: 33940622.
Reply.Chew M, Garcia-Tsao G. Clin Gastroenterol Hepatol. 2021 Oct; 2021 Jun 18. PMID: 34147681.
The Level of Alcohol Consumption in the Prior Year Does Not Impact Clinical Outcomes in Patients With Alcohol-Associated Hepatitis.Musto JA, Eickhoff J, Ventura-Cots M, Abraldes JG, Bosques-Padilla F, Verna EC, Brown RS Jr, Vargas V, Altamirano J, Caballería J, Shawcross D, Louvet A, Mathurin P, Garcia-Tsao G, Schnabl B, Bataller R, Lucey MR. Liver Transpl. 2021 Oct; 2021 Jul 31. PMID: 34109723.
Significant Liver Injury During Hospitalization for COVID-19 Is Not Associated With Liver Insufficiency or Death.Chew M, Tang Z, Radcliffe C, Caruana D, Doilicho N, Ciarleglio MM, Deng Y, Garcia-Tsao G. Clin Gastroenterol Hepatol. 2021 Oct; 2021 May 15. PMID: 34004326.
Increased Risk of ACLF and Inpatient Mortality in Hospitalized Patients with Cirrhosis and Hepatic Hydrothorax.O'Leary JG, Rajender Reddy K, Tandon P, Biggins SW, Wong F, Kamath PS, Garcia-Tsao G, Maliakkal B, Lai JC, Fallon M, Vargas HE, Thuluvath P, Subramanian R, Thacker LR, Bajaj JS. Dig Dis Sci. 2021 Oct; 2020 Nov 13. PMID: 33185787.
Nonselective Beta-Blockers in Compensated Cirrhosis: Preventing Variceal Hemorrhage or Preventing Decompensation?Garcia-Tsao G, Abraldes JG. Gastroenterology. 2021 Sep; 2021 May 11. PMID: 33989660.
Reply to "Acute kidney injury in patients with decompensated cirrhosis".Campello E, Zanetto A, Garcia-Tsao G, Simioni P. Dig Liver Dis. 2021 Sep; 2021 Apr 27. PMID: 33926815.
Cirrhosis Is Associated With High Mortality and Readmissions Over 90 Days Regardless of COVID-19: A Multicenter Cohort.Bajaj JS, Garcia-Tsao G, Wong F, Biggins SW, Kamath PS, McGeorge S, Chew M, Pearson M, Shaw J, Kalluri A, Fagan A, Olofson A, Moini M, de la Rosa Rodriguez R, Reddy KR. Liver Transpl. 2021 Sep; 2021 Mar 15. PMID: 33427401.
Current knowledge and management of portal vein thrombosis in cirrhosis.Senzolo M, Garcia-Tsao G, García-Pagán JC. J Hepatol. 2021 Aug; 2021 Apr 27. PMID: 33930474.
Progression of Stage 2 and 3 Acute Kidney Injury in Patients With Decompensated Cirrhosis and Ascites.Wong F, Reddy KR, Tandon P, O'Leary JG, Garcia-Tsao G, Vargas HE, Lai JC, Biggins SW, Maliakkal B, Fallon M, Subramanian R, Thuluvath P, Kamath PS, Thacker L, Bajaj JS. Clin Gastroenterol Hepatol. 2021 Aug; 2020 Aug 13. PMID: 32798707.
Determinants of increased thrombotic tendency in NASH cirrhosis: not there yet!Zanetto A, Senzolo M, Campello E, Bulato C, Gavasso S, Saggiorato G, Feltracco P, Farinati F, Russo FP, Burra P, Garcia-Tsao G, Simioni P. Transpl Int. 2021 Jul; 2021 May 21. PMID: 33932057.
Acute kidney injury is associated with increased levels of circulating microvesicles in patients with decompensated cirrhosis.Campello E, Zanetto A, Radu CM, Bulato C, Truma A, Spiezia L, Senzolo M, Garcia-Tsao G, Simioni P. Dig Liver Dis. 2021 Jul; 2021 Jan 8. PMID: 33431230.
Urinary NGAL as a Diagnostic and Prognostic Marker for Acute Kidney Injury in Cirrhosis: A Prospective Study.Allegretti AS, Parada XV, Endres P, Zhao S, Krinsky S, St Hillien SA, Kalim S, Nigwekar SU, Flood JG, Nixon A, Simonetto DA, Juncos LA, Karakala N, Wadei HM, Regner KR, Belcher JM, Nadim MK, Garcia-Tsao G, Velez JCQ, Parikh SM, Chung RT. Clin Transl Gastroenterol. 2021 May 11; 2021 May 11. PMID: 33979307.
Terlipressin and Intravenous Albumin in Advanced Cirrhosis - Friend and Foe.Garcia-Tsao G. N Engl J Med. 2021 Mar 4. PMID: 33657300.
Sleep Disturbance Is Associated With the Presence of Portosystemic Collaterals in Patients With Compensated Cirrhosis.Balakrishnan M, Falker C, Conley S, Ciarleglio M, Deng Y, Redeker NS, Garcia-Tsao G. Hepatol Commun. 2021 Mar; 2021 Feb 3. PMID: 33681681.
SGLT2 inhibitors in patients with cirrhosis and diabetes mellitus: A tertiary center cohort study and insights about a potential therapeutic target for portal hypertension.Saffo S, Garcia-Tsao G, Taddei T. J Diabetes. 2021 Mar; 2020 Dec 6. PMID: 33210815.
Comparison of mortality risk in patients with cirrhosis and COVID-19 compared with patients with cirrhosis alone and COVID-19 alone: multicentre matched cohort.Bajaj JS, Garcia-Tsao G, Biggins SW, Kamath PS, Wong F, McGeorge S, Shaw J, Pearson M, Chew M, Fagan A, de la Rosa Rodriguez R, Worthington J, Olofson A, Weir V, Trisolini C, Dwyer S, Reddy KR. Gut. 2021 Mar; 2020 Jul 13. PMID: 32660964.
Insurance Status But Not Race and Ethnicity Are Associated With Outcomes in a Large Hospitalized Cohort of Patients With Cirrhosis.Bajaj JS, O'Leary JG, Tandon P, Wong F, Kamath PS, Biggins SW, Garcia-Tsao G, Lai J, Fallon MB, Thuluvath PJ, Vargas HE, Maliakkal B, Subramanian RM, Thacker LR, Reddy KR. Clin Gastroenterol Hepatol. 2021 Mar; 2020 May 8. PMID: 32389884.
Low Predictability of Readmissions and Death Using Machine Learning in Cirrhosis.Hu C, Anjur V, Saboo K, Reddy KR, O'Leary J, Tandon P, Wong F, Garcia-Tsao G, Kamath PS, Lai JC, Biggins SW, Fallon MB, Thuluvath P, Subramanian RM, Maliakkal B, Vargas H, Thacker LR, Iyer RK, Bajaj JS. Am J Gastroenterol. 2021 Feb 1. PMID: 33038139.
Overview of Current Management of Portal Hypertension.Garcia-Tsao G. Gastroenterol Hepatol (N Y). 2021 Jan. PMID: 34035762.
Vascular Liver Disorders, Portal Vein Thrombosis, and Procedural Bleeding in Patients With Liver Disease: 2020 Practice Guidance by the American Association for the Study of Liver Diseases.Northup PG, Garcia-Pagan JC, Garcia-Tsao G, Intagliata NM, Superina RA, Roberts LN, Lisman T, Valla DC. Hepatology. 2021 Jan; 2021 Jan 20. PMID: 33219529.
Factors associated with health-related quality of life in patients with cirrhosis: a systematic review.Rabiee A, Ximenes RO, Nikayin S, Hickner A, Juthani P, Rosen RH, Garcia-Tsao G. Liver Int. 2021 Jan; 2020 Nov 2. PMID: 32998172.
Intestinal Virome in Patients With Alcoholic Hepatitis.Jiang L, Lang S, Duan Y, Zhang X, Gao B, Chopyk J, Schwanemann LK, Ventura-Cots M, Bataller R, Bosques-Padilla F, Verna EC, Abraldes JG, Brown RS Jr, Vargas V, Altamirano J, Caballería J, Shawcross DL, Ho SB, Louvet A, Lucey MR, Mathurin P, Garcia-Tsao G, Kisseleva T, Brenner DA, Tu XM, Stärkel P, Pride D, Fouts DE, Schnabl B. Hepatology. 2020 Dec; 2020 Oct 10. PMID: 32654263.
Clinical Research in Hepatology in the COVID-19 Pandemic and Post-Pandemic Era: Challenges and the Need for Innovation.Verna EC, Serper M, Chu J, Corey K, Fix OK, Hoyt K, Page KA, Loomba R, Li M, Everson GT, Fried MW, Garcia-Tsao G, Terrault N, Lok AS, Chung RT, Reddy KR. Hepatology. 2020 Nov. PMID: 32740969.
Sodium-Glucose Cotransporter 2 Inhibitors Ameliorate Ascites and Peripheral Edema in Patients With Cirrhosis and Diabetes.Montalvo-Gordon I, Chi-Cervera LA, García-Tsao G. Hepatology. 2020 Nov. PMID: 32294260.
Getting to implementation: a protocol for a Hybrid III stepped wedge cluster randomized evaluation of using data-driven implementation strategies to improve cirrhosis care for Veterans.Rogal SS, Yakovchenko V, Morgan T, Bajaj JS, Gonzalez R, Park A, Beste L, Miech EJ, Lamorte C, Neely B, Gibson S, Malone PS, Chartier M, Taddei T, Garcia-Tsao G, Powell BJ, Dominitz JA, Ross D, Chinman MJ. Implement Sci. 2020 Oct 21; 2020 Oct 21. PMID: 33087156.
Subaortic Membranes in Patients With Hereditary Hemorrhagic Telangiectasia and Liver Vascular Malformations.Kim AS, Henderson KJ, Pawar S, Kim MJ, Punjani S, Pollak JS, Fahey JT, Garcia-Tsao G, Sugeng L, Young LH. J Am Heart Assoc. 2020 Oct 20; 2020 Oct 15. PMID: 33054561.
Acute Kidney Injury in Decompensated Cirrhosis Is Associated With Both Hypo-coagulable and Hyper-coagulable Features.Zanetto A, Rinder HM, Campello E, Saggiorato G, Deng Y, Ciarleglio M, Wilson FP, Senzolo M, Gavasso S, Bulato C, Simioni P, Garcia-Tsao G. Hepatology. 2020 Oct. PMID: 32614088.
Some Answers and More Questions About Portal Vein Thrombosis in Patients With Decompensated Cirrhosis.Zanetto A, Garcia-Tsao G. Clin Gastroenterol Hepatol. 2020 Oct; 2020 Apr 14. PMID: 32302710.
Underutilization of Hospice in Inpatients with Cirrhosis: The NACSELD Experience.O'Leary JG, Tandon P, Reddy KR, Biggins SW, Wong F, Kamath PS, Garcia-Tsao G, Maliakkal B, Lai J, Fallon M, Vargas HE, Thuluvath P, Subramanian R, Thacker LR, Bajaj JS. Dig Dis Sci. 2020 Sep; 2020 Mar 7. PMID: 32146602.
Ordinal Outcomes Are Superior to Binary Outcomes for Designing and Evaluating Clinical Trials in Compensated Cirrhosis.D'Amico G, Abraldes JG, Rebora P, Valsecchi MG, Garcia-Tsao G. Hepatology. 2020 Sep; 2020 Jul 6. PMID: 31837238.
#LiverTwitter: An Emerging Tool for Liver Education and Research.Mikolajczyk AE, Ufere N, Breu AC, Parikh ND, Garcia-Tsao G, Tapper EB. Hepatol Commun. 2020 Aug; 2020 Jul 5. PMID: 32766481.
Where does TIPS fit in the management of patients with cirrhosis?García-Pagán JC, Saffo S, Mandorfer M, Garcia-Tsao G. JHEP Rep. 2020 Aug; 2020 May 23. PMID: 32671331.
Evaluation and Management of Esophageal and Gastric Varices in Patients with Cirrhosis.Jakab SS, Garcia-Tsao G. Clin Liver Dis. 2020 Aug; 2020 May 31. PMID: 32620275.
Update to the Society of Radiologists in Ultrasound Liver Elastography Consensus Statement.Barr RG, Wilson SR, Rubens D, Garcia-Tsao G, Ferraioli G. Radiology. 2020 Aug; 2020 Jun 9. PMID: 32515681.
Response to Mancuso et al.Simonetto DA, Singal AK, Garcia-Tsao G, Caldwell SH, Ahn J, Kamath PS. Am J Gastroenterol. 2020 Jun. PMID: 32427682.
Randomized placebo-controlled trial of emricasan for non-alcoholic steatohepatitis-related cirrhosis with severe portal hypertension.Garcia-Tsao G, Bosch J, Kayali Z, Harrison SA, Abdelmalek MF, Lawitz E, Satapathy SK, Ghabril M, Shiffman ML, Younes ZH, Thuluvath PJ, Berzigotti A, Albillos A, Robinson JM, Hagerty DT, Chan JL, Sanyal AJ. J Hepatol. 2020 May; 2019 Dec 21. PMID: 31870950.
Effects of Belapectin, an Inhibitor of Galectin-3, in Patients With Nonalcoholic Steatohepatitis With Cirrhosis and Portal Hypertension.Chalasani N, Abdelmalek MF, Garcia-Tsao G, Vuppalanchi R, Alkhouri N, Rinella M, Noureddin M, Pyko M, Shiffman M, Sanyal A, Allgood A, Shlevin H, Horton R, Zomer E, Irish W, Goodman Z, Harrison SA, Traber PG. Gastroenterology. 2020 Apr; 2019 Dec 5. PMID: 31812510.
Author response to Letter to the Editor: 'Dynamics of platelet count after sustained virologic response do not mirror those of hepatic venous pressure gradient'.Ortiz GA, Sayyar M, Garcia-Tsao G. Liver Int. 2020 Apr; 2019 Dec 3. PMID: 31749290.
Reply to: "Lack of evidence for a continuum between hepatorenal syndrome and acute tubular necrosis".Garcia-Tsao G, Angeli P, Nadim MK, Parikh CR. J Hepatol. 2020 Mar; 2019 Dec 4. PMID: 31810532.
Intestinal Fungal Dysbiosis and Systemic Immune Response to Fungi in Patients With Alcoholic Hepatitis.Lang S, Duan Y, Liu J, Torralba MG, Kuelbs C, Ventura-Cots M, Abraldes JG, Bosques-Padilla F, Verna EC, Brown RS Jr, Vargas V, Altamirano J, Caballería J, Shawcross D, Lucey MR, Louvet A, Mathurin P, Garcia-Tsao G, Ho SB, Tu XM, Bataller R, Stärkel P, Fouts DE, Schnabl B. Hepatology. 2020 Feb; 2019 Aug 20. PMID: 31228214.
Lowering Portal Pressure Improves Outcomes of Patients With Cirrhosis, With or Without Ascites: A Meta-Analysis.Turco L, Villanueva C, La Mura V, García-Pagán JC, Reiberger T, Genescà J, Groszmann RJ, Sharma BC, Merkel C, Bureau C, Alvarado E, Abraldes JG, Albillos A, Bañares R, Peck-Radosavljevic M, Augustin S, Sarin SK, Bosch J, García-Tsao G. Clin Gastroenterol Hepatol. 2020 Feb; 2019 Jun 5. PMID: 31176013.
ACG Clinical Guideline: Disorders of the Hepatic and Mesenteric Circulation.Simonetto DA, Singal AK, Garcia-Tsao G, Caldwell SH, Ahn J, Kamath PS. Am J Gastroenterol. 2020 Jan. PMID: 31895720.
Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease.Duan Y, Llorente C, Lang S, Brandl K, Chu H, Jiang L, White RC, Clarke TH, Nguyen K, Torralba M, Shao Y, Liu J, Hernandez-Morales A, Lessor L, Rahman IR, Miyamoto Y, Ly M, Gao B, Sun W, Kiesel R, Hutmacher F, Lee S, Ventura-Cots M, Bosques-Padilla F, Verna EC, Abraldes JG, Brown RS Jr, Vargas V, Altamirano J, Caballería J, Shawcross DL, Ho SB, Louvet A, Lucey MR, Mathurin P, Garcia-Tsao G, Bataller R, Tu XM, Eckmann L, van der Donk WA, Young R, Lawley TD, Stärkel P, Pride D, Fouts DE, Schnabl B. Nature. 2019 Nov; 2019 Nov 13. PMID: 31723265.
Venous Thromboembolism in Patients with Liver Cirrhosis: Findings from the RIETE (Registro Informatizado de la Enfermedad TromboEmbolica) Registry.Bikdeli B, Jiménez D, Garcia-Tsao G, Barba R, Font C, Díaz-Pedroche MDC, Mazzolai L, Little DHW, Tufano A, Tafur AJ, Siegal D, Lip GYH, Monreal M. Semin Thromb Hemost. 2019 Nov; 2019 Oct 15. PMID: 31614388.
Portal Hypertension: Pathogenesis and Diagnosis.Turco L, Garcia-Tsao G. Clin Liver Dis. 2019 Nov. PMID: 31563212.
Platelet count increases after viral elimination in chronic HCV, independent of the presence or absence of cirrhosis.Sayyar M, Saidi M, Zapatka S, Deng Y, Ciarleglio M, Garcia-Tsao G. Liver Int. 2019 Nov; 2019 Aug 21. PMID: 31365178.
Prophylactic Antibiotics in Cirrhosis: Are They Promoting or Preventing Infections?Garcia-Tsao G. Clin Liver Dis (Hoboken). 2019 Sep; 2019 Oct 9. PMID: 31632658.

Fred Gorelick, MD

Trypsin in pancreatitis: The culprit, a mediator, or epiphenomenon?Gukovskaya AS, Lerch MM, Mayerle J, Sendler M, Ji B, Saluja AK, Gorelick FS, Gukovsky I. World J Gastroenterol. 2024 Nov 7. PMID: 39534420.
Chemical complementarity of tumor resident, T-cell receptor CDR3s and renalase-1 correlates with increased melanoma survival.Zaman S, Gorelick FS, Chrobrutskiy A, Chobrutskiy BI, Desir GV, Blanck G. Oncotarget. 2024 Aug 5; 2024 Aug 5. PMID: 39102218.
Early Hypophosphatemia as a Prognostic Marker in Acute Pancreatitis.Stewart CF, Adeniran EA, Yadav D, Gorelick FS, Liddle RA, Wu B, Pandol SJ, Jeon CY. Pancreas. 2024 Aug 1; 2024 May 1. PMID: 38696363.
Clinical predictive value of renalase in post-ERCP pancreatitis.Muniraj T, Desir G, Gorelick FS, Guo X, Ciarleglio MM, Deng Y, Jamidar PA, Farrell J, Aslanian HR, Laine L. Gastrointest Endosc. 2024 May; 2023 Dec 14. PMID: 38103747.
Has a Hundred Years of Pursuing Proteases Helped to Palliate Pain in Chronic Pancreatitis More Than Placebo?Singh VP, Gorelick FS. Gastroenterology. 2024 Apr; 2024 Feb 2. PMID: 38311123.
Interventions to support fellowship application success among predoctoral physician-scientists.Fitzsimonds RM, Gorelick FS, Kazmierczak BI. JCI Insight. 2024 Mar 8; 2024 Mar 8. PMID: 38456505.
Plasma renalase levels are associated with the development of acute pancreatitis.Wang M, Weiss FU, Guo X, Kolodecik T, Bewersdorf JP, Laine L, Lerch MM, Desir G, Gorelick FS. Pancreatology. 2023 Mar; 2023 Jan 3. PMID: 36697349.
Renalase is a novel tissue and serological biomarker in pancreatic ductal adenocarcinoma.Gao Y, Wang M, Guo X, Hu J, Chen TM, Finn SMB, Lacy J, Kunstman JW, Cha CH, Bellin MD, Robert ME, Desir GV, Gorelick FS. PLoS One. 2021; 2021 Sep 29. PMID: 34587190.
Renalase: A Multi-Functional Signaling Molecule with Roles in Gastrointestinal Disease.Pointer TC, Gorelick FS, Desir GV. Cells. 2021 Aug 6; 2021 Aug 6. PMID: 34440775.
Dysregulation of mannose-6-phosphate-dependent cholesterol homeostasis in acinar cells mediates pancreatitis.Mareninova OA, Vegh ET, Shalbueva N, Wightman CJ, Dillon DL, Malla S, Xie Y, Takahashi T, Rakonczay Z Jr, French SW, Gaisano HY, Gorelick FS, Pandol SJ, Bensinger SJ, Davidson NO, Dawson DW, Gukovsky I, Gukovskaya AS. J Clin Invest. 2021 Aug 2. PMID: 34128834.
Ketamine and xylazine effects in murine model of acute pancreatitis.Wang M, Gorelick FS. Am J Physiol Gastrointest Liver Physiol. 2021 Jun 1; 2021 Apr 21. PMID: 33881355.
Protein Lysine Acetylation: An Unexpected Mediator in Pancreatitis.Gorelick FS. Cell Mol Gastroenterol Hepatol. 2021; 2020 Dec 3. PMID: 33279460.
American Pancreatic Association Frank Brooks Symposium: Fifty Years of Pancreatic Cell Biology.Williams JA, Groblewski GE, Gorelick FS, Mayerle J, Apte M, Gukovskaya AS. Pancreas. 2020 May/Jun. PMID: 32433396.
Early trypsin activation develops independently of autophagy in caerulein-induced pancreatitis in mice.Malla SR, Krueger B, Wartmann T, Sendler M, Mahajan UM, Weiss FU, Thiel FG, De Boni C, Gorelick FS, Halangk W, Aghdassi AA, Reinheckel T, Gukovskaya AS, Lerch MM, Mayerle J. Cell Mol Life Sci. 2020 May; 2019 Jul 30. PMID: 31363815.
Precision Medicine in Pancreatic Disease-Knowledge Gaps and Research Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.Lowe ME, Andersen DK, Caprioli RM, Choudhary J, Cruz-Monserrate Z, Dasyam AK, Forsmark CE, Gorelick FS, Gray JW, Haupt M, Kelly KA, Olive KP, Plevritis SK, Rappaport N, Roth HR, Steen H, Swamidass SJ, Tirkes T, Uc A, Veselkov K, Whitcomb DC, Habtezion A. Pancreas. 2019 Nov/Dec. PMID: 31688587.
CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation.Esteghamat F, Broughton JS, Smith E, Cardone R, Tyagi T, Guerra M, Szabó A, Ugwu N, Mani MV, Azari B, Kayingo G, Chung S, Fathzadeh M, Weiss E, Bender J, Mane S, Lifton RP, Adeniran A, Nathanson MH, Gorelick FS, Hwa J, Sahin-Tóth M, Belfort-DeAguiar R, Kibbey RG, Mani A. Nat Genet. 2019 Aug; 2019 Jul 29. PMID: 31358993.
Cigarette toxin 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces experimental pancreatitis through α7 nicotinic acetylcholine receptors (nAChRs) in mice.Alahmari AA, Sreekumar B, Patel V, Ashat M, Alexandre M, Uduman AK, Akinbiyi EO, Ceplenski A, Shugrue CA, Kolodecik TR, Tashkandi N, Messenger SW, Groblewski GE, Gorelick FS, Thrower EC. PLoS One. 2018; 2018 Jun 5. PMID: 29870540.
Mitochondrial Dysfunction, Through Impaired Autophagy, Leads to Endoplasmic Reticulum Stress, Deregulated Lipid Metabolism, and Pancreatitis in Animal Models.Biczo G, Vegh ET, Shalbueva N, Mareninova OA, Elperin J, Lotshaw E, Gretler S, Lugea A, Malla SR, Dawson D, Ruchala P, Whitelegge J, French SW, Wen L, Husain SZ, Gorelick FS, Hegyi P, Rakonczay Z Jr, Gukovsky I, Gukovskaya AS. Gastroenterology. 2018 Feb; 2017 Oct 23. PMID: 29074451.
The serum protein renalase reduces injury in experimental pancreatitis.Kolodecik TR, Reed AM, Date K, Shugrue CA, Patel V, Chung SL, Desir GV, Gorelick FS. J Biol Chem. 2017 Dec 22; 2017 Oct 17. PMID: 29042438.
Human Pancreatic Acinar Cells: Proteomic Characterization, Physiologic Responses, and Organellar Disorders in ex Vivo Pancreatitis.Lugea A, Waldron RT, Mareninova OA, Shalbueva N, Deng N, Su HY, Thomas DD, Jones EK, Messenger SW, Yang J, Hu C, Gukovsky I, Liu Z, Groblewski GE, Gukovskaya AS, Gorelick FS, Pandol SJ. Am J Pathol. 2017 Dec; 2017 Sep 19. PMID: 28935577.
Do Animal Models of Acute Pancreatitis Reproduce Human Disease?Gorelick FS, Lerch MM. Cell Mol Gastroenterol Hepatol. 2017 Sep; 2017 Jun 10. PMID: 28752114.
Bidirectional regulation of Aβ levels by Presenilin 1.Bustos V, Pulina MV, Kelahmetoglu Y, Sinha SC, Gorelick FS, Flajolet M, Greengard P. Proc Natl Acad Sci U S A. 2017 Jul 3; 2017 May 22. PMID: 28533411.
Phosphorylated Presenilin 1 decreases β-amyloid by facilitating autophagosome-lysosome fusion.Bustos V, Pulina MV, Bispo A, Lam A, Flajolet M, Gorelick FS, Greengard P. Proc Natl Acad Sci U S A. 2017 Jul 3; 2017 May 22. PMID: 28533369.
Advances in pancreatology: 2016.Gorelick FS. Curr Opin Gastroenterol. 2016 Sep. PMID: 27454030.
Targeting αv Integrins in Pancreatic Fibrosis: Progress in Resolving the Scar.Chung C, Gorelick FS. Cell Mol Gastroenterol Hepatol. 2016 Jul; 2016 May 24. PMID: 28090563.
Inhibition of pancreatic acinar mitochondrial thiamin pyrophosphate uptake by the cigarette smoke component 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.Srinivasan P, Thrower EC, Gorelick FS, Said HM. Am J Physiol Gastrointest Liver Physiol. 2016 May 15; 2016 Mar 17. PMID: 26999808.
Chronic Nicotine Exposure In Vivo and In Vitro Inhibits Vitamin B1 (Thiamin) Uptake by Pancreatic Acinar Cells.Srinivasan P, Thrower EC, Loganathan G, Balamurugan AN, Subramanian VS, Gorelick FS, Said HM. PLoS One. 2015; 2015 Dec 3. PMID: 26633299.
Early to Late Endosome Trafficking Controls Secretion and Zymogen Activation in Rodent and Human Pancreatic Acinar Cells.Messenger SW, Thomas DD, Cooley MM, Jones EK, Falkowski MA, August BK, Fernandez LA, Gorelick FS, Groblewski GE. Cell Mol Gastroenterol Hepatol. 2015 Nov 1. PMID: 26618189.
Low pH enhances connexin32 degradation in the pancreatic acinar cell.Reed AM, Kolodecik T, Husain SZ, Gorelick FS. Am J Physiol Gastrointest Liver Physiol. 2014 Jul 1; 2014 May 8. PMID: 24812055.
Tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone initiates and enhances pancreatitis responses.Alexandre M, Uduman AK, Minervini S, Raoof A, Shugrue CA, Akinbiyi EO, Patel V, Shitia M, Kolodecik TR, Patton R, Gorelick FS, Thrower EC. Am J Physiol Gastrointest Liver Physiol. 2012 Sep 15; 2012 Jul 26. PMID: 22837343.
Cerulein hyperstimulation decreases AMP-activated protein kinase levels at the site of maximal zymogen activation.Shugrue CA, Alexandre M, Diaz de Villalvilla A, Kolodecik TR, Young LH, Gorelick FS, Thrower EC. Am J Physiol Gastrointest Liver Physiol. 2012 Sep 15; 2012 Jul 19. PMID: 22821946.
Activation of soluble adenylyl cyclase protects against secretagogue stimulated zymogen activation in rat pancreaic acinar cells.Kolodecik TR, Shugrue CA, Thrower EC, Levin LR, Buck J, Gorelick FS. PLoS One. 2012; 2012 Jul 23. PMID: 22844459.
Low extracellular pH induces damage in the pancreatic acinar cell by enhancing calcium signaling.Reed AM, Husain SZ, Thrower E, Alexandre M, Shah A, Gorelick FS, Nathanson MH. J Biol Chem. 2011 Jan 21; 2010 Nov 17. PMID: 21084290.
The emerging role of smoking in the development of pancreatitis.Alexandre M, Pandol SJ, Gorelick FS, Thrower EC. Pancreatology. 2011; 2011 Oct 5. PMID: 21986098.
Molecular and cellular mechanisms of pancreatic injury.Thrower EC, Gorelick FS, Husain SZ. Curr Opin Gastroenterol. 2010 Sep. PMID: 20651589.
The acinar cell and early pancreatitis responses.Gorelick FS, Thrower E. Clin Gastroenterol Hepatol. 2009 Nov. PMID: 19896090.
Protein kinase C delta-mediated processes in cholecystokinin-8-stimulated pancreatic acini.Thrower EC, Wang J, Cheriyan S, Lugea A, Kolodecik TR, Yuan J, Reeve JR Jr, Gorelick FS, Pandol SJ. Pancreas. 2009 Nov. PMID: 19752773.
Reducing extracellular pH sensitizes the acinar cell to secretagogue-induced pancreatitis responses in rats.Bhoomagoud M, Jung T, Atladottir J, Kolodecik TR, Shugrue C, Chaudhuri A, Thrower EC, Gorelick FS. Gastroenterology. 2009 Sep; 2009 May 18. PMID: 19454288.
The novel protein kinase C isoforms -delta and -epsilon modulate caerulein-induced zymogen activation in pancreatic acinar cells.Thrower EC, Osgood S, Shugrue CA, Kolodecik TR, Chaudhuri AM, Reeve JR Jr, Pandol SJ, Gorelick FS. Am J Physiol Gastrointest Liver Physiol. 2008 Jun; 2008 Apr 3. PMID: 18388183.
Caerulein-induced intracellular pancreatic zymogen activation is dependent on calcineurin.Husain SZ, Grant WM, Gorelick FS, Nathanson MH, Shah AU. Am J Physiol Gastrointest Liver Physiol. 2007 Jun; 2007 Mar 1. PMID: 17332472.
Cyclic AMP-dependent protein kinase and Epac mediate cyclic AMP responses in pancreatic acini.Chaudhuri A, Husain SZ, Kolodecik TR, Grant WM, Gorelick FS. Am J Physiol Gastrointest Liver Physiol. 2007 May; 2007 Jan 18. PMID: 17234888.
Vacuolar adenosine triphosphatase and pancreatic acinar cell function.Gorelick FS, Shugrue CA, Kolodecik TR, Thrower EC. J Gastroenterol Hepatol. 2006 Oct. PMID: 16958663.
The identification of a novel endoplasmic reticulum to Golgi SNARE complex used by the prechylomicron transport vesicle.Siddiqi SA, Siddiqi S, Mahan J, Peggs K, Gorelick FS, Mansbach CM 2nd. J Biol Chem. 2006 Jul 28; 2006 May 30. PMID: 16735505.
Zymogen activation in a reconstituted pancreatic acinar cell system.Thrower EC, Diaz de Villalvilla AP, Kolodecik TR, Gorelick FS. Am J Physiol Gastrointest Liver Physiol. 2006 May; 2005 Dec 8. PMID: 16339296.
The ryanodine receptor mediates early zymogen activation in pancreatitis.Husain SZ, Prasad P, Grant WM, Kolodecik TR, Nathanson MH, Gorelick FS. Proc Natl Acad Sci U S A. 2005 Oct 4; 2005 Sep 26. PMID: 16186498.
Acute pancreatitis.Nagar AB, Gorelick FS. Curr Opin Gastroenterol. 2004 Sep. PMID: 15689676.
Alcohol and zymogen activation in the pancreatic acinar cell.Gorelick FS. Pancreas. 2003 Nov. PMID: 14576492.
Impaired membrane resealing and autoimmune myositis in synaptotagmin VII-deficient mice.Chakrabarti S, Kobayashi KS, Flavell RA, Marks CB, Miyake K, Liston DR, Fowler KT, Gorelick FS, Andrews NW. J Cell Biol. 2003 Aug 18. PMID: 12925704.
Pancreas cell physiology and pancreatitis cell biology. Summary of a symposium held at the joint meeting of the EPC and the IAP, Heidelberg 2002.Gorelick FS. Pancreatology. 2003. PMID: 12771516.
Acute pancreatitis.Nagar AB, Gorelick FS. Curr Opin Gastroenterol. 2002 Sep. PMID: 17033332.
Exiting the endoplasmic reticulum.Gorelick FS, Shugrue C. Mol Cell Endocrinol. 2001 May 25. PMID: 11377815.
Etiopathogenesis of acute pancreatitis.Karne S, Gorelick FS. Surg Clin North Am. 1999 Aug. PMID: 10470320.
Mechanisms of intracellular zymogen activation.Gorelick FS, Otani T. Baillieres Best Pract Res Clin Gastroenterol. 1999 Jul. PMID: 11030603.
Co-distribution of calmodulin-dependent protein kinase II and inositol trisphosphate receptors in an apical domain of gastrointestinal mucosal cells.Matovcik LM, Maranto AR, Soroka CJ, Gorelick FS, Smith J, Goldenring JR. J Histochem Cytochem. 1996 Nov. PMID: 8918899.
Effect of cerulein hyperstimulation on the paracellular barrier of rat exocrine pancreas.Fallon MB, Gorelick FS, Anderson JM, Mennone A, Saluja A, Steer ML. Gastroenterology. 1995 Jun. PMID: 7539388.
Antibodies to an epitope on synapsin I detect a protein associated with the endocytic compartment in non-neuronal cells.Matovcik LM, Karapetian O, Czernik AJ, Marino CR, Kinder BK, Gorelick FS. Eur J Cell Biol. 1994 Dec. PMID: 7536673.
Calcium/calmodulin-dependent protein kinase-II activation in rat pituitary cells in the presence of thyrotropin-releasing hormone and dopamine.Cui ZJ, Gorelick FS, Dannies PS. Endocrinology. 1994 May. PMID: 8156928.
Cell cycle-dependent and kinase-specific regulation of the apical Na/H exchanger and the Na,K-ATPase in the kidney cell line LLC-PK1 by calcitonin.Chakraborty M, Chatterjee D, Gorelick FS, Baron R. Proc Natl Acad Sci U S A. 1994 Mar 15. PMID: 8134357.
Characterization of cAMP-dependent protein kinase activation by CCK in rat pancreas.Marino CR, Leach SD, Schaefer JF, Miller LJ, Gorelick FS. FEBS Lett. 1993 Jan 18. PMID: 7678554.
Scientific advances in cystic fibrosis.Marino CR, Gorelick FS. Gastroenterology. 1992 Aug. PMID: 1378805.
New perspectives on acute pancreatitis.Leach SD, Gorelick FS, Modlin IM. Scand J Gastroenterol Suppl. 1992. PMID: 1439566.
Acute pancreatitis at its centenary. The contribution of Reginald Fitz.Leach SD, Gorelick FS, Modlin IM. Ann Surg. 1990 Jul. PMID: 2194439.
Regulated phosphorylation of secretory granule membrane proteins of the rat parotid gland.Marino CR, Castle JD, Gorelick FS. Am J Physiol. 1990 Jul. PMID: 1695488.
Development of secretagogue responsiveness in the pancreas.Jamieson JD, Gorelick FS, Chang A. Scand J Gastroenterol Suppl. 1988. PMID: 2852401.
Calcium-calmodulin-stimulated protein kinase in developing pancreas.Gorelick FS, Chang A, Jamieson JD. Am J Physiol. 1987 Oct. PMID: 3116856.
Second messenger systems and adaptation.Gorelick FS. Gut. 1987. PMID: 2826313.

Mateus Tavares Guerra, PhD

Cytosolic calcium regulates hepatic mitochondrial oxidation, intrahepatic lipolysis, and gluconeogenesis via CAMKII activation.LaMoia TE, Hubbard BT, Guerra MT, Nasiri A, Sakuma I, Kahn M, Zhang D, Goodman RP, Nathanson MH, Sancak Y, Perelis M, Mootha VK, Shulman GI. Cell Metab. 2024 Oct 1; 2024 Aug 16. PMID: 39153480.
Neutrophils insert elastase into hepatocytes to regulate calcium signaling in alcohol-associated hepatitis.Ogino N, Leite MF, Guerra MT, Kruglov E, Asashima H, Hafler DA, Ito T, Pereira JP, Peiffer BJ, Sun Z, Ehrlich BE, Nathanson MH. J Clin Invest. 2024 Jun 25; 2024 Jun 25. PMID: 38916955.
Above the legal limit: Alcohol brings ER and mitochondria too close together.Guerra MT, Nathanson MH. Cell Calcium. 2023 Jul; 2023 May 22. PMID: 37235972.
Molecular determinants of peri-apical targeting of inositol 1,4,5-trisphosphate receptor type 3 in cholangiocytes.Rodrigues MA, Gomes DA, Fiorotto R, Guerra MT, Weerachayaphorn J, Bo T, Sessa WC, Strazzabosco M, Nathanson MH. Hepatol Commun. 2022 Oct; 2022 Jul 19. PMID: 35852334.
Correlation Between Clinical and Pathological Findings of Liver Injury in 27 Patients With Lethal COVID-19 Infections in Brazil.Santana MF, Guerra MT, Hundt MA, Ciarleglio MM, Pinto RAA, Dutra BG, Xavier MS, Lacerda MVG, Ferreira AJ, Wanderley DC, Borges do Nascimento IJ, Araújo RFA, Pinheiro SVB, Araújo SA, Leite MF, Ferreira LCL, Nathanson MH, Vieira Teixeira Vidigal P. Hepatol Commun. 2022 Feb; 2021 Sep 14. PMID: 34520633.
Neutrophils interact with cholangiocytes to cause cholestatic changes in alcoholic hepatitis.Takeuchi M, Vidigal PT, Guerra MT, Hundt MA, Robert ME, Olave-Martinez M, Aoki S, Khamphaya T, Kersten R, Kruglov E, de la Rosa Rodriguez R, Banales JM, Nathanson MH, Weerachayaphorn J. Gut. 2021 Feb; 2020 Nov 19. PMID: 33214166.
Inositol 1,4,5-trisphosphate receptor type 3 plays a protective role in hepatocytes during hepatic ischemia-reperfusion injury.Lima Filho ACM, França A, Florentino RM, Dos Santos ML, de Oliveira Lemos F, Missiaggia DG, Fonseca RC, Gustavo Oliveira A, Ananthanarayanan M, Guerra MT, de Castro Fonseca M, Vidigal PVT, Lima CX, Nathanson MH, Fatima Leite M. Cell Calcium. 2020 Nov; 2020 Aug 11. PMID: 32957029.
Glucagon stimulates gluconeogenesis by INSP3R1-mediated hepatic lipolysis.Perry RJ, Zhang D, Guerra MT, Brill AL, Goedeke L, Nasiri AR, Rabin-Court A, Wang Y, Peng L, Dufour S, Zhang Y, Zhang XM, Butrico GM, Toussaint K, Nozaki Y, Cline GW, Petersen KF, Nathanson MH, Ehrlich BE, Shulman GI. Nature. 2020 Mar; 2020 Mar 4. PMID: 32132708.
Type 3 Inositol 1,4,5-Trisphosphate Receptor Is Increased and Enhances Malignant Properties in Cholangiocarcinoma.Ueasilamongkol P, Khamphaya T, Guerra MT, Rodrigues MA, Gomes DA, Kong Y, Wei W, Jain D, Trampert DC, Ananthanarayanan M, Banales JM, Roberts LR, Farshidfar F, Nathanson MH, Weerachayaphorn J. Hepatology. 2020 Feb; 2019 Aug 19. PMID: 31251815.
Type 3 inositol 1,4,5-trisphosphate receptor: A calcium channel for all seasons.Mangla A, Guerra MT, Nathanson MH. Cell Calcium. 2020 Jan; 2019 Nov 25. PMID: 31790953.
Expression of the type 3 InsP(3) receptor is a final common event in the development of hepatocellular carcinoma.Guerra MT, Florentino RM, Franca A, Lima Filho AC, Dos Santos ML, Fonseca RC, Lemos FO, Fonseca MC, Kruglov E, Mennone A, Njei B, Gibson J, Guan F, Cheng YC, Ananthanarayanan M, Gu J, Jiang J, Zhao H, Lima CX, Vidigal PT, Oliveira AG, Nathanson MH, Leite MF. Gut. 2019 Sep; 2019 Jul 17. PMID: 31315892.
Effects of Endotoxin on Type 3 Inositol 1,4,5-Trisphosphate Receptor in Human Cholangiocytes.Franca A, Carlos Melo Lima Filho A, Guerra MT, Weerachayaphorn J, Loiola Dos Santos M, Njei B, Robert M, Xavier Lima C, Vieira Teixeira Vidigal P, Banales JM, Ananthanarayanam M, Leite MF, Nathanson MH. Hepatology. 2019 Feb; 2018 Dec 31. PMID: 30141207.
Type 2 inositol trisphosphate receptor gene expression in hepatocytes is regulated by cyclic AMP.Kruglov E, Ananthanarayanan M, Sousa P, Weerachayaphorn J, Guerra MT, Nathanson MH. Biochem Biophys Res Commun. 2017 May 6; 2017 Mar 19. PMID: 28327356.
Hepatic Inositol 1,4,5 Trisphosphate Receptor Type 1 Mediates Fatty Liver.Feriod CN, Oliveira AG, Guerra MT, Nguyen L, Richards KM, Jurczak MJ, Ruan HB, Camporez JP, Yang X, Shulman GI, Bennett AM, Nathanson MH, Ehrlich BE. Hepatol Commun. 2017 Feb; 2016 Nov 11. PMID: 28966992.
Mitochondrial MIsCUes in liver regeneration.Guerra MT. Hepatology. 2016 Nov; 2016 Sep 30. PMID: 27629287.
Calcium signaling and secretion in cholangiocytes.Guerra MT, Nathanson MH. Pancreatology. 2015 Jul; 2015 Jun 12. PMID: 26100660.
Post-translational regulation of the type III inositol 1,4,5-trisphosphate receptor by miRNA-506.Ananthanarayanan M, Banales JM, Guerra MT, Spirli C, Munoz-Garrido P, Mitchell-Richards K, Tafur D, Saez E, Nathanson MH. J Biol Chem. 2015 Jan 2; 2014 Nov 5. PMID: 25378392.
Type 2 inositol 1,4,5-trisphosphate receptor modulates bile salt export pump activity in rat hepatocytes.Kruglov EA, Gautam S, Guerra MT, Nathanson MH. Hepatology. 2011 Nov; 2011 Aug 30. PMID: 21748767.
Regulation of multidrug resistance-associated protein 2 by calcium signaling in mouse liver.Cruz LN, Guerra MT, Kruglov E, Mennone A, Garcia CR, Chen J, Nathanson MH. Hepatology. 2010 Jul. PMID: 20578149.
Lipid rafts establish calcium waves in hepatocytes.Nagata J, Guerra MT, Shugrue CA, Gomes DA, Nagata N, Nathanson MH. Gastroenterology. 2007 Jul; 2007 Apr 11. PMID: 17631147.
The spatial distribution of inositol 1,4,5-trisphosphate receptor isoforms shapes Ca2+ waves.Hernandez E, Leite MF, Guerra MT, Kruglov EA, Bruna-Romero O, Rodrigues MA, Gomes DA, Giordano FJ, Dranoff JA, Nathanson MH. J Biol Chem. 2007 Mar 30; 2007 Feb 6. PMID: 17284437.
Calcium release from ryanodine receptors in the nucleoplasmic reticulum.Marius P, Guerra MT, Nathanson MH, Ehrlich BE, Leite MF. Cell Calcium. 2006 Jan; 2005 Nov 9. PMID: 16289270.
Protein 4.1N does not interact with the inositol 1,4,5-trisphosphate receptor in an epithelial cell line.Sehgal S, Guerra MT, Kruglov EA, Wang J, Nathanson MH. Cell Calcium. 2005 Nov. PMID: 16122796.
Endotoxin unmasks the role of gap junctions in the liver.Correa PR, Guerra MT, Leite MF, Spray DC, Nathanson MH. Biochem Biophys Res Commun. 2004 Sep 24. PMID: 15336523.
Regulation of calcium signals in the nucleus by a nucleoplasmic reticulum.Echevarría W, Leite MF, Guerra MT, Zipfel WR, Nathanson MH. Nat Cell Biol. 2003 May. PMID: 12717445.

Matija Hedl, PhD

Ubiquitination of ATF6 by disease-associated RNF186 promotes the innate receptor-induced unfolded protein response.Ranjan K, Hedl M, Sinha S, Zhang X, Abraham C. J Clin Invest. 2021 Sep 1. PMID: 34623328.
The E3 ubiquitin ligase RNF186 and RNF186 risk variants regulate innate receptor-induced outcomes.Ranjan K, Hedl M, Abraham C. Proc Natl Acad Sci U S A. 2021 Aug 10. PMID: 34353900.
TNFSF15 Promotes Antimicrobial Pathways in Human Macrophages and These Are Modulated by TNFSF15 Disease-Risk Variants.Sun R, Hedl M, Abraham C. Cell Mol Gastroenterol Hepatol. 2021; 2020 Aug 19. PMID: 32827707.
Disease Risk-Associated Genetic Variants in STAT1 and STAT4 Function in a Complementary Manner to Increase Pattern-Recognition Receptor-Induced Outcomes in Human Macrophages.Hedl M, Sun R, Abraham C. J Immunol. 2020 Sep 1; 2020 Jul 13. PMID: 32661180.
Myeloid Cell-Intrinsic IRF5 Promotes T Cell Responses through Multiple Distinct Checkpoints In Vivo, and IRF5 Immune-Mediated Disease Risk Variants Modulate These Myeloid Cell Functions.Yan J, Hedl M, Abraham C. J Immunol. 2020 Aug 15; 2020 Jul 20. PMID: 32690658.
IL23 induces IL23R recycling and amplifies innate receptor-induced signalling and cytokines in human macrophages, and the IBD-protective IL23R R381Q variant modulates these outcomes.Sun R, Hedl M, Abraham C. Gut. 2020 Feb; 2019 May 16. PMID: 31097538.
LACC1 Required for NOD2-Induced, ER Stress-Mediated Innate Immune Outcomes in Human Macrophages and LACC1 Risk Variants Modulate These Outcomes.Huang C, Hedl M, Ranjan K, Abraham C. Cell Rep. 2019 Dec 24. PMID: 31875558.
STAT3 and STAT5 Signaling Thresholds Determine Distinct Regulation for Innate Receptor-Induced Inflammatory Cytokines, and STAT3/STAT5 Disease Variants Modulate These Outcomes.Hedl M, Sun R, Huang C, Abraham C. J Immunol. 2019 Dec 15; 2019 Nov 15. PMID: 31732533.
Twist1 and Twist2 Induce Human Macrophage Memory upon Chronic Innate Receptor Treatment by HDAC-Mediated Deacetylation of Cytokine Promoters.Sun R, Hedl M, Abraham C. J Immunol. 2019 Jun 1; 2019 Apr 26. PMID: 31028123.
IRF5 Is Required for Bacterial Clearance in Human M1-Polarized Macrophages, and IRF5 Immune-Mediated Disease Risk Variants Modulate This Outcome.Hedl M, Yan J, Witt H, Abraham C. J Immunol. 2019 Feb 1; 2018 Dec 28. PMID: 30593537.
INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling.Luong P, Hedl M, Yan J, Zuo T, Fu TM, Jiang X, Thiagarajah JR, Hansen SH, Lesser CF, Wu H, Abraham C, Lencer WI. Elife. 2018 Oct 25; 2018 Oct 25. PMID: 30355448.
E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP.Bist P, Cheong WS, Ng A, Dikshit N, Kim BH, Pulloor NK, Khameneh HJ, Hedl M, Shenoy AR, Balamuralidhar V, Malik NBA, Hong M, Neutzner A, Chin KC, Kobayashi KS, Bertoletti A, Mortellaro A, Abraham C, MacMicking JD, Xavier RJ, Sukumaran B. Nat Commun. 2017 Jun 28; 2017 Jun 28. PMID: 28656966.
Human LACC1 increases innate receptor-induced responses and a LACC1 disease-risk variant modulates these outcomes.Lahiri A, Hedl M, Yan J, Abraham C. Nat Commun. 2017 Jun 8; 2017 Jun 8. PMID: 28593945.
ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation.Schumacher MA, Hedl M, Abraham C, Bernard JK, Lozano PR, Hsieh JJ, Almohazey D, Bucar EB, Punit S, Dempsey PJ, Frey MR. Cell Death Dis. 2017 Feb 23; 2017 Feb 23. PMID: 28230865.
JAK2 Disease-Risk Variants Are Gain of Function and JAK Signaling Threshold Determines Innate Receptor-Induced Proinflammatory Cytokine Secretion in Macrophages.Hedl M, Proctor DD, Abraham C. J Immunol. 2016 Nov 1; 2016 Sep 23. PMID: 27664279.
A TPL2 (MAP3K8) disease-risk polymorphism increases TPL2 expression thereby leading to increased pattern recognition receptor-initiated caspase-1 and caspase-8 activation, signalling and cytokine secretion.Hedl M, Abraham C. Gut. 2016 Nov; 2015 Jul 27. PMID: 26215868.
IRF5 and IRF5 Disease-Risk Variants Increase Glycolysis and Human M1 Macrophage Polarization by Regulating Proximal Signaling and Akt2 Activation.Hedl M, Yan J, Abraham C. Cell Rep. 2016 Aug 30; 2016 Aug 18. PMID: 27545875.
MTMR3 risk allele enhances innate receptor-induced signaling and cytokines by decreasing autophagy and increasing caspase-1 activation.Lahiri A, Hedl M, Abraham C. Proc Natl Acad Sci U S A. 2015 Aug 18; 2015 Aug 3. PMID: 26240347.
Twist1 and Twist2 Contribute to Cytokine Downregulation following Chronic NOD2 Stimulation of Human Macrophages through the Coordinated Regulation of Transcriptional Repressors and Activators.Zheng S, Hedl M, Abraham C. J Immunol. 2015 Jul 1; 2015 May 27. PMID: 26019273.
TAM receptor-dependent regulation of SOCS3 and MAPKs contributes to proinflammatory cytokine downregulation following chronic NOD2 stimulation of human macrophages.Zheng S, Hedl M, Abraham C. J Immunol. 2015 Feb 15; 2015 Jan 7. PMID: 25567680.
A TNFSF15 disease-risk polymorphism increases pattern-recognition receptor-induced signaling through caspase-8-induced IL-1.Hedl M, Abraham C. Proc Natl Acad Sci U S A. 2014 Sep 16; 2014 Sep 2. PMID: 25197060.
The IL18RAP region disease polymorphism decreases IL-18RAP/IL-18R1/IL-1R1 expression and signaling through innate receptor-initiated pathways.Hedl M, Zheng S, Abraham C. J Immunol. 2014 Jun 15; 2014 May 19. PMID: 24842757.
Pattern recognition receptor signaling in human dendritic cells is enhanced by ICOS ligand and modulated by the Crohn's disease ICOSLG risk allele.Hedl M, Lahiri A, Ning K, Cho JH, Abraham C. Immunity. 2014 May 15. PMID: 24837102.
NLRP1 and NLRP3 inflammasomes are essential for distinct outcomes of decreased cytokines but enhanced bacterial killing upon chronic Nod2 stimulation.Hedl M, Abraham C. Am J Physiol Gastrointest Liver Physiol. 2013 Mar 15; 2013 Jan 3. PMID: 23287275.
Negative regulation of human mononuclear phagocyte function.Hedl M, Abraham C. Mucosal Immunol. 2013 Mar; 2013 Jan 23. PMID: 23340822.
Nod2-induced autocrine interleukin-1 alters signaling by ERK and p38 to differentially regulate secretion of inflammatory cytokines.Hedl M, Abraham C. Gastroenterology. 2012 Dec; 2012 Sep 8. PMID: 22967725.
IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine.Huber S, Gagliani N, Zenewicz LA, Huber FJ, Bosurgi L, Hu B, Hedl M, Zhang W, O'Connor W Jr, Murphy AJ, Valenzuela DM, Yancopoulos GD, Booth CJ, Cho JH, Ouyang W, Abraham C, Flavell RA. Nature. 2012 Nov 8; 2012 Oct 17. PMID: 23075849.
IRF5 risk polymorphisms contribute to interindividual variance in pattern recognition receptor-mediated cytokine secretion in human monocyte-derived cells.Hedl M, Abraham C. J Immunol. 2012 Jun 1; 2012 Apr 27. PMID: 22544929.
Distinct roles for Nod2 protein and autocrine interleukin-1beta in muramyl dipeptide-induced mitogen-activated protein kinase activation and cytokine secretion in human macrophages.Hedl M, Abraham C. J Biol Chem. 2011 Jul 29; 2011 Jun 9. PMID: 21659536.
Secretory mediators regulate Nod2-induced tolerance in human macrophages.Hedl M, Abraham C. Gastroenterology. 2011 Jan; 2010 Sep 18. PMID: 20854823.

Avlin Barlow Imaeda, MD, PhD

Preclinical endoscopic training using a part-task simulator: learning curve assessment and determination of threshold score for advancement to clinical endoscopy.Jirapinyo P, Abidi WM, Aihara H, Zaki T, Tsay C, Imaeda AB, Thompson CC. Surg Endosc. 2017 Oct; 2017 Feb 22. PMID: 28229238.
Unsuspected Colonic Hemorrhage Found on Screening Colonoscopy.Jangouk P, Chang JJ, Imaeda AB. Gastroenterology. 2017 May; 2017 Apr 4. PMID: 28384453.
Small Intestinal Angioectasias Are Not Randomly Distributed in the Small Bowel and Most May Be Reached by Push Enteroscopy.Plotkin E, Imaeda A. J Clin Gastroenterol. 2016 Aug. PMID: 26485105.
Quantification of Adequate Bowel Preparation for Screening or Surveillance Colonoscopy in Men.Clark BT, Protiva P, Nagar A, Imaeda A, Ciarleglio MM, Deng Y, Laine L. Gastroenterology. 2016 Feb; 2015 Oct 9. PMID: 26439436.
Endoscopic training in gastroenterology fellowship: adherence to core curriculum guidelines.Jirapinyo P, Imaeda AB, Thompson CC. Surg Endosc. 2015 Dec; 2015 Mar 24. PMID: 25801105.
Confocal laser endomicroscopy for the detection of atrophic gastritis: a new application for confocal endomicroscopy?Imaeda A. J Clin Gastroenterol. 2015 May-Jun. PMID: 25811115.
Cell death and fibrogenesis.Mehal W, Imaeda A. Semin Liver Dis. 2010 Aug; 2010 Jul 21. PMID: 20665375.
What is most important to patients when deciding about colorectal screening?Imaeda A, Bender D, Fraenkel L. J Gen Intern Med. 2010 Jul; 2010 Mar 23. PMID: 20309740.
Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome.Imaeda AB, Watanabe A, Sohail MA, Mahmood S, Mohamadnejad M, Sutterwala FS, Flavell RA, Mehal WZ. J Clin Invest. 2009 Feb; 2009 Jan 26. PMID: 19164858.
A pilot project examining the predicted preferences of patients and physicians in the primary prophylaxis of variceal hemorrhage.Longacre AV, Imaeda A, Garcia-Tsao G, Fraenkel L. Hepatology. 2008 Jan. PMID: 17935182.

Yasuko Iwakiri, PhD

Guidelines for the diagnosis and treatment of idiopathic portal hypertension, extrahepatic portal obstruction, and Budd-Chiari syndrome in Japan.Furuichi Y, Kage M, Ohta M, Ohfuji S, Sasaki H, Hidaka H, Yoshida H, Kanto T, Kusano H, Akahoshi T, Obara K, Hashizume M, Kuniyoshi Y, Kawaguchi T, Okubo H, Ishikawa T, Hirooka M, Iwakiri Y, Nio M, Tanaka A. Hepatol Res. 2024 Nov; 2024 Oct 4. PMID: 39364631.
Carbon monoxide-loaded red blood cells ameliorate metabolic dysfunction-associated steatohepatitis progression via enhancing AMP-activated protein kinase activity and inhibiting Kupffer cell activation.Yanagisawa H, Maeda H, Noguchi I, Tanaka M, Wada N, Nagasaki T, Kobayashi K, Kanazawa G, Taguchi K, Chuang VTG, Sakai H, Nakashima H, Kinoshita M, Kitagishi H, Iwakiri Y, Sasaki Y, Tanaka Y, Otagiri M, Watanabe H, Maruyama T. Redox Biol. 2024 Oct; 2024 Aug 17. PMID: 39163766.
Unlocking the role of liver sinusoidal endothelial cells: Key players in liver fibrosis: Editorial on "Liver sinusoidal endothelial cell: An important yet often overlooked player in the liver fibrosis".Iwakiri Y. Clin Mol Hepatol. 2024 Oct; 2024 May 10. PMID: 38726502.
Nogo-B inhibition facilitates cholesterol metabolism to reduce hypercholesterolemia.Xue C, Zeng P, Gong K, Li Q, Feng Z, Wang M, Chen S, Yang Y, Li J, Zhang S, Yin Z, Liang Y, Yan T, Yu M, Feng K, Zhao D, Yang X, Zhang X, Ma L, Iwakiri Y, Chen L, Tang X, Chen Y, Chen H, Duan Y. Cell Rep. 2024 Sep 24; 2024 Sep 3. PMID: 39235944.
Publisher Correction: Intestinal Nogo-B reduces GLP1 levels by binding to proglucagon on the endoplasmic reticulum to inhibit PCSK1 cleavage.Gong K, Xue C, Feng Z, Pan R, Wang M, Chen S, Chen Y, Guan Y, Dai L, Zhang S, Jiang L, Li L, Wang B, Yin Z, Ma L, Iwakiri Y, Tang J, Liao C, Chen H, Duan Y. Nat Commun. 2024 Sep 10; 2024 Sep 10. PMID: 39256382.
Intestinal Nogo-B reduces GLP1 levels by binding to proglucagon on the endoplasmic reticulum to inhibit PCSK1 cleavage.Gong K, Xue C, Feng Z, Pan R, Wang M, Chen S, Chen Y, Guan Y, Dai L, Zhang S, Jiang L, Li L, Wang B, Yin Z, Ma L, Iwakiri Y, Tang J, Liao C, Chen H, Duan Y. Nat Commun. 2024 Aug 10; 2024 Aug 10. PMID: 39122737.
Interleukin-7-based identification of liver lymphatic endothelial cells reveals their unique structural features.Yang Y, Jeong J, Su T, Lai S, Zhang P, Garcia-Milian R, Graham M, Liu X, McConnell MJ, Utsumi T, Pereira J, Iwakiri Y. JHEP Rep. 2024 Jul; 2024 Mar 18. PMID: 38966234.
Berberine protects mice against type 2 diabetes by promoting PPARγ-FGF21-GLUT2-regulated insulin sensitivity and glucose/lipid homeostasis.Chen Y, Li Q, Zhao S, Sun L, Yin Z, Wang X, Li X, Iwakiri Y, Han J, Duan Y. Biochem Pharmacol. 2023 Dec; 2023 Nov 17. PMID: 37979703.
Lymphatic drainage dysfunction is related to clinically significant portal hypertension.Ma R, Iwakiri Y. Hepatol Int. 2023 Dec; 2023 Sep 24. PMID: 37743398.
The Sympathetic Nervous System Promotes Hepatic Lymphangiogenesis, which Is Protective Against Liver Fibrosis.Tanaka M, Jeong J, Thomas C, Zhang X, Zhang P, Saruwatari J, Kondo R, McConnell MJ, Utsumi T, Iwakiri Y. Am J Pathol. 2023 Dec; 2023 Sep 4. PMID: 37673329.
An optimized visualization and quantitative protocol for in-depth evaluation of lymphatic vessel architecture in the liver.Jeong J, Tanaka M, Yang Y, Arefyev N, DiRito J, Tietjen G, Zhang X, McConnell MJ, Utsumi T, Iwakiri Y. Am J Physiol Gastrointest Liver Physiol. 2023 Nov 1; 2023 Aug 22. PMID: 37605828.
S-nitrosylation of EMMPRIN influences the migration of HSCs and MMP activity in liver fibrosis.Zhu X, Tang Z, Li W, Li X, Iwakiri Y, Liu F. Acta Biochim Biophys Sin (Shanghai). 2023 Oct 25. PMID: 37700592.
What is in a name? Toward culturally sensitive nomenclature for liver disease in the east and west.Kim 金雄來 WR, Iwakiri 岩切泰子 Y, Lok 駱淑芳 ASF. Hepatology. 2023 Oct 1; 2023 Apr 19. PMID: 37070237.
Protocol for enrichment, purification, and cytocentrifugation of mouse liver endothelial cells.Chowdhury S, Fried KD, Iwakiri Y, Brancale J, Vilarinho S. STAR Protoc. 2023 Sep 15; 2023 Jul 28. PMID: 37515764.
Encapsulation of an Antioxidant in Redox-Sensitive Self-Assembled Albumin Nanoparticles for the Treatment of Hepatitis.Yasuda K, Maeda H, Kinoshita R, Minayoshi Y, Mizuta Y, Nakamura Y, Imoto S, Nishi K, Yamasaki K, Sakuragi M, Nakamura T, Ikeda-Imafuku M, Iwao Y, Ishima Y, Ishida T, Iwakiri Y, Otagiri M, Watanabe H, Maruyama T. ACS Nano. 2023 Sep 12; 2023 Aug 14. PMID: 37579503.
Endotheliopathy of liver sinusoidal endothelial cells in liver disease.Kondo R, Iwakiri Y, Kage M, Yano H. Pathol Int. 2023 Sep; 2023 Aug 17. PMID: 37589433.
The evolving role of liver sinusoidal endothelial cells in liver health and disease.McConnell MJ, Kostallari E, Ibrahim SH, Iwakiri Y. Hepatology. 2023 Aug 1; 2023 Jan 3. PMID: 36626620.
Lymphatics in the liver for translational science.Iwakiri Y. Clin Liver Dis (Hoboken). 2023 Apr; 2023 Feb 24. PMID: 37936952.
Overexpression of NgBR inhibits high-fat diet-induced atherosclerosis in ApoE-deficiency mice.Gong K, Wang M, Wang D, Gao Y, Ma L, Yang X, Zhu X, Chen S, Zhang M, Li H, Chen Y, Hu W, Miao QR, Iwakiri Y, Liao C, Duan Y, Han J. Hepatol Commun. 2023 Apr 1; 2023 Mar 30. PMID: 36996002.
Portal Hypertension in Alcohol-Associated Hepatitis.McConnell MJ, Iwakiri Y. Curr Hepatol Rep. 2023; 2023 Apr 5. PMID: 37214274.
Hepatic lymphatic vascular system in health and disease.Jeong J, Tanaka M, Iwakiri Y. J Hepatol. 2022 Jul; 2022 Feb 11. PMID: 35157960.
Inhibition of high-fat diet-induced obesity via reduction of ER-resident protein Nogo occurs through multiple mechanisms.Wang X, Yang Y, Zhao D, Zhang S, Chen Y, Chen Y, Feng K, Li X, Han J, Iwakiri Y, Duan Y, Yang X. J Biol Chem. 2022 Feb; 2022 Jan 5. PMID: 34998825.
Covid-19 and Liver Injury: Role of Inflammatory Endotheliopathy, Platelet Dysfunction, and Thrombosis.McConnell MJ, Kondo R, Kawaguchi N, Iwakiri Y. Hepatol Commun. 2022 Feb; 2021 Nov 10. PMID: 34658172.
Nitric oxide facilitates the targeting Kupffer cells of a nano-antioxidant for the treatment of NASH.Maeda H, Ishima Y, Saruwatari J, Mizuta Y, Minayoshi Y, Ichimizu S, Yanagisawa H, Nagasaki T, Yasuda K, Oshiro S, Taura M, McConnell MJ, Oniki K, Sonoda K, Wakayama T, Kinoshita M, Shuto T, Kai H, Tanaka M, Sasaki Y, Iwakiri Y, Otagiri M, Watanabe H, Maruyama T. J Control Release. 2022 Jan; 2021 Nov 29. PMID: 34856227.
Pathological characteristics of liver sinusoidal thrombosis in COVID-19 patients: A series of 43 cases.Kondo R, Kawaguchi N, McConnell MJ, Sonzogni A, Licini L, Valle C, Bonaffini PA, Sironi S, Alessio MG, Previtali G, Seghezzi M, Zhang X, Sun Z, Utsumi T, Strazzabosco M, Iwakiri Y. Hepatol Res. 2021 Sep; 2021 Aug 2. PMID: 34260803.
Liver injury in COVID-19 and IL-6 trans-signaling-induced endotheliopathy.McConnell MJ, Kawaguchi N, Kondo R, Sonzogni A, Licini L, Valle C, Bonaffini PA, Sironi S, Alessio MG, Previtali G, Seghezzi M, Zhang X, Lee AI, Pine AB, Chun HJ, Zhang X, Fernandez-Hernando C, Qing H, Wang A, Price C, Sun Z, Utsumi T, Hwa J, Strazzabosco M, Iwakiri Y. J Hepatol. 2021 Sep; 2021 May 13. PMID: 33991637.
Portal hypertension in cirrhosis: Pathophysiological mechanisms and therapy.Iwakiri Y, Trebicka J. JHEP Rep. 2021 Aug; 2021 Jun 4. PMID: 34337369.
Alcohol-induced Hsp90 acetylation is a novel driver of liver sinusoidal endothelial dysfunction and alcohol-related liver disease.Yang Y, Sangwung P, Kondo R, Jung Y, McConnell MJ, Jeong J, Utsumi T, Sessa WC, Iwakiri Y. J Hepatol. 2021 Aug; 2021 Mar 3. PMID: 33675874.
Enhanced Meningeal Lymphatic Drainage Ameliorates Neuroinflammation and Hepatic Encephalopathy in Cirrhotic Rats.Hsu SJ, Zhang C, Jeong J, Lee SI, McConnell M, Utsumi T, Iwakiri Y. Gastroenterology. 2021 Mar; 2020 Nov 20. PMID: 33227282.
Single-Cell Transcriptomics Reveals Zone-Specific Alterations of Liver Sinusoidal Endothelial Cells in Cirrhosis.Su T, Yang Y, Lai S, Jeong J, Jung Y, McConnell M, Utsumi T, Iwakiri Y. Cell Mol Gastroenterol Hepatol. 2021; 2020 Dec 16. PMID: 33340713.
Lymphatic Dysfunction as a Novel Therapeutic Target in Nonalcoholic Steatohepatitis.Jeong J, Iwakiri Y. Cell Mol Gastroenterol Hepatol. 2021; 2020 Nov 18. PMID: 33220266.
Reduced Nogo expression inhibits diet-induced metabolic disorders by regulating ChREBP and insulin activity.Zhang S, Guo F, Yu M, Yang X, Yao Z, Li Q, Wei Z, Feng K, Zeng P, Zhao D, Li X, Zhu Y, Miao QR, Iwakiri Y, Chen Y, Han J, Duan Y. J Hepatol. 2020 Dec; 2020 Jul 29. PMID: 32738448.
The lymphatic system in alcohol-associated liver disease.Kondo R, Iwakiri Y. Clin Mol Hepatol. 2020 Oct; 2020 Sep 21. PMID: 32951411.
Endothelial Leukocyte Cell-Derived Chemotaxin 2/Tyrosine Kinase With Immunoglobulin-Like and Epidermal Growth Factor-Like Domains 1 Signaling in Liver Fibrosis.Su T, Iwakiri Y. Hepatology. 2020 Jul. PMID: 32060947.
O-GlcNAc transferase suppresses necroptosis and liver fibrosis.Zhang B, Li MD, Yin R, Liu Y, Yang Y, Mitchell-Richards KA, Nam JH, Li R, Wang L, Iwakiri Y, Chung D, Robert ME, Ehrlich BE, Bennett AM, Yu J, Nathanson MH, Yang X. JCI Insight. 2019 Nov 1; 2019 Nov 1. PMID: 31672932.
Digoxin improves steatohepatitis with differential involvement of liver cell subsets in mice through inhibition of PKM2 transactivation.Zhao P, Han SN, Arumugam S, Yousaf MN, Qin Y, Jiang JX, Torok NJ, Chen Y, Mankash MS, Liu J, Li J, Iwakiri Y, Ouyang X. Am J Physiol Gastrointest Liver Physiol. 2019 Oct 1; 2019 Aug 14. PMID: 31411894.
Poly(amine-co-ester) nanoparticles for effective Nogo-B knockdown in the liver.Cui J, Piotrowski-Daspit AS, Zhang J, Shao M, Bracaglia LG, Utsumi T, Seo YE, DiRito J, Song E, Wu C, Inada A, Tietjen GT, Pober JS, Iwakiri Y, Saltzman WM. J Control Release. 2019 Jun 28; 2019 May 1. PMID: 31054286.
Integrated analysis of microRNA and mRNA expression profiles in splenomegaly induced by non-cirrhotic portal hypertension in rats.Saruwatari J, Dong C, Utsumi T, Tanaka M, McConnell M, Iwakiri Y. Sci Rep. 2018 Dec 20; 2018 Dec 20. PMID: 30573742.
Development of Kupffer cell targeting type-I interferon for the treatment of hepatitis via inducing anti-inflammatory and immunomodulatory actions.Minayoshi Y, Maeda H, Yanagisawa H, Hamasaki K, Mizuta Y, Nishida K, Kinoshita R, Enoki Y, Imafuku T, Chuang VTG, Koga T, Fujiwara Y, Takeya M, Sonoda K, Wakayama T, Taguchi K, Ishima Y, Ishida T, Iwakiri Y, Tanaka M, Sasaki Y, Watanabe H, Otagiri M, Maruyama T. Drug Deliv. 2018 Nov. PMID: 29688069.
Lymphatics in the liver.Tanaka M, Iwakiri Y. Curr Opin Immunol. 2018 Aug; 2018 May 14. PMID: 29772409.
Is miR-21 a potent target for liver fibrosis?Lai S, Iwakiri Y. Hepatology. 2018 Jun; 2018 Apr 19. PMID: 29315674.
Biology of portal hypertension.McConnell M, Iwakiri Y. Hepatol Int. 2018 Feb; 2017 Oct 26. PMID: 29075990.
The portal hypertension syndrome: etiology, classification, relevance, and animal models.Bosch J, Iwakiri Y. Hepatol Int. 2018 Feb; 2017 Oct 24. PMID: 29064029.
Novel application and serial evaluation of tissue-engineered portal vein grafts in a murine model.Maxfield MW, Stacy MR, Kurobe H, Tara S, Yi T, Cleary MA, Zhuang ZW, Rodriguez-Davalos MI, Emre SH, Iwakiri Y, Shinoka T, Breuer CK. Regen Med. 2017 Dec; 2017 Dec 7. PMID: 29215317.
Corrigendum to "Hepatic dimethylarginine-dimethylaminohydrolase1 is reduced in cirrhosis and is a target for therapy in portal hypertension" [J Hepatol 62 (2015) 325-331].Mookerjee RP, Mehta G, Balasubramaniyan V, Mohamed FEZ, Davies N, Sharma V, Iwakiri Y, Jalan R. J Hepatol. 2017 Nov. PMID: 28893453.
Reply.Park JK, Iwakiri Y. Hepatology. 2017 Nov; 2017 Sep 29. PMID: 28745830.
Comparative efficacy and safety of antibody induction therapy for the treatment of kidney: a network meta-analysis.Shao M, Tian T, Zhu X, Ming Y, Iwakiri Y, Ye S, Ye Q. Oncotarget. 2017 Sep 12; 2017 Aug 2. PMID: 29029524.
Reply.Iwakiri Y. Hepatology. 2017 Jun; 2017 Apr 28. PMID: 28195342.
Alcohol and calcium make a potent cocktail.Iwakiri Y, Nathanson MH. J Physiol. 2017 May 15; 2017 Apr 18. PMID: 28295353.
An endoplasmic reticulum protein, Nogo-B, facilitates alcoholic liver disease through regulation of kupffer cell polarization.Park JK, Shao M, Kim MY, Baik SK, Cho MY, Utsumi T, Satoh A, Ouyang X, Chung C, Iwakiri Y. Hepatology. 2017 May; 2017 Mar 22. PMID: 28090670.
The Hepatic Lymphatic Vascular System: Structure, Function, Markers, and Lymphangiogenesis.Tanaka M, Iwakiri Y. Cell Mol Gastroenterol Hepatol. 2016 Nov; 2016 Sep 14. PMID: 28105461.
The lymphatic system: A new frontier in hepatology.Iwakiri Y. Hepatology. 2016 Sep; 2016 Jun 23. PMID: 27228259.
Cellular distribution of injected PLGA-nanoparticles in the liver.Park JK, Utsumi T, Seo YE, Deng Y, Satoh A, Saltzman WM, Iwakiri Y. Nanomedicine. 2016 Jul; 2016 Mar 4. PMID: 26961463.
Nitric oxide in liver fibrosis: The role of inducible nitric oxide synthase.Iwakiri Y. Clin Mol Hepatol. 2015 Dec; 2015 Dec 24. PMID: 26770919.
Pigment Epithelium-Derived Factor (PEDF) Inhibits Wnt/β-catenin Signaling in the Liver.Protiva P, Gong J, Sreekumar B, Torres R, Zhang X, Belinsky GS, Cornwell M, Crawford SE, Iwakiri Y, Chung C. Cell Mol Gastroenterol Hepatol. 2015 Sep 1; 2015 Jul 4. PMID: 26473164.
Nitric oxide in liver diseases.Iwakiri Y, Kim MY. Trends Pharmacol Sci. 2015 Aug; 2015 May 28. PMID: 26027855.
Nonalcoholic fatty liver disease induced by noncanonical Wnt and its rescue by Wnt3a.Wang S, Song K, Srivastava R, Dong C, Go GW, Li N, Iwakiri Y, Mani A. FASEB J. 2015 Aug; 2015 Apr 27. PMID: 25917329.
Can hypersplenism secondary to portal hypertension be treated by non-selective beta blockers?Kim MY, Iwakiri Y. Hepatol Int. 2015 Jul; 2015 Jan 25. PMID: 25788189.
Development of small diameter nanofiber tissue engineered arterial grafts.Kurobe H, Maxfield MW, Tara S, Rocco KA, Bagi PS, Yi T, Udelsman B, Zhuang ZW, Cleary M, Iwakiri Y, Breuer CK, Shinoka T. PLoS One. 2015; 2015 Apr 1. PMID: 25830942.
Hepatic dimethylarginine-dimethylaminohydrolase1 is reduced in cirrhosis and is a target for therapy in portal hypertension.Mookerjee RP, Mehta G, Balasubramaniyan V, Mohamed Fel Z, Davies N, Sharma V, Iwakiri Y, Jalan R. J Hepatol. 2015 Feb; 2014 Aug 23. PMID: 25152204.
Vascular pathobiology in chronic liver disease and cirrhosis - current status and future directions.Iwakiri Y, Shah V, Rockey DC. J Hepatol. 2014 Oct; 2014 Jun 6. PMID: 24911462.
Pathophysiology of portal hypertension.Iwakiri Y. Clin Liver Dis. 2014 May; 2014 Feb 25. PMID: 24679494.
Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling.Gattu AK, Birkenfeld AL, Iwakiri Y, Jay S, Saltzman M, Doll J, Protiva P, Samuel VT, Crawford SE, Chung C. Endocrinology. 2014 Apr; 2014 Jan 23. PMID: 24456163.
eNOS-derived nitric oxide regulates endothelial barrier function through VE-cadherin and Rho GTPases.Di Lorenzo A, Lin MI, Murata T, Landskroner-Eiger S, Schleicher M, Kothiya M, Iwakiri Y, Yu J, Huang PL, Sessa WC. J Cell Sci. 2013 Dec 15; 2013 Sep 17. PMID: 24046447.
Determination of mesenchymal stem cell fate by pigment epithelium-derived factor (PEDF) results in increased adiposity and reduced bone mineral content.Gattu AK, Swenson ES, Iwakiri Y, Samuel VT, Troiano N, Berry R, Church CD, Rodeheffer MS, Carpenter TO, Chung C. FASEB J. 2013 Nov; 2013 Jul 25. PMID: 23887690.
The lymphatic vascular system in liver diseases: its role in ascites formation.Chung C, Iwakiri Y. Clin Mol Hepatol. 2013 Jun; 2013 Jun 27. PMID: 23837133.
Reticulon 4B (Nogo-B) facilitates hepatocyte proliferation and liver regeneration in mice.Gao L, Utsumi T, Tashiro K, Liu B, Zhang D, Swenson ES, Iwakiri Y. Hepatology. 2013 May; 2013 Mar 19. PMID: 23299899.
Absence of Nogo-B (reticulon 4B) facilitates hepatic stellate cell apoptosis and diminishes hepatic fibrosis in mice.Tashiro K, Satoh A, Utsumi T, Chung C, Iwakiri Y. Am J Pathol. 2013 Mar; 2013 Jan 9. PMID: 23313137.
Activated hepatic stellate cells: negative regulators of hepatocyte proliferation in liver diseases.Chung C, Iwakiri Y. Hepatology. 2012 Jul. PMID: 22876366.
Intestinal and plasma VEGF levels in cirrhosis: the role of portal pressure.Huang HC, Haq O, Utsumi T, Sethasine S, Abraldes JG, Groszmann RJ, Iwakiri Y. J Cell Mol Med. 2012 May. PMID: 21801303.
A role of miR-33 for cell cycle progression and cell proliferation.Iwakiri Y. Cell Cycle. 2012 Mar 15; 2012 Mar 15. PMID: 22395363.
Endothelial dysfunction in the regulation of cirrhosis and portal hypertension.Iwakiri Y. Liver Int. 2012 Feb; 2011 Jul 5. PMID: 21745318.
Proteomic identification of S-nitrosylated Golgi proteins: new insights into endothelial cell regulation by eNOS-derived NO.Sangwung P, Greco TM, Wang Y, Ischiropoulos H, Sessa WC, Iwakiri Y. PLoS One. 2012; 2012 Feb 21. PMID: 22363674.
S-nitrosylation of proteins: a new insight into endothelial cell function regulated by eNOS-derived NO.Iwakiri Y. Nitric Oxide. 2011 Aug 1; 2011 Apr 30. PMID: 21554971.
Reticulon 4B (Nogo-B) is a novel regulator of hepatic fibrosis.Zhang D, Utsumi T, Huang HC, Gao L, Sangwung P, Chung C, Shibao K, Okamoto K, Yamaguchi K, Groszmann RJ, Jozsef L, Hao Z, Sessa WC, Iwakiri Y. Hepatology. 2011 Apr. PMID: 21480333.
Vascular biology and pathobiology of the liver: Report of a single-topic symposium.Iwakiri Y, Grisham M, Shah V. Hepatology. 2008 May. PMID: 18393322.
Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease.Fernández-Hernando C, Ackah E, Yu J, Suárez Y, Murata T, Iwakiri Y, Prendergast J, Miao RQ, Birnbaum MJ, Sessa WC. Cell Metab. 2007 Dec. PMID: 18054314.
The molecules: mechanisms of arterial vasodilatation observed in the splanchnic and systemic circulation in portal hypertension.Iwakiri Y. J Clin Gastroenterol. 2007 Nov-Dec. PMID: 17975478.
Nitric oxide synthase generates nitric oxide locally to regulate compartmentalized protein S-nitrosylation and protein trafficking.Iwakiri Y, Satoh A, Chatterjee S, Toomre DK, Chalouni CM, Fulton D, Groszmann RJ, Shah VH, Sessa WC. Proc Natl Acad Sci U S A. 2006 Dec 26; 2006 Dec 14. PMID: 17170139.
Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis.Ackah E, Yu J, Zoellner S, Iwakiri Y, Skurk C, Shibata R, Ouchi N, Easton RM, Galasso G, Birnbaum MJ, Walsh K, Sessa WC. J Clin Invest. 2005 Aug. PMID: 16075056.
Targeting of endothelial nitric-oxide synthase to the cytoplasmic face of the Golgi complex or plasma membrane regulates Akt- versus calcium-dependent mechanisms for nitric oxide release.Fulton D, Babbitt R, Zoellner S, Fontana J, Acevedo L, McCabe TJ, Iwakiri Y, Sessa WC. J Biol Chem. 2004 Jul 16; 2004 May 10. PMID: 15136572.
Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progression in mice.Gratton JP, Lin MI, Yu J, Weiss ED, Jiang ZL, Fairchild TA, Iwakiri Y, Groszmann R, Claffey KP, Cheng YC, Sessa WC. Cancer Cell. 2003 Jul. PMID: 12892711.
Mice with targeted deletion of eNOS develop hyperdynamic circulation associated with portal hypertension.Iwakiri Y, Cadelina G, Sessa WC, Groszmann RJ. Am J Physiol Gastrointest Liver Physiol. 2002 Nov. PMID: 12381520.
Phosphorylation of eNOS initiates excessive NO production in early phases of portal hypertension.Iwakiri Y, Tsai MH, McCabe TJ, Gratton JP, Fulton D, Groszmann RJ, Sessa WC. Am J Physiol Heart Circ Physiol. 2002 Jun. PMID: 12003815.

Priya Arvind Jamidar, FACG, FASGE, MBChB

EUS-guided Gastroenterostomy: A Multicenter International Study Comparing Benign and Malignant Diseases.Kahaleh M, Tyberg A, Sameera S, Sarkar A, Shahid HM, Abdelqader A, Gjeorgjievski M, Gaidhane M, Muniraj T, Jamidar PA, Aslanian HR, Abraham M, Lajin M, Kedia P, Nieto J, Parsa N, Andalib I, Bashir M, Kowalski TE, Loren DE, Kumar A, Schlachterman A, Chiang A, Holmes I, Mendoza Ladd AH, Oleas R, Zolotarevsky E, Robles-Medranda C, Barthet M. J Clin Gastroenterol. 2024 Jul 1; 2024 Jul 1. PMID: 37646532.
Clinical predictive value of renalase in post-ERCP pancreatitis.Muniraj T, Desir G, Gorelick FS, Guo X, Ciarleglio MM, Deng Y, Jamidar PA, Farrell J, Aslanian HR, Laine L. Gastrointest Endosc. 2024 May; 2023 Dec 14. PMID: 38103747.
GIE Editorial Board Top 10: advances in GI endoscopy in 2021.Qayed E, Chua TY, Mulki R, Yang D, Jamidar PA, Singh A, Leung FW, Yu JX, Lightdale JR. Gastrointest Endosc. 2022 Dec; 2022 Aug 7. PMID: 35948180.
Comorbidities Drive the Majority of Overall Mortality in Low-Risk Mucinous Pancreatic Cysts Under Surveillance.Chhoda A, Yousaf MN, Madhani K, Aslanian H, Jamidar PA, Suarez AL, Salem RR, Muniraj T, Kunstman JW, Farrell JJ. Clin Gastroenterol Hepatol. 2022 Mar; 2020 Dec 10. PMID: 33309984.
Juxta-papillary duodenal diverticula are associated with pyogenic liver abscesses: a case control study.Shankar U, Bhandari P, Panchal A, Weeks D, Wu H, Chen F, Maheshwari N, Bansal R, Walfish A, Baum J, Jamidar PA, Aron J. BMC Gastroenterol. 2022 Feb 7; 2022 Feb 7. PMID: 35130860.
Digital single-operator cholangioscopy interobserver study using a new classification: the Mendoza Classification (with video).Kahaleh M, Gaidhane M, Shahid HM, Tyberg A, Sarkar A, Ardengh JC, Kedia P, Andalib I, Gress F, Sethi A, Gan SI, Suresh S, Makar M, Bareket R, Slivka A, Widmer JL, Jamidar PA, Alkhiari R, Oleas R, Kim D, Robles-Medranda CA, Raijman I. Gastrointest Endosc. 2022 Feb; 2021 Aug 31. PMID: 34478737.
Evaluation of socioeconomic and healthcare disparities on same admission cholecystectomy after endoscopic retrograde cholangiopancreatography among patients with acute gallstone pancreatitis.Chouairi F, McCarty TR, Hathorn KE, Sharma P, Aslanian HR, Jamidar PA, Thompson CC, Muniraj T. Surg Endosc. 2022 Jan; 2021 Jan 22. PMID: 33481109.
GIE Editorial Board top 10 topics: advances in GI endoscopy in 2020.Chua TY, Kyanam Kabir Baig KR, Leung FW, Ashat M, Jamidar PA, Mulki R, Singh A, Yu JX, Lightdale JR. Gastrointest Endosc. 2021 Sep; 2021 Jun 17. PMID: 34147512.
Resection of pancreatic cystic neoplasms in recurrent acute pancreatitis prevents recurrent pancreatitis but does not identify more malignancies.Muniraj T, Aslanian HR, Laine L, Jamidar PA, Farrell JF, Mitchell KA, Salem RR. World J Gastroenterol. 2021 Apr 21. PMID: 33958848.
The Reply.Lam R, Jamidar PA, Aslanian HR, Muniraj T. Am J Med. 2020 Oct. PMID: 33004185.
Fitz-Hugh-Curtis Syndrome Presenting as Acute Abdomen.Lam R, Jamidar PA, Aslanian HR, Muniraj T. Am J Med. 2020 Oct; 2020 Apr 9. PMID: 32277885.
Endoscopic Resection of a Giant Duodenal Lipoma.Gnanapandithan K, Aslanian HR, Jamidar PA, Muniraj T. ACG Case Rep J. 2020 Mar; 2020 Mar 17. PMID: 32337302.
Comparative effectiveness of pharmacologic and endoscopic interventions for prevention of post-ERCP pancreatitis: a network meta-analysis.Njei B, McCarty TR, Muniraj T, Sharma P, Jamidar PA, Aslanian HR, Varadarajulu S, Navaneethan U. Endosc Int Open. 2020 Jan; 2020 Jan 8. PMID: 31921982.
Barium in the Bronchi: A Tracheoesophageal Fistula.Gnanapandithan K, Bramley K, Jamidar PA. ACG Case Rep J. 2019 Aug; 2019 Aug 21. PMID: 31737720.
Endoscopic Management of Pancreatic Fluid Collections.Muniraj T, Jamidar PA, Nealon WH, Aslanian HR. J Clin Gastroenterol. 2017 Jan. PMID: 27548730.
Can a Computerized Simulator Assess Skill Level and Improvement in Performance of ERCP?Sahakian AB, Laine L, Jamidar PA, Siddiqui UD, Duffy A, Ciarleglio MM, Deng Y, Nagar A, Aslanian HR. Dig Dis Sci. 2016 Mar; 2015 Nov 14. PMID: 26572779.
Incidence and predictors of post-ERCP pancreatitis in patients with suspected sphincter of Oddi dysfunction undergoing biliary or dual sphincterotomy: results from the EPISOD prospective multicenter randomized sham-controlled study.Yaghoobi M, Pauls Q, Durkalski V, Romagnuolo J, Fogel EL, Tarnasky PR, Aliperti G, Freeman ML, Kozarek RA, Jamidar PA, Wilcox CM, Elta GH, Hawes RH, Wood-Williams A, Cotton PB. Endoscopy. 2015 Oct; 2015 Jul 10. PMID: 26165739.
Is Advanced Endoscopy Training Worth it?Aslanian HR, Ahmed AM, Jamidar PA. Clin Gastroenterol Hepatol. 2015 Jul. PMID: 26091939.
A double-blind, randomized, sham-controlled trial of the effect of a radiation-attenuating drape on radiation exposure to endoscopy staff during ERCP.Muniraj T, Aslanian HR, Laine L, Farrell J, Ciarleglio MM, Deng Y, Ho H, Jamidar PA. Am J Gastroenterol. 2015 May; 2015 Mar 31. PMID: 25823765.
Endoscopic treatment of malignant biliary strictures.Rustagi T, Jamidar PA. Curr Gastroenterol Rep. 2015 Jan. PMID: 25613178.
Endoscopic management of benign biliary strictures.Rustagi T, Jamidar PA. Curr Gastroenterol Rep. 2015 Jan. PMID: 25613176.
Endoscopic retrograde cholangiopancreatography (ERCP)-related adverse events: post-ERCP pancreatitis.Rustagi T, Jamidar PA. Gastrointest Endosc Clin N Am. 2015 Jan. PMID: 25442962.
Endoscopic retrograde cholangiopancreatography-related adverse events: general overview.Rustagi T, Jamidar PA. Gastrointest Endosc Clin N Am. 2015 Jan. PMID: 25442961.
Intraductal radiofrequency ablation for management of malignant biliary obstruction.Rustagi T, Jamidar PA. Dig Dis Sci. 2014 Nov; 2014 Jun 7. PMID: 24906696.
Single-port pancreatectomy: ready for prime time.Rustagi T, Jamidar PA. J Clin Gastroenterol. 2014 Jul. PMID: 24781386.
Can patient and pain characteristics predict manometric sphincter of Oddi dysfunction in patients with clinically suspected sphincter of Oddi dysfunction?Romagnuolo J, Cotton PB, Durkalski V, Pauls Q, Brawman-Mintzer O, Drossman DA, Mauldin P, Orrell K, Williams AW, Fogel EL, Tarnasky PR, Aliperti G, Freeman ML, Kozarek RA, Jamidar PA, Wilcox CM, Serrano J, Elta GH. Gastrointest Endosc. 2014 May; 2014 Jan 25. PMID: 24472759.
Emphysematous Cholecystitis Resulting in Secondary Biliary Cirrhosis: A Rare Complication of Endoscopic Retrograde Cholangiopancreatography.Bari K, Aslanian HR, Pollak J, Reiner E, Salem RR, Taddei TH, Emre SH, Jamidar PA. ACG Case Rep J. 2013 Oct; 2013 Oct 8. PMID: 26157820.
Nurse observation during colonoscopy increases polyp detection: a randomized prospective study.Aslanian HR, Shieh FK, Chan FW, Ciarleglio MM, Deng Y, Rogart JN, Jamidar PA, Siddiqui UD. Am J Gastroenterol. 2013 Feb. PMID: 23381064.
High-definition confocal endomicroscopy of the common bile duct.Shieh FK, Drumm H, Nathanson MH, Jamidar PA. J Clin Gastroenterol. 2012 May-Jun. PMID: 22011583.
Endoscopic ultrasound and endoscopic retrograde cholangiopancreatography for obstructing pancreas head masses: combined or separate procedures?Aslanian HR, Estrada JD, Rossi F, Dziura J, Jamidar PA, Siddiqui UD. J Clin Gastroenterol. 2011 Sep. PMID: 21301359.
Fellow involvement may increase adenoma detection rates during colonoscopy.Rogart JN, Siddiqui UD, Jamidar PA, Aslanian HR. Am J Gastroenterol. 2008 Nov; 2008 Aug 27. PMID: 18759826.
Laparoscopic-assisted transgastric endoscopy: current indications and future implications.Roberts KE, Panait L, Duffy AJ, Jamidar PA, Bell RL. JSLS. 2008 Jan-Mar. PMID: 18402736.

Loren Laine, MD

Influence of patient characteristics on Helicobacter pylori eradication with Vonoprazan: A subgroup analysis of the pHalcon-HP trial.Chey WD, Mégraud F, Laine L, Smith N, Leifke E, Hunt B, Howden CW. JGH Open. 2024 Nov; 2024 Nov 15. PMID: 39554983.
AGA Clinical Practice Update on Integrating Potassium-Competitive Acid Blockers Into Clinical Practice: Expert Review.Patel A, Laine L, Moayyedi P, Wu J. Gastroenterology. 2024 Nov; 2024 Sep 11. PMID: 39269391.
Validation of an Electronic Health Record-Based Machine Learning Model Compared With Clinical Risk Scores for Gastrointestinal Bleeding.Shung DL, Chan CE, You K, Nakamura S, Saarinen T, Zheng NS, Simonov M, Li DK, Tsay C, Kawamura Y, Shen M, Hsiao A, Sekhon JS, Laine L. Gastroenterology. 2024 Nov; 2024 Jul 5. PMID: 38971198.
Vonoprazan is Efficacious for Treatment of Heartburn in Non-erosive Reflux Disease: A Randomized Trial.Laine L, Spechler S, Yadlapati R, Schnoll-Sussman F, Smith N, Leifke E, Harris T, Hunt B, Fass R, Katz P. Clin Gastroenterol Hepatol. 2024 Nov; 2024 May 14. PMID: 38750866.
Detection of Gastrointestinal Bleeding With Large Language Models to Aid Quality Improvement and Appropriate Reimbursement.Zheng NS, Keloth VK, You K, Kats D, Li DK, Deshpande O, Sachar H, Xu H, Laine L, Shung DL. Gastroenterology. 2024 Sep 18; 2024 Sep 18. PMID: 39304088.
Letter to the Editor: Endoscopy for potential variceal bleeding within 12 hours-Not so fast!Laine L, Barkun AN, Leontiadis GI. Hepatology. 2024 Jul 1; 2024 Apr 12. PMID: 38607699.
Comparison of Los Angeles Grades of Erosive Esophagitis Scored by Local Investigators vs Central Adjudicators in a Clinical Trial.Spechler SJ, Laine L, DeVault KR, Nabulsi A, Hunt B, Katz P. Clin Gastroenterol Hepatol. 2024 May 20; 2024 May 20. PMID: 38777170.
Review article: Upper gastrointestinal bleeding - review of current evidence and implications for management.Shung DL, Laine L. Aliment Pharmacol Ther. 2024 May; 2024 Mar 22. PMID: 38517201.
AGA Clinical Practice Update on High-Quality Upper Endoscopy: Expert Review.Nagula S, Parasa S, Laine L, Shah SC. Clin Gastroenterol Hepatol. 2024 May; 2024 Feb 22. PMID: 38385942.
Clinical predictive value of renalase in post-ERCP pancreatitis.Muniraj T, Desir G, Gorelick FS, Guo X, Ciarleglio MM, Deng Y, Jamidar PA, Farrell J, Aslanian HR, Laine L. Gastrointest Endosc. 2024 May; 2023 Dec 14. PMID: 38103747.
Impact of large scale, multicomponent intervention to reduce proton pump inhibitor overuse in integrated healthcare system: difference-in-difference study.Kurlander JE, Laine L, Kim HM, Roberts CB, Saffar D, Myers A, Holleman R, Gao Y, Shank M, Nelson R, Forman J, Helfrich CD, Krein SL, Saini SD, Yang YX. BMJ. 2024 Apr 11; 2024 Apr 11. PMID: 38604668.
Achieving Value by Risk Stratification With Machine Learning Model or Clinical Risk Score in Acute Upper Gastrointestinal Bleeding: A Cost Minimization Analysis.Shung DL, Lin JK, Laine L. Am J Gastroenterol. 2024 Feb 1; 2023 Nov 23. PMID: 37753930.
Trends in Upper Gastrointestinal Bleeding in Patients on Primary Prevention Aspirin: A Nationwide Emergency Department Sample Analysis, 2016-2020.Li DK, Laine L, Shung DL. Am J Med. 2023 Dec; 2023 Sep 9. PMID: 37696350.
Management of Bleeding Due to Small-Intestinal Angiodysplasias.Laine L. N Engl J Med. 2023 Nov 2. PMID: 37913510.
Letter: factors influencing discontinuation of aspirin in patients after gastrointestinal bleeding - authors' reply.Li DK, Laine L. Aliment Pharmacol Ther. 2023 Jun. PMID: 37161633.
Presentation of the Julius M. Friedenwald Medal to Sheila E. Crowe, MD.Laine L, Hecht G. Gastroenterology. 2023 Jun; 2023 Apr 16. PMID: 37061896.
Disparities in Access to Endoscopy for Patients With Upper Gastrointestinal Bleeding Presenting to Emergency Departments.Rodriguez NJ, Zheng NS, Mezzacappa C, Canavan M, Laine L, Shung DL. Gastroenterology. 2023 Jun; 2022 Oct 10. PMID: 36228735.
The Reply.Kurlander JE, Laine L. Am J Med. 2023 Apr. PMID: 36958908.
Plasma renalase levels are associated with the development of acute pancreatitis.Wang M, Weiss FU, Guo X, Kolodecik T, Bewersdorf JP, Laine L, Lerch MM, Desir G, Gorelick FS. Pancreatology. 2023 Mar; 2023 Jan 3. PMID: 36697349.
Over-the-scope clips versus standard treatment.Barkun AN, Laine L, Leontiadis GI, Saltzman JR. Gut. 2023 Mar; 2022 May 9. PMID: 35534090.
Deprescription of aspirin for primary prevention is uncommon at discharge in hospitalised patients with gastrointestinal bleeding.Li DK, Ong SY, Hughes ML, Hung KW, Agarwal R, Alexis J, Damianos J, Sharma S, Pires J, Nanna M, Laine L. Aliment Pharmacol Ther. 2023 Jan; 2022 Nov 16. PMID: 36394111.
Vonoprazan Versus Lansoprazole for Healing and Maintenance of Healing of Erosive Esophagitis: A Randomized Trial.Laine L, DeVault K, Katz P, Mitev S, Lowe J, Hunt B, Spechler S. Gastroenterology. 2023 Jan; 2022 Oct 10. PMID: 36228734.
Trends in characteristics, management, and outcomes of patients presenting with gastrointestinal bleeding to emergency departments in the United States from 2006 to 2019.Zheng NS, Tsay C, Laine L, Shung DL. Aliment Pharmacol Ther. 2022 Dec; 2022 Sep 29. PMID: 36173090.
Rebleeding in peptic ulcer bleeding - a nationwide cohort study of 19,537 patients.Laursen SB, Stanley AJ, Laine L, Schaffalitzky de Muckadell OB. Scand J Gastroenterol. 2022 Dec; 2022 Jul 19. PMID: 35853234.
Response to Graham.Laine L, Sharma P, Mulford DJ, Hunt B, Leifke E, Smith N, Howden CW. Am J Gastroenterol. 2022 Nov 1. PMID: 36327440.
Association of Antisecretory Drugs with Upper Gastrointestinal Bleeding in Patients Using Oral Anticoagulants: A Systematic Review and Meta-Analysis.Kurlander JE, Barnes GD, Fisher A, Gonzalez JJ, Helminski D, Saini SD, Sengupta N, Yang YX, Scheiman J, Laine L. Am J Med. 2022 Oct; 2022 Jun 7. PMID: 35679879.
Vonoprazan Triple and Dual Therapy for Helicobacter pylori Infection in the United States and Europe: Randomized Clinical Trial.Chey WD, Mégraud F, Laine L, López LJ, Hunt BJ, Howden CW. Gastroenterology. 2022 Sep; 2022 Jun 6. PMID: 35679950.
Antiplatelet Monotherapy Is Associated with an Increased Risk of Bleeding After Endoscopic Sphincterotomy.Zakko A, Zakko L, Grimshaw AA, Laine L. Dig Dis Sci. 2022 Aug; 2021 Nov 18. PMID: 34796411.
Pharmacodynamics and Pharmacokinetics of the Potassium-Competitive Acid Blocker Vonoprazan and the Proton Pump Inhibitor Lansoprazole in US Subjects.Laine L, Sharma P, Mulford DJ, Hunt B, Leifke E, Smith N, Howden CW. Am J Gastroenterol. 2022 Jul 1; 2022 Mar 16. PMID: 35294415.
International multicenter study comparing demographics, therapy and outcomes in bleeding from Mallory Weiss tears and peptic ulcers.Tham JE, Lynch L, Laursen SB, Laine L, Dalton HR, Ngu J, Redondo-Cerezo E, Schultz M, Murray I, Michell N, Morris AJ, Nielsen MM, Stanley AJ. Endosc Int Open. 2022 May; 2022 May 13. PMID: 35571482.
American College of Gastroenterology-Canadian Association of Gastroenterology Clinical Practice Guideline: Management of Anticoagulants and Antiplatelets During Acute Gastrointestinal Bleeding and the Periendoscopic Period.Abraham NS, Barkun AN, Sauer BG, Douketis J, Laine L, Noseworthy PA, Telford JJ, Leontiadis GI. J Can Assoc Gastroenterol. 2022 Apr; 2022 Mar 17. PMID: 35368325.
Management of Patients on Anticoagulants and Antiplatelets During Acute Gastrointestinal Bleeding and the Peri-Endoscopic Period: A Clinical Practice Guideline Dissemination Tool.Barkun AN, Douketis J, Noseworthy PA, Laine L, Telford JJ, Abraham NS. Am J Gastroenterol. 2022 Apr 1. PMID: 35354773.
American College of Gastroenterology-Canadian Association of Gastroenterology Clinical Practice Guideline: Management of Anticoagulants and Antiplatelets During Acute Gastrointestinal Bleeding and the Periendoscopic Period.Abraham NS, Barkun AN, Sauer BG, Douketis J, Laine L, Noseworthy PA, Telford JJ, Leontiadis GI. Am J Gastroenterol. 2022 Apr 1. PMID: 35297395.
Long-term Outcomes Following Multiply Recurrent Clostridioides difficile Infection and Fecal Microbiota Transplantation.Dawwas GK, Brensinger CM, Vajravelu RK, Wu Q, Kelly CR, Laine L, Wu GD, Lewis JD. Clin Gastroenterol Hepatol. 2022 Apr; 2020 Dec 8. PMID: 33307184.
Adapting to the Challenge of Hospital-Based Care: The Evolving Role of Gastroenterology Hospitalists.Hughes ML, Li DK, Hung KW, Laine L. Am J Gastroenterol. 2022 Mar 1. PMID: 34904965.
Gastrointestinal Injury Caused by Aspirin or Clopidogrel Monotherapy Versus Dual Antiplatelet Therapy.Bittl JA, Laine L. J Am Coll Cardiol. 2022 Jan 18; 2021 Nov 6. PMID: 34752903.
Correction to: ACG Clinical Guideline: Upper Gastrointestinal and Ulcer Bleeding.Laine L, Barkun AN, Saltzman JR, Martel M, Leontiadis GI. Am J Gastroenterol. 2021 Nov 1. PMID: 34732677.
Immune Checkpoint Inhibitor-associated Diarrhea and Colitis: A Systematic Review and Meta-analysis of Observational Studies.Tran AN, Wang M, Hundt M, Chugh R, Ohm J, Grimshaw A, Ciarleglio M, Hung KW, Proctor DD, Price CC, Laine L, Al-Bawardy B. J Immunother. 2021 Oct 1. PMID: 34380976.
Ozanimod as Induction and Maintenance Therapy for Ulcerative Colitis.Sandborn WJ, Feagan BG, D'Haens G, Wolf DC, Jovanovic I, Hanauer SB, Ghosh S, Petersen A, Hua SY, Lee JH, Charles L, Chitkara D, Usiskin K, Colombel JF, Laine L, Danese S. N Engl J Med. 2021 Sep 30. PMID: 34587385.
Fresh frozen plasma transfusion in acute variceal haemorrhage: Results from a multicentre cohort study.Mohanty A, Kapuria D, Canakis A, Lin H, Amat MJ, Rangel Paniz G, Placone NT, Thomasson R, Roy H, Chak E, Baffy G, Curry MP, Laine L, Rustagi T. Liver Int. 2021 Aug; 2021 May 24. PMID: 33969607.
Reply.Kelly CR, Wu GD, Laine LA. Gastroenterology. 2021 Jun; 2021 Feb 25. PMID: 33639155.
Early identification of patients with acute gastrointestinal bleeding using natural language processing and decision rules.Shung D, Tsay C, Laine L, Chang D, Li F, Thomas P, Partridge C, Simonov M, Hsiao A, Tay JK, Taylor A. J Gastroenterol Hepatol. 2021 Jun; 2021 Jan 25. PMID: 33105045.
ACG Clinical Guideline: Upper Gastrointestinal and Ulcer Bleeding.Laine L, Barkun AN, Saltzman JR, Martel M, Leontiadis GI. Am J Gastroenterol. 2021 May 1. PMID: 33929377.
Towards personalised management for non-variceal upper gastrointestinal bleeding.Sung JJY, Laine L, Kuipers EJ, Barkun AN. Gut. 2021 May; 2021 Mar 1. PMID: 33649044.
Neural network predicts need for red blood cell transfusion for patients with acute gastrointestinal bleeding admitted to the intensive care unit.Shung D, Huang J, Castro E, Tay JK, Simonov M, Laine L, Batra R, Krishnaswamy S. Sci Rep. 2021 Apr 23; 2021 Apr 23. PMID: 33893364.
Resection of pancreatic cystic neoplasms in recurrent acute pancreatitis prevents recurrent pancreatitis but does not identify more malignancies.Muniraj T, Aslanian HR, Laine L, Jamidar PA, Farrell JF, Mitchell KA, Salem RR. World J Gastroenterol. 2021 Apr 21. PMID: 33958848.
ABC score: a new risk score that accurately predicts mortality in acute upper and lower gastrointestinal bleeding: an international multicentre study.Laursen SB, Oakland K, Laine L, Bieber V, Marmo R, Redondo-Cerezo E, Dalton HR, Ngu J, Schultz M, Soncini M, Gralnek I, Jairath V, Murray IA, Stanley AJ. Gut. 2021 Apr; 2020 Jul 28. PMID: 32723845.
Fecal Microbiota Transplantation Is Highly Effective in Real-World Practice: Initial Results From the FMT National Registry.Kelly CR, Yen EF, Grinspan AM, Kahn SA, Atreja A, Lewis JD, Moore TA, Rubin DT, Kim AM, Serra S, Nersesova Y, Fredell L, Hunsicker D, McDonald D, Knight R, Allegretti JR, Pekow J, Absah I, Hsu R, Vincent J, Khanna S, Tangen L, Crawford CV, Mattar MC, Chen LA, Fischer M, Arsenescu RI, Feuerstadt P, Goldstein J, Kerman D, Ehrlich AC, Wu GD, Laine L. Gastroenterology. 2021 Jan; 2020 Oct 1. PMID: 33011173.
Use of Proton Pump Inhibitors Increases Risk of Incident Kidney Stones.Simonov M, Abel EA, Skanderson M, Masoud A, Hauser RG, Brandt CA, Wilson FP, Laine L. Clin Gastroenterol Hepatol. 2021 Jan; 2020 Mar 6. PMID: 32147588.
Musculoskeletal Pain Symptoms and Injuries Among Endoscopists Who Perform ERCP.Campbell EV 3rd, Muniraj T, Aslanian HR, Laine L, Jamidar P. Dig Dis Sci. 2021 Jan; 2020 Mar 6. PMID: 32144599.
Monitoring Fecal Microbiota Transplantation Practice in a Rapidly Evolving Health and Regulatory Environment.Kelly CR, Laine LA, Wu GD. Gastroenterology. 2020 Dec; 2020 Aug 22. PMID: 32841646.
Intestinal metaplasia around the gastroesophageal junction is frequently associated with antral reactive gastropathy: implications for carcinoma at the gastroesophageal junction.Vyas M, Celli R, Singh M, Patel N, Aslanian HR, Boffa D, Deng Y, Ciarleglio MM, Laine L, Jain D. Hum Pathol. 2020 Nov; 2020 Sep 14. PMID: 32941964.
Machine Learning Prognostic Models for Gastrointestinal Bleeding Using Electronic Health Record Data.Shung D, Laine L. Am J Gastroenterol. 2020 Aug. PMID: 32530828.
Early Colonoscopy Does Not Improve Outcomes of Patients With Lower Gastrointestinal Bleeding: Systematic Review of Randomized Trials.Tsay C, Shung D, Stemmer Frumento K, Laine L. Clin Gastroenterol Hepatol. 2020 Jul; 2019 Dec 13. PMID: 31843595.
Reply.Shung D, Laine L. Gastroenterology. 2020 Jun; 2020 Mar 28. PMID: 32234305.
Physicians' Perceptions of Proton Pump Inhibitor Risks and Recommendations to Discontinue: A National Survey.Kurlander JE, Rubenstein JH, Richardson CR, Krein SL, De Vries R, Zikmund-Fisher BJ, Yang YX, Laine L, Weissman A, Saini SD. Am J Gastroenterol. 2020 May. PMID: 32091419.
Use of Fecal Occult Blood Testing as a Diagnostic Tool for Clinical Indications: A Systematic Review and Meta-Analysis.Lee MW, Pourmorady JS, Laine L. Am J Gastroenterol. 2020 May. PMID: 31972617.
Management of Nonvariceal Upper Gastrointestinal Bleeding.Barkun AN, Laine L, Leontiadis GI, Bardou M. Ann Intern Med. 2020 Apr 21. PMID: 32311706.
Timing of Endoscopy in Patients Hospitalized with Upper Gastrointestinal Bleeding.Laine L. N Engl J Med. 2020 Apr 2. PMID: 32242363.
Chromoendoscopy meta-analysis: correcting subgroup analysis interpretation.Laine L, Kaltenbach T, Barkun A, Soetikno R. Gastrointest Endosc. 2020 Mar. PMID: 32087902.
Colonoscopy for Lower Gastrointestinal Bleeding-Time Is Not of the Essence.Laine L. Gastroenterology. 2020 Jan; 2019 Nov 12. PMID: 31730767.
The Shock Index is not accurate at predicting outcomes in patients with upper gastrointestinal bleeding.Saffouri E, Blackwell C, Laursen SB, Laine L, Dalton HR, Ngu J, Shultz M, Norton R, Stanley AJ. Aliment Pharmacol Ther. 2020 Jan; 2019 Oct 23. PMID: 31642558.
Validation of a Machine Learning Model That Outperforms Clinical Risk Scoring Systems for Upper Gastrointestinal Bleeding.Shung DL, Au B, Taylor RA, Tay JK, Laursen SB, Stanley AJ, Dalton HR, Ngu J, Schultz M, Laine L. Gastroenterology. 2020 Jan; 2019 Sep 25. PMID: 31562847.
MAP(ASH): A new scoring system for the prediction of intervention and mortality in upper gastrointestinal bleeding.Redondo-Cerezo E, Vadillo-Calles F, Stanley AJ, Laursen S, Laine L, Dalton HR, Ngu JH, Schultz M, Jiménez-Rosales R. J Gastroenterol Hepatol. 2020 Jan; 2019 Aug 19. PMID: 31359521.
Management of Nonvariceal Upper Gastrointestinal Bleeding: Guideline Recommendations From the International Consensus Group.Barkun AN, Almadi M, Kuipers EJ, Laine L, Sung J, Tse F, Leontiadis GI, Abraham NS, Calvet X, Chan FKL, Douketis J, Enns R, Gralnek IM, Jairath V, Jensen D, Lau J, Lip GYH, Loffroy R, Maluf-Filho F, Meltzer AC, Reddy N, Saltzman JR, Marshall JK, Bardou M. Ann Intern Med. 2019 Dec 3; 2019 Oct 22. PMID: 31634917.
Randomized Trial of Medical versus Surgical Treatment for Refractory Heartburn.Spechler SJ, Hunter JG, Jones KM, Lee R, Smith BR, Mashimo H, Sanchez VM, Dunbar KB, Pham TH, Murthy UK, Kim T, Jackson CS, Wallen JM, von Rosenvinge EC, Pearl JP, Laine L, Kim AW, Kaz AM, Tatum RP, Gellad ZF, Lagoo-Deenadayalan S, Rubenstein JH, Ghaferi AA, Lo WK, Fernando RS, Chan BS, Paski SC, Provenzale D, Castell DO, Lieberman D, Souza RF, Chey WD, Warren SR, Davis-Karim A, Melton SD, Genta RM, Serpi T, Biswas K, Huang GD. N Engl J Med. 2019 Oct 17. PMID: 31618539.
Machine Learning to Predict Outcomes in Patients with Acute Gastrointestinal Bleeding: A Systematic Review.Shung D, Simonov M, Gentry M, Au B, Laine L. Dig Dis Sci. 2019 Aug; 2019 May 4. PMID: 31055722.
Presentation of the Julius M. Friedenwald Medal to John I. Allen.Laine L, Ganz RA. Gastroenterology. 2019 Jun; 2019 Apr 25. PMID: 31029707.
Interventions for Primary Prevention of Esophageal Variceal Bleeding.Laine L. Hepatology. 2019 Apr; 2019 Mar 4. PMID: 30561058.
Management of acute upper gastrointestinal bleeding.Stanley AJ, Laine L. BMJ. 2019 Mar 25; 2019 Mar 25. PMID: 30910853.
Previous Use of Antithrombotic Agents Reduces Mortality and Length of Hospital Stay in Patients With High-risk Upper Gastrointestinal Bleeding.Dunne PDJ, Laursen SB, Laine L, Dalton HR, Ngu JH, Schultz M, Rahman A, Anderloni A, Murray IA, Stanley AJ. Clin Gastroenterol Hepatol. 2019 Feb; 2018 Apr 26. PMID: 29705263.
Outcomes with Bloody vs. Coffee-Grounds Hematemesis.Laine L, Laursen SB, Stanley AJ. Am J Gastroenterol. 2018 Nov; 2018 Oct 17. PMID: 30333532.
Impact of Changeover to Newer Endoscopic Systems on Quality and Efficiency of Screening and Surveillance Colonoscopy: Equipment or Endoscopist.Singh M, Sacatos M, Laine L. J Clin Gastroenterol. 2018 Nov/Dec. PMID: 28906425.
Analyses of Bloody vs. Coffee-Grounds Hematemesis.Laine L, Laursen SB, Stanley AJ. Am J Gastroenterol. 2018 Aug; 2018 Jun 29. PMID: 29955117.
Treatment of thrombocytopenic patients with GI bleeding.Laine L. Gastrointest Endosc. 2018 Jul. PMID: 29935628.
Editorial: gastrointestinal safety of COX-2 selective and nonselective NSAIDs-the impact of the PRECISION trial.Laine L. Aliment Pharmacol Ther. 2018 Jun. PMID: 29878414.
Continued midazolam versus diphenhydramine in difficult-to-sedate patients: a randomized double-blind trial.Sachar H, Pichetshote N, Nandigam K, Vaidya K, Laine L. Gastrointest Endosc. 2018 May; 2017 Jan 31. PMID: 28159539.
Effects of gastroprotectant drugs for the prevention and treatment of peptic ulcer disease and its complications: a meta-analysis of randomised trials.Scally B, Emberson JR, Spata E, Reith C, Davies K, Halls H, Holland L, Wilson K, Bhala N, Hawkey C, Hochberg M, Hunt R, Laine L, Lanas A, Patrono C, Baigent C. Lancet Gastroenterol Hepatol. 2018 Apr; 2018 Feb 21. PMID: 29475806.
Randomized trial of cholangioscopy-guided laser lithotripsy versus conventional therapy for large bile duct stones (with videos).Buxbaum J, Sahakian A, Ko C, Jayaram P, Lane C, Yu CY, Kankotia R, Laine L. Gastrointest Endosc. 2018 Apr; 2017 Sep 1. PMID: 28866457.
Severity and Outcomes of Upper Gastrointestinal Bleeding With Bloody Vs. Coffee-Grounds Hematemesis.Laine L, Laursen SB, Zakko L, Dalton HR, Ngu JH, Schultz M, Stanley AJ. Am J Gastroenterol. 2018 Mar; 2018 Jan 30. PMID: 29380820.
Image-enhanced endoscopy is specific for the diagnosis of non-erosive gastroesophageal reflux disease.Parikh ND, Viana AV, Shah S, Laine L. Scand J Gastroenterol. 2018 Mar; 2018 Jan 25. PMID: 29368532.
Optimizing the quality of endoscopy in inflammatory bowel disease: focus on surveillance and management of colorectal dysplasia using interactive image- and video-based teaching.Kaltenbach TR, Soetikno RM, DeVivo R, Laine LA, Barkun A, McQuaid KR. Gastrointest Endosc. 2017 Dec; 2017 Aug 15. PMID: 28818507.
Relationship of time to presentation after onset of upper GI bleeding with patient characteristics and outcomes: a prospective study.Laine L, Laursen SB, Dalton HR, Ngu JH, Schultz M, Stanley AJ. Gastrointest Endosc. 2017 Dec; 2017 Apr 7. PMID: 28396275.
Bleeding With Direct Oral Anticoagulants: The Gastrointestinal Tract and Beyond.Laine L. Clin Gastroenterol Hepatol. 2017 Nov; 2017 Jun 27. PMID: 28666949.
Narrow-band imaging versus white light versus mapping biopsy for gastric intestinal metaplasia: a prospective blinded trial.Buxbaum JL, Hormozdi D, Dinis-Ribeiro M, Lane C, Dias-Silva D, Sahakian A, Jayaram P, Pimentel-Nunes P, Shue D, Pepper M, Cho D, Laine L. Gastrointest Endosc. 2017 Nov; 2017 Mar 30. PMID: 28366441.
Predictors and outcomes of delayed plastic biliary stent removal following endoscopic retrograde cholangiopancreatography.Kim SJ, Ohanian E, Lee F, Nam B, Che K, Laine L, Kim SE, Kim JJ. Scand J Gastroenterol. 2017 Oct; 2017 Jun 28. PMID: 28657377.
Accuracy of ASGE high-risk criteria in evaluation of patients with suspected common bile duct stones.He H, Tan C, Wu J, Dai N, Hu W, Zhang Y, Laine L, Scheiman J, Kim JJ. Gastrointest Endosc. 2017 Sep; 2017 Feb 4. PMID: 28174126.
Transparency ethics in practice: Revisiting financial conflicts of interest disclosure forms in clinical practice guidelines.Lu Y, Jones DJ, Sharara N, Kaltenbach T, Laine L, McQuaid K, Soetikno R, Subramanian V, Barkun A. PLoS One. 2017; 2017 Aug 25. PMID: 28841650.
Is there a role for combined sclerotherapy and ligation in the endoscopic treatment of gastroesophageal varices?Laine L. Gastrointest Endosc. 2017 Aug. PMID: 28728669.
Optimal Timing of Endoscopic Retrograde Cholangiopancreatography in Acute Cholangitis.Hou LA, Laine L, Motamedi N, Sahakian A, Lane C, Buxbaum J. J Clin Gastroenterol. 2017 Jul. PMID: 27875357.
AGA White Paper: Training and Implementation of Endoscopic Image Enhancement Technologies.Gupta N, Brill JV, Canto M, DeMarco D, Fennerty BM, Laine L, Lieberman D, Lightdale C, Montgomery E, Odze R, Rex D, Sharma P, Tokar JL, Kochman ML. Clin Gastroenterol Hepatol. 2017 Jun. PMID: 28528939.
Early Aggressive Hydration Hastens Clinical Improvement in Mild Acute Pancreatitis.Buxbaum JL, Quezada M, Da B, Jani N, Lane C, Mwengela D, Kelly T, Jhun P, Dhanireddy K, Laine L. Am J Gastroenterol. 2017 May; 2017 Mar 7. PMID: 28266591.
Reply.Sheibani S, Laine L. Hepatology. 2017 Apr; 2016 Nov 29. PMID: 27783417.
Early transjugular intrahepatic portosystemic shunt in US patients hospitalized with acute esophageal variceal bleeding.Njei B, McCarty TR, Laine L. J Gastroenterol Hepatol. 2017 Apr. PMID: 27624167.
The AGA's Fecal Microbiota Transplantation National Registry: An Important Step Toward Understanding Risks and Benefits of Microbiota Therapeutics.Kelly CR, Kim AM, Laine L, Wu GD. Gastroenterology. 2017 Mar; 2017 Jan 29. PMID: 28143773.
Comparison of risk scoring systems for patients presenting with upper gastrointestinal bleeding: international multicentre prospective study.Stanley AJ, Laine L, Dalton HR, Ngu JH, Schultz M, Abazi R, Zakko L, Thornton S, Wilkinson K, Khor CJ, Murray IA, Laursen SB. BMJ. 2017 Jan 4; 2017 Jan 4. PMID: 28053181.
No Benefit From Platelet Transfusion for Gastrointestinal Bleeding in Patients Taking Antiplatelet Agents.Zakko L, Rustagi T, Douglas M, Laine L. Clin Gastroenterol Hepatol. 2017 Jan; 2016 Jul 25. PMID: 27464591.
Histological Disease Activity as a Predictor of Clinical Relapse Among Patients With Ulcerative Colitis: Systematic Review and Meta-Analysis.Park S, Abdi T, Gentry M, Laine L. Am J Gastroenterol. 2016 Dec; 2016 Oct 11. PMID: 27725645.
Randomized Trial of Endoscopist-Controlled vs. Assistant-Controlled Wire-Guided Cannulation of the Bile Duct.Buxbaum J, Leonor P, Tung J, Lane C, Sahakian A, Laine L. Am J Gastroenterol. 2016 Dec; 2016 Jul 5. PMID: 27377519.
Risk Assessment Tools for Gastrointestinal Bleeding.Laine L. Clin Gastroenterol Hepatol. 2016 Nov; 2016 Aug 10. PMID: 27521511.

Annmarie Huysman Liapakis, MD

Psychosocial Evaluation of Living Kidney Donors: A Survey of Current Practices in the United States.Clifton E, Winder GS, Lentine KL, Zimbrean PC, Yadav A, Rubman S, Kalil R, Kumar V, Prashar R, Gan G, Deng Y, Joyce M, Holmes R, Laflen J, Bakhai D, Liapakis A, Doshi MD. Transplantation. 2024 Nov 1; 2024 Jun 13. PMID: 38867351.
Psychosocial evaluation of living liver donors-State of current practices in the United States.Zimbrean PC, Rubman S, Andacoglu O, Bakhai D, Clifton E, Deng Y, Doshi M, Emamaullee J, Gan G, Holmes R, Jaber L, Jackson WE, Joyce M, Kalil R, Kumar V, Laflen J, Lentine KL, Prashar R, Winder GS, Yadav A, Liapakis A. Liver Transpl. 2024 May 1; 2023 Oct 23. PMID: 37861339.
Feasibility of an Interprofessional Inpatient Educational Intervention for Patients With Decompensated Cirrhosis.Haque LY, McDonough M, Deng Y, Ciarleglio MM, Liapakis A, Jakab S. Gastro Hep Adv. 2024; 2024 Mar 22. PMID: 39165423.
Living Donor Liver Transplantation for Hepatocellular Carcinoma Within and Outside Traditional Selection Criteria: A Multicentric North American Experience.Ivanics T, Claasen MPAW, Samstein B, Emond JC, Fox AN, Pomfret E, Pomposelli J, Tabrizian P, Florman SS, Mehta N, Roberts JP, Emamaullee JA, Genyk Y, Hernandez-Alejandro R, Tomiyama K, Sasaki K, Hashimoto K, Nagai S, Abouljoud M, Olthoff KM, Hoteit MA, Heimbach J, Taner T, Liapakis AH, Mulligan DC, Sapisochin G, Halazun KJ. Ann Surg. 2024 Jan 1; 2023 Jul 31. PMID: 37522174.
Advancing diagnosis and management of liver disease in adults through exome sequencing.Zheng M, Hakim A, Konkwo C, Deaton AM, Ward LD, Silveira MG, Assis DN, Liapakis A, Jaffe A, Jiang ZG, Curry MP, Lai M, Cho MH, Dykas D, Bale A, Mistry PK, Vilarinho S. EBioMedicine. 2023 Sep; 2023 Aug 9. PMID: 37566928.
Advances and innovations in living donor liver transplant techniques, matching and surgical training: Meeting report from the living donor liver transplant consensus conference.Sturdevant M, Ganesh S, Samstein B, Verna EC, Rodriguez-Davalos M, Kumar V, Abouljoud M, Andacoglu O, Askar M, Broering D, Emamaullee J, Emond JC, Haugen CE, Jesse MT, Kasahara M, Liapakis A, Mandelbrot D, Pillai A, Roll GR, Selzner N, Emre S. Clin Transplant. 2023 Jul; 2023 Apr 11. PMID: 37039541.
A survey of transplant providers regarding attitudes, barriers, and facilitators to living donor liver transplantation in the United States.Liapakis A, Agbim U, Bittermann T, Dew MA, Deng Y, Gan G, Emre S, Hunt HF, Olthoff KM, Locke JE, Jesse MT, Kumar V, Pillai A, Verna E, Lentine KL. Clin Transplant. 2023 Jul; 2023 Mar 20. PMID: 36938716.
Living donor liver transplant candidate and donor selection and engagement: Meeting report from the living donor liver transplant consensus conference.Jesse MT, Jackson WE, Liapakis A, Ganesh S, Humar A, Goldaracena N, Levitsky J, Mulligan D, Pomfret EA, Ladner DP, Roberts JP, Mavis A, Thiessen C, Trotter J, Winder GS, Griesemer AD, Pillai A, Kumar V, Verna EC, LaPointe Rudow D, Han HH. Clin Transplant. 2023 Jul; 2023 Mar 16. PMID: 36892182.
Living donor liver transplantation: A multi-disciplinary collaboration towards growth, consensus, and a change in culture.Liapakis A, Jesse MT, Pillai A, Bittermann T, Dew MA, Emre S, Hunt H, Kumar V, Locke J, Mohammad S, Olthoff K, Verna EC, Lentine KL. Clin Transplant. 2023 Jul; 2023 Mar 20. PMID: 36890717.
Financial, policy, and ethical barriers to the expansion of living donor liver transplant: Meeting report from a living donor liver transplant consensus conference.Pillai A, Verna EC, Parikh ND, Cooper M, Thiessen C, Heimbach J, Gordon EJ, Sapisochin G, Selzner N, Mathur A, Perito ER, Jesse M, Liapakis A, Kumar V. Clin Transplant. 2023 Jul; 2023 Mar 23. PMID: 36880375.
Variation in adult living donor liver transplantation in the United States: Identifying opportunities for increased utilization.Lentine KL, Tanaka T, Xiao H, Bittermann T, Dew MA, Schnitzler MA, Olthoff KM, Locke JE, Emre S, Hunt HF, Liapakis A, Axelrod DA. Clin Transplant. 2023 Jul; 2023 Feb 22. PMID: 36733213.
Practice patterns of the medical evaluation of living liver donors in the United States.Jackson WE, Kaplan A, Saben JL, Kriss MS, Cisek J, Samstein B, Liapakis A, Pillai AA, Brown RS Jr, Pomfret EA. Liver Transpl. 2023 Feb 1; 2023 Jan 17. PMID: 36111606.
The use of nondirected donor organs in living donor liver transplantation: Perspectives and guidance.Fox AN, Liapakis A, Batra R, Bittermann T, Emamaullee J, Emre S, Genyk Y, Han H, Jackson W, Pomfret E, Raza M, Rodriguez-Davalos M, Rubman Gold S, Samstein B, Shenoy A, Taner T, Roberts JP. Hepatology. 2022 Jun; 2022 Jan 8. PMID: 34859474.
The ALT upper reference interval debate: Blame it on the alcohol.Vera MA, Koch CD, Liapakis A, Lim JK, El-Khoury JM. Clin Chim Acta. 2022 Feb 1; 2021 Dec 29. PMID: 34973184.
Equitable Access to Liver Transplant: Bridging the Gaps in the Social Determinants of Health.Rosenblatt R, Lee H, Liapakis A, Lunsford KE, Scott A, Sharma P, Wilder J. Hepatology. 2021 Nov; 2021 Jul 13. PMID: 34060678.
Pregnancy Outcomes After Living Liver Donation: A Multi-Institutional Study.Sonnenberg EM, Lee-Riddle GS, Walls DO, Caicedo JC, Jackson WE, Hughes L, Ladner DP, Liapakis A, Pomfret EA, Sarkar M, Selzner N, Torres AM, Abt PL, Olthoff KM. Liver Transpl. 2021 Sep; 2021 Jul 13. PMID: 33993632.
Frailty in liver transplantation: A comprehensive review.Liapakis A, Morris E, Emre S. Hepatol Forum. 2021 May; 2021 May 24. PMID: 35783898.
Expansion of Patient Education Programming Regarding Live Donor Liver Transplantation via Virtual Group Encounters During the COVID-19 Pandemic.Joyce M, Durant L, Emre S, Haakinson D, Hammers L, Hughes L, Ventura K, Wuerth D, Liapakis A. Transplant Proc. 2021 May; 2021 Jan 31. PMID: 33676742.
A window into portal hemodynamics in adult fontan patients?Simmons MA, Revzin M, To U, Liapakis A, Fahey J, Elder RW. Int J Cardiol. 2021 Jan 15; 2020 Sep 24. PMID: 32979426.
A Patient Decision Support Tool for Hepatitis C Virus and CKD Treatment.George N, Liapakis A, Korenblat KM, Li T, Roth D, Yee J, Fowler KJ, Howard L, Liu J, Politi MC. Kidney Med. 2019 Jul-Aug; 2019 Jul 11. PMID: 32734200.
Pharmacokinetics and important drug-drug interactions to remember when treating advanced chronic kidney disease patients with hepatitis C direct acting anti-viral therapy.Cohen E, Liapakis A. Semin Dial. 2019 Mar; 2018 Dec 17. PMID: 30557903.
Safety and Effectiveness of Ledipasvir and Sofosbuvir, With or Without Ribavirin, in Treatment-Experienced Patients With Genotype 1 Hepatitis C Virus Infection and Cirrhosis.Lim JK, Liapakis AM, Shiffman ML, Lok AS, Zeuzem S, Terrault NA, Park JS, Landis CS, Hassan M, Gallant J, Kuo A, Pockros PJ, Vainorius M, Akushevich L, Michael L, Fried MW, Nelson DR, Ben-Ari Z. Clin Gastroenterol Hepatol. 2018 Nov; 2018 Jan 3. PMID: 29306043.
Successful treatment of primary donor-derived human herpesvirus-8 infection and hepatic Kaposi Sarcoma in an adult liver transplant recipient.Fu W, Merola J, Malinis M, Lacy J, Barbieri A, Liapakis AH, Mulligan DC, Yoo PS. Transpl Infect Dis. 2018 Oct; 2018 Aug 23. PMID: 30014622.
Solid organ transplantation of viral hepatitis C positive donor organs into viral hepatitis C negative recipients.Liapakis A, Formica RN, Levitsky J. Curr Opin Organ Transplant. 2018 Apr. PMID: 29432255.
Management of Chronic Hepatitis C in End-stage Renal Disease.Angulo-Diaz V, Lim JK, Martin P, Liapakis A. J Clin Gastroenterol. 2018 Apr. PMID: 29099465.
Project HELP: a study protocol to pilot test a shared decision-making tool about treatment options for patients with hepatitis C and chronic kidney disease.Politi MC, George N, Li T, Korenblat KM, Fowler KJ, Ho C, Liapakis A, Roth D, Yee J. Pilot Feasibility Stud. 2018; 2018 Feb 21. PMID: 29484199.
Simultaneous Liver-Kidney Transplantation: Impact on Liver Transplant Patients and the Kidney Transplant Waiting List.Miles CD, Westphal S, Liapakis A, Formica R. Curr Transplant Rep. 2018; 2018 Jan 19. PMID: 29564203.
The American Society of Transplantation Consensus Conference on the Use of Hepatitis C Viremic Donors in Solid Organ Transplantation.Levitsky J, Formica RN, Bloom RD, Charlton M, Curry M, Friedewald J, Friedman J, Goldberg D, Hall S, Ison M, Kaiser T, Klassen D, Klintmalm G, Kobashigawa J, Liapakis A, O'Conner K, Reese P, Stewart D, Terrault N, Theodoropoulos N, Trotter J, Verna E, Volk M. Am J Transplant. 2017 Nov; 2017 Jul 1. PMID: 28556422.
Vanishing bile duct syndrome in Hodgkin's lymphoma: A case report and literature review.Bakhit M, McCarty TR, Park S, Njei B, Cho M, Karagozian R, Liapakis A. World J Gastroenterol. 2017 Jan 14. PMID: 28127210.
Treatment of chronic hepatitis C virus infection in patients with end-stage renal disease on hemodialysis.Mittal Y, Liapakis A, Lim JK. Clin Liver Dis (Hoboken). 2016 Sep; 2016 Oct 2. PMID: 31041068.
Vanishing Bile Duct Syndrome in Hodgkin's Lymphoma: A Single Center Experience and Clinical Pearls.Bakhit M, McCarty TR, Park S, Njei B, Cho M, Karagozian R, Liapakis A. J Clin Gastroenterol. 2016 Sep. PMID: 27203429.
Safety and efficacy of sofosbuvir-containing regimens in hepatitis C-infected patients with impaired renal function.Saxena V, Koraishy FM, Sise ME, Lim JK, Schmidt M, Chung RT, Liapakis A, Nelson DR, Fried MW, Terrault NA. Liver Int. 2016 Jun; 2016 Mar 24. PMID: 26923436.
Revision of immunosuppression in a solid organ transplant recipient leads to complete remission of metastatic undifferentiated carcinoma.Waldman AH, McNiff JM, Liapakis A, Asch WS, Smith-Marrone S, Colegio OR. JAAD Case Rep. 2015 Nov; 2015 Nov 24. PMID: 27051810.
Grazoprevir plus elbasvir in treatment-naive and treatment-experienced patients with hepatitis C virus genotype 1 infection and stage 4-5 chronic kidney disease (the C-SURFER study): a combination phase 3 study.Roth D, Nelson DR, Bruchfeld A, Liapakis A, Silva M, Monsour H Jr, Martin P, Pol S, Londoño MC, Hassanein T, Zamor PJ, Zuckerman E, Wan S, Jackson B, Nguyen BY, Robertson M, Barr E, Wahl J, Greaves W. Lancet. 2015 Oct 17; 2015 Oct 5. PMID: 26456905.
Non-alcoholic fatty liver disease following liver transplantation: a clinical review.Merola J, Liapakis A, Mulligan DC, Yoo PS. Clin Transplant. 2015 Sep; 2015 Aug 11. PMID: 26147308.
Drug Authorization for Sofosbuvir/Ledipasvir (Harvoni) for Chronic HCV Infection in a Real-World Cohort: A New Barrier in the HCV Care Cascade.Do A, Mittal Y, Liapakis A, Cohen E, Chau H, Bertuccio C, Sapir D, Wright J, Eggers C, Drozd K, Ciarleglio M, Deng Y, Lim JK. PLoS One. 2015; 2015 Aug 27. PMID: 26312999.
Impact of rapid point-of-care screening tests for the identification of chronic hepatitis C infection.Liapakis A, Lim JK. Hepatology. 2013 Aug. PMID: 23744577.

Joseph K Lim, MD

Risk Score for Hepatocellular Cancer in Adults Without Viral Hepatitis or Cirrhosis.Ilagan-Ying YC, Gordon KS, Tate JP, Lim JK, Torgersen J, Lo Re V 3rd, Justice AC, Taddei TH. JAMA Netw Open. 2024 Nov 4; 2024 Nov 4. PMID: 39504020.
Outcomes of a 1-Year Pilot Study Implementing Universal Hepatitis Delta Virus Testing Among Veterans With Chronic Hepatitis B.Wong RJ, Liao M, Chen Y, Kwan M, Lee JH, Jou JH, Lim JK, Cheung R. J Viral Hepat. 2024 Nov; 2024 Aug 5. PMID: 39101377.
Unmet needs in the clinical management of chronic hepatitis B infection.Block PD, Lim JK. J Formos Med Assoc. 2024 Aug 17; 2024 Aug 17. PMID: 39155176.
Severe Acute Liver Injury After Hepatotoxic Medication Initiation in Real-World Data.Torgersen J, Mezochow AK, Newcomb CW, Carbonari DM, Hennessy S, Rentsch CT, Park LS, Tate JP, Bräu N, Bhattacharya D, Lim JK, Mezzacappa C, Njei B, Roy JA, Taddei TH, Justice AC, Lo Re V 3rd. JAMA Intern Med. 2024 Aug 1. PMID: 38913369.
Identification of hepatic steatosis among persons with and without HIV using natural language processing.Torgersen J, Skanderson M, Kidwai-Khan F, Carbonari DM, Tate JP, Park LS, Bhattacharya D, Lim JK, Taddei TH, Justice AC, Lo Re V 3rd. Hepatol Commun. 2024 Jul 1; 2024 Jun 19. PMID: 38896066.
Editorial: Redefining liver health-Personalised approach to assessment of serum ALT in clinical practice.Njei B, Lim JK. Aliment Pharmacol Ther. 2024 Jul; 2024 Apr 21. PMID: 38643498.
Association of Baseline Hepatitis B Virus DNA and On-Treatment Risk of Cirrhosis and Hepatocellular Carcinoma.Yang Z, Cheung RC, Jou JH, Lim JK, Lim YS, Wong RJ. Gastroenterology Res. 2024 Jun; 2024 Jun 29. PMID: 38993547.
Management of HBV reactivation: Challenges and opportunities.Mezzacappa C, Lim JK. Clin Liver Dis (Hoboken). 2024 Jan-Jun; 2024 May 8. PMID: 38720793.
Prevalence and characteristics of hepatitis delta virus infection in patients with hepatitis B in the United States: An analysis of the All-Payer Claims Database.Gish RG, Jacobson IM, Lim JK, Waters-Banker C, Kaushik A, Kim C, Cyhaniuk A, Wong RJ. Hepatology. 2024 May 1; 2023 Nov 16. PMID: 37976395.
An explainable machine learning model for prediction of high-risk nonalcoholic steatohepatitis.Njei B, Osta E, Njei N, Al-Ajlouni YA, Lim JK. Sci Rep. 2024 Apr 13; 2024 Apr 13. PMID: 38615137.
Clinical Liver Disease: Legacy of innovation in hepatology education.Lim JK. Clin Liver Dis (Hoboken). 2024 Jan-Jun; 2024 Apr 2. PMID: 38567095.
Advances in discovery of novel investigational agents for functional cure of chronic hepatitis B: A comprehensive review of phases II and III therapeutic agents.Lam R, Lim JK. World J Hepatol. 2024 Mar 27. PMID: 38577537.
Hepatitis C in Black Individuals in the US: A Review.Falade-Nwulia O, Kelly SM, Amanor-Boadu S, Nnodum BN, Lim JK, Sulkowski M. JAMA. 2023 Dec 12. PMID: 37943553.
Precipitous changes in nomenclature and definitions-NAFLD becomes SLD: Implications for and expectations of AASLD journals.Malhi H, Brown RS Jr, Lim JK, Reau N, Tapper EB, Wong CC, Gores GJ. Clin Liver Dis (Hoboken). 2023 Dec; 2023 Nov 9. PMID: 38143807.
Precipitous changes in nomenclature and definitions-NAFLD becomes SLD: Implications for and expectations of AASLD journals.Malhi H, Brown RS Jr, Lim JK, Reau N, Tapper EB, Wong CC, Gores GJ. Hepatology. 2023 Dec 1; 2023 Nov 9. PMID: 37941421.
Precipitous changes in nomenclature and definitions-NAFLD becomes SLD: Implications for and expectations of AASLD journals.Malhi H, Brown RS Jr, Lim JK, Reau N, Tapper EB, Wong CC, Gores GJ. Liver Transpl. 2023 Dec 1; 2023 Nov 9. PMID: 37941408.
Precipitous changes in nomenclature and definitions-NAFLD becomes SLD: Implications for and expectations of AASLD journals.Malhi H, Brown RS Jr, Lim JK, Reau N, Tapper EB, Wong CC, Gores GJ. Hepatol Commun. 2023 Nov 1; 2023 Nov 9. PMID: 37941420.
Clinical and Histopathological Discoveries in Patients with Hepatic Injury and Cholangiopathy Who Have Died of COVID-19: Insights and Opportunities for Intervention.Lim JK, Njei B. Hepat Med. 2023; 2023 Oct 4. PMID: 37814605.
Screening, Diagnosis, and Staging of Non-Alcoholic Fatty Liver Disease (NAFLD): Application of Society Guidelines to Clinical Practice.Ilagan-Ying YC, Banini BA, Do A, Lam R, Lim JK. Curr Gastroenterol Rep. 2023 Oct; 2023 Sep 28. PMID: 37768417.
AGA Clinical Practice Update on the Role of Noninvasive Biomarkers in the Evaluation and Management of Nonalcoholic Fatty Liver Disease: Expert Review.Wattacheril JJ, Abdelmalek MF, Lim JK, Sanyal AJ. Gastroenterology. 2023 Oct; 2023 Aug 4. PMID: 37542503.
Performance of an automated deep learning algorithm to identify hepatic steatosis within noncontrast computed tomography scans among people with and without HIV.Torgersen J, Akers S, Huo Y, Terry JG, Carr JJ, Ruutiainen AT, Skanderson M, Levin W, Lim JK, Taddei TH, So-Armah K, Bhattacharya D, Rentsch CT, Shen L, Carr R, Shinohara RT, McClain M, Freiberg M, Justice AC, Lo Re V 3rd. Pharmacoepidemiol Drug Saf. 2023 Oct; 2023 Jun 8. PMID: 37276449.
Exercise Does Not Independently Improve Histological Outcomes in Biopsy-Proven Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis.Chen G, Banini BA, Do A, Gunderson C, Zaman S, Lim JK. Genes (Basel). 2023 Sep 17; 2023 Sep 17. PMID: 37761951.
Hepatitis B care cascade among people with HIV/HBV coinfection in the North American AIDS Cohort Collaboration on Research and Design, 2012-2016.Kim J, Newcomb CW, Carbonari DM, Torgersen J, Althoff KN, Kitahata MM, Klein MB, Moore RD, Reddy KR, Silverberg MJ, Mayor AM, Horberg MA, Cachay ER, Lim JK, Gill MJ, Chew K, Sterling TR, Hull M, Seaberg EC, Kirk GD, Coburn SB, Lang R, McGinnis KA, Gebo KA, Napravnik S, Kim HN, Lo Re V 3rd. PLoS One. 2023; 2023 Sep 1. PMID: 37656704.
Lean NAFLD is associated with adverse liver events and mortality: Moving beyond BMI.Do A, Lim JK. Hepatology. 2023 Jul 1; 2023 Mar 13. PMID: 36896961.
Chronic Hepatitis B Virus: What an Internist Needs to Know: Serologic Diagnosis, Treatment Options, and Hepatitis B Virus Reactivation.Block PD, Lim JK. Med Clin North Am. 2023 May; 2023 Feb 20. PMID: 37001946.
Screening for Cholangiocarcinoma in Patients With Primary Sclerosing Cholangitis.Lim JK. Gastroenterol Hepatol (N Y). 2023 Mar. PMID: 37706112.
AGA Clinical Practice Update on Diagnosis and Management of Acute Hepatic Porphyrias: Expert Review.Wang B, Bonkovsky HL, Lim JK, Balwani M. Gastroenterology. 2023 Mar; 2023 Jan 13. PMID: 36642627.
Reply.Long MT, Noureddin M, Lim JK. Gastroenterology. 2023 Mar; 2022 Nov 13. PMID: 36379247.
Tailoring stepwise treatment for Budd-Chiari syndrome: insights from the Asian Pacific Association for the Study of the Liver (APASL) consensus guidance.Haque LY, Lim JK. Hepatobiliary Surg Nutr. 2023 Feb 28; 2023 Jan 9. PMID: 36860254.
The independent effect of exercise on biopsy-proven non-alcoholic fatty liver disease: A systematic review.Chen G, Banini B, Do A, Lim JK. Clin Mol Hepatol. 2023 Feb; 2022 Dec 14. PMID: 36517000.
Treating Hepatitis C in Individuals With Previous Incarceration: The Veterans Health Administration, 2012-2019.Hawks L, Wang EA, Butt AA, Crystal S, Keith McInnes D, Re VL, Cartwright EJ, Puglisi LB, Haque LYK, Lim JK, Justice AC, McGinnis KA. Am J Public Health. 2023 Feb; 2022 Dec 8. PMID: 36480765.
Simplifying the Diagnosis and Treatment of Hepatitis B Infection: One Step for Addressing Deficits in the Care Cascade, One Leap for Elimination.Rabiee A, Lim JK. Gastro Hep Adv. 2023; 2022 Dec 15. PMID: 39132614.
Left Atrial Mechanics and Diastolic Function Among People Living With Human Immunodeficiency Virus (from the Veterans Aging Cohort Study).Berg CJ, Patel B, Reynolds M, Tuzovic M, Chew KW, Sico JJ, Bhattacharya D, Butt AA, Lim JK, Bedimo RJ, Brown ST, Gottdiener JS, Warner AL, Freiberg MS, So-Armah KA, Nguyen KL. Am J Cardiol. 2023 Jan 1; 2022 Nov 5. PMID: 36343446.
Association Between Alcohol Use Disorder and Receipt of Direct-Acting Antiviral Hepatitis C Virus Treatment.Haque LY, Fiellin DA, Tate JP, Esserman D, Bhattacharya D, Butt AA, Crystal S, Edelman EJ, Gordon AJ, Lim JK, Tetrault JM, Williams EC, Bryant K, Cartwright EJ, Rentsch CT, Justice AC, Lo Re V 3rd, McGinnis KA. JAMA Netw Open. 2022 Dec 1; 2022 Dec 1. PMID: 36515952.
Non-responders to sofosbuvir/velpatasvir/voxilaprevir in the treatment of chronic hepatitis C infection.Karimi-Sari H, Rezaee-Zavareh MS, Falade-Nwulia O, Lim JK. J Hepatol. 2022 Oct; 2022 Jul 5. PMID: 35798132.
Combination strategies for pharmacologic treatment of non-alcoholic steatohepatitis.Suri J, Borja S, Lim JK. World J Gastroenterol. 2022 Sep 21. PMID: 36188726.
AGA Clinical Practice Update: Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Lean Individuals: Expert Review.Long MT, Noureddin M, Lim JK. Gastroenterology. 2022 Sep; 2022 Jul 14. PMID: 35842345.
Acute Hepatitis of Unknown Origin in Children: Early Observations from the 2022 Outbreak.Zhang LY, Huang LS, Yue YH, Fawaz R, Lim JK, Fan JG. J Clin Transl Hepatol. 2022 Jun 28; 2022 Jun 22. PMID: 35836761.
NASH and the Gut Microbiome: Implications for New Therapies.Tsay CJ, Lim JK. Clin Liver Dis (Hoboken). 2022 Mar; 2022 Jan 28. PMID: 35355843.
The ALT upper reference interval debate: Blame it on the alcohol.Vera MA, Koch CD, Liapakis A, Lim JK, El-Khoury JM. Clin Chim Acta. 2022 Feb 1; 2021 Dec 29. PMID: 34973184.
Oral Cyanobacteria and Hepatocellular Carcinoma.Hernandez BY, Zhu X, Risch HA, Lu L, Ma X, Irwin ML, Lim JK, Taddei TH, Pawlish KS, Stroup AM, Brown R, Wang Z, Wong LL, Yu H. Cancer Epidemiol Biomarkers Prev. 2022 Jan; 2021 Oct 25. PMID: 34697061.
Genetic susceptibility to hepatocellular carcinoma in chromosome 22q13.31, findings of a genome-wide association study.Wang Z, Budhu AS, Shen Y, Wong LL, Hernandez BY, Tiirikainen M, Ma X, Irwin ML, Lu L, Zhao H, Lim JK, Taddei T, Mishra L, Pawlish K, Stroup A, Brown R, Nguyen MH, Koshiol J, Hernandez MO, Forgues M, Yang HI, Lee MH, Huang YH, Iwasaki M, Goto A, Suzuki S, Matsuda K, Tanikawa C, Kamatani Y, Mann D, Guarnera M, Shetty K, Thomas CE, Yuan JM, Khor CC, Koh WP, Risch H, Wang XW, Yu H. JGH Open. 2021 Dec; 2021 Nov 27. PMID: 34950780.
Protease inhibitor-based direct-acting antivirals are associated with increased risk of aminotransferase elevations but not hepatic dysfunction or decompensation.Torgersen J, Newcomb CW, Carbonari DM, Rentsch CT, Park LS, Mezochow A, Mehta RL, Buchwalder L, Tate JP, Bräu N, Bhattacharya D, Lim JK, Taddei TH, Justice AC, Lo Re V 3rd. J Hepatol. 2021 Dec; 2021 Jul 29. PMID: 34333102.
Care of the Patient With Abnormal Liver Test Results.Tran AN, Lim JK. Ann Intern Med. 2021 Sep; 2021 Sep 14. PMID: 34516271.
AGA Rapid Review and Guideline for SARS-CoV2 Testing and Endoscopy Post-Vaccination: 2021 Update.Sultan S, Siddique SM, Singh S, Altayar O, Caliendo AM, Davitkov P, Feuerstein JD, Kaul V, Lim JK, Mustafa RA, Falck-Ytter Y, Inadomi JM. Gastroenterology. 2021 Sep; 2021 May 21. PMID: 34029569.
Risk of HCC With Hepatitis B Viremia Among HIV/HBV-Coinfected Persons in North America.Kim HN, Newcomb CW, Carbonari DM, Roy JA, Torgersen J, Althoff KN, Kitahata MM, Reddy KR, Lim JK, Silverberg MJ, Mayor AM, Horberg MA, Cachay ER, Kirk GD, Sun J, Hull M, Gill MJ, Sterling TR, Kostman JR, Peters MG, Moore RD, Klein MB, Lo Re V 3rd. Hepatology. 2021 Sep; 2021 Jun 22. PMID: 33780007.
The effect of chronic viral hepatitis on prognostic value of inflammatory biomarkers in hepatocellular carcinoma.Sellers CM, Uhlig J, Ludwig JM, Pollak JS, Taddei TH, Stein SM, Lim JK, Kim HS. Cancer Med. 2021 Aug; 2021 Jul 28. PMID: 34318618.
Association between HIV and incident pulmonary hypertension in US Veterans: a retrospective cohort study.Duncan MS, Alcorn CW, Freiberg MS, So-Armah K, Patterson OV, DuVall SL, Crothers KA, Re VL 3rd, Butt AA, Lim JK, Kim JW, Tindle HA, Justice AC, Brittain EL. Lancet Healthy Longev. 2021 Jul; 2021 Jun 16. PMID: 34296203.
Willingness to participate in research among black patients with liver disease: A national cross-sectional study.McGuire FH, André K, Bradsher ML, Harrison D, Sterling RK, Reddy KR, Serper M, Golin CE, Reau N, Lim JK, Nelson DR, Sarkar S, Evon DM. J Viral Hepat. 2021 Jul; 2021 Apr 26. PMID: 33665897.
Patient-reported outcomes 12 months after hepatitis C treatment with direct-acting antivirals: Results from the PROP UP study.Serper M, Evon DM, Amador J, Stewart PW, Sarkar S, Lok AS, Sterling RK, Reeve BB, Golin CE, Rajender Reddy K, Lim JK, Reau N, Nelson DR, Di Bisceglie AM, Fried MW. Liver Int. 2021 Apr; 2021 Jan 22. PMID: 33387381.
AGA Clinical Practice Update on Diagnosis and Management of Immune Checkpoint Inhibitor Colitis and Hepatitis: Expert Review.Dougan M, Wang Y, Rubio-Tapia A, Lim JK. Gastroenterology. 2021 Mar; 2020 Oct 17. PMID: 33080231.
Low real-world eligibility rates for nonalcoholic steatohepatitis patients for phase 3 clinical trial criteria application in a large academic health system.Ilagan-Ying YC, Xu J, Lim JK, Do A. Eur J Gastroenterol Hepatol. 2021 Mar 1. PMID: 32433419.
Trends in Hepatocellular Carcinoma Incidence and Risk Among Persons With HIV in the US and Canada, 1996-2015.Sun J, Althoff KN, Jing Y, Horberg MA, Buchacz K, Gill MJ, Justice AC, Rabkin CS, Goedert JJ, Sigel K, Cachay E, Park L, Lim JK, Kim HN, Lo Re V 3rd, Moore R, Sterling T, Peters MG, Achenbach CJ, Silverberg M, Thorne JE, Mayor AM, Crane HM, Kitahata MM, Klein M, Kirk GD. JAMA Netw Open. 2021 Feb 1; 2021 Feb 1. PMID: 33595662.
AGA Clinical Practice Update on Lifestyle Modification Using Diet and Exercise to Achieve Weight Loss in the Management of Nonalcoholic Fatty Liver Disease: Expert Review.Younossi ZM, Corey KE, Lim JK. Gastroenterology. 2021 Feb; 2020 Dec 9. PMID: 33307021.
Drug development of nonalcoholic fatty liver disease: challenges in research, regulatory pathways, and study endpoints.Do A, Ilagan-Ying YC, Mehal WZ, Lim JK. Expert Opin Drug Discov. 2021 Feb; 2020 Oct 22. PMID: 33086894.
Clinical Outcome Event Adjudication in a 10-Year Prospective Study of Nucleos(t)ide Analogue Therapy for Chronic Hepatitis B.Lim JK, Chang AY, Zaman A, Martin P, Fernandez-Rodriguez CM, Korkmaz M, Rossi S, Ford JM, Noonan T, Cooney E, Navarro V, Colombato L. J Clin Transl Hepatol. 2020 Dec 28; 2020 Oct 10. PMID: 33447520.
Brief Report: Accuracy of FIB-4 for Cirrhosis in People Living With HIV and Hepatocellular Carcinoma.Torgersen J, Kallan MJ, Carbonari DM, Park LS, Mehta RL, D'Addeo K, Tate JP, Lim JK, Goetz MB, Rodriguez-Barradas MC, Bräu N, Brown ST, Taddei TH, Justice AC, Lo Re V 3rd. J Acquir Immune Defic Syndr. 2020 Dec 15. PMID: 33185999.
Waking Up the Sleeping Giant: Treatment of Hepatitis B Reactivation During Immunosuppressive Drug Therapy.Saffo S, Lim JK. Clin Liver Dis (Hoboken). 2020 Nov; 2020 Dec 10. PMID: 33318788.
AGA Institute Rapid Review and Recommendations on the Role of Pre-Procedure SARS-CoV-2 Testing and Endoscopy.Sultan S, Siddique SM, Altayar O, Caliendo AM, Davitkov P, Feuerstein JD, Francis D, Inadomi JM, Lim JK, Falck-Ytter Y, Mustafa RA. Gastroenterology. 2020 Nov; 2020 Jul 28. PMID: 32735862.
HIV- and HCV-specific markers and echocardiographic pulmonary artery systolic pressure among United States veterans.Zola CE, Duncan MS, So-Armah K, Crothers KA, Butt AA, Gibert CL, Kim JWW, Lim JK, Re VL 3rd, Tindle HA, Freiberg MS, Brittain EL. Sci Rep. 2020 Oct 30; 2020 Oct 30. PMID: 33127959.
Correction to: Excess Weight Gain After Cure of Hepatitis C Infection with Direct-Acting Antivirals.Do A, Esserman DA, Krishnan S, Lim JK, Taddei TH, Hauser RG 3rd, Tate JP, Re VL 3rd, Justice AC. J Gen Intern Med. 2020 Oct. PMID: 33021712.
Abnormal Liver Tests in COVID-19: A Retrospective Observational Cohort Study of 1,827 Patients in a Major U.S. Hospital Network.Hundt MA, Deng Y, Ciarleglio MM, Nathanson MH, Lim JK. Hepatology. 2020 Oct. PMID: 32725890.
Prevalence of Chronic Hepatitis B Virus Infection in the United States.Lim JK, Nguyen MH, Kim WR, Gish R, Perumalswami P, Jacobson IM. Am J Gastroenterol. 2020 Sep. PMID: 32483003.
DAA therapy and long-term hepatic function in advanced/decompensated cirrhosis: Real-world experience from HCV-TARGET cohort.Verna EC, Morelli G, Terrault NA, Lok AS, Lim JK, Di Bisceglie AM, Zeuzem S, Landis CS, Kwo P, Hassan M, Manns MP, Vainorius M, Akushevich L, Nelson DR, Fried MW, Reddy KR. J Hepatol. 2020 Sep; 2020 Mar 31. PMID: 32243960.
Evaluating the Therapeutic Potential of Cenicriviroc in the Treatment of Nonalcoholic Steatohepatitis with Fibrosis: A Brief Report on Emerging Data.Diaz Soto MP, Lim JK. Hepat Med. 2020; 2020 Aug 13. PMID: 32884369.
Budd-Chiari Syndrome: An Uncommon Cause of Chronic Liver Disease that Cannot Be Missed.Haque LYK, Lim JK. Clin Liver Dis. 2020 Aug; 2020 Jun 2. PMID: 32620283.
Spotlight: COVID-19 PPE and Endoscopy.Siddique SM, Sultan S, Lim JK, Altayar O, Davitkov P, Feuerstein JD, Falck-Ytter Y, El-Serag HB. Gastroenterology. 2020 Aug; 2020 Jun 23. PMID: 32590006.
AGA Rapid Recommendations for Gastrointestinal Procedures During the COVID-19 Pandemic.Sultan S, Lim JK, Altayar O, Davitkov P, Feuerstein JD, Siddique SM, Falck-Ytter Y, El-Serag HB. Gastroenterology. 2020 Aug; 2020 Apr 1. PMID: 32247018.
Management of Hepatitis C in Special Populations: HIV Coinfection, Renal Disease, and Decompensated Cirrhosis.Lim JK. Clin Liver Dis (Hoboken). 2020 Jul; 2020 Jul 21. PMID: 32714521.
AGA Institute Rapid Review of the Gastrointestinal and Liver Manifestations of COVID-19, Meta-Analysis of International Data, and Recommendations for the Consultative Management of Patients with COVID-19.Sultan S, Altayar O, Siddique SM, Davitkov P, Feuerstein JD, Lim JK, Falck-Ytter Y, El-Serag HB. Gastroenterology. 2020 Jul; 2020 May 11. PMID: 32407808.
Excess Weight Gain After Cure of Hepatitis C Infection with Direct-Acting Antivirals.Do A, Esserman DA, Krishnan S, Lim JK, Taddei TH, Hauser RG 3rd, Tate JP, Re VL 3rd, Justice AC. J Gen Intern Med. 2020 Jul; 2020 Apr 27. PMID: 32342483.
HIV RNA, CD4+ Percentage, and Risk of Hepatocellular Carcinoma by Cirrhosis Status.Torgersen J, Kallan MJ, Carbonari DM, Park LS, Mehta RL, D'Addeo K, Tate JP, Lim JK, Goetz MB, Rodriguez-Barradas MC, Gibert CL, Bräu N, Brown ST, Roy JA, Taddei TH, Justice AC, Lo Re V. J Natl Cancer Inst. 2020 Jul 1. PMID: 31687755.
AGA Clinical Practice Update on Interaction Between Oral Direct-Acting Antivirals for Chronic Hepatitis C Infection and Hepatocellular Carcinoma: Expert Review.Singal AG, Lim JK, Kanwal F. Clin Liver Dis (Hoboken). 2020 Jun; 2020 Jun 30. PMID: 32617150.
Hepatitis C: How Good Are Real-Life Data and Do Generics Work.Tran AN, Lim JK. Gastroenterol Clin North Am. 2020 Jun; 2020 Mar 29. PMID: 32389363.
Direct-Acting Antivirals Improve Overall Survival in Interventional Oncology Patients with Hepatitis C and Hepatocellular Carcinoma.Kamp WM, Sellers CM, Stein S, Lim JK, Kim HS. J Vasc Interv Radiol. 2020 Jun; 2020 May 4. PMID: 32376182.
Pathophysiology of Hepatic Encephalopathy.Jaffe A, Lim JK, Jakab SS. Clin Liver Dis. 2020 May; 2020 Feb 19. PMID: 32245525.
AGA Clinical Practice Update on Screening and Surveillance for Hepatocellular Carcinoma in Patients With Nonalcoholic Fatty Liver Disease: Expert Review.Loomba R, Lim JK, Patton H, El-Serag HB. Gastroenterology. 2020 May; 2020 Jan 30. PMID: 32006545.
Risk factors for hepatocellular carcinoma (HCC) in the northeast of the United States: results of a case-control study.Shen Y, Risch H, Lu L, Ma X, Irwin ML, Lim JK, Taddei T, Pawlish K, Stroup A, Brown R, Wang Z, Jia W, Wong L, Mayne ST, Yu H. Cancer Causes Control. 2020 Apr; 2020 Feb 14. PMID: 32060838.
Medication Non-adherence in a Prospective, Multi-center Cohort Treated with Hepatitis C Direct-Acting Antivirals.Serper M, Evon DM, Stewart PW, Lok AS, Amador J, Reeve BB, Golin CE, Fried MW, Reddy KR, Sterling RK, Sarkar S, Di Bisceglie AM, Lim JK, Nelson DR, Reau N. J Gen Intern Med. 2020 Apr; 2019 Oct 28. PMID: 31659661.
Assessing the Effectiveness of Strategies in US Birth Cohort Screening for Hepatitis C Infection.Tsay CJ, Lim JK. J Clin Transl Hepatol. 2020 Mar 28; 2020 Mar 24. PMID: 32274343.
FIB-4 stage of liver fibrosis is associated with incident heart failure with preserved, but not reduced, ejection fraction among people with and without HIV or hepatitis C.So-Armah KA, Lim JK, Lo Re V 3rd, Tate JP, Chang CH, Butt AA, Gibert CL, Rimland D, Marconi VC, Goetz MB, Ramachandran V, Brittain E, Long M, Nguyen KL, Rodriguez-Barradas MC, Budoff MJ, Tindle HA, Samet JH, Justice AC, Freiberg MS. Prog Cardiovasc Dis. 2020 Mar-Apr; 2020 Feb 15. PMID: 32068085.
Reply to: "Patient-reported symptoms during direct-acting antiviral treatment: A real-life study in HIV-HCV coinfected patients (ANRS CO13 HEPAVIH)".Evon DM, Sarkar S, Amador J, Lok AS, Sterling RK, Stewart PW, Reeve BB, Serper M, Reau N, Reddy KR, Di Bisceglie AM, Nelson DR, Golin CE, Lim JK, Fried MW. J Hepatol. 2020 Mar; 2019 Dec 27. PMID: 31889556.
Liver fibrosis and accelerated immune dysfunction (immunosenescence) among HIV-infected Russians with heavy alcohol consumption - an observational cross-sectional study.So-Armah K, Freiberg M, Cheng D, Lim JK, Gnatienko N, Patts G, Doyle M, Fuster D, Lioznov D, Krupitsky E, Samet J. BMC Gastroenterol. 2019 Dec 31; 2019 Dec 31. PMID: 31892306.
Impact of Direct Acting Antivirals on Survival in Patients with Chronic Hepatitis C and Hepatocellular Carcinoma.Kamp WM, Sellers CM, Stein S, Lim JK, Kim HS. Sci Rep. 2019 Nov 19; 2019 Nov 19. PMID: 31745132.
Hepatitis B Virus Reactivation in the Setting of Immunosuppressive Drug Therapy.Su J, Lim JK. Gastroenterol Hepatol (N Y). 2019 Nov. PMID: 31802984.
AGA Clinical Practice Update on Surveillance for Hepatobiliary Cancers in Patients With Primary Sclerosing Cholangitis: Expert Review.Bowlus CL, Lim JK, Lindor KD. Clin Gastroenterol Hepatol. 2019 Nov; 2019 Jul 12. PMID: 31306801.
Increasing contribution of non-alcoholic fatty liver disease to hepatocellular carcinoma incidence and mortality in U.S. Medicare.Wong CR, Lim JK. Hepatobiliary Surg Nutr. 2019 Oct. PMID: 31673540.
Treatment Status of Hepatocellular Carcinoma Does Not Influence Rates of Sustained Virologic Response: An HCV-TARGET Analysis.Radhakrishnan K, Di Bisceglie AM, Reddy KR, Lim JK, Levitsky J, Hassan MA, Darling JM, Feld JJ, Akushevich L, Vainorius M, Nelson DR, Fried MW, Brown RS Jr, Terrault NA. Hepatol Commun. 2019 Oct; 2019 Aug 7. PMID: 31592494.
The impact of socioeconomic status on outcomes in hepatocellular carcinoma: Inferences from primary insurance.Sellers CM, Uhlig J, Ludwig JM, Taddei T, Stein SM, Lim JK, Kim HS. Cancer Med. 2019 Oct; 2019 Aug 22. PMID: 31436905.
Determinants of Liver Complications Among HIV/Hepatitis B Virus-Coinfected Patients.Lo Re V 3rd, Newcomb CW, Carbonari DM, Roy JA, Althoff KN, Kitahata MM, Reddy KR, Lim JK, Silverberg MJ, Mayor AM, Horberg MA, Cachay ER, Kirk GD, Hull M, Gill J, Sterling TR, Kostman JR, Peters MG, Moore RD, Klein MB, Kim HN. J Acquir Immune Defic Syndr. 2019 Sep 1. PMID: 31107304.
Patient-reported symptoms during and after direct-acting antiviral therapies for chronic hepatitis C: The PROP UP study.Evon DM, Sarkar S, Amador J, Lok AS, Sterling RK, Stewart PW, Reeve BB, Serper M, Reau N, Rajender Reddy K, Di Bisceglie AM, Nelson DR, Golin CE, Lim JK, Fried MW. J Hepatol. 2019 Sep; 2019 May 13. PMID: 31096006.
AGA Clinical Practice Update on Interaction Between Oral Direct-Acting Antivirals for Chronic Hepatitis C Infection and Hepatocellular Carcinoma: Expert Review.Singal AG, Lim JK, Kanwal F. Gastroenterology. 2019 Jun; 2019 Mar 13. PMID: 30878469.
Contemporary HCV pangenotypic DAA treatment protocols are exclusionary to real world HIV-HCV co-infected patients.Maughan A, Sadigh K, Angulo-Diaz V, Mandimika C, Villanueva M, Lim JK, Ogbuagu O. BMC Infect Dis. 2019 May 3; 2019 May 3. PMID: 31053098.
Comparison of the prevalence, severity, and risk factors for hepatic steatosis in HIV-infected and uninfected people.Torgersen J, So-Armah K, Freiberg MS, Goetz MB, Budoff MJ, Lim JK, Taddei T, Butt AA, Rodriguez-Barradas MC, Justice AC, Kostman JR, Lo Re V 3rd. BMC Gastroenterol. 2019 Apr 15; 2019 Apr 15. PMID: 30987601.
Advancing Age and Comorbidity in a US Insured Population-Based Cohort of Patients With Chronic Hepatitis B.Nguyen MH, Lim JK, Burak Ozbay A, Fraysse J, Liou I, Meyer N, Dusheiko G, Gordon SC. Hepatology. 2019 Mar; 2019 Feb 11. PMID: 30175482.
A Comparison Between Community and Academic Practices in the USA in the Management of Chronic Hepatitis B Patients Receiving Entecavir: Results of the ENUMERATE Study.Lee HM, Ahn J, Kim WR, Lim JK, Nguyen M, Pan CQ, Kim D, Mannalithara A, Te H, Trinh H, Chu D, Tran T, Woog J, Lok AS. Dig Dis Sci. 2019 Feb; 2018 Sep 20. PMID: 30238203.
Status of Direct-Acting Antiviral Therapy for Hepatitis C Virus Infection and Remaining Challenges.Baumert TF, Berg T, Lim JK, Nelson DR. Gastroenterology. 2019 Jan; 2018 Oct 17. PMID: 30342035.
Healthcare resource utilization and costs by disease severity in an insured national sample of US patients with chronic hepatitis B.Nguyen MH, Burak Ozbay A, Liou I, Meyer N, Gordon SC, Dusheiko G, Lim JK. J Hepatol. 2019 Jan; 2018 Oct 1. PMID: 30287341.
Hepatitis C Vaccine Development in the Era of Direct-Acting Antivirals.McConnell M, Lim JK. Clin Liver Dis (Hoboken). 2018 Nov; 2018 Dec 14. PMID: 30988925.
Safety and Effectiveness of Ledipasvir and Sofosbuvir, With or Without Ribavirin, in Treatment-Experienced Patients With Genotype 1 Hepatitis C Virus Infection and Cirrhosis.Lim JK, Liapakis AM, Shiffman ML, Lok AS, Zeuzem S, Terrault NA, Park JS, Landis CS, Hassan M, Gallant J, Kuo A, Pockros PJ, Vainorius M, Akushevich L, Michael L, Fried MW, Nelson DR, Ben-Ari Z. Clin Gastroenterol Hepatol. 2018 Nov; 2018 Jan 3. PMID: 29306043.

Xavier Llor, MD, PhD

NCCN Guidelines® Insights: Colorectal Cancer Screening, Version 1.2024.Ness RM, Llor X, Abbass MA, Bishu S, Chen CT, Cooper G, Early DS, Friedman M, Fudman D, Giardiello FM, Glaser K, Gurudu S, Hall M, Huang LC, Issaka R, Katona B, Kidambi T, Lazenby AJ, Maratt J, Markowitz AJ, Marsano J, May FP, Mayer RJ, Olortegui K, Patel S, Peter S, Porter LD, Shafi M, Stanich PP, Terdiman J, Vu P, Weiss JM, Wood E, Cassara CJ, Sambandam V. J Natl Compr Canc Netw. 2024 Sep. PMID: 39236750.
Systems approach to enhance Lynch syndrome diagnosis through tumour testing.Singh V, Mezzacappa C, Gershkovich P, Di Giovanna J, Ganzak A, Gibson J, Sinard J, Xicola RM, Llor X. J Med Genet. 2023 Jun; 2022 Sep 17. PMID: 36115663.
Molecular and Sociodemographic Colorectal Cancer Disparities in Latinos Living in Puerto Rico.Perez-Mayoral J, Gonzalez-Pons M, Centeno-Girona H, Montes-Rodríguez IM, Soto-Salgado M, Suárez B, Rodríguez N, Colón G, Sevilla J, Jorge D, Llor X, Xicola RM, Toro DH, Tous-López L, Torres-Torres M, Reyes JS, López-Acevedo N, Goel A, Rodríguez-Quilichini S, Cruz-Correa M. Genes (Basel). 2023 Apr 11; 2023 Apr 11. PMID: 37107652.
Simplified and more sensitive criteria for identifying individuals with pathogenic CDH1 variants.Lerner BA, Xicola RM, Rodriguez NJ, Karam R, Llor X. J Med Genet. 2023 Jan; 2022 Jan 25. PMID: 35078942.
Mutational signature profiling classifies subtypes of clinically different mismatch-repair-deficient tumours with a differential immunogenic response potential.Giner-Calabuig M, De Leon S, Wang J, Fehlmann TD, Ukaegbu C, Gibson J, Alustiza-Fernandez M, Pico MD, Alenda C, Herraiz M, Carrillo-Palau M, Salces I, Reyes J, Ortega SP, Obrador-Hevia A, Cecchini M, Syngal S, Stoffel E, Ellis NA, Sweasy J, Jover R, Llor X, Xicola RM. Br J Cancer. 2022 Jun; 2022 Feb 23. PMID: 35197584.
Colorectal Cancer Risk in Lynch Syndrome: Of Genes and More.Mezzacappa C, Llor X. Gastroenterology. 2022 Apr; 2021 Dec 1. PMID: 34863785.
Molecular drivers of tumor progression in microsatellite stable APC mutation-negative colorectal cancers.Grant A, Xicola RM, Nguyen V, Lim J, Thorne C, Salhia B, Llor X, Ellis N, Padi M. Sci Rep. 2021 Dec 6; 2021 Dec 6. PMID: 34873211.
xDEEP-MSI: Explainable Bias-Rejecting Microsatellite Instability Deep Learning System in Colorectal Cancer.Bustos A, Payá A, Torrubia A, Jover R, Llor X, Bessa X, Castells A, Carracedo Á, Alenda C. Biomolecules. 2021 Nov 29; 2021 Nov 29. PMID: 34944430.
NCCN Guidelines® Insights: Genetic/Familial High-Risk Assessment: Colorectal, Version 1.2021.Weiss JM, Gupta S, Burke CA, Axell L, Chen LM, Chung DC, Clayback KM, Dallas S, Felder S, Gbolahan O, Giardiello FM, Grady W, Hall MJ, Hampel H, Hodan R, Idos G, Kanth P, Katona B, Lamps L, Llor X, Lynch PM, Markowitz AJ, Pirzadeh-Miller S, Samadder NJ, Shibata D, Swanson BJ, Szymaniak BM, Wiesner GL, Wolf A, Yurgelun MB, Zakhour M, Darlow SD, Dwyer MA, Campbell M. J Natl Compr Canc Netw. 2021 Oct 15; 2021 Oct 15. PMID: 34666312.
Analysis of Survival Among Adults With Early-Onset Colorectal Cancer in the National Cancer Database.Cheng E, Blackburn HN, Ng K, Spiegelman D, Irwin ML, Ma X, Gross CP, Tabung FK, Giovannucci EL, Kunz PL, Llor X, Billingsley K, Meyerhardt JA, Ahuja N, Fuchs CS. JAMA Netw Open. 2021 Jun 1; 2021 Jun 1. PMID: 34132794.
Exome sequencing of early-onset patients supports genetic heterogeneity in colorectal cancer.Fernández-Rozadilla C, Álvarez-Barona M, Quintana I, López-Novo A, Amigo J, Cameselle-Teijeiro JM, Roman E, Gonzalez D, Llor X, Bujanda L, Bessa X, Jover R, Balaguer F, Castells A, Castellví-Bel S, Capellá G, Carracedo A, Valle L, Ruiz-Ponte C. Sci Rep. 2021 May 27; 2021 May 27. PMID: 34045552.
Dickkopf-2 regulates the stem cell marker LGR5 in colorectal cancer via HNF4α1.Shin JH, Jeong J, Choi J, Lim J, Dinesh RK, Braverman J, Hong JY, Maher SE, Amezcua Vesely MC, Kim W, Koo JH, Tang W, Wu D, Blackburn HN, Xicola RM, Llor X, Yilmaz O, Choi JM, Bothwell ALM. iScience. 2021 May 21; 2021 Apr 15. PMID: 33997693.
Phenotypic Differences in Juvenile Polyposis Syndrome With or Without a Disease-causing SMAD4/BMPR1A Variant.MacFarland SP, Ebrahimzadeh JE, Zelley K, Begum L, Bass LM, Brand RE, Dudley B, Fishman DS, Ganzak A, Karloski E, Latham A, Llor X, Plon S, Riordan MK, Scollon SR, Stadler ZK, Syngal S, Ukaegbu C, Weiss JM, Yurgelun MB, Brodeur GM, Mamula P, Katona BW. Cancer Prev Res (Phila). 2021 Feb; 2020 Oct 23. PMID: 33097490.
Genetic Gastric Cancer Risk Syndromes.Lerner BA, Llor X. Curr Treat Options Gastroenterol. 2020 Dec; 2020 Oct 19. PMID: 33776403.
AGA White Paper: Roadmap for the Future of Colorectal Cancer Screening in the United States.Melson JE, Imperiale TF, Itzkowitz SH, Llor X, Kochman ML, Grady WM, Schoen RE, Burke CA, Shaukat A, Rabeneck L, Ladabaum U, Bresalier R, Spiegel B, Yee J, Wang T, Lieberman D, Komanduri S, Muthusamy VR, Dey N. Clin Gastroenterol Hepatol. 2020 Nov; 2020 Jul 4. PMID: 32634626.
NCCN Guidelines Insights: Colorectal Cancer Screening, Version 2.2020.Provenzale D, Ness RM, Llor X, Weiss JM, Abbadessa B, Cooper G, Early DS, Friedman M, Giardiello FM, Glaser K, Gurudu S, Halverson AL, Issaka R, Jain R, Kanth P, Kidambi T, Lazenby AJ, Maguire L, Markowitz AJ, May FP, Mayer RJ, Mehta S, Patel S, Peter S, Stanich PP, Terdiman J, Keller J, Dwyer MA, Ogba N. J Natl Compr Canc Netw. 2020 Oct 1; 2020 Oct 1. PMID: 33022639.
Decreased copy-neutral loss of heterozygosity in African American colorectal cancers.Augustus GJ, Xicola RM, Llor X, Ellis NA. Genes Chromosomes Cancer. 2020 Aug; 2020 Apr 29. PMID: 32293075.
Clinical features and cancer risk in families with pathogenic CDH1 variants irrespective of clinical criteria.Xicola RM, Li S, Rodriguez N, Reinecke P, Karam R, Speare V, Black MH, LaDuca H, Llor X. J Med Genet. 2019 Dec; 2019 Jul 11. PMID: 31296550.
Lynch Syndrome: Widening the Net.Llor X. Gastroenterology. 2019 Nov; 2019 Oct 3. PMID: 31586568.
NCCN Guidelines Insights: Genetic/Familial High-Risk Assessment: Colorectal, Version 2.2019.Gupta S, Provenzale D, Llor X, Halverson AL, Grady W, Chung DC, Haraldsdottir S, Markowitz AJ, Slavin TP Jr, Hampel H, Ness RM, Weiss JM, Ahnen DJ, Chen LM, Cooper G, Early DS, Giardiello FM, Hall MJ, Hamilton SR, Kanth P, Klapman JB, Lazenby AJ, Lynch PM, Mayer RJ, Mikkelson J, Peter S, Regenbogen SE, Dwyer MA, Ogba N. J Natl Compr Canc Netw. 2019 Sep 1. PMID: 31487681.
Scoring colorectal cancer risk with an artificial neural network based on self-reportable personal health data.Nartowt BJ, Hart GR, Roffman DA, Llor X, Ali I, Muhammad W, Liang Y, Deng J. PLoS One. 2019; 2019 Aug 22. PMID: 31437221.
Implication of DNA repair genes in Lynch-like syndrome.Xicola RM, Clark JR, Carroll T, Alvikas J, Marwaha P, Regan MR, Lopez-Giraldez F, Choi J, Emmadi R, Alagiozian-Angelova V, Kupfer SS, Ellis NA, Llor X. Fam Cancer. 2019 Jul. PMID: 30989425.
Lack of APC somatic mutation is associated with early-onset colorectal cancer in African Americans.Xicola RM, Manojlovic Z, Augustus GJ, Kupfer SS, Emmadi R, Alagiozian-Angelova V, Triche T Jr, Salhia B, Carpten J, Llor X, Ellis NA. Carcinogenesis. 2018 Dec 13. PMID: 30239619.
Colorectal cancer molecular classification using BRAF, KRAS, microsatellite instability and CIMP status: Prognostic implications and response to chemotherapy.Murcia O, Juárez M, Rodríguez-Soler M, Hernández-Illán E, Giner-Calabuig M, Alustiza M, Egoavil C, Castillejo A, Alenda C, Barberá V, Mangas-Sanjuan C, Yuste A, Bujanda L, Clofent J, Andreu M, Castells A, Llor X, Zapater P, Jover R. PLoS One. 2018; 2018 Sep 6. PMID: 30188916.
Genetic testing for hereditary prostate cancer: Current status and limitations.Zhen JT, Syed J, Nguyen KA, Leapman MS, Agarwal N, Brierley K, Llor X, Hofstatter E, Shuch B. Cancer. 2018 Aug 1; 2018 Apr 18. PMID: 29669169.
TFAP2E Methylation and Expression Status Does Not Predict Response to 5-FU-based Chemotherapy in Colorectal Cancer.Murcia O, Jover R, Egoavil C, Perez-Carbonell L, Juárez M, Hernández-Illán E, Rojas E, Alenda C, Balaguer F, Andreu M, Llor X, Castells A, Boland CR, Goel A. Clin Cancer Res. 2018 Jun 15; 2018 Mar 13. PMID: 29535127.
Race-dependent association of sulfidogenic bacteria with colorectal cancer.Yazici C, Wolf PG, Kim H, Cross TL, Vermillion K, Carroll T, Augustus GJ, Mutlu E, Tussing-Humphreys L, Braunschweig C, Xicola RM, Jung B, Llor X, Ellis NA, Gaskins HR. Gut. 2017 Nov; 2017 Feb 2. PMID: 28153960.
Methylation of WNT target genes AXIN2 and DKK1 as robust biomarkers for recurrence prediction in stage II colon cancer.Kandimalla R, Linnekamp JF, van Hooff S, Castells A, Llor X, Andreu M, Jover R, Goel A, Medema JP. Oncogenesis. 2017 Apr 3; 2017 Apr 3. PMID: 28368388.
Building a Cancer Genetics and Prevention Program.Llor X. Clin Gastroenterol Hepatol. 2016 Nov; 2016 Aug 13. PMID: 27531499.
Association of a let-7 miRNA binding region of TGFBR1 with hereditary mismatch repair proficient colorectal cancer (MSS HNPCC).Xicola RM, Bontu S, Doyle BJ, Rawson J, Garre P, Lee E, de la Hoya M, Bessa X, Clofent J, Bujanda L, Balaguer F, Castellví-Bel S, Alenda C, Jover R, Ruiz-Ponte C, Syngal S, Andreu M, Carracedo A, Castells A, Newcomb PA, Lindor N, Potter JD, Baron JA, Ellis NA, Caldes T, LLor X. Carcinogenesis. 2016 Aug; 2016 May 27. PMID: 27234654.
Kinase-Dependent and -Independent Roles for PTK6 in Colon Cancer.Mathur PS, Gierut JJ, Guzman G, Xie H, Xicola RM, Llor X, Chastkofsky MI, Perekatt AO, Tyner AL. Mol Cancer Res. 2016 Jun; 2016 Mar 16. PMID: 26983689.
A meta-analysis of MSI frequency and race in colorectal cancer.Ashktorab H, Ahuja S, Kannan L, Llor X, Ellis NA, Xicola RM, Laiyemo AO, Carethers JM, Brim H, Nouraie M. Oncotarget. 2016 Apr 23. PMID: 27120810.
Efficacy of Adjuvant 5-Fluorouracil Therapy for Patients with EMAST-Positive Stage II/III Colorectal Cancer.Hamaya Y, Guarinos C, Tseng-Rogenski SS, Iwaizumi M, Das R, Jover R, Castells A, Llor X, Andreu M, Carethers JM. PLoS One. 2015; 2015 May 21. PMID: 25996601.
Enrichment of inflammatory bowel disease and colorectal cancer risk variants in colon expression quantitative trait loci.Hulur I, Gamazon ER, Skol AD, Xicola RM, Llor X, Onel K, Ellis NA, Kupfer SS. BMC Genomics. 2015 Feb 27; 2015 Feb 27. PMID: 25766683.
Excess of proximal microsatellite-stable colorectal cancer in African Americans from a multiethnic study.Xicola RM, Gagnon M, Clark JR, Carroll T, Gao W, Fernandez C, Mijic D, Rawson JB, Janoski A, Pusatcioglu CK, Rajaram P, Gluskin AB, Regan M, Chaudhry V, Abcarian H, Blumetti J, Cintron J, Melson J, Xie H, Guzman G, Emmadi R, Alagiozian-Angelova V, Kupfer SS, Braunschweig C, Ellis NA, Llor X. Clin Cancer Res. 2014 Sep 15; 2014 Jul 10. PMID: 25013126.
Colorectal cancer: from the laboratory to the patient, a now indispensable step.Llor X. Rev Gastroenterol Mex. 2014 Apr-Jun. PMID: 24934514.

Amir Masoud, MBBS

SPLIT-DOSE BOWEL PREPARATION IS SUPERIOR TO STRAIGHT-DOSE IN HOSPITALIZED PATIENTS UNDERGOING INPATIENT COLONOSCOPY.Magier S, Jahandideh D, Pourmorady J, Masoud A. Arq Gastroenterol. 2023 Jan-Mar. PMID: 37194778.
Chronic opioid use is associated with obstructive and spastic disorders in the esophagus.Sanchez MJ, Olivier S, Gediklioglu F, Almeida M, Gaeta M, Nigro M, de la Rosa R, Nguyen M, Lalehzari M, Regala F, Njei B, Deng Y, Ciarleglio M, Masoud A. Neurogastroenterol Motil. 2022 Mar; 2021 Sep 16. PMID: 34532898.
Effectiveness of esophagogastroduodenoscopy in changing treatment outcome in refractory gastro-esophageal reflux disease.Kwak YE, Saleh A, Abdelwahed A, Sanchez M, Masoud A. Scand J Gastroenterol. 2022 Jan; 2021 Oct 20. PMID: 34669534.
Impact of COVID-19 on gastroenterology fellowship training: a multicenter analysis of endoscopy volumes.Paleti S, Sobani ZA, McCarty TR, Gutta A, Gremida A, Shah R, Nutalapati V, Bazerbachi F, Jesudoss R, Amin S, Okwara C, Kathi PR, Ahmed A, Gessel L, Hung K, Masoud A, Yu J, Mony S, Akshintala V, Jamil L, Nasereddin T, Kochhar G, Vyas N, Saligram S, Garg R, Sandhu D, Benrajab K, Konjeti R, Agnihotri A, Trivedi H, Grunwald M, Mayer I, Mohanty A, Rustagi T. Endosc Int Open. 2021 Oct; 2021 Sep 16. PMID: 34540553.
Use of Proton Pump Inhibitors Increases Risk of Incident Kidney Stones.Simonov M, Abel EA, Skanderson M, Masoud A, Hauser RG, Brandt CA, Wilson FP, Laine L. Clin Gastroenterol Hepatol. 2021 Jan; 2020 Mar 6. PMID: 32147588.
Burkitt lymphoma as a lead point for jejunojejunal intussusception in a human immunodeficiency virus patient.Sharma P, Balasingham S, Stawiarski K, Rahmani M, Costantino A, Sharma P, Xu M, Masoud A. Clin J Gastroenterol. 2017 Aug; 2017 May 18. PMID: 28523628.

Wajahat Zafar Mehal, PhD, MD

Corrigendum to: "From mice to humans: Unravelling the genetic levers of NASH" [J Hepatol (2020) 749-751].Mehal WZ. J Hepatol. 2024 Nov 7; 2024 Nov 7. PMID: 39516051.
Glucagon promotes increased hepatic mitochondrial oxidation and pyruvate carboxylase flux in humans with fatty liver disease.Petersen KF, Dufour S, Mehal WZ, Shulman GI. Cell Metab. 2024 Nov 5; 2024 Aug 27. PMID: 39197461.
Corrigendum to: "A gold mine of information from a deep dive into the liver transcriptome" [J Hepatol (2024) 540-542].Mehal WZ. J Hepatol. 2024 Oct 22; 2024 Oct 22. PMID: 39443197.
RNA modifications in the progression of liver diseases: from fatty liver to cancer.Li S, Mehal WZ, Ouyang X. Sci China Life Sci. 2024 Oct; 2024 May 27. PMID: 38809498.
Acute kidney injury in severe alcohol-associated hepatitis treated with anakinra plus zinc or prednisone.Patidar KR, Tu W, Cotter TG, Simonetto DA, Asgharpour A, Jan MY, Tang Q, Yu Y, Li Y, Taiwo M, Thevkar Nagesh P, Dasarathy S, Kamath PS, McClain CJ, Chalasani N, Szabo G, Bataller R, Mitchell M, Mehal WZ, Nagy LE, Shah VH, Gawrieh S, Sanyal AJ. Hepatology. 2024 Jul 19; 2024 Jul 19. PMID: 39028887.
The effect of a fermented soy beverage among patients with localized prostate cancer prior to radical prostatectomy.Lokeshwar SD, Ali A, Weiss TR, Reynolds J, Shuch BM, Ferencz T, Kyriakides TC, Mehal WZ, Brito J, Renzulli J, Leapman MS. BMC Urol. 2024 May 3; 2024 May 3. PMID: 38702664.
Letter to the Editor: Concerns regarding the use of fatty liver index in studies of lean NAFLD.Zahrawi FM, Mehal WZ. Hepatology. 2024 May 1; 2024 Jan 12. PMID: 38214551.
Proteomics identifies complement protein signatures in patients with alcohol-associated hepatitis.Taiwo M, Huang E, Pathak V, Bellar A, Welch N, Dasarathy J, Streem D, McClain CJ, Mitchell MC, Barton BA, Szabo G, Dasarathy S, Schaefer EA, Luther J, Day LZ, Ouyang X, Suyavaran A, Mehal WZ, Jacobs JM, Goodman RP, Rotroff DM, Nagy LE. JCI Insight. 2024 Apr 4; 2024 Apr 4. PMID: 38573776.
A gold mine of information from a deep dive into the liver transcriptome.Mehal WZ. J Hepatol. 2024 Apr; 2024 Jan 18. PMID: 38244846.
Multiomics identifies metabolic subtypes based on fatty acid degradation allocating personalized treatment in hepatocellular carcinoma.Li B, Li Y, Zhou H, Xu Y, Cao Y, Cheng C, Peng J, Li H, Zhang L, Su K, Xu Z, Hu Y, Lu J, Lu Y, Qian L, Wang Y, Zhang Y, Liu Q, Xie Y, Guo S, Mehal WZ, Yu D. Hepatology. 2024 Feb 1; 2023 Aug 7. PMID: 37540187.
Bioactive signalling lipids as drivers of chronic liver diseases.Kaffe E, Tisi A, Magkrioti C, Aidinis V, Mehal WZ, Flavell RA, Maccarrone M. J Hepatol. 2024 Jan; 2023 Sep 21. PMID: 37741346.
Mitochondrial DNA and the STING pathway are required for hepatic stellate cell activation.Arumugam S, Li B, Boodapati SLT, Nathanson MH, Sun B, Ouyang X, Mehal WZ. Hepatology. 2023 Nov 1; 2023 Apr 5. PMID: 37013923.
Humanized mouse liver reveals endothelial control of essential hepatic metabolic functions.Kaffe E, Roulis M, Zhao J, Qu R, Sefik E, Mirza H, Zhou J, Zheng Y, Charkoftaki G, Vasiliou V, Vatner DF, Mehal WZ, Yuval Kluger, Flavell RA. Cell. 2023 Aug 31; 2023 Aug 9. PMID: 37562401.
Digoxin as an emerging therapy in noncardiac diseases.Dashti F, Jamshed F, Ouyang X, Mehal WZ, Banini BA. Trends Pharmacol Sci. 2023 Apr; 2022 Nov 14. PMID: 36396496.
New uses for an old remedy: Digoxin as a potential treatment for steatohepatitis and other disorders.Jamshed F, Dashti F, Ouyang X, Mehal WZ, Banini BA. World J Gastroenterol. 2023 Mar 28. PMID: 37032732.
Pharmacologic Management of Obesity after Liver Transplantation: A Critical Review.Zahrawi F, Fathma S, Mehal WZ, Banini BA. Ann Gastroenterol Dig Disord. 2023; 2023 Jun 7. PMID: 38098758.
GSK3β mediates the spatiotemporal dynamics of NLRP3 inflammasome activation.Arumugam S, Qin Y, Liang Z, Han SN, Boodapati SLT, Li J, Lu Q, Flavell RA, Mehal WZ, Ouyang X. Cell Death Differ. 2022 Oct; 2022 Apr 27. PMID: 35477991.
A disease-promoting role of the intestinal mycobiome in non-alcoholic fatty liver disease.Mehal WZ, Schwabe RF. J Hepatol. 2022 Apr; 2022 Jan 21. PMID: 35066086.
A digital pathology tool for quantification of color features in histologic specimens.Reschke M, DiRito JR, Stern D, Day W, Plebanek N, Harris M, Hosgood SA, Nicholson ML, Haakinson DJ, Zhang X, Mehal WZ, Ouyang X, Pober JS, Saltzman WM, Tietjen GT. Bioeng Transl Med. 2022 Jan; 2021 Aug 24. PMID: 35111944.
Drug development of nonalcoholic fatty liver disease: challenges in research, regulatory pathways, and study endpoints.Do A, Ilagan-Ying YC, Mehal WZ, Lim JK. Expert Opin Drug Discov. 2021 Feb; 2020 Oct 22. PMID: 33086894.
From mice to humans: Unravelling the genetic levers of NASH.Mehal WZ. J Hepatol. 2020 Oct; 2020 Aug 14. PMID: 32807574.
Incorporating Weight Loss Medications Into Hepatology Practice for Nonalcoholic Steatohepatitis.Do A, Kuszewski EJ, Langberg KA, Mehal WZ. Hepatology. 2019 Oct. PMID: 30991446.
The Intestinal Microbiome, Plasma Metabolome, and Liver Transcriptome: A Conspiracy Driving Hepatic Steatosis.Mehal WZ, Loomba R. Hepatology. 2019 Aug; 2019 Apr 11. PMID: 30779368.
Ammonia-Induced Brain Edema Requires Macrophage and T Cell Expression of Toll-Like Receptor 9.Manakkat Vijay GK, Hu C, Peng J, Garcia-Martinez I, Hoque R, Verghis RM, Ma Y, Mehal WZ, Shawcross DL, Wen L. Cell Mol Gastroenterol Hepatol. 2019; 2019 Aug 8. PMID: 31401214.
Acetyl-Coenzyme A carboxylase inhibition Delivers, as Anticipated, for Patients With Nonalcoholic Steatohepatitis.Mehal WZ. Gastroenterology. 2018 Nov; 2018 Oct 8. PMID: 30308191.
The multi-dimensional role of intestinal HIFs in liver pathobiology.Ouyang X, Mehal WZ. J Hepatol. 2018 Oct; 2018 Aug 10. PMID: 30104025.
β-Hydroxybutyrate protects from alcohol-induced liver injury via a Hcar2-cAMP dependent pathway.Chen Y, Ouyang X, Hoque R, Garcia-Martinez I, Yousaf MN, Tonack S, Offermanns S, Dubuquoy L, Louvet A, Mathurin P, Massey V, Schnabl B, Bataller RA, Mehal WZ. J Hepatol. 2018 Sep; 2018 Apr 27. PMID: 29705237.
Dysregulation of serum bile acids and FGF19 in alcoholic hepatitis.Brandl K, Hartmann P, Jih LJ, Pizzo DP, Argemi J, Ventura-Cots M, Coulter S, Liddle C, Ling L, Rossi SJ, DePaoli AM, Loomba R, Mehal WZ, Fouts DE, Lucey MR, Bosques-Padilla F, Mathurin P, Louvet A, Garcia-Tsao G, Verna EC, Abraldes JG, Brown RS Jr, Vargas V, Altamirano J, Caballería J, Shawcross D, Stärkel P, Ho SB, Bataller R, Schnabl B. J Hepatol. 2018 Aug; 2018 Apr 12. PMID: 29654817.
A leukocyte activation test identifies food items which induce release of DNA by innate immune peripheral blood leucocytes.Garcia-Martinez I, Weiss TR, Yousaf MN, Ali A, Mehal WZ. Nutr Metab (Lond). 2018; 2018 Apr 11. PMID: 29651299.
Digoxin Suppresses Pyruvate Kinase M2-Promoted HIF-1α Transactivation in Steatohepatitis.Ouyang X, Han SN, Zhang JY, Dioletis E, Nemeth BT, Pacher P, Feng D, Bataller R, Cabezas J, Stärkel P, Caballeria J, Pongratz RL, Cai SY, Schnabl B, Hoque R, Chen Y, Yang WH, Garcia-Martinez I, Wang FS, Gao B, Torok NJ, Kibbey RG, Mehal WZ. Cell Metab. 2018 Feb 6. PMID: 29414684.
Efficacy of individualised diets in patients with irritable bowel syndrome: a randomised controlled trial.Ali A, Weiss TR, McKee D, Scherban A, Khan S, Fields MR, Apollo D, Mehal WZ. BMJ Open Gastroenterol. 2017; 2017 Sep 20. PMID: 29018540.
Intestinal fungi contribute to development of alcoholic liver disease.Yang AM, Inamine T, Hochrath K, Chen P, Wang L, Llorente C, Bluemel S, Hartmann P, Xu J, Koyama Y, Kisseleva T, Torralba MG, Moncera K, Beeri K, Chen CS, Freese K, Hellerbrand C, Lee SM, Hoffman HM, Mehal WZ, Garcia-Tsao G, Mutlu EA, Keshavarzian A, Brown GD, Ho SB, Bataller R, Stärkel P, Fouts DE, Schnabl B. J Clin Invest. 2017 Jun 30; 2017 May 22. PMID: 28530644.
Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response.Cai SY, Ouyang X, Chen Y, Soroka CJ, Wang J, Mennone A, Wang Y, Mehal WZ, Jain D, Boyer JL. JCI Insight. 2017 Mar 9; 2017 Mar 9. PMID: 28289714.
The novel TLR9 antagonist COV08-0064 protects from ischemia/reperfusion injury in non-steatotic and steatotic mice livers.Shaker ME, Trawick BN, Mehal WZ. Biochem Pharmacol. 2016 Jul 15; 2016 May 6. PMID: 27157410.
We are not in Kansas anymore: The unfamiliar landscape of NASH.Mehal WZ. Hepatology. 2016 Mar; 2016 Jan 5. PMID: 26567082.
Targeting Cell Death and Sterile Inflammation Loop for the Treatment of Nonalcoholic Steatohepatitis.Wree A, Mehal WZ, Feldstein AE. Semin Liver Dis. 2016 Feb; 2016 Feb 12. PMID: 26870930.
Caspase-12, but Not Caspase-11, Inhibits Obesity and Insulin Resistance.Skeldon AM, Morizot A, Douglas T, Santoro N, Kursawe R, Kozlitina J, Caprio S, Mehal WZ, Saleh M. J Immunol. 2016 Jan 1; 2015 Nov 18. PMID: 26582949.
Therapeutic Opportunities in Damage-Associated Molecular Pattern-Driven Metabolic Diseases.Garcia-Martinez I, Shaker ME, Mehal WZ. Antioxid Redox Signal. 2015 Dec 10; 2015 Jul 27. PMID: 26055926.
Systemic inflammatory response and serum lipopolysaccharide levels predict multiple organ failure and death in alcoholic hepatitis.Michelena J, Altamirano J, Abraldes JG, Affò S, Morales-Ibanez O, Sancho-Bru P, Dominguez M, García-Pagán JC, Fernández J, Arroyo V, Ginès P, Louvet A, Mathurin P, Mehal WZ, Caballería J, Bataller R. Hepatology. 2015 Sep; 2015 Apr 13. PMID: 25761863.
Antifibrotic therapies in the liver.Mehal WZ, Schuppan D. Semin Liver Dis. 2015 May; 2015 May 14. PMID: 25974903.
Inflammasomes in pancreatic physiology and disease.Hoque R, Mehal WZ. Am J Physiol Gastrointest Liver Physiol. 2015 Apr 15; 2015 Feb 19. PMID: 25700081.
DNA: adding injury to insult.Garcia-Martinez I, Mehal WZ. Hepatology. 2015 Jan; 2014 Nov 26. PMID: 25145786.
Activation of N-methyl-d-aspartate receptor downregulates inflammasome activity and liver inflammation via a β-arrestin-2 pathway.Farooq A, Hoque R, Ouyang X, Farooq A, Ghani A, Ahsan K, Guerra M, Mehal WZ. Am J Physiol Gastrointest Liver Physiol. 2014 Oct 1; 2014 Aug 7. PMID: 25104498.
Lactate reduces liver and pancreatic injury in Toll-like receptor- and inflammasome-mediated inflammation via GPR81-mediated suppression of innate immunity.Hoque R, Farooq A, Ghani A, Gorelick F, Mehal WZ. Gastroenterology. 2014 Jun; 2014 Mar 20. PMID: 24657625.
Activation of adenosine receptor A2A increases HSC proliferation and inhibits death and senescence by down-regulation of p53 and Rb.Ahsan MK, Mehal WZ. Front Pharmacol. 2014; 2014 Apr 10. PMID: 24782773.
Who is the scientist in bio-medical research, the author or the reviewer?Mehal WZ. Front Pharmacol. 2014; 2014 Mar 26. PMID: 24723888.
Constitutive NLRP3 activation: too much of a bad thing.Mehal WZ. Hepatology. 2014 Mar; 2014 Jan 13. PMID: 23929761.
The inflammasome in liver injury and non-alcoholic fatty liver disease.Mehal WZ. Dig Dis. 2014; 2014 Jul 14. PMID: 25034283.
The Gordian Knot of dysbiosis, obesity and NAFLD.Mehal WZ. Nat Rev Gastroenterol Hepatol. 2013 Nov; 2013 Aug 20. PMID: 23958600.
Sterile inflammation in the liver and pancreas.Hoque R, Farooq A, Mehal WZ. J Gastroenterol Hepatol. 2013 Aug. PMID: 23855298.
Nilotinib induces apoptosis and autophagic cell death of activated hepatic stellate cells via inhibition of histone deacetylases.Shaker ME, Ghani A, Shiha GE, Ibrahim TM, Mehal WZ. Biochim Biophys Acta. 2013 Aug; 2013 Mar 13. PMID: 23499874.
Inflammasome biology in fibrogenesis.Ouyang X, Ghani A, Mehal WZ. Biochim Biophys Acta. 2013 Jul; 2013 Apr 3. PMID: 23562491.
Adenosine is required for sustained inflammasome activation via the A₂A receptor and the HIF-1α pathway.Ouyang X, Ghani A, Malik A, Wilder T, Colegio OR, Flavell RA, Cronstein BN, Mehal WZ. Nat Commun. 2013. PMID: 24352507.
Sterile inflammation in the liver.Kubes P, Mehal WZ. Gastroenterology. 2012 Nov; 2012 Sep 13. PMID: 22982943.
Pathogenesis of liver injury in acute liver failure.Chung RT, Stravitz RT, Fontana RJ, Schiodt FV, Mehal WZ, Reddy KR, Lee WM. Gastroenterology. 2012 Sep; 2012 Jul 13. PMID: 22796239.
Adenine induces differentiation of rat hepatic stellate cells.Watanabe A, Sohail MA, Gautam S, Gomes DA, Mehal WZ. Dig Dis Sci. 2012 Sep; 2012 May 10. PMID: 22573344.
Gaucher disease gene GBA functions in immune regulation.Liu J, Halene S, Yang M, Iqbal J, Yang R, Mehal WZ, Chuang WL, Jain D, Yuen T, Sun L, Zaidi M, Mistry PK. Proc Natl Acad Sci U S A. 2012 Jun 19; 2012 Jun 4. PMID: 22665763.
P2X7 receptor-mediated purinergic signaling promotes liver injury in acetaminophen hepatotoxicity in mice.Hoque R, Sohail MA, Salhanick S, Malik AF, Ghani A, Robson SC, Mehal WZ. Am J Physiol Gastrointest Liver Physiol. 2012 May 15; 2012 Mar 1. PMID: 22383490.
Sterile inflammatory response in acute pancreatitis.Hoque R, Malik AF, Gorelick F, Mehal WZ. Pancreas. 2012 Apr. PMID: 22415665.
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.Henao-Mejia J, Elinav E, Jin C, Hao L, Mehal WZ, Strowig T, Thaiss CA, Kau AL, Eisenbarth SC, Jurczak MJ, Camporez JP, Shulman GI, Gordon JI, Hoffman HM, Flavell RA. Nature. 2012 Feb 1; 2012 Feb 1. PMID: 22297845.
Inflammasome components Asc and caspase-1 mediate biomaterial-induced inflammation and foreign body response.Malik AF, Hoque R, Ouyang X, Ghani A, Hong E, Khan K, Moore LB, Ng G, Munro F, Flavell RA, Shi Y, Kyriakides TR, Mehal WZ. Proc Natl Acad Sci U S A. 2011 Dec 13; 2011 Nov 22. PMID: 22109549.
Scraping fibrosis: expressway to the core of fibrosis.Mehal WZ, Iredale J, Friedman SL. Nat Med. 2011 May. PMID: 21546973.
Glucocerebrosidase gene-deficient mouse recapitulates Gaucher disease displaying cellular and molecular dysregulation beyond the macrophage.Mistry PK, Liu J, Yang M, Nottoli T, McGrath J, Jain D, Zhang K, Keutzer J, Chuang WL, Mehal WZ, Zhao H, Lin A, Mane S, Liu X, Peng YZ, Li JH, Agrawal M, Zhu LL, Blair HC, Robinson LJ, Iqbal J, Sun L, Zaidi M. Proc Natl Acad Sci U S A. 2010 Nov 9; 2010 Oct 20. PMID: 20962279.
A distinct nitric oxide and adenosine A1 receptor dependent hepatic artery vasodilatatory response in the CCl-cirrhotic liver.Zipprich A, Mehal WZ, Ripoll C, Groszmann RJ. Liver Int. 2010 Aug; 2010 May 24. PMID: 20500549.
Adenosine inhibits chemotaxis and induces hepatocyte-specific genes in bone marrow mesenchymal stem cells.Mohamadnejad M, Sohail MA, Watanabe A, Krause DS, Swenson ES, Mehal WZ. Hepatology. 2010 Mar. PMID: 20044808.
Inflammasome-mediated regulation of hepatic stellate cells.Watanabe A, Sohail MA, Gomes DA, Hashmi A, Nagata J, Sutterwala FS, Mahmood S, Jhandier MN, Shi Y, Flavell RA, Mehal WZ. Am J Physiol Gastrointest Liver Physiol. 2009 Jun; 2009 Apr 9. PMID: 19359429.
Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome.Imaeda AB, Watanabe A, Sohail MA, Mahmood S, Mohamadnejad M, Sutterwala FS, Flavell RA, Mehal WZ. J Clin Invest. 2009 Feb; 2009 Jan 26. PMID: 19164858.
Adenosine induces loss of actin stress fibers and inhibits contraction in hepatic stellate cells via Rho inhibition.Sohail MA, Hashmi AZ, Hakim W, Watanabe A, Zipprich A, Groszmann RJ, Dranoff JA, Torok NJ, Mehal WZ. Hepatology. 2009 Jan. PMID: 18844235.
Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll-like receptor 9.Watanabe A, Hashmi A, Gomes DA, Town T, Badou A, Flavell RA, Mehal WZ. Hepatology. 2007 Nov. PMID: 17705260.
Adenosine inhibits cytosolic calcium signals and chemotaxis in hepatic stellate cells.Hashmi AZ, Hakim W, Kruglov EA, Watanabe A, Watkins W, Dranoff JA, Mehal WZ. Am J Physiol Gastrointest Liver Physiol. 2007 Jan; 2006 Oct 19. PMID: 17053161.
Critical role for the beta regulatory subunits of Cav channels in T lymphocyte function.Badou A, Jha MK, Matza D, Mehal WZ, Freichel M, Flockerzi V, Flavell RA. Proc Natl Acad Sci U S A. 2006 Oct 17; 2006 Oct 6. PMID: 17028169.
Modulation of cell adhesion and motility in the immune system by Myo1f.Kim SV, Mehal WZ, Dong X, Heinrich V, Pypaert M, Mellman I, Dembo M, Mooseker MS, Wu D, Flavell RA. Science. 2006 Oct 6. PMID: 17023661.
In vitro and in vivo protection of stellate cells from apoptosis by leptin.Qamar A, Sheikh SZ, Masud A, Jhandier MN, Inayat IB, Hakim W, Mehal WZ. Dig Dis Sci. 2006 Oct. PMID: 16957995.
Caspases 3 and 7: key mediators of mitochondrial events of apoptosis.Lakhani SA, Masud A, Kuida K, Porter GA Jr, Booth CJ, Mehal WZ, Inayat I, Flavell RA. Science. 2006 Feb 10. PMID: 16469926.
Blocking intrahepatic deletion of activated CD8+ T cells by an altered peptide ligand.Kuniyasu Y, Qamar A, Sheikh SZ, Jhandier MN, Hakim W, Mehal WZ. Cell Immunol. 2005 Nov; 2006 Jan 30. PMID: 16445896.
TGF-beta signaling regulates CD8+ T cell responses to high- and low-affinity TCR interactions.Mehal WZ, Sheikh SZ, Gorelik L, Flavell RA. Int Immunol. 2005 May; 2005 Apr 11. PMID: 15824070.
Requirement of voltage-gated calcium channel beta4 subunit for T lymphocyte functions.Badou A, Basavappa S, Desai R, Peng YQ, Matza D, Mehal WZ, Kaczmarek LK, Boulpaep EL, Flavell RA. Science. 2005 Jan 7. PMID: 15637280.
Kupffer cells required for high affinity peptide-induced deletion, not retention, of activated CD8+ T cells by mouse liver.Kuniyasu Y, Marfani SM, Inayat IB, Sheikh SZ, Mehal WZ. Hepatology. 2004 Apr. PMID: 15057906.
Phosphatidylserine receptor is required for clearance of apoptotic cells.Li MO, Sarkisian MR, Mehal WZ, Rakic P, Flavell RA. Science. 2003 Nov 28. PMID: 14645847.
Antigen presentation by liver cells controls intrahepatic T cell trapping, whereas bone marrow-derived cells preferentially promote intrahepatic T cell apoptosis.Mehal WZ, Azzaroli F, Crispe IN. J Immunol. 2001 Jul 15. PMID: 11441069.
Involvement of CD1 in peripheral deletion of T lymphocytes is independent of NK T cells.Dao T, Exley M, Mehal WZ, Tahir SM, Snapper S, Taniguchi M, Balk SP, Crispe IN. J Immunol. 2001 Mar 1. PMID: 11207260.
Immunology of the healthy liver: old questions and new insights.Mehal WZ, Azzaroli F, Crispe IN. Gastroenterology. 2001 Jan. PMID: 11208734.
The liver as a site of T-cell apoptosis: graveyard, or killing field?Crispe IN, Dao T, Klugewitz K, Mehal WZ, Metz DP. Immunol Rev. 2000 Apr. PMID: 10807506.
Selective retention of activated CD8+ T cells by the normal liver.Mehal WZ, Juedes AE, Crispe IN. J Immunol. 1999 Sep 15. PMID: 10477588.
IL-18 augments perforin-dependent cytotoxicity of liver NK-T cells.Dao T, Mehal WZ, Crispe IN. J Immunol. 1998 Sep 1. PMID: 9725214.
TCR ligation on CD8+ T cells creates double-negative cells in vivo.Mehal WZ, Crispe IN. J Immunol. 1998 Aug 15. PMID: 9712032.
Strange brew: T cells in the liver.Crispe IN, Mehal WZ. Immunol Today. 1996 Nov. PMID: 8961629.

Thiruvengadam Muniraj, MD, MRCP

Effect of endoscopic ultrasound guided celiac plexus block on the palliation of pain in chronic pancreatitis (EPOCH Trial): study protocol for a randomized multicenter sham-controlled trial {1}.Wilcox CM, Bang JY, Buxbaum J, Gardner TB, Hawes R, Kedia P, Mardini SH, Muniraj T, Navaneethan U, Oza VM, Tarnasky P, Thakkar S, Waxman I, Varadarajulu S. Trials. 2024 Oct 14; 2024 Oct 14. PMID: 39396987.
EUS-guided Gastroenterostomy: A Multicenter International Study Comparing Benign and Malignant Diseases.Kahaleh M, Tyberg A, Sameera S, Sarkar A, Shahid HM, Abdelqader A, Gjeorgjievski M, Gaidhane M, Muniraj T, Jamidar PA, Aslanian HR, Abraham M, Lajin M, Kedia P, Nieto J, Parsa N, Andalib I, Bashir M, Kowalski TE, Loren DE, Kumar A, Schlachterman A, Chiang A, Holmes I, Mendoza Ladd AH, Oleas R, Zolotarevsky E, Robles-Medranda C, Barthet M. J Clin Gastroenterol. 2024 Jul 1; 2024 Jul 1. PMID: 37646532.
Outcomes of cold snare EMR of nonampullary duodenal adenomas ≥1 cm: a multicenter study.Wilson N, Abdallah M, Schulman AR, Mosko JD, Saeed A, Kothari S, Kaul V, Kothari TH, Phan J, Kumar A, Tofani C, Kim RE, Westanmo A, Moy BM, Dang F, Canakis A, Sharma N, Muniraj T, Azeem N, Bilal M. Gastrointest Endosc. 2024 Jun; 2023 Dec 11. PMID: 38092125.
Clinical predictive value of renalase in post-ERCP pancreatitis.Muniraj T, Desir G, Gorelick FS, Guo X, Ciarleglio MM, Deng Y, Jamidar PA, Farrell J, Aslanian HR, Laine L. Gastrointest Endosc. 2024 May; 2023 Dec 14. PMID: 38103747.
Endoscopic Ultrasound in Cancer Staging.Aslanian HR, Muniraj T, Nagar A, Parsons D. Gastrointest Endosc Clin N Am. 2024 Jan; 2023 Sep 27. PMID: 37973230.
Hyperamylasemia.Lam R, Muniraj T. 2024 Jan. PMID: 32644699.
Amylase.Akinfemiwa O, Zubair M, Muniraj T. 2024 Jan. PMID: 32491670.
Management of Antithrombotics Around Gastrointestinal Procedures.Gnanapandithan K, Muniraj T. 2024 Jan. PMID: 31985991.
Advancing surveillance protocols for dysplastic Barrett's esophagus after complete remission of intestinal metaplasia: Time to rethink biopsy strategy?Burton SJ, Muniraj T. Gastrointest Endosc. 2023 Nov. PMID: 37863568.
Spontaneous Hyperinflation of Gastric Weight Loss Balloon.Mathialagan K, Parsons D, Muniraj T. Dig Dis Sci. 2023 Nov; 2023 Sep 7. PMID: 37676629.
Improving Pancreatic Cyst Management: Artificial Intelligence-Powered Prediction of Advanced Neoplasms through Endoscopic Ultrasound-Guided Confocal Endomicroscopy.Jiang J, Chao WL, Cao T, Culp S, Napoléon B, El-Dika S, Machicado JD, Pannala R, Mok S, Luthra AK, Akshintala VS, Muniraj T, Krishna SG. Biomimetics (Basel). 2023 Oct 19; 2023 Oct 19. PMID: 37887627.
Serial serum lipase testing after the initial diagnostic workup for inpatients with acute pancreatitis: What is the evidence?Magier SJ, Muniraj T, Merchant N. Cleve Clin J Med. 2023 Jun 1; 2023 Jun 1. PMID: 37263664.
Acute pancreatitis precedes chronic pancreatitis in the majority of patients: Results from the NAPS2 consortium.Singh VK, Whitcomb DC, Banks PA, AlKaade S, Anderson MA, Amann ST, Brand RE, Conwell DL, Cote GA, Gardner TB, Gelrud A, Guda N, Forsmark CE, Lewis M, Sherman S, Muniraj T, Romagnuolo J, Tan X, Tang G, Sandhu BS, Slivka A, Wilcox CM, Yadav D. Pancreatology. 2022 Dec; 2022 Oct 31. PMID: 36404201.
Novel 15-mm-long lumen-apposing metal stent for endoscopic ultrasound-guided drainage of pancreatic fluid collections located ≥10 mm from the luminal wall.Zhang LY, Kunda R, Aerts M, Messaoudi N, Pawa R, Pawa S, Robles-Medranda C, Oleas R, Al-Haddad MA, Obaitan I, Muniraj T, Fabbri C, Binda C, Anderloni A, Tarantino I, Bejjani M, Ghandour B, Singh V, Khashab MA. Endoscopy. 2022 Jul; 2021 Dec 14. PMID: 34905796.
Post-liver transplantation bile leaks and strictures.Muniraj T. Gastrointest Endosc. 2022 Jun; 2022 Feb 3. PMID: 35124073.
Endoscopic Removal of Ingested Wire Bristle from the Pancreas.Lerner BA, Aslanian HR, Muniraj T. Clin Gastroenterol Hepatol. 2022 Apr; 2021 Feb 17. PMID: 33609785.
Comorbidities Drive the Majority of Overall Mortality in Low-Risk Mucinous Pancreatic Cysts Under Surveillance.Chhoda A, Yousaf MN, Madhani K, Aslanian H, Jamidar PA, Suarez AL, Salem RR, Muniraj T, Kunstman JW, Farrell JJ. Clin Gastroenterol Hepatol. 2022 Mar; 2020 Dec 10. PMID: 33309984.
Correction to: Pain Experience in Pancreatitis: Strong Association of Genetic Risk Loci for Anxiety and PTSD in Patients With Severe, Constant, and Constant-Severe Pain.Dunbar EK, Greer PJ, Amann ST, Alkaade S, Banks P, Brand R, Conwell DL, Forsmark CE, Gardner TB, Guda NM, Lewis MD, Machicado JD, Muniraj T, Papachristou GI, Romagnuolo J, Sandhu BS, Sherman S, Slivka A, Wilcox CM, Yadav D, Whitcomb DC. Am J Gastroenterol. 2022 Feb 1. PMID: 34738548.
Double pigtail stent placement as an adjunct to lumen-apposing metal stentsfor drainage of pancreatic fluid collections may not affect outcomes: A multicenter experience.Shamah SP, Sahakian AB, Chapman CG, Buxbaum JL, Muniraj T, Aslanian HA, Villa E, Cho J, Haider HI, Waxman I, Siddiqui UD. Endosc Ultrasound. 2022 Jan-Feb. PMID: 35102901.
Evaluation of socioeconomic and healthcare disparities on same admission cholecystectomy after endoscopic retrograde cholangiopancreatography among patients with acute gallstone pancreatitis.Chouairi F, McCarty TR, Hathorn KE, Sharma P, Aslanian HR, Jamidar PA, Thompson CC, Muniraj T. Surg Endosc. 2022 Jan; 2021 Jan 22. PMID: 33481109.
Ileosigmoid Anastomotic Perforation Three Weeks After Placement of Lumen-Apposing Metal Stent (LAMS).Mekheal N, Aslanian H, Kesar V, Jamidar P, Muniraj T. Cureus. 2021 Dec; 2021 Dec 21. PMID: 35103144.
Gallbladder Cryoablation: Other Endoscopic Options for High-Risk Patients with Cholecystitis.Jones J, Aslanian HR, Muniraj T. Am J Med. 2021 Nov. PMID: 34799010.
Fully covered metal biliary stents: A review of the literature.Lam R, Muniraj T. World J Gastroenterol. 2021 Oct 14. PMID: 34720527.
Pain Experience in Pancreatitis: Strong Association of Genetic Risk Loci for Anxiety and PTSD in Patients With Severe, Constant, and Constant-Severe Pain.Dunbar EK, Greer PJ, Amann ST, Alkaade S, Banks P, Brand R, Conwell DL, Forsmark CE, Gardner TB, Guda NM, Lewis MD, Machicado JD, Muniraj T, Papachristou GI, Romagnuolo J, Sandhu BS, Sherman S, Slivka A, Wilcox CM, Yadav D, Whitcomb DC. Am J Gastroenterol. 2021 Oct 1. PMID: 34236339.
Education and gastroenterology fellow knowledge about endoscopic mucosal resection of colon adenomas: a survey-based study.Garg S, Inamdar S, Tharian B, Muniraj T, Aslanian HR. Endosc Int Open. 2021 Aug; 2021 Jul 16. PMID: 34447869.
Gallbladder Disorders: A Comprehensive Review.Lam R, Zakko A, Petrov JC, Kumar P, Duffy AJ, Muniraj T. Dis Mon. 2021 Jul; 2021 Jan 18. PMID: 33478678.
Prospective evaluation of an assessment tool for technical performance of duodenoscopes.Bang JY, Rösch T, Kim HM, Thakkar S, Robalino Gonzaga E, Tharian B, Inamdar S, Lee LS, Yachimski P, Jamidar P, Muniraj T, DiMaio C, Kumta N, Sethi A, Draganov P, Yang D, Seoud T, Perisetti A, Bondi G, Kirtane S, Hawes R, Wilcox CM, Kozarek R, Reddy DN, Varadarajulu S. Dig Endosc. 2021 Jul; 2020 Nov 17. PMID: 33007136.
Resection of pancreatic cystic neoplasms in recurrent acute pancreatitis prevents recurrent pancreatitis but does not identify more malignancies.Muniraj T, Aslanian HR, Laine L, Jamidar PA, Farrell JF, Mitchell KA, Salem RR. World J Gastroenterol. 2021 Apr 21. PMID: 33958848.
AGA Clinical Practice Guidelines on Intragastric Balloons in the Management of Obesity.Muniraj T, Day LW, Teigen LM, Ho EY, Sultan S, Davitkov P, Shah R, Murad MH. Gastroenterology. 2021 Apr. PMID: 33832655.
Healthcare Disparities in the Management of Acute Cholecystitis: Impact of Race, Gender, and Socioeconomic Factors on Cholecystectomy vs Percutaneous Cholecystostomy.McCarty TR, Chouairi F, Hathorn KE, Sharma P, Muniraj T, Thompson CC. J Gastrointest Surg. 2021 Apr; 2021 Feb 24. PMID: 33629232.
Role of Prophylactic Cholecystectomy After Endoscopic Sphincterotomy for Biliary Stone Disease: A Systematic Review and Meta-analysis.McCarty TR, Farrelly J, Njei B, Jamidar P, Muniraj T. Ann Surg. 2021 Apr 1. PMID: 32590541.
Endoscopic ultrasound-guided fine needle aspiration cytology diagnosis of upper gastrointestinal tract mesenchymal tumors: Impact of rapid onsite evaluation and correlation with histopathologic follow-up.Gilani SM, Muniraj T, Aslanian HR, Cai G. Diagn Cytopathol. 2021 Feb; 2020 Oct 2. PMID: 33006819.
Access fistulotomy: technical tips for success.Magulick JP, Campbell EV 3rd, Muniraj T, Jamidar P, Aslanian H. VideoGIE. 2021 Jan; 2020 Nov 19. PMID: 33490758.
Musculoskeletal Pain Symptoms and Injuries Among Endoscopists Who Perform ERCP.Campbell EV 3rd, Muniraj T, Aslanian HR, Laine L, Jamidar P. Dig Dis Sci. 2021 Jan; 2020 Mar 6. PMID: 32144599.
Endoscopic Retrograde Cholangiopancreatography: Deciphering the Black and White.Mahalingam S, Langdon J, Muniraj T, Do A, Guo Y, Spektor M, Mathur M. Curr Probl Diagn Radiol. 2021 Jan-Feb; 2020 Jan 11. PMID: 32063296.
Endoscopic management of gastric outlet obstruction of remnant stomach in a patient with Roux-en-Y gastric bypass.Kesar V, Magulick J, Kesar V, Muniraj T, Aslanian HR. VideoGIE. 2020 Nov; 2020 Aug 20. PMID: 33204916.
The Reply.Lam R, Jamidar PA, Aslanian HR, Muniraj T. Am J Med. 2020 Oct. PMID: 33004185.
Low serum trypsinogen levels in chronic pancreatitis: Correlation with parenchymal loss, exocrine pancreatic insufficiency, and diabetes but not CT-based cambridge severity scores for fibrosis.Zhan W, Akshintala V, Greer PJ, Greer JB, Alkaade S, Anderson MA, Muniraj T, Papachristou GI, Sandhu BS, Slivka A, Wilcox CM, Bellin MD, Singh VK, Yadav D, Brand RE, Whitcomb DC. Pancreatology. 2020 Oct; 2020 Sep 5. PMID: 32967795.
Constant-severe pain in chronic pancreatitis is associated with genetic loci for major depression in the NAPS2 cohort.Dunbar E, Greer PJ, Melhem N, Alkaade S, Amann ST, Brand R, Coté GA, Forsmark CE, Gardner TB, Gelrud A, Guda NM, LaRusch J, Lewis MD, Machicado JD, Muniraj T, Papachristou GI, Romagnuolo J, Sandhu BS, Sherman S, Wilcox CM, Singh VK, Yadav D, Whitcomb DC. J Gastroenterol. 2020 Oct; 2020 Jul 17. PMID: 32681239.
Fitz-Hugh-Curtis Syndrome Presenting as Acute Abdomen.Lam R, Jamidar PA, Aslanian HR, Muniraj T. Am J Med. 2020 Oct; 2020 Apr 9. PMID: 32277885.
Endoscopic Ultrasound-Guided, Percutaneous, and Transjugular Liver Biopsy: A Comparative Systematic Review and Meta-Analysis.McCarty TR, Bazarbashi AN, Njei B, Ryou M, Aslanian HR, Muniraj T. Clin Endosc. 2020 Sep; 2020 Sep 29. PMID: 33027584.
Disseminated Burkitt lymphoma presenting as massive gastrointestinal bleed.Harne PS, Macklin J, Muniraj T. Proc (Bayl Univ Med Cent). 2020 Jul; 2020 Apr 20. PMID: 32675976.
Endoscopic ultrasound-guided fine needle aspiration of accessory spleen: Cytomorphologic features and diagnostic considerations.Gilani SM, Muniraj T, Farrell JJ, Aslanian HR, Cai G. Diagn Cytopathol. 2020 Jul; 2020 Apr 21. PMID: 32315514.
Alternative uses of lumen apposing metal stents.Sharma P, McCarty TR, Chhoda A, Costantino A, Loeser C, Muniraj T, Ryou M, Thompson CC. World J Gastroenterol. 2020 Jun 7. PMID: 32550749.
Endoscopic rectal variceal ligation.Campbell EV 3rd, Aslanian HR, Muniraj T. VideoGIE. 2020 Jun; 2020 Jun 3. PMID: 32529163.
Endoscopic ultrasound (EUS) and the management of pancreatic cancer.Yousaf MN, Chaudhary FS, Ehsan A, Suarez AL, Muniraj T, Jamidar P, Aslanian HR, Farrell JJ. BMJ Open Gastroenterol. 2020 May. PMID: 32414753.
Fine needle aspiration cytology of peripancreatic myelolipoma.Huang Q, Parmer C, Muniraj T, Aslanian HR, Cai G. Diagn Cytopathol. 2020 May; 2020 Mar 9. PMID: 32150351.
Endoscopic Resection of a Giant Duodenal Lipoma.Gnanapandithan K, Aslanian HR, Jamidar PA, Muniraj T. ACG Case Rep J. 2020 Mar; 2020 Mar 17. PMID: 32337302.
Comparative effectiveness of pharmacologic and endoscopic interventions for prevention of post-ERCP pancreatitis: a network meta-analysis.Njei B, McCarty TR, Muniraj T, Sharma P, Jamidar PA, Aslanian HR, Varadarajulu S, Navaneethan U. Endosc Int Open. 2020 Jan; 2020 Jan 8. PMID: 31921982.
Postampullectomy syndrome: old mechanism, new location.Langberg K, Israel G, Kesar V, Muniraj T, Jamidar P. Gastrointest Endosc. 2019 Aug; 2019 Apr 14. PMID: 30995445.
Genetic Risk Score in Diabetes Associated With Chronic Pancreatitis Versus Type 2 Diabetes Mellitus.Goodarzi MO, Nagpal T, Greer P, Cui J, Chen YI, Guo X, Pankow JS, Rotter JI, Alkaade S, Amann ST, Baillie J, Banks PA, Brand RE, Conwell DL, Cote GA, Forsmark CE, Gardner TB, Gelrud A, Guda N, LaRusch J, Lewis MD, Money ME, Muniraj T, Papachristou GI, Romagnuolo J, Sandhu BS, Sherman S, Singh VK, Wilcox CM, Pandol SJ, Park WG, Andersen DK, Bellin MD, Hart PA, Yadav D, Whitcomb DC. Clin Transl Gastroenterol. 2019 Jul. PMID: 31232720.
Increased awareness enhances physician recognition of the role of smoking in chronic pancreatitis.Muniraj T, Yadav D, Abberbock JN, Alkaade S, Amann ST, Anderson MA, Banks PA, Brand RE, Conwell D, Cote GA, Forsmark CE, Gardner TB, Gelrud A, Guda N, Lewis MD, Romagnuolo J, Sandhu BS, Sherman S, Singh VK, Slivka A, Tang G, Whitcomb DC, Wilcox CM. Pancreatology. 2019 Jun; 2019 Feb 26. PMID: 30910452.
Nutrition and Inflammatory Biomarkers in Chronic Pancreatitis Patients.Greer JB, Greer P, Sandhu BS, Alkaade S, Wilcox CM, Anderson MA, Sherman S, Gardner TB, Lewis MD, Guda NM, Muniraj T, Conwell D, Cote GA, Forsmark CE, Banks PA, Tang G, Stello K, Gelrud A, Brand RE, Slivka A, Whitcomb DC, Yadav D. Nutr Clin Pract. 2019 Jun; 2018 Aug 13. PMID: 30101991.
Perforation of the duodenum 2 weeks after lumen-apposing metal stent placement for malignant pyloric stricture.Muniraj T, Salem R, Olave-Martinez M, Suarez A, Aslanian HR. Gastrointest Endosc. 2019 May; 2019 Jan 10. PMID: 30639540.
Impact of endoscopic ultrasound on diagnosis and management of presumed mucinous neoplasms when done for pancreatic cyst morphology change on non-invasive surveillance imaging.Madhani K, Yousaf M, Aamar A, Ooka K, Muniraj T, Aslanian H, Salem R, Farrell JJ. Endosc Int Open. 2019 Apr; 2019 Mar 15. PMID: 30931368.
Chronic Pancreatitis: Pediatric and Adult Cohorts Show Similarities in Disease Progress Despite Different Risk Factors.Schwarzenberg SJ, Uc A, Zimmerman B, Wilschanski M, Wilcox CM, Whitcomb DC, Werlin SL, Troendle D, Tang G, Slivka A, Singh VK, Sherman S, Shah U, Sandhu BS, Romagnuolo J, Rhee S, Pohl JF, Perito ER, Ooi CY, Nathan JD, Muniraj T, Morinville VD, McFerron B, Mascarenhas M, Maqbool A, Liu Q, Lin TK, Lewis M, Husain SZ, Himes R, Heyman MB, Guda N, Gonska T, Giefer MJ, Gelrud A, Gariepy CE, Gardner TB, Freedman SD, Forsmark CE, Fishman DS, Cote GA, Conwell D, Brand RE, Bellin M, Barth B, Banks PA, Anderson MA, Amann ST, Alkaade S, Abu-El-Haija M, Abberbock JN, Lowe ME, Yadav D. J Pediatr Gastroenterol Nutr. 2019 Apr. PMID: 30897605.
Endoscopic Ultrasound for the Diagnosis and Staging of Liver Tumors.Lange A, Muniraj T, Aslanian HR. Gastrointest Endosc Clin N Am. 2019 Apr. PMID: 30846157.
Pancreatic Tail Neoplasm Masquerading as Recurrent Splenic Abscesses.Gnanapandithan K, Karthik N, Muniraj T. J Gastrointest Cancer. 2018 Dec. PMID: 28349307.
Endoscopic gallbladder drainage in high-risk surgical patients.Suarez AL, Mingjun S, Muniraj T, Jamidar P, Aslanian H. VideoGIE. 2018 Nov; 2018 Oct 4. PMID: 30402587.
Barrett's esophagus: A comprehensive review for the internist.Klavan H, Russell MB, Macklin J, Lee E, Aslanian HR, Muniraj T. Dis Mon. 2018 Nov; 2018 Jun 5. PMID: 29880269.
Long-Term Follow-Up of Low-Risk Branch Duct IPMNs of the Pancreas: Watch for Main Pancreatic Duct Dilatation, and for How Long?Muniraj T, Aslanian HR. Clin Transl Gastroenterol. 2018 Oct 24; 2018 Oct 24. PMID: 30353003.
Safety and rate of delayed adverse events with lumen-apposing metal stents (LAMS) for pancreatic fluid collections: a multicenter study.Yang D, Perbtani YB, Mramba LK, Kerdsirichairat T, Prabhu A, Manvar A, Ho S, Pannu D, Keswani RN, Strand DS, Wang AY, Quintero E, Buscaglia JM, Muniraj T, Aslanian HR, Draganov PV, Siddiqui AS. Endosc Int Open. 2018 Oct; 2018 Oct 8. PMID: 30302385.
Cannabis Use Is Associated With Increased Risk of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis: Analysis of the US Nationwide Inpatient Sample Database, 2004-2014.Njei B, Sharma P, McCarty TR, Singh M, Haque L, Aslanian HR, Jamidar P, Muniraj T. Pancreas. 2018 Oct. PMID: 30134357.
Known genetic susceptibility factors for chronic pancreatitis in patients of European ancestry are rare in patients of African ancestry.Phillips AE, LaRusch J, Greer P, Abberbock J, Alkaade S, Amann ST, Anderson MA, Baillie J, Banks PA, Brand RE, Conwell D, Coté GA, Forsmark CE, Gardner TB, Gelrud A, Guda N, Lewis M, Money ME, Muniraj T, Sandhu BS, Sherman S, Singh VK, Slivka A, Tang G, Wilcox CM, Whitcomb DC, Yadav D. Pancreatology. 2018 Jul; 2018 May 19. PMID: 29859674.
Recurrent Acute Pancreatitis Significantly Reduces Quality of Life Even in the Absence of Overt Chronic Pancreatitis.Coté GA, Yadav D, Abberbock JA, Whitcomb DC, Sherman S, Sandhu BS, Anderson MA, Lewis MD, Alkaade S, Singh VK, Baillie J, Banks PA, Conwell D, Guda NM, Muniraj T, Tang G, Brand R, Gelrud A, Amann ST, Forsmark CE, Wilcox MC, Slivka A, Gardner TB. Am J Gastroenterol. 2018 Jun; 2018 Jun 5. PMID: 29867178.
Endoscopic management of pancreatic duct disruption with large mediastinal pseudocyst.Ortiz V, Yousaf MN, Muniraj T, Jamidar P, Aslanian HR. VideoGIE. 2018 May; 2018 Mar 16. PMID: 29917026.
New Developments in Endoscopic Ultrasound Tissue Acquisition.Muniraj T, Aslanian HR. Gastrointest Endosc Clin N Am. 2017 Oct. PMID: 28918800.
Patient and Disease Characteristics Associated With the Presence of Diabetes Mellitus in Adults With Chronic Pancreatitis in the United States.Bellin MD, Whitcomb DC, Abberbock J, Sherman S, Sandhu BS, Gardner TB, Anderson MA, Lewis MD, Alkaade S, Singh VK, Baillie J, Banks PA, Conwell D, Cote GA, Guda NM, Muniraj T, Tang G, Brand RE, Gelrud A, Amann ST, Forsmark CE, Wilcox CM, Slivka A, Yadav D. Am J Gastroenterol. 2017 Sep; 2017 Jul 25. PMID: 28741615.
Quality of Life in Chronic Pancreatitis is Determined by Constant Pain, Disability/Unemployment, Current Smoking, and Associated Co-Morbidities.Machicado JD, Amann ST, Anderson MA, Abberbock J, Sherman S, Conwell DL, Cote GA, Singh VK, Lewis MD, Alkaade S, Sandhu BS, Guda NM, Muniraj T, Tang G, Baillie J, Brand RE, Gardner TB, Gelrud A, Forsmark CE, Banks PA, Slivka A, Wilcox CM, Whitcomb DC, Yadav D. Am J Gastroenterol. 2017 Apr; 2017 Feb 28. PMID: 28244497.
Endoscopic Management of Pancreatic Fluid Collections.Muniraj T, Jamidar PA, Nealon WH, Aslanian HR. J Clin Gastroenterol. 2017 Jan. PMID: 27548730.
Racial Differences in the Clinical Profile, Causes, and Outcome of Chronic Pancreatitis.Wilcox CM, Sandhu BS, Singh V, Gelrud A, Abberbock JN, Sherman S, Cote GA, Al-Kaade S, Anderson MA, Gardner TB, Lewis MD, Forsmark CE, Guda NM, Romagnuolo J, Baillie J, Amann ST, Muniraj T, Tang G, Conwell DL, Banks PA, Brand RE, Slivka A, Whitcomb D, Yadav D. Am J Gastroenterol. 2016 Oct; 2016 Aug 16. PMID: 27527745.
Pharmacologic Therapies in Gastrointestinal Diseases.Fox RK, Muniraj T. Med Clin North Am. 2016 Jul. PMID: 27235617.
Awash in a Multitude of Pancreas Cysts: Can We Stop Looking?Muniraj T, Aslanian HR. Clin Gastroenterol Hepatol. 2016 Jun; 2016 Feb 4. PMID: 26851707.
PANCREATITIS OR NOT?--Elevated lipase and amylase in ICU patients.Muniraj T, Dang S, Pitchumoni CS. J Crit Care. 2015 Dec; 2015 Sep 1. PMID: 26411523.
A double-blind, randomized, sham-controlled trial of the effect of a radiation-attenuating drape on radiation exposure to endoscopy staff during ERCP.Muniraj T, Aslanian HR, Laine L, Farrell J, Ciarleglio MM, Deng Y, Ho H, Jamidar PA. Am J Gastroenterol. 2015 May; 2015 Mar 31. PMID: 25823765.
Cold snare polypectomy for large sessile colonic polyps: a single-center experience.Muniraj T, Sahakian A, Ciarleglio MM, Deng Y, Aslanian HR. Gastroenterol Res Pract. 2015; 2015 Mar 23. PMID: 25878658.
Laparoscopic staging and surgical treatment of pancreatic cancer.Muniraj T, Barve P. N Am J Med Sci. 2013 Jan. PMID: 23378948.
Pancreatic neuroendocrine tumors.Muniraj T, Vignesh S, Shetty S, Thiruvengadam S, Aslanian HR. Dis Mon. 2013 Jan. PMID: 23312533.
Diabetes and pancreatic cancer.Muniraj T, Chari ST. Minerva Gastroenterol Dietol. 2012 Dec. PMID: 23207610.
Hypertriglyceridemia independent propofol-induced pancreatitis.Muniraj T, Aslanian HR. JOP. 2012 Jul 10; 2012 Jul 10. PMID: 22797405.

Michael Harris Nathanson, MD, PhD

Cytosolic calcium regulates hepatic mitochondrial oxidation, intrahepatic lipolysis, and gluconeogenesis via CAMKII activation.LaMoia TE, Hubbard BT, Guerra MT, Nasiri A, Sakuma I, Kahn M, Zhang D, Goodman RP, Nathanson MH, Sancak Y, Perelis M, Mootha VK, Shulman GI. Cell Metab. 2024 Oct 1; 2024 Aug 16. PMID: 39153480.
Neutrophils insert elastase into hepatocytes to regulate calcium signaling in alcohol-associated hepatitis.Ogino N, Leite MF, Guerra MT, Kruglov E, Asashima H, Hafler DA, Ito T, Pereira JP, Peiffer BJ, Sun Z, Ehrlich BE, Nathanson MH. J Clin Invest. 2024 Jun 25; 2024 Jun 25. PMID: 38916955.
Mitochondrial DNA and the STING pathway are required for hepatic stellate cell activation.Arumugam S, Li B, Boodapati SLT, Nathanson MH, Sun B, Ouyang X, Mehal WZ. Hepatology. 2023 Nov 1; 2023 Apr 5. PMID: 37013923.
Above the legal limit: Alcohol brings ER and mitochondria too close together.Guerra MT, Nathanson MH. Cell Calcium. 2023 Jul; 2023 May 22. PMID: 37235972.
Molecular determinants of peri-apical targeting of inositol 1,4,5-trisphosphate receptor type 3 in cholangiocytes.Rodrigues MA, Gomes DA, Fiorotto R, Guerra MT, Weerachayaphorn J, Bo T, Sessa WC, Strazzabosco M, Nathanson MH. Hepatol Commun. 2022 Oct; 2022 Jul 19. PMID: 35852334.
Role of the IgG4-related cholangitis autoantigen annexin A11 in cholangiocyte protection.Herta T, Kersten R, Chang JC, Hubers L, Go S, Tolenaars D, Paulusma CC, Nathanson MH, Elferink RO, van de Graaf SFJ, Beuers U. J Hepatol. 2022 Feb; 2021 Oct 27. PMID: 34718050.
Correlation Between Clinical and Pathological Findings of Liver Injury in 27 Patients With Lethal COVID-19 Infections in Brazil.Santana MF, Guerra MT, Hundt MA, Ciarleglio MM, Pinto RAA, Dutra BG, Xavier MS, Lacerda MVG, Ferreira AJ, Wanderley DC, Borges do Nascimento IJ, Araújo RFA, Pinheiro SVB, Araújo SA, Leite MF, Ferreira LCL, Nathanson MH, Vieira Teixeira Vidigal P. Hepatol Commun. 2022 Feb; 2021 Sep 14. PMID: 34520633.
Inositol 1,4,5-trisphosphate receptor type 3 is involved in resistance to apoptosis and maintenance of human hepatocellular carcinoma.Dos Santos ML, França A, Lima Filho ACM, Florentino RM, Diniz PH, Oliveira Lemos F, Gonçalves CAX, Coelho VL, Lima CX, Foureaux G, Nathanson MH, Vidigal PVT, Leite MF. Oncol Lett. 2022 Jan; 2021 Nov 25. PMID: 34966448.
Trefoil factor 2 secreted from damaged hepatocytes activates hepatic stellate cells to induce fibrogenesis.Zhang B, Lapenta K, Wang Q, Nam JH, Chung D, Robert ME, Nathanson MH, Yang X. J Biol Chem. 2021 Jul; 2021 Jun 17. PMID: 34146542.
Neutrophils interact with cholangiocytes to cause cholestatic changes in alcoholic hepatitis.Takeuchi M, Vidigal PT, Guerra MT, Hundt MA, Robert ME, Olave-Martinez M, Aoki S, Khamphaya T, Kersten R, Kruglov E, de la Rosa Rodriguez R, Banales JM, Nathanson MH, Weerachayaphorn J. Gut. 2021 Feb; 2020 Nov 19. PMID: 33214166.
Inositol 1,4,5-trisphosphate receptor type 3 plays a protective role in hepatocytes during hepatic ischemia-reperfusion injury.Lima Filho ACM, França A, Florentino RM, Dos Santos ML, de Oliveira Lemos F, Missiaggia DG, Fonseca RC, Gustavo Oliveira A, Ananthanarayanan M, Guerra MT, de Castro Fonseca M, Vidigal PVT, Lima CX, Nathanson MH, Fatima Leite M. Cell Calcium. 2020 Nov; 2020 Aug 11. PMID: 32957029.
Abnormal Liver Tests in COVID-19: A Retrospective Observational Cohort Study of 1,827 Patients in a Major U.S. Hospital Network.Hundt MA, Deng Y, Ciarleglio MM, Nathanson MH, Lim JK. Hepatology. 2020 Oct. PMID: 32725890.
Molecular Mechanism for Protection Against Liver Failure in Human Yellow Fever Infection.Lemos FO, França A, Lima Filho ACM, Florentino RM, Santos ML, Missiaggia DG, Rodrigues GOL, Dias FF, Souza Passos IB, Teixeira MM, Andrade AMF, Lima CX, Vidigal PVT, Costa VV, Fonseca MC, Nathanson MH, Leite MF. Hepatol Commun. 2020 May; 2020 Mar 16. PMID: 32363317.
TRPV4 helps Piezo1 put the squeeze on pancreatic acinar cells.Gorelick F, Nathanson MH. J Clin Invest. 2020 May 1. PMID: 32281947.
Glucagon stimulates gluconeogenesis by INSP3R1-mediated hepatic lipolysis.Perry RJ, Zhang D, Guerra MT, Brill AL, Goedeke L, Nasiri AR, Rabin-Court A, Wang Y, Peng L, Dufour S, Zhang Y, Zhang XM, Butrico GM, Toussaint K, Nozaki Y, Cline GW, Petersen KF, Nathanson MH, Ehrlich BE, Shulman GI. Nature. 2020 Mar; 2020 Mar 4. PMID: 32132708.
Type 3 Inositol 1,4,5-Trisphosphate Receptor Is Increased and Enhances Malignant Properties in Cholangiocarcinoma.Ueasilamongkol P, Khamphaya T, Guerra MT, Rodrigues MA, Gomes DA, Kong Y, Wei W, Jain D, Trampert DC, Ananthanarayanan M, Banales JM, Roberts LR, Farshidfar F, Nathanson MH, Weerachayaphorn J. Hepatology. 2020 Feb; 2019 Aug 19. PMID: 31251815.
Type 3 inositol 1,4,5-trisphosphate receptor: A calcium channel for all seasons.Mangla A, Guerra MT, Nathanson MH. Cell Calcium. 2020 Jan; 2019 Nov 25. PMID: 31790953.
Epidermal growth factor (EGF) triggers nuclear calcium signaling through the intranuclear phospholipase Cδ-4 (PLCδ4).de Miranda MC, Rodrigues MA, de Angelis Campos AC, Faria JAQA, Kunrath-Lima M, Mignery GA, Schechtman D, Goes AM, Nathanson MH, Gomes DA. J Biol Chem. 2019 Nov 8; 2019 Sep 19. PMID: 31537645.
O-GlcNAc transferase suppresses necroptosis and liver fibrosis.Zhang B, Li MD, Yin R, Liu Y, Yang Y, Mitchell-Richards KA, Nam JH, Li R, Wang L, Iwakiri Y, Chung D, Robert ME, Ehrlich BE, Bennett AM, Yu J, Nathanson MH, Yang X. JCI Insight. 2019 Nov 1; 2019 Nov 1. PMID: 31672932.
Expression of the type 3 InsP(3) receptor is a final common event in the development of hepatocellular carcinoma.Guerra MT, Florentino RM, Franca A, Lima Filho AC, Dos Santos ML, Fonseca RC, Lemos FO, Fonseca MC, Kruglov E, Mennone A, Njei B, Gibson J, Guan F, Cheng YC, Ananthanarayanan M, Gu J, Jiang J, Zhao H, Lima CX, Vidigal PT, Oliveira AG, Nathanson MH, Leite MF. Gut. 2019 Sep; 2019 Jul 17. PMID: 31315892.
CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation.Esteghamat F, Broughton JS, Smith E, Cardone R, Tyagi T, Guerra M, Szabó A, Ugwu N, Mani MV, Azari B, Kayingo G, Chung S, Fathzadeh M, Weiss E, Bender J, Mane S, Lifton RP, Adeniran A, Nathanson MH, Gorelick FS, Hwa J, Sahin-Tóth M, Belfort-DeAguiar R, Kibbey RG, Mani A. Nat Genet. 2019 Aug; 2019 Jul 29. PMID: 31358993.
Polymorphism in the Promoter Region of NFE2L2 Gene Is a Genetic Marker of Susceptibility to Cirrhosis Associated with Alcohol Abuse.Nunes Dos Santos K, Florentino RM, França A, Lima Filho ACM, Santos MLD, Missiaggia D, Fonseca MC, Brasil Costa I, Vidigal PVT, Nathanson MH, Lemos FO, Leite MF. Int J Mol Sci. 2019 Jul 23; 2019 Jul 23. PMID: 31340446.
Effects of Endotoxin on Type 3 Inositol 1,4,5-Trisphosphate Receptor in Human Cholangiocytes.Franca A, Carlos Melo Lima Filho A, Guerra MT, Weerachayaphorn J, Loiola Dos Santos M, Njei B, Robert M, Xavier Lima C, Vieira Teixeira Vidigal P, Banales JM, Ananthanarayanam M, Leite MF, Nathanson MH. Hepatology. 2019 Feb; 2018 Dec 31. PMID: 30141207.
Calcium Signaling in Cholangiocytes: Methods, Mechanisms, and Effects.Rodrigues MA, Gomes DA, Nathanson MH. Int J Mol Sci. 2018 Dec 6; 2018 Dec 6. PMID: 30563259.
Regulation of bile secretion by calcium signaling in health and disease.Trampert DC, Nathanson MH. Biochim Biophys Acta Mol Cell Res. 2018 Nov; 2018 May 19. PMID: 29787781.
Cholesterol-enriched membrane microdomains are needed for insulin signaling and proliferation in hepatic cells.Fonseca MC, França A, Florentino RM, Fonseca RC, Lima Filho ACM, Vidigal PTV, Oliveira AG, Dubuquoy L, Nathanson MH, Leite MF. Am J Physiol Gastrointest Liver Physiol. 2018 Jul 1; 2018 Feb 22. PMID: 29471671.
Nonalcoholic fatty liver disease impairs expression of the type II inositol 1,4,5-trisphosphate receptor.Khamphaya T, Chukijrungroat N, Saengsirisuwan V, Mitchell-Richards KA, Robert ME, Mennone A, Ananthanarayanan M, Nathanson MH, Weerachayaphorn J. Hepatology. 2018 Feb; 2018 Jan 2. PMID: 29023819.
Calcium-dependent O-GlcNAc signaling drives liver autophagy in adaptation to starvation.Ruan HB, Ma Y, Torres S, Zhang B, Feriod C, Heck RM, Qian K, Fu M, Li X, Nathanson MH, Bennett AM, Nie Y, Ehrlich BE, Yang X. Genes Dev. 2017 Aug 15; 2017 Sep 13. PMID: 28903979.
Alcohol and calcium make a potent cocktail.Iwakiri Y, Nathanson MH. J Physiol. 2017 May 15; 2017 Apr 18. PMID: 28295353.
Type 2 inositol trisphosphate receptor gene expression in hepatocytes is regulated by cyclic AMP.Kruglov E, Ananthanarayanan M, Sousa P, Weerachayaphorn J, Guerra MT, Nathanson MH. Biochem Biophys Res Commun. 2017 May 6; 2017 Mar 19. PMID: 28327356.
Hepatic Inositol 1,4,5 Trisphosphate Receptor Type 1 Mediates Fatty Liver.Feriod CN, Oliveira AG, Guerra MT, Nguyen L, Richards KM, Jurczak MJ, Ruan HB, Camporez JP, Yang X, Shulman GI, Bennett AM, Nathanson MH, Ehrlich BE. Hepatol Commun. 2017 Feb; 2016 Nov 11. PMID: 28966992.
Effects of andrographolide on intrahepatic cholestasis induced by alpha-naphthylisothiocyanate in rats.Khamphaya T, Chansela P, Piyachaturawat P, Suksamrarn A, Nathanson MH, Weerachayaphorn J. Eur J Pharmacol. 2016 Oct 15; 2016 Jul 27. PMID: 27475677.
Hepatitis B surface antigen loss: Not all that we hoped it would be.Nathanson MH, Terrault N. Hepatology. 2016 Aug; 2016 Jun 16. PMID: 27178231.
Calcium signaling and secretion in cholangiocytes.Guerra MT, Nathanson MH. Pancreatology. 2015 Jul; 2015 Jun 12. PMID: 26100660.
Nuclear Factor, Erythroid 2-Like 2 Regulates Expression of Type 3 Inositol 1,4,5-Trisphosphate Receptor and Calcium Signaling in Cholangiocytes.Weerachayaphorn J, Amaya MJ, Spirli C, Chansela P, Mitchell-Richards KA, Ananthanarayanan M, Nathanson MH. Gastroenterology. 2015 Jul; 2015 Mar 18. PMID: 25796361.
What is Hepatology looking for?Nathanson MH. Hepatology. 2015 Apr; 2015 Mar 10. PMID: 25581014.
Post-translational regulation of the type III inositol 1,4,5-trisphosphate receptor by miRNA-506.Ananthanarayanan M, Banales JM, Guerra MT, Spirli C, Munoz-Garrido P, Mitchell-Richards K, Tafur D, Saez E, Nathanson MH. J Biol Chem. 2015 Jan 2; 2014 Nov 5. PMID: 25378392.
Apical localization of inositol 1,4,5-trisphosphate receptors is independent of extended synaptotagmins in hepatocytes.Amaya MJ, Oliveira AG, Schroeder LK, Allgeyer ES, Bewersdorf J, Nathanson MH. PLoS One. 2014; 2014 Dec 1. PMID: 25437447.
Inositol 1,4,5-trisphosphate receptor type II (InsP3R-II) is reduced in obese mice, but metabolic homeostasis is preserved in mice lacking InsP3R-II.Feriod CN, Nguyen L, Jurczak MJ, Kruglov EA, Nathanson MH, Shulman GI, Bennett AM, Ehrlich BE. Am J Physiol Endocrinol Metab. 2014 Dec 1; 2014 Oct 14. PMID: 25315698.
Calcium signaling and the secretory activity of bile duct epithelia.Amaya MJ, Nathanson MH. Cell Calcium. 2014 Jun; 2014 Feb 12. PMID: 24612866.
Evaluation of Barrett esophagus by multiphoton microscopy.Chen J, Wong S, Nathanson MH, Jain D. Arch Pathol Lab Med. 2014 Feb. PMID: 24476518.
The insulin receptor translocates to the nucleus to regulate cell proliferation in liver.Amaya MJ, Oliveira AG, Guimarães ES, Casteluber MC, Carvalho SM, Andrade LM, Pinto MC, Mennone A, Oliveira CA, Resende RR, Menezes GB, Nathanson MH, Leite MF. Hepatology. 2014 Jan; 2013 Jul 29. PMID: 23839970.
Calcium signaling in the liver.Amaya MJ, Nathanson MH. Compr Physiol. 2013 Jan. PMID: 23720295.
High-definition confocal endomicroscopy of the common bile duct.Shieh FK, Drumm H, Nathanson MH, Jamidar PA. J Clin Gastroenterol. 2012 May-Jun. PMID: 22011583.
Type 2 inositol 1,4,5-trisphosphate receptor modulates bile salt export pump activity in rat hepatocytes.Kruglov EA, Gautam S, Guerra MT, Nathanson MH. Hepatology. 2011 Nov; 2011 Aug 30. PMID: 21748767.
Nucleoplasmic calcium regulates cell proliferation through legumain.Andrade V, Guerra M, Jardim C, Melo F, Silva W, Ortega JM, Robert M, Nathanson MH, Leite F. J Hepatol. 2011 Sep; 2011 Jan 13. PMID: 21237226.
Confocal endomicroscopic examination of malignant biliary strictures and histologic correlation with lymphatics.Loeser CS, Robert ME, Mennone A, Nathanson MH, Jamidar P. J Clin Gastroenterol. 2011 Mar. PMID: 21063210.
Needle-based confocal laser endomicroscopy to assess liver histology in vivo.Mennone A, Nathanson MH. Gastrointest Endosc. 2011 Feb; 2010 Dec 8. PMID: 21145055.
Low extracellular pH induces damage in the pancreatic acinar cell by enhancing calcium signaling.Reed AM, Husain SZ, Thrower E, Alexandre M, Shah A, Gorelick FS, Nathanson MH. J Biol Chem. 2011 Jan 21; 2010 Nov 17. PMID: 21084290.
The type I inositol 1,4,5-trisphosphate receptor interacts with protein 4.1N to mediate neurite formation through intracellular Ca waves.Fiedler MJ, Nathanson MH. Neurosignals. 2011; 2011 Mar 10. PMID: 21389686.
Regulation of multidrug resistance-associated protein 2 by calcium signaling in mouse liver.Cruz LN, Guerra MT, Kruglov E, Mennone A, Garcia CR, Chen J, Nathanson MH. Hepatology. 2010 Jul. PMID: 20578149.
Intracellular calcium signals regulate growth of hepatic stellate cells via specific effects on cell cycle progression.Soliman EM, Rodrigues MA, Gomes DA, Sheung N, Yu J, Amaya MJ, Nathanson MH, Dranoff JA. Cell Calcium. 2009 Mar; 2009 Jan 7. PMID: 19131107.
Insulin induces calcium signals in the nucleus of rat hepatocytes.Rodrigues MA, Gomes DA, Andrade VA, Leite MF, Nathanson MH. Hepatology. 2008 Nov. PMID: 18798337.
c-Met must translocate to the nucleus to initiate calcium signals.Gomes DA, Rodrigues MA, Leite MF, Gomez MV, Varnai P, Balla T, Bennett AM, Nathanson MH. J Biol Chem. 2008 Feb 15; 2007 Dec 11. PMID: 18073207.
Multiphoton imaging can be used for microscopic examination of intact human gastrointestinal mucosa ex vivo.Rogart JN, Nagata J, Loeser CS, Roorda RD, Aslanian H, Robert ME, Zipfel WR, Nathanson MH. Clin Gastroenterol Hepatol. 2008 Jan; 2007 Dec 18. PMID: 18065276.
Portal hypertension: from the patient to the molecule and back: a symposium honoring Roberto J. Groszmann, MD.Garcia-Tsao G, Nathanson MH. J Clin Gastroenterol. 2007 Nov-Dec. PMID: 17975470.
Cyclic AMP regulates bicarbonate secretion in cholangiocytes through release of ATP into bile.Minagawa N, Nagata J, Shibao K, Masyuk AI, Gomes DA, Rodrigues MA, Lesage G, Akiba Y, Kaunitz JD, Ehrlich BE, Larusso NF, Nathanson MH. Gastroenterology. 2007 Nov; 2007 Aug 14. PMID: 17916355.
Succinate is a paracrine signal for liver damage.Correa PR, Kruglov EA, Thompson M, Leite MF, Dranoff JA, Nathanson MH. J Hepatol. 2007 Aug; 2007 Apr 5. PMID: 17451837.
Lipid rafts establish calcium waves in hepatocytes.Nagata J, Guerra MT, Shugrue CA, Gomes DA, Nagata N, Nathanson MH. Gastroenterology. 2007 Jul; 2007 Apr 11. PMID: 17631147.
Nucleoplasmic calcium is required for cell proliferation.Rodrigues MA, Gomes DA, Leite MF, Grant W, Zhang L, Lam W, Cheng YC, Bennett AM, Nathanson MH. J Biol Chem. 2007 Jun 8; 2007 Apr 9. PMID: 17420246.
Caerulein-induced intracellular pancreatic zymogen activation is dependent on calcineurin.Husain SZ, Grant WM, Gorelick FS, Nathanson MH, Shah AU. Am J Physiol Gastrointest Liver Physiol. 2007 Jun; 2007 Mar 1. PMID: 17332472.
Molecular basis for calcium signaling in hepatic stellate cells.Kruglov EA, Correa PR, Arora G, Yu J, Nathanson MH, Dranoff JA. Am J Physiol Gastrointest Liver Physiol. 2007 Apr; 2007 Jan 4. PMID: 17204544.
The spatial distribution of inositol 1,4,5-trisphosphate receptor isoforms shapes Ca2+ waves.Hernandez E, Leite MF, Guerra MT, Kruglov EA, Bruna-Romero O, Rodrigues MA, Gomes DA, Giordano FJ, Dranoff JA, Nathanson MH. J Biol Chem. 2007 Mar 30; 2007 Feb 6. PMID: 17284437.
Hormonal regulation of nuclear permeability.O'Brien EM, Gomes DA, Sehgal S, Nathanson MH. J Biol Chem. 2007 Feb 9; 2006 Dec 7. PMID: 17158097.
Calcium signaling in cholangiocytes.Minagawa N, Ehrlich BE, Nathanson MH. World J Gastroenterol. 2006 Jun 14. PMID: 16773703.
Calcium release from ryanodine receptors in the nucleoplasmic reticulum.Marius P, Guerra MT, Nathanson MH, Ehrlich BE, Leite MF. Cell Calcium. 2006 Jan; 2005 Nov 9. PMID: 16289270.
Protein 4.1N does not interact with the inositol 1,4,5-trisphosphate receptor in an epithelial cell line.Sehgal S, Guerra MT, Kruglov EA, Wang J, Nathanson MH. Cell Calcium. 2005 Nov. PMID: 16122796.
The ryanodine receptor mediates early zymogen activation in pancreatitis.Husain SZ, Prasad P, Grant WM, Kolodecik TR, Nathanson MH, Gorelick FS. Proc Natl Acad Sci U S A. 2005 Oct 4; 2005 Sep 26. PMID: 16186498.
The anti-apoptotic protein Mcl-1 inhibits mitochondrial Ca2+ signals.Minagawa N, Kruglov EA, Dranoff JA, Robert ME, Gores GJ, Nathanson MH. J Biol Chem. 2005 Sep 30; 2005 Jul 18. PMID: 16027162.
Endotoxin unmasks the role of gap junctions in the liver.Correa PR, Guerra MT, Leite MF, Spray DC, Nathanson MH. Biochem Biophys Res Commun. 2004 Sep 24. PMID: 15336523.
Loss of inositol 1,4,5-trisphosphate receptors from bile duct epithelia is a common event in cholestasis.Shibao K, Hirata K, Robert ME, Nathanson MH. Gastroenterology. 2003 Oct. PMID: 14517800.
Regulation of calcium signals in the nucleus by a nucleoplasmic reticulum.Echevarría W, Leite MF, Guerra MT, Zipfel WR, Nathanson MH. Nat Cell Biol. 2003 May. PMID: 12717445.
Regulation of Ca(2+) signaling in rat bile duct epithelia by inositol 1,4,5-trisphosphate receptor isoforms.Hirata K, Dufour JF, Shibao K, Knickelbein R, O'Neill AF, Bode HP, Cassio D, St-Pierre MV, Larusso NF, Leite MF, Nathanson MH. Hepatology. 2002 Aug. PMID: 12143036.
Epidermal growth factor-mediated activation of the ETS domain transcription factor Elk-1 requires nuclear calcium.Pusl T, Wu JJ, Zimmerman TL, Zhang L, Ehrlich BE, Berchtold MW, Hoek JB, Karpen SJ, Nathanson MH, Bennett AM. J Biol Chem. 2002 Jul 26; 2002 Apr 23. PMID: 11971908.
Regulation of the type III InsP(3) receptor by InsP(3) and calcium.O'Neill AF, Hagar RE, Zipfel WR, Nathanson MH, Ehrlich BE. Biochem Biophys Res Commun. 2002 Jun 14. PMID: 12056830.
The type II inositol 1,4,5-trisphosphate receptor can trigger Ca2+ waves in rat hepatocytes.Hirata K, Pusl T, O'Neill AF, Dranoff JA, Nathanson MH. Gastroenterology. 2002 Apr. PMID: 11910359.

Hamita Sachar, MD

Detection of Gastrointestinal Bleeding With Large Language Models to Aid Quality Improvement and Appropriate Reimbursement.Zheng NS, Keloth VK, You K, Kats D, Li DK, Deshpande O, Sachar H, Xu H, Laine L, Shung DL. Gastroenterology. 2024 Sep 18; 2024 Sep 18. PMID: 39304088.
Continued midazolam versus diphenhydramine in difficult-to-sedate patients: a randomized double-blind trial.Sachar H, Pichetshote N, Nandigam K, Vaidya K, Laine L. Gastrointest Endosc. 2018 May; 2017 Jan 31. PMID: 28159539.
Intermittent vs continuous proton pump inhibitor therapy for high-risk bleeding ulcers: a systematic review and meta-analysis.Sachar H, Vaidya K, Laine L. JAMA Intern Med. 2014 Nov. PMID: 25201154.

Michael Schilsky, MD

Non-ceruloplasmin copper and urinary copper in clinically stable Wilson disease: Alignment with recommended targets.Ott P, Sandahl T, Ala A, Cassiman D, Couchonnal-Bedoya E, Cury RG, Czlonkowska A, Denk G, D'Inca R, de Assis Aquino Gondim F, Moore J, Poujois A, Twardowschy CA, Weiss KH, Zuin M, Kamlin COF, Schilsky ML. JHEP Rep. 2024 Aug; 2024 May 6. PMID: 39139457.
Accurate non-ceruloplasmin bound copper: a new biomarker for the assessment and monitoring of Wilson disease patients using HPLC coupled to ICP-MS/MS.Harrington CF, Carpenter G, Coverdale JPC, Douglas L, Mills C, Willis K, Schilsky ML. Clin Chem Lab Med. 2024 Jul 30; 2024 Jul 30. PMID: 39072400.
An abbreviated history of liver transplantation.Schilsky ML, Emre SH. Clin Liver Dis (Hoboken). 2024 Jan-Jun; 2024 Jun 28. PMID: 38952697.
Wilson Disease and the COVID-19 pandemic: exploring patients' mental health and vaccination attitudes in a longitudinal study.Coskun AK, Aydin A, Tosun S, To U, Rubman S, Schilsky ML, Zimbrean PC. Front Psychol. 2024; 2024 May 13. PMID: 38803830.
Effects of trientine and penicillamine on intestinal copper uptake: A mechanistic 64 Cu PET/CT study in healthy humans.Kirk FT, Munk DE, Swenson ES, Quicquaro AM, Vendelbo MH, Schilsky ML, Ott P, Sandahl TD. Hepatology. 2024 May 1; 2023 Dec 13. PMID: 38088886.
Effects of tetrathiomolybdate on copper metabolism in healthy volunteers and in patients with Wilson disease.Kirk FT, Munk DE, Swenson ES, Quicquaro AM, Vendelbo MH, Larsen A, Schilsky ML, Ott P, Sandahl TD. J Hepatol. 2024 Apr; 2023 Dec 10. PMID: 38081365.
Current and Emerging Issues in Wilson's Disease.Roberts EA, Schilsky ML. N Engl J Med. 2023 Sep 7. PMID: 37672695.
A multidisciplinary approach to the diagnosis and management of Wilson disease: Executive summary of the 2022 Practice Guidance on Wilson disease from the American Association for the Study of Liver Diseases.Schilsky ML, Roberts EA, Bronstein JM, Dhawan A, Hamilton JP, Rivard AM, Washington MK, Weiss KH, Zimbrean PC. Hepatology. 2023 Apr 1; 2022 Dec 7. PMID: 36152019.
Major Depressive Disorder in an International Multisite Wilson Disease Registry.Camarata MA, Ala A, Coskun AK, Deng Y, Embel VK, Gonzalez-Peralta R, Maciejewski KR, Patel A, Rubman S, To U, Tomlin R, Schilsky ML, Zimbrean PC. J Acad Consult Liaison Psychiatry. 2023 Mar-Apr; 2022 Dec 13. PMID: 36521682.
A multidisciplinary approach to the diagnosis and management of Wilson disease: 2022 Practice Guidance on Wilson disease from the American Association for the Study of Liver Diseases.Schilsky ML, Roberts EA, Bronstein JM, Dhawan A, Hamilton JP, Rivard AM, Washington MK, Weiss KH, Zimbrean PC. Hepatology. 2022 Dec 7; 2022 Dec 7. PMID: 36151586.
Trientine tetrahydrochloride versus penicillamine for maintenance therapy in Wilson disease (CHELATE): a randomised, open-label, non-inferiority, phase 3 trial.Schilsky ML, Czlonkowska A, Zuin M, Cassiman D, Twardowschy C, Poujois A, Gondim FAA, Denk G, Cury RG, Ott P, Moore J, Ala A, D'Inca R, Couchonnal-Bedoya E, D'Hollander K, Dubois N, Kamlin COF, Weiss KH. Lancet Gastroenterol Hepatol. 2022 Dec; 2022 Sep 30. PMID: 36183738.
Sustained Improvement in Patient Experience by Optimizing Patient Flow in Ambulatory Settings.Pashankar DS, Brown T, Votto P, Follo M, Formica RN, Schilsky ML, Mulligan DC, Khokhar B. J Patient Exp. 2022; 2022 Apr 6. PMID: 35402702.
Connecting copper and cancer: from transition metal signalling to metalloplasia.Ge EJ, Bush AI, Casini A, Cobine PA, Cross JR, DeNicola GM, Dou QP, Franz KJ, Gohil VM, Gupta S, Kaler SG, Lutsenko S, Mittal V, Petris MJ, Polishchuk R, Ralle M, Schilsky ML, Tonks NK, Vahdat LT, Van Aelst L, Xi D, Yuan P, Brady DC, Chang CJ. Nat Rev Cancer. 2022 Feb; 2021 Nov 11. PMID: 34764459.
Designing Clinical Trials in Wilson's Disease.Ott P, Ala A, Askari FK, Czlonkowska A, Hilgers RD, Poujois A, Roberts EA, Sandahl TD, Weiss KH, Ferenci P, Schilsky ML. Hepatology. 2021 Dec; 2021 Oct 5. PMID: 34320232.
Structural and functional brain changes in hepatic and neurological Wilson disease.Tinaz S, Arora J, Nalamada K, Vives-Rodriguez A, Sezgin M, Robakis D, Patel A, Constable RT, Schilsky ML. Brain Imaging Behav. 2021 Oct; 2020 Nov 26. PMID: 33244627.
The Effect of Mental Health, Neurological Disease, and Liver Disease on Quality of Life in Patients With Wilson Disease.Camarata MA, Ala A, Coskun AK, Deng Y, Gonzalez-Peralta RP, Maciejewski KR, Patel A, Rubman S, To U, Tomlin R, Schilsky ML, Zimbrean PC. J Acad Consult Liaison Psychiatry. 2021 Sep-Oct; 2021 May 25. PMID: 34044196.
American Association for the Study of Liver Diseases Expert Panel Consensus Statement: Vaccines to Prevent Coronavirus Disease 2019 Infection in Patients With Liver Disease.Fix OK, Blumberg EA, Chang KM, Chu J, Chung RT, Goacher EK, Hameed B, Kaul DR, Kulik LM, Kwok RM, McGuire BM, Mulligan DC, Price JC, Reau NS, Reddy KR, Reynolds A, Rosen HR, Russo MW, Schilsky ML, Verna EC, Ward JW, Fontana RJ. Hepatology. 2021 Aug. PMID: 33577086.
Direct Measurement of ATP7B Peptides Is Highly Effective in the Diagnosis of Wilson Disease.Collins CJ, Yi F, Dayuha R, Duong P, Horslen S, Camarata M, Coskun AK, Houwen RHJ, Pop TL, Zoller H, Yoo HW, Jung SW, Weiss KH, Schilsky ML, Ferenci P, Hahn SH. Gastroenterology. 2021 Jun; 2021 Feb 25. PMID: 33640437.
Recent advances in Wilson disease.Moini M, To U, Schilsky ML. Transl Gastroenterol Hepatol. 2021; 2021 Apr 5. PMID: 33824925.
Liver Transplantation in the Time of COVID19: Barriers and Ethical Considerations for Management and Next Steps.Jaffe A, Schilsky ML, Deshpande R, Batra R. Hepatol Commun. 2020 Sep; 2020 Jul 24. PMID: 32838103.
The macrophage activation marker soluble CD163 is elevated and associated with liver disease phenotype in patients with Wilson's disease.Glavind E, Gotthardt DN, Pfeiffenberger J, Sandahl TD, Bashlekova T, Willemoe GL, Hasselby JP, Weiss KH, Møller HJ, Vilstrup H, Lee WM, Schilsky ML, Ott P, Grønbæk H. Orphanet J Rare Dis. 2020 Jul 2; 2020 Jul 2. PMID: 32615997.
Clinical Best Practice Advice for Hepatology and Liver Transplant Providers During the COVID-19 Pandemic: AASLD Expert Panel Consensus Statement.Fix OK, Hameed B, Fontana RJ, Kwok RM, McGuire BM, Mulligan DC, Pratt DS, Russo MW, Schilsky ML, Verna EC, Loomba R, Cohen DE, Bezerra JA, Reddy KR, Chung RT. Hepatology. 2020 Jul. PMID: 32298473.
Management of Wilson Disease Diagnosed in Infancy: An Appraisal of Available Experience to Generate Discussion.Valentino PL, Roberts EA, Beer S, Miloh T, Arnon R, Vittorio JM, Schilsky ML. J Pediatr Gastroenterol Nutr. 2020 May. PMID: 31899725.
Outcomes of Acute Liver Injury in Adults Due to Wilson's Disease: Is Survival Without Transplant Possible?Camarata MA, Gottfried M, Rule JA, Ala A, Lee WM, Todd Stravitz R, Schilsky ML. Liver Transpl. 2020 Mar. PMID: 31838773.
Zinc Maintenance Therapy for Wilson Disease: A Comparison Between Zinc Acetate and Alternative Zinc Preparations.Camarata MA, Ala A, Schilsky ML. Hepatol Commun. 2019 Aug; 2019 Jul 23. PMID: 31388634.
Clinical practice guidelines in Wilson disease.Saroli Palumbo C, Schilsky ML. Ann Transl Med. 2019 Apr. PMID: 31179302.
Transjugular intrahepatic portosystemic shunt as a bridge to liver transplant: Current state and future directions.Sellers CM, Nezami N, Schilsky ML, Kim HS. Transplant Rev (Orlando). 2019 Apr; 2018 Oct 31. PMID: 30477811.
A Case for Not Going Global: "Americanization" of Diet Accelerates Hepatic Mitochondrial Injury in a Model of Wilson Disease.To U, Schilsky ML. Cell Mol Gastroenterol Hepatol. 2019; 2019 Jan 29. PMID: 30707887.
Wilson disease.Członkowska A, Litwin T, Dusek P, Ferenci P, Lutsenko S, Medici V, Rybakowski JK, Weiss KH, Schilsky ML. Nat Rev Dis Primers. 2018 Sep 6; 2018 Sep 6. PMID: 30190489.
Getting Better With Age and Time: A Look Back at the European Experience for Liver Transplantation for Pediatric Patients With Wilson's Disease.Schilsky ML. Liver Transpl. 2018 Sep. PMID: 30021047.
Text Messaging to Reduce Alcohol Relapse in Prelisting Liver Transplant Candidates: A Pilot Feasibility Study.DeMartini KS, Schilsky ML, Palmer A, Fehon DC, Zimbrean P, O'Malley SS, Lee HB, Toll BA. Alcohol Clin Exp Res. 2018 Apr; 2018 Mar 2. PMID: 29498753.
Pregnancy in Wilson's disease: Management and outcome.Pfeiffenberger J, Beinhardt S, Gotthardt DN, Haag N, Freissmuth C, Reuner U, Gauss A, Stremmel W, Schilsky ML, Ferenci P, Weiss KH. Hepatology. 2018 Apr; 2018 Feb 18. PMID: 28859232.
De-novo hepatocellular carcinoma after pediatric living donor liver transplantation.Torres-Landa S, Muñoz-Abraham AS, Fortune BE, Gurung A, Pollak J, Emre SH, Rodriguez-Davalos MI, Schilsky ML. World J Hepatol. 2017 Dec 28. PMID: 29359020.
Bis-choline tetrathiomolybdate in patients with Wilson's disease: an open-label, multicentre, phase 2 study.Weiss KH, Askari FK, Czlonkowska A, Ferenci P, Bronstein JM, Bega D, Ala A, Nicholl D, Flint S, Olsson L, Plitz T, Bjartmar C, Schilsky ML. Lancet Gastroenterol Hepatol. 2017 Dec; 2017 Oct 5. PMID: 28988934.
Wilson Disease: Diagnosis, Treatment, and Follow-up.Schilsky ML. Clin Liver Dis. 2017 Nov; 2017 Aug 10. PMID: 28987261.
The Natural History of Severe Acute Liver Injury.Koch DG, Speiser JL, Durkalski V, Fontana RJ, Davern T, McGuire B, Stravitz RT, Larson AM, Liou I, Fix O, Schilsky ML, McCashland T, Hay JE, Murray N, Shaikh OS, Ganger D, Zaman A, Han SB, Chung RT, Brown RS, Munoz S, Reddy KR, Rossaro L, Satyanarayana R, Hanje AJ, Olson J, Subramanian RM, Karvellas C, Hameed B, Sherker AH, Lee WM, Reuben A. Am J Gastroenterol. 2017 Sep; 2017 Apr 25. PMID: 28440304.
Hepatic features of Wilson disease.Boga S, Ala A, Schilsky ML. Handb Clin Neurol. 2017. PMID: 28433114.
Patient support groups in the management of Wilson disease.Graper ML, Schilsky ML. Handb Clin Neurol. 2017. PMID: 28433107.
Liver transplantation for Wilson disease.Ahmad A, Torrazza-Perez E, Schilsky ML. Handb Clin Neurol. 2017. PMID: 28433103.
Neuropsychiatric Presentation of Wilson Disease in an Adolescent Male.Schindler EA, Guo XM, Schrag M, Ghoshal S, Schilsky ML, Beslow LA. Neuropediatrics. 2016 Oct; 2016 Aug 4. PMID: 27490186.
Acute liver injury and acute liver failure from mushroom poisoning in North America.Karvellas CJ, Tillman H, Leung AA, Lee WM, Schilsky ML, Hameed B, Stravitz RT, McGuire BM, Fix OK. Liver Int. 2016 Jul; 2016 Mar 4. PMID: 26837055.
Host factors are dominant in the development of post-liver transplant non-alcoholic steatohepatitis.Boga S, Munoz-Abraham AS, Rodriguez-Davalos MI, Emre SH, Jain D, Schilsky ML. World J Hepatol. 2016 May 28. PMID: 27239259.
Advances in liver transplantation allocation systems.Schilsky ML, Moini M. World J Gastroenterol. 2016 Mar 14. PMID: 26973389.
Gene therapy of Wilson disease: A "golden" opportunity using rAAV on the 50th anniversary of the discovery of the virus.Roy-Chowdhury J, Schilsky ML. J Hepatol. 2016 Feb; 2015 Nov 27. PMID: 26639392.
Trientine induced colitis during therapy for Wilson disease: a case report and review of the literature.Boga S, Jain D, Schilsky ML. BMC Pharmacol Toxicol. 2015 Nov 20; 2015 Nov 20. PMID: 26589720.
The spectrum of psychiatric symptoms in Wilson's disease: treatment and prognostic considerations.Zimbrean PC, Schilsky ML. Am J Psychiatry. 2015 Nov 1. PMID: 26575449.
Presentation of Progressive Familial Intrahepatic Cholestasis Type 3 Mimicking Wilson Disease: Molecular Genetic Diagnosis and Response to Treatment.Boga S, Jain D, Schilsky ML. Pediatr Gastroenterol Hepatol Nutr. 2015 Sep; 2015 Sep 25. PMID: 26473142.
Reply: To PMID 25308108.Karvellas CJ, Stravitz RT, Battenhouse H, Lee WM, Schilsky ML. Liver Transpl. 2015 Jul. PMID: 25779618.
Costly choices for treating Wilson's disease.Schilsky ML, Roberts EA, Hahn S, Askari F. Hepatology. 2015 Apr; 2015 Mar 10. PMID: 25524500.
A century for progress in the diagnosis of Wilson disease.Schilsky ML. J Trace Elem Med Biol. 2014 Oct; 2014 Jul 4. PMID: 25087157.
Wilson disease: Clinical manifestations, diagnosis, and treatment.Schilsky ML. Clin Liver Dis (Hoboken). 2014 May; 2014 May 27. PMID: 30992899.
Liver transplantation for Wilson's disease.Schilsky ML. Ann N Y Acad Sci. 2014 May. PMID: 24820352.
Long-term outcome for Wilson disease: 85% good.Schilsky ML. Clin Gastroenterol Hepatol. 2014 Apr; 2013 Nov 16. PMID: 24246766.
Psychiatric aspects of Wilson disease: a review.Zimbrean PC, Schilsky ML. Gen Hosp Psychiatry. 2014 Jan-Feb; 2013 Oct 9. PMID: 24120023.
Hepatitis B "360".Schilsky ML. Transplant Proc. 2013 Apr. PMID: 23622604.
Transplantation for inherited metabolic disorders of the liver.Schilsky ML. Transplant Proc. 2013 Mar. PMID: 23498779.
Successful treatment of a bleeding umbilical varix by percutaneous umbilical vein embolization with sclerotherapy.Assis DN, Pollak J, Schilsky ML, Emre S. J Clin Gastroenterol. 2012 Feb. PMID: 21897280.
Acute liver failure and liver assist devices.Schilsky ML. Transplant Proc. 2011 Apr. PMID: 21486619.
Testing and management of thrombocytopenia and coagulopathy in the pre- and postliver transplant patient.Assis DN, Schilsky ML. Minerva Gastroenterol Dietol. 2010 Sep. PMID: 21037549.
Genetic testing for Wilson disease: availability and utility.Schilsky ML, Ala A. Curr Gastroenterol Rep. 2010 Feb. PMID: 20425485.
Wilson disease: current status and the future.Schilsky ML. Biochimie. 2009 Oct; 2009 Jul 30. PMID: 19647032.
ICU management of acute liver failure.Schilsky ML, Honiden S, Arnott L, Emre S. Clin Chest Med. 2009 Mar. PMID: 19186281.

Marina Silveira, MD

Advancing diagnosis and management of liver disease in adults through exome sequencing.Zheng M, Hakim A, Konkwo C, Deaton AM, Ward LD, Silveira MG, Assis DN, Liapakis A, Jaffe A, Jiang ZG, Curry MP, Lai M, Cho MH, Dykas D, Bale A, Mistry PK, Vilarinho S. EBioMedicine. 2023 Sep; 2023 Aug 9. PMID: 37566928.
Outcomes of immunomodulator and advanced therapies for primary sclerosing cholangitis-associated inflammatory bowel disease.Sayed A, Assis DN, Silveira MG, Deng Y, Ciarleglio M, Gaidos JKJ, Proctor DD, Al-Bawardy B. Eur J Gastroenterol Hepatol. 2023 Mar 1; 2023 Jan 17. PMID: 36708297.
Mindfulness-based stress reduction may decrease stress, disease activity, and inflammatory cytokine levels in patients with autoimmune hepatitis.Alrabadi LS, Dutton A, Rabiee A, Roberts SJ, Deng Y, Cusack L, Silveira MG, Ciarleglio M, Bucala R, Sinha R, Boyer JL, Assis DN. JHEP Rep. 2022 May; 2022 Feb 18. PMID: 35434588.
Primary sclerosing cholangitis.Rabiee A, Silveira MG. Transl Gastroenterol Hepatol. 2021; 2021 Apr 5. PMID: 33824933.
Surveillance for hepatobiliary cancers in patients with primary sclerosing cholangitis.Ali AH, Tabibian JH, Nasser-Ghodsi N, Lennon RJ, DeLeon T, Borad MJ, Hilscher M, Silveira MG, Carey EJ, Lindor KD. Hepatology. 2018 Jun; 2018 Apr 19. PMID: 29244227.
Investigational drugs in phase II clinical trials for primary biliary cholangitis.Silveira MG, Lindor KD. Expert Opin Investig Drugs. 2017 Oct; 2017 Aug 31. PMID: 28836457.

Carol J Soroka, PhD

Human vascularized bile duct-on-a chip: a multi-cellular micro-physiological system for studying cholestatic liver disease.Du Y, de Jong IEM, Gupta K, Waisbourd-Zinman O, Har-Zahav A, Soroka CJ, Boyer JL, Llewellyn J, Liu C, Naji A, Polacheck WJ, Wells RG. Biofabrication. 2023 Oct 20; 2023 Oct 20. PMID: 37820623.
Bile formation and secretion: An update.Boyer JL, Soroka CJ. J Hepatol. 2021 Jul; 2021 Feb 20. PMID: 33617926.
Role of Biliary Organoids in Cholestasis Research and Regenerative Medicine.Soroka CJ, Roberts SJ, Boyer JL, Assis DN. Semin Liver Dis. 2021 May; 2021 May 6. PMID: 33957696.
Hepatic NFAT signaling regulates the expression of inflammatory cytokines in cholestasis.Cai SY, Yu D, Soroka CJ, Wang J, Boyer JL. J Hepatol. 2021 Mar; 2020 Oct 9. PMID: 33039404.
Organic Solute Transporter Alpha Deficiency: A Disorder With Cholestasis, Liver Fibrosis, and Congenital Diarrhea.Gao E, Cheema H, Waheed N, Mushtaq I, Erden N, Nelson-Williams C, Jain D, Soroka CJ, Boyer JL, Khalil Y, Clayton PT, Mistry PK, Lifton RP, Vilarinho S. Hepatology. 2020 May. PMID: 31863603.
Bile-Derived Organoids From Patients With Primary Sclerosing Cholangitis Recapitulate Their Inflammatory Immune Profile.Soroka CJ, Assis DN, Alrabadi LS, Roberts S, Cusack L, Jaffe AB, Boyer JL. Hepatology. 2019 Sep; 2019 Mar 13. PMID: 30561836.
Patient-Derived Organoids from Human Bile: An In Vitro Method to Study Cholangiopathies.Soroka CJ, Assis DN, Boyer JL. Methods Mol Biol. 2019. PMID: 31016667.
Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response.Cai SY, Ouyang X, Chen Y, Soroka CJ, Wang J, Mennone A, Wang Y, Mehal WZ, Jain D, Boyer JL. JCI Insight. 2017 Mar 9; 2017 Mar 9. PMID: 28289714.
CFTR-associated ligand is a negative regulator of Mrp2 expression.Li M, Soroka CJ, Harry K, Boyer JL. Am J Physiol Cell Physiol. 2017 Jan 1; 2016 Nov 9. PMID: 27834195.
Sirtuin 1 activation alleviates cholestatic liver injury in a cholic acid-fed mouse model of cholestasis.Kulkarni SR, Soroka CJ, Hagey LR, Boyer JL. Hepatology. 2016 Dec; 2016 Oct 28. PMID: 27639250.
A Novel Di-Leucine Motif at the N-Terminus of Human Organic Solute Transporter Beta Is Essential for Protein Association and Membrane Localization.Xu S, Soroka CJ, Sun AQ, Backos DS, Mennone A, Suchy FJ, Boyer JL. PLoS One. 2016; 2016 Jun 28. PMID: 27351185.
Na(+) /H(+) exchanger regulatory factor 1 knockout mice have an attenuated hepatic inflammatory response and are protected from cholestatic liver injury.Li M, Mennone A, Soroka CJ, Hagey LR, Ouyang X, Weinman EJ, Boyer JL. Hepatology. 2015 Oct; 2015 Aug 22. PMID: 26108984.
Biosynthesis and trafficking of the bile salt export pump, BSEP: therapeutic implications of BSEP mutations.Soroka CJ, Boyer JL. Mol Aspects Med. 2014 Jun; 2013 May 15. PMID: 23685087.
Altered expression and function of canalicular transporters during early development of cholestatic liver injury in Abcb4-deficient mice.Cai SY, Mennone A, Soroka CJ, Boyer JL. Am J Physiol Gastrointest Liver Physiol. 2014 Apr 15; 2014 Jan 30. PMID: 24481602.
All-trans-retinoic acid improves cholestasis in α-naphthylisothiocyanate-treated rats and Mdr2-/- mice.Cai SY, Mennone A, Soroka CJ, Boyer JL. J Pharmacol Exp Ther. 2014 Apr; 2014 Feb 3. PMID: 24492652.
Peroxisome proliferator-activated receptor α activates human multidrug resistance transporter 3/ATP-binding cassette protein subfamily B4 transcription and increases rat biliary phosphatidylcholine secretion.Ghonem NS, Ananthanarayanan M, Soroka CJ, Boyer JL. Hepatology. 2014 Mar; 2014 Jan 27. PMID: 24122873.
Deleterious effect of oltipraz on extrahepatic cholestasis in bile duct-ligated mice.Weerachayaphorn J, Luo Y, Mennone A, Soroka CJ, Harry K, Boyer JL. J Hepatol. 2014 Jan; 2013 Aug 23. PMID: 23978715.
Adult sea lamprey tolerates biliary atresia by altering bile salt composition and renal excretion.Cai SY, Lionarons DA, Hagey L, Soroka CJ, Mennone A, Boyer JL. Hepatology. 2013 Jun. PMID: 23175353.
Identification of functionally distinct Na-HCO3 co-transporters in colon.Barmeyer C, Ye JH, Soroka C, Geibel P, Hingsammer LM, Weitgasser L, Atway D, Geibel JP, Binder HJ, Rajendran VM. PLoS One. 2013; 2013 May 14. PMID: 23690961.
A C-terminal tyrosine-based motif in the bile salt export pump directs clathrin-dependent endocytosis.Lam P, Xu S, Soroka CJ, Boyer JL. Hepatology. 2012 Jun; 2012 Apr 25. PMID: 22161577.
Nuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestine.Weerachayaphorn J, Mennone A, Soroka CJ, Harry K, Hagey LR, Kensler TW, Boyer JL. Am J Physiol Gastrointest Liver Physiol. 2012 May 1; 2012 Feb 16. PMID: 22345550.
Ostα depletion protects liver from oral bile acid load.Soroka CJ, Velazquez H, Mennone A, Ballatori N, Boyer JL. Am J Physiol Gastrointest Liver Physiol. 2011 Sep; 2011 Jun 30. PMID: 21719738.
Role of breast cancer resistance protein in the adaptive response to cholestasis.Mennone A, Soroka CJ, Harry KM, Boyer JL. Drug Metab Dispos. 2010 Oct; 2010 Jul 2. PMID: 20601550.
Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression.Xu S, Weerachayaphorn J, Cai SY, Soroka CJ, Boyer JL. Am J Physiol Gastrointest Liver Physiol. 2010 Jul; 2010 Apr 15. PMID: 20395535.
NHERF-1 binds to Mrp2 and regulates hepatic Mrp2 expression and function.Li M, Wang W, Soroka CJ, Mennone A, Harry K, Weinman EJ, Boyer JL. J Biol Chem. 2010 Jun 18; 2010 Apr 19. PMID: 20404332.
Organic solute transporter, OSTalpha-OSTbeta: its role in bile acid transport and cholestasis.Soroka CJ, Ballatori N, Boyer JL. Semin Liver Dis. 2010 May; 2010 Apr 26. PMID: 20422499.
The bile salt export pump: clinical and experimental aspects of genetic and acquired cholestatic liver disease.Lam P, Soroka CJ, Boyer JL. Semin Liver Dis. 2010 May; 2010 Apr 26. PMID: 20422495.
Mouse organic solute transporter alpha deficiency enhances renal excretion of bile acids and attenuates cholestasis.Soroka CJ, Mennone A, Hagey LR, Ballatori N, Boyer JL. Hepatology. 2010 Jan. PMID: 19902485.
Nuclear factor erythroid 2-related factor 2 is a positive regulator of human bile salt export pump expression.Weerachayaphorn J, Cai SY, Soroka CJ, Boyer JL. Hepatology. 2009 Nov. PMID: 19821532.
ATP8B1 deficiency disrupts the bile canalicular membrane bilayer structure in hepatocytes, but FXR expression and activity are maintained.Cai SY, Gautam S, Nguyen T, Soroka CJ, Rahner C, Boyer JL. Gastroenterology. 2009 Mar; 2008 Nov 1. PMID: 19027009.
Degradation of the bile salt export pump at endoplasmic reticulum in progressive familial intrahepatic cholestasis type II.Wang L, Dong H, Soroka CJ, Wei N, Boyer JL, Hochstrasser M. Hepatology. 2008 Nov. PMID: 18798335.
N-Glycosylation of the alpha subunit does not influence trafficking or functional activity of the human organic solute transporter alpha/beta.Soroka CJ, Xu S, Mennone A, Lam P, Boyer JL. BMC Cell Biol. 2008 Oct 10; 2008 Oct 10. PMID: 18847488.
Levels of plasma membrane expression in progressive and benign mutations of the bile salt export pump (Bsep/Abcb11) correlate with severity of cholestatic diseases.Lam P, Pearson CL, Soroka CJ, Xu S, Mennone A, Boyer JL. Am J Physiol Cell Physiol. 2007 Nov; 2007 Sep 13. PMID: 17855769.
Nuclear receptors RXRalpha:RARalpha are repressors for human MRP3 expression.Chen W, Cai SY, Xu S, Denson LA, Soroka CJ, Boyer JL. Am J Physiol Gastrointest Liver Physiol. 2007 May; 2007 Feb 1. PMID: 17272513.
Radixin is required to maintain apical canalicular membrane structure and function in rat hepatocytes.Wang W, Soroka CJ, Mennone A, Rahner C, Harry K, Pypaert M, Boyer JL. Gastroenterology. 2006 Sep. PMID: 16952556.
Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents.Boyer JL, Trauner M, Mennone A, Soroka CJ, Cai SY, Moustafa T, Zollner G, Lee JY, Ballatori N. Am J Physiol Gastrointest Liver Physiol. 2006 Jun; 2006 Jan 19. PMID: 16423920.
Mrp4-/- mice have an impaired cytoprotective response in obstructive cholestasis.Mennone A, Soroka CJ, Cai SY, Harry K, Adachi M, Hagey L, Schuetz JD, Boyer JL. Hepatology. 2006 May. PMID: 16628672.
A comparison of gene expression in mouse liver and kidney in obstructive cholestasis utilizing high-density oligonucleotide microarray technology.Denk GU, Cai SY, Chen WS, Lin A, Soroka CJ, Boyer JL. World J Gastroenterol. 2006 Apr 28. PMID: 16688799.
Down-regulation of the organic cation transporter 1 of rat liver in obstructive cholestasis.Denk GU, Soroka CJ, Mennone A, Koepsell H, Beuers U, Boyer JL. Hepatology. 2004 May. PMID: 15122767.
Multidrug resistance-associated protein 4 is up-regulated in liver but down-regulated in kidney in obstructive cholestasis in the rat.Denk GU, Soroka CJ, Takeyama Y, Chen WS, Schuetz JD, Boyer JL. J Hepatol. 2004 Apr. PMID: 15030973.
Molecular characterization of a multidrug resistance-associated protein, Mrp2, from the little skate.Cai SY, Soroka CJ, Ballatori N, Boyer JL. Am J Physiol Regul Integr Comp Physiol. 2003 Jan; 2002 Oct 3. PMID: 12388433.
The role of bile salt export pump mutations in progressive familial intrahepatic cholestasis type II.Wang L, Soroka CJ, Boyer JL. J Clin Invest. 2002 Oct. PMID: 12370274.
Ursodeoxycholic acid diminishes Fas-ligand-induced apoptosis in mouse hepatocytes.Azzaroli F, Mehal W, Soroka CJ, Wang L, Lee J, Crispe IN, Boyer JL. Hepatology. 2002 Jul. PMID: 12085348.
An evolutionarily ancient Oatp: insights into conserved functional domains of these proteins.Cai SY, Wang W, Soroka CJ, Ballatori N, Boyer JL. Am J Physiol Gastrointest Liver Physiol. 2002 Apr. PMID: 11897630.

Carlo Spirli, PhD

Cell Interactions in Biliary Diseases: Clues from Pathophysiology and Repair Mechanisms to Foster Early Assessment.Fabris L, Spirli C, Mertens J. Int J Mol Sci. 2019 Aug 14; 2019 Aug 14. PMID: 31416247.
Pathobiology of inherited biliary diseases: a roadmap to understand acquired liver diseases.Fabris L, Fiorotto R, Spirli C, Cadamuro M, Mariotti V, Perugorria MJ, Banales JM, Strazzabosco M. Nat Rev Gastroenterol Hepatol. 2019 Aug. PMID: 31165788.
Animal models of cholestasis: An update on inflammatory cholangiopathies.Mariotti V, Cadamuro M, Spirli C, Fiorotto R, Strazzabosco M, Fabris L. Biochim Biophys Acta Mol Basis Dis. 2019 May 1; 2018 Aug 11. PMID: 30398152.
Liver diseases in the dish: iPSC and organoids as a new approach to modeling liver diseases.Fiorotto R, Amenduni M, Mariotti V, Fabris L, Spirli C, Strazzabosco M. Biochim Biophys Acta Mol Basis Dis. 2019 May 1; 2018 Sep 5. PMID: 30264693.
Animal models for cystic fibrosis liver disease (CFLD).Fiorotto R, Amenduni M, Mariotti V, Cadamuro M, Fabris L, Spirli C, Strazzabosco M. Biochim Biophys Acta Mol Basis Dis. 2019 May 1; 2018 Jul 30. PMID: 30071276.
Platelet-derived growth factor-D enables liver myofibroblasts to promote tumor lymphangiogenesis in cholangiocarcinoma.Cadamuro M, Brivio S, Mertens J, Vismara M, Moncsek A, Milani C, Fingas C, Cristina Malerba M, Nardo G, Dall'Olmo L, Milani E, Mariotti V, Stecca T, Massani M, Spirli C, Fiorotto R, Indraccolo S, Strazzabosco M, Fabris L. J Hepatol. 2019 Apr; 2018 Dec 14. PMID: 30553841.
Animal models of cholangiocarcinoma: What they teach us about the human disease.Cadamuro M, Brivio S, Stecca T, Kaffe E, Mariotti V, Milani C, Fiorotto R, Spirli C, Strazzabosco M, Fabris L. Clin Res Hepatol Gastroenterol. 2018 Oct; 2018 May 9. PMID: 29753731.
β-Catenin and interleukin-1β-dependent chemokine (C-X-C motif) ligand 10 production drives progression of disease in a mouse model of congenital hepatic fibrosis.Kaffe E, Fiorotto R, Pellegrino F, Mariotti V, Amenduni M, Cadamuro M, Fabris L, Strazzabosco M, Spirli C. Hepatology. 2018 May; 2018 Mar 25. PMID: 29140564.
The deleterious interplay between tumor epithelia and stroma in cholangiocarcinoma.Cadamuro M, Stecca T, Brivio S, Mariotti V, Fiorotto R, Spirli C, Strazzabosco M, Fabris L. Biochim Biophys Acta Mol Basis Dis. 2018 Apr; 2017 Jul 27. PMID: 28757170.
Pathophysiologic implications of innate immunity and autoinflammation in the biliary epithelium.Strazzabosco M, Fiorotto R, Cadamuro M, Spirli C, Mariotti V, Kaffe E, Scirpo R, Fabris L. Biochim Biophys Acta Mol Basis Dis. 2018 Apr; 2017 Jul 25. PMID: 28754453.
Src kinase inhibition reduces inflammatory and cytoskeletal changes in ΔF508 human cholangiocytes and improves cystic fibrosis transmembrane conductance regulator correctors efficacy.Fiorotto R, Amenduni M, Mariotti V, Fabris L, Spirli C, Strazzabosco M. Hepatology. 2018 Mar; 2018 Jan 26. PMID: 28836688.
Emerging concepts in biliary repair and fibrosis.Fabris L, Spirli C, Cadamuro M, Fiorotto R, Strazzabosco M. Am J Physiol Gastrointest Liver Physiol. 2017 Aug 1; 2017 May 19. PMID: 28526690.
Adenylyl cyclase 5 links changes in calcium homeostasis to cAMP-dependent cyst growth in polycystic liver disease.Spirli C, Mariotti V, Villani A, Fabris L, Fiorotto R, Strazzabosco M. J Hepatol. 2017 Mar; 2016 Nov 5. PMID: 27826057.
Autocrine and Paracrine Mechanisms Promoting Chemoresistance in Cholangiocarcinoma.Cadamuro M, Brivio S, Spirli C, Joplin RE, Strazzabosco M, Fabris L. Int J Mol Sci. 2017 Jan 13; 2017 Jan 13. PMID: 28098760.
The cystic fibrosis transmembrane conductance regulator controls biliary epithelial inflammation and permeability by regulating Src tyrosine kinase activity.Fiorotto R, Villani A, Kourtidis A, Scirpo R, Amenduni M, Geibel PJ, Cadamuro M, Spirli C, Anastasiadis PZ, Strazzabosco M. Hepatology. 2016 Dec; 2016 Oct 27. PMID: 27629435.
Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma.Cadamuro M, Spagnuolo G, Sambado L, Indraccolo S, Nardo G, Rosato A, Brivio S, Caslini C, Stecca T, Massani M, Bassi N, Novelli E, Spirli C, Fabris L, Strazzabosco M. Cancer Res. 2016 Aug 15; 2016 Jun 21. PMID: 27328733.
Macrophage recruitment by fibrocystin-defective biliary epithelial cells promotes portal fibrosis in congenital hepatic fibrosis.Locatelli L, Cadamuro M, Spirlì C, Fiorotto R, Lecchi S, Morell CM, Popov Y, Scirpo R, De Matteis M, Amenduni M, Pietrobattista A, Torre G, Schuppan D, Fabris L, Strazzabosco M. Hepatology. 2016 Mar; 2016 Jan 16. PMID: 26645994.
Posttranslational regulation of polycystin-2 protein expression as a novel mechanism of cholangiocyte reaction and repair from biliary damage.Spirli C, Villani A, Mariotti V, Fabris L, Fiorotto R, Strazzabosco M. Hepatology. 2015 Dec; 2015 Oct 10. PMID: 26313562.
Stimulation of nuclear receptor peroxisome proliferator-activated receptor-γ limits NF-κB-dependent inflammation in mouse cystic fibrosis biliary epithelium.Scirpo R, Fiorotto R, Villani A, Amenduni M, Spirli C, Strazzabosco M. Hepatology. 2015 Nov; 2015 Aug 28. PMID: 26199136.
Biliary Epithelial Cells Are Not the Predominant Source of Hepatic CXCL12.Saiman Y, Sugiyama T, Simchoni N, Spirli C, Bansal MB. Am J Pathol. 2015 Jul; 2015 Apr 29. PMID: 25934614.
Nuclear Factor, Erythroid 2-Like 2 Regulates Expression of Type 3 Inositol 1,4,5-Trisphosphate Receptor and Calcium Signaling in Cholangiocytes.Weerachayaphorn J, Amaya MJ, Spirli C, Chansela P, Mitchell-Richards KA, Ananthanarayanan M, Nathanson MH. Gastroenterology. 2015 Jul; 2015 Mar 18. PMID: 25796361.
Post-translational regulation of the type III inositol 1,4,5-trisphosphate receptor by miRNA-506.Ananthanarayanan M, Banales JM, Guerra MT, Spirli C, Munoz-Garrido P, Mitchell-Richards K, Tafur D, Saez E, Nathanson MH. J Biol Chem. 2015 Jan 2; 2014 Nov 5. PMID: 25378392.
Protein kinase A-dependent pSer(675) -β-catenin, a novel signaling defect in a mouse model of congenital hepatic fibrosis.Spirli C, Locatelli L, Morell CM, Fiorotto R, Morton SD, Cadamuro M, Fabris L, Strazzabosco M. Hepatology. 2013 Nov; 2013 Sep 30. PMID: 23744610.
Notch signaling regulates tubular morphogenesis during repair from biliary damage in mice.Fiorotto R, Raizner A, Morell CM, Torsello B, Scirpo R, Fabris L, Spirli C, Strazzabosco M. J Hepatol. 2013 Jul; 2013 Mar 7. PMID: 23500150.
Vascular endothelial growth factors in progenitor cells mediated liver repair.Spirli C, Strazzabosco M. Hepatobiliary Surg Nutr. 2013 Apr. PMID: 24570918.
Cyclic AMP/PKA-dependent paradoxical activation of Raf/MEK/ERK signaling in polycystin-2 defective mice treated with sorafenib.Spirli C, Morell CM, Locatelli L, Okolicsanyi S, Ferrero C, Kim AK, Fabris L, Fiorotto R, Strazzabosco M. Hepatology. 2012 Dec; 2012 Aug 27. PMID: 22653837.
Altered store operated calcium entry increases cyclic 3',5'-adenosine monophosphate production and extracellular signal-regulated kinases 1 and 2 phosphorylation in polycystin-2-defective cholangiocytes.Spirli C, Locatelli L, Fiorotto R, Morell CM, Fabris L, Pozzan T, Strazzabosco M. Hepatology. 2012 Mar. PMID: 21987453.
Loss of CFTR affects biliary epithelium innate immunity and causes TLR4-NF-κB-mediated inflammatory response in mice.Fiorotto R, Scirpo R, Trauner M, Fabris L, Hoque R, Spirli C, Strazzabosco M. Gastroenterology. 2011 Oct; 2011 Jun 26. PMID: 21712022.
Mammalian target of rapamycin regulates vascular endothelial growth factor-dependent liver cyst growth in polycystin-2-defective mice.Spirli C, Okolicsanyi S, Fiorotto R, Fabris L, Cadamuro M, Lecchi S, Tian X, Somlo S, Strazzabosco M. Hepatology. 2010 May. PMID: 20131403.
ERK1/2-dependent vascular endothelial growth factor signaling sustains cyst growth in polycystin-2 defective mice.Spirli C, Okolicsanyi S, Fiorotto R, Fabris L, Cadamuro M, Lecchi S, Tian X, Somlo S, Strazzabosco M. Gastroenterology. 2010 Jan; 2009 Sep 18. PMID: 19766642.
Differentially expressed adenylyl cyclase isoforms mediate secretory functions in cholangiocyte subpopulation.Strazzabosco M, Fiorotto R, Melero S, Glaser S, Francis H, Spirli C, Alpini G. Hepatology. 2009 Jul. PMID: 19444869.
Transcriptional regulation of IL-6 in bile duct epithelia by extracellular ATP.Yu J, Sheung N, Soliman EM, Spirli C, Dranoff JA. Am J Physiol Gastrointest Liver Physiol. 2009 Mar; 2009 Jan 8. PMID: 19136380.
Ursodeoxycholic acid stimulates cholangiocyte fluid secretion in mice via CFTR-dependent ATP secretion.Fiorotto R, Spirlì C, Fabris L, Cadamuro M, Okolicsanyi L, Strazzabosco M. Gastroenterology. 2007 Nov; 2007 Sep 2. PMID: 17983806.

Mario Strazzabosco, MD, PhD

Procoagulant phenotype of virus-infected pericytes is associated with portal thrombosis and intrapulmonary vascular dilations in fatal COVID-19.Cadamuro M, Lasagni A, Radu CM, Calistri A, Pilan M, Valle C, Bonaffini PA, Vitiello A, Toffanin S, Venturin C, Friòn-Herrera Y, Sironi S, Alessio MG, Previtali G, Seghezzi M, Gianatti A, Strazzabosco M, Strain AJ, Campello E, Spiezia L, Palù G, Frigo AC, Tosoni A, Nebuloni M, Parolin C, Sonzogni A, Simioni P, Fabris L. J Hepatol. 2024 Nov; 2024 Jun 20. PMID: 38908437.
Automated graded prognostic assessment for patients with hepatocellular carcinoma using machine learning.Gross M, Haider SP, Ze'evi T, Huber S, Arora S, Kucukkaya AS, Iseke S, Gebauer B, Fleckenstein F, Dewey M, Jaffe A, Strazzabosco M, Chapiro J, Onofrey JA. Eur Radiol. 2024 Oct; 2024 Mar 27. PMID: 38536464.
Portal Fibrosis and the Ductular Reaction: Pathophysiological Role in the Progression of Liver Disease and Translational Opportunities.Gupta V, Sehrawat TS, Pinzani M, Strazzabosco M. Gastroenterology. 2024 Sep 7; 2024 Sep 7. PMID: 39251168.
Prominent role of gut dysbiosis in the pathogenesis of cystic fibrosis-related liver disease in mice.Bertolini A, Nguyen M, Zehra SA, Taleb SA, Bauer-Pisani T, Palm N, Strazzabosco M, Fiorotto R. J Hepatol. 2024 Sep; 2024 Mar 28. PMID: 38554847.
Automated MRI liver segmentation for anatomical segmentation, liver volumetry, and the extraction of radiomics.Gross M, Huber S, Arora S, Ze'evi T, Haider SP, Kucukkaya AS, Iseke S, Kuhn TN, Gebauer B, Michallek F, Dewey M, Vilgrain V, Sartoris R, Ronot M, Jaffe A, Strazzabosco M, Chapiro J, Onofrey JA. Eur Radiol. 2024 Aug; 2024 Jan 13. PMID: 38217704.
Tumor response assessment in hepatocellular carcinoma treated with immunotherapy: imaging biomarkers for clinical decision-making.Sobirey R, Matuschewski N, Gross M, Lin M, Kao T, Kasolowsky V, Strazzabosco M, Stein S, Savic LJ, Gebauer B, Jaffe A, Duncan J, Madoff DC, Chapiro J. Eur Radiol. 2024 Jul 20; 2024 Jul 20. PMID: 39033181.
Cost-effectiveness analysis: The missing factor in the management of HCC.Njei B, Yi I, Strazzabosco M. Clin Liver Dis (Hoboken). 2024 Jan-Jun; 2024 Jun 7. PMID: 38860130.
Safety and Efficacy of Atezolizumab/Bevacizumab in Patients with Hepatocellular Carcinoma and Impaired Liver Function: A Systematic Review and Meta-Analysis.Pasta A, Calabrese F, Jaffe A, Labanca S, Marenco S, Pieri G, Plaz Torres MC, Strazzabosco M, Giannini EG. Liver Cancer. 2024 Jun; 2023 Oct 14. PMID: 38756146.
Approach to immunotherapy for HCC in the liver transplant population.Block PD, Strazzabosco M, Jaffe A. Clin Liver Dis (Hoboken). 2024 Jan-Jun; 2024 May 3. PMID: 38707244.
It could happen in your backyard.Strazzabosco M. Hepatology. 2024 Apr 1; 2023 Sep 18. PMID: 37722133.
Community-Level Factors Associated with Hepatocellular Carcinoma Incidence and Mortality: An Observational Registry Study.Mezzacappa C, Rossi R, Jaffe A, Taddei TH, Strazzabosco M. Cancer Epidemiol Biomarkers Prev. 2024 Feb 6. PMID: 38059831.
May we actually help clinicians select the best systemic treatment for patients with intermediate-stage hepatocellular carcinoma?Giannini EG, Strazzabosco M. Liver Int. 2024 Feb. PMID: 38289589.
European Society for Organ Transplantation (ESOT) Consensus Statement on Outcome Measures in Liver Transplantation According to Value-Based Health Care.Carbone M, Neuberger J, Rowe I, Polak WG, Forsberg A, Fondevila C, Mantovani L, Nardi A, Colli A, Rockell K, Schick L, Cristoferi L, Oniscu GC, Strazzabosco M, Cillo U. Transpl Int. 2023; 2024 Jan 25. PMID: 38332850.
Reply: Novel antidiabetic drugs and the risk for HCC. What else to expect from these "wonderful" drug classes?Plaz Torres MC, Jaffe A, Perry R, Marabotto E, Strazzabosco M, Giannini EG. Hepatology. 2023 Jun 1; 2023 Feb 3. PMID: 36724446.
Adherence to Tumor Board Recommendations in the Treatment of Patients with Hepatocellular Carcinoma.Cao Y, Mezzacappa C, Jaffe A, Strazzabosco M, Taddei TH. J Multidiscip Healthc. 2023; 2023 May 31. PMID: 37283950.
Cell-matrix interactions control biliary organoid polarity, architecture, and differentiation.Fiorotto R, Mariotti V, Taleb SA, Zehra SA, Nguyen M, Amenduni M, Strazzabosco M. Hepatol Commun. 2023 Apr 1; 2023 Mar 24. PMID: 36972396.
Intrahepatic Cholangiocarcinoma Developing in Patients with Metabolic Syndrome Is Characterized by Osteopontin Overexpression in the Tumor Stroma.Cadamuro M, Sarcognato S, Camerotto R, Girardi N, Lasagni A, Zanus G, Cillo U, Gringeri E, Morana G, Strazzabosco M, Campello E, Simioni P, Guido M, Fabris L. Int J Mol Sci. 2023 Mar 1; 2023 Mar 1. PMID: 36902188.
Alternative HCC prognostic biomarkers and use of artificial intelligence in the management of HCC.Jaffe A, Taddei TH, Giannini EG, Ilagan-Ying YC, Colombo M, Strazzabosco M. Liver Int. 2023 Jan; 2022 Dec 5. PMID: 36426717.
Immune checkpoint inhibitors in malignancies after liver transplantation: A systematic review and pooled analysis.Kayali S, Pasta A, Plaz Torres MC, Jaffe A, Strazzabosco M, Marenco S, Giannini EG. Liver Int. 2023 Jan; 2022 Sep 27. PMID: 36102312.
Locoregional Therapy in the Management of Intrahepatic Cholangiocarcinoma: Is There Sufficient Evidence to Guide Current Clinical Practice?Wang Y, Strazzabosco M, Madoff DC. Curr Oncol Rep. 2022 Dec; 2022 Oct 18. PMID: 36255606.
Holistic management of hepatocellular carcinoma: The hepatologist's comprehensive playbook.Jaffe A, Taddei TH, Giannini EG, Ilagan-Ying YC, Colombo M, Strazzabosco M. Liver Int. 2022 Dec; 2022 Oct 11. PMID: 36161463.
ESOT Consensus Platform for Organ Transplantation: Setting the Stage for a Rigorous, Regularly Updated Development Process.Cillo U, Weissenbacher A, Pengel L, Jochmans I, Roppolo D, Amarelli C, Belli LS, Berenguer M, De Vries A, Ferrer J, Friedewald J, Furian L, Greenwood S, Monbaliu D, Nadalin S, Neyrinck A, Strazzabosco M, Toso C, Zaza G, Thuraisingham R, Berney T, Potena L, Montserrat N, Selzner N. Transpl Int. 2022; 2022 Oct 24. PMID: 36406781.
Molecular determinants of peri-apical targeting of inositol 1,4,5-trisphosphate receptor type 3 in cholangiocytes.Rodrigues MA, Gomes DA, Fiorotto R, Guerra MT, Weerachayaphorn J, Bo T, Sessa WC, Strazzabosco M, Nathanson MH. Hepatol Commun. 2022 Oct; 2022 Jul 19. PMID: 35852334.
Bile acids and their receptors: modulators and therapeutic targets in liver inflammation.Bertolini A, Fiorotto R, Strazzabosco M. Semin Immunopathol. 2022 Jul; 2022 Apr 12. PMID: 35415765.
Optimization of the BCLC Staging System for Locoregional Therapy for Hepatocellular Carcinoma by Using Quantitative Tumor Burden Imaging Biomarkers at MRI.Borde T, Nezami N, Laage Gaupp F, Savic LJ, Taddei T, Jaffe A, Strazzabosco M, Lin M, Duran R, Georgiades C, Hong K, Chapiro J. Radiology. 2022 Jul; 2022 Apr 12. PMID: 35412368.
Translational Value of Tumor-Associated Lymphangiogenesis in Cholangiocarcinoma.Cadamuro M, Romanzi A, Guido M, Sarcognato S, Cillo U, Gringeri E, Zanus G, Strazzabosco M, Simioni P, Villa E, Fabris L. J Pers Med. 2022 Jun 30; 2022 Jun 30. PMID: 35887583.
Dysregulation of the Scribble/YAP/β-catenin axis sustains the fibroinflammatory response in a PKHD1(-/-) mouse model of congenital hepatic fibrosis.Fabris L, Milani C, Fiorotto R, Mariotti V, Kaffe E, Seller B, Sonzogni A, Strazzabosco M, Cadamuro M. FASEB J. 2022 Jun. PMID: 35593740.
Adjusting Barcelona Clinic Liver Cancer Staging System to the Evolving Landscape of Hepatocellular Carcinoma: A Look to the Future.Strazzabosco M, Cabibbo G, Colombo M. Gastroenterology. 2022 Jun; 2022 Feb 2. PMID: 35122767.
The Neglected Role of Bile Duct Epithelial Cells in NASH.Cadamuro M, Lasagni A, Sarcognato S, Guido M, Fabris R, Strazzabosco M, Strain AJ, Simioni P, Villa E, Fabris L. Semin Liver Dis. 2022 Feb; 2021 Nov 18. PMID: 34794182.
Tumor microenvironment and immunology of cholangiocarcinoma.Cadamuro M, Fabris L, Zhang X, Strazzabosco M. Hepatoma Res. 2022; 2022 Mar 10. PMID: 39301518.
Inflammatory pathways and cholangiocarcinoma risk mechanisms and prevention.Cadamuro M, Strazzabosco M. Adv Cancer Res. 2022; 2022 Mar 10. PMID: 35961707.
Improved performance and consistency of deep learning 3D liver segmentation with heterogeneous cancer stages in magnetic resonance imaging.Gross M, Spektor M, Jaffe A, Kucukkaya AS, Iseke S, Haider SP, Strazzabosco M, Chapiro J, Onofrey JA. PLoS One. 2021; 2021 Dec 1. PMID: 34852007.
Pathological characteristics of liver sinusoidal thrombosis in COVID-19 patients: A series of 43 cases.Kondo R, Kawaguchi N, McConnell MJ, Sonzogni A, Licini L, Valle C, Bonaffini PA, Sironi S, Alessio MG, Previtali G, Seghezzi M, Zhang X, Sun Z, Utsumi T, Strazzabosco M, Iwakiri Y. Hepatol Res. 2021 Sep; 2021 Aug 2. PMID: 34260803.
Liver injury in COVID-19 and IL-6 trans-signaling-induced endotheliopathy.McConnell MJ, Kawaguchi N, Kondo R, Sonzogni A, Licini L, Valle C, Bonaffini PA, Sironi S, Alessio MG, Previtali G, Seghezzi M, Zhang X, Lee AI, Pine AB, Chun HJ, Zhang X, Fernandez-Hernando C, Qing H, Wang A, Price C, Sun Z, Utsumi T, Hwa J, Strazzabosco M, Iwakiri Y. J Hepatol. 2021 Sep; 2021 May 13. PMID: 33991637.
Thermal ablation alone vs thermal ablation combined with transarterial chemoembolization for patients with small (<3 cm) hepatocellular carcinoma.Chai NX, Chapiro J, Petukhova A, Gross M, Kucukkaya A, Raju R, Zeevi T, Elbanan M, Lin M, Perez-Lozada JC, Schlachter T, Strazzabosco M, Pollak JS, Madoff DC. Clin Imaging. 2021 Aug; 2021 Feb 11. PMID: 33592550.
New insights on the role of vascular endothelial growth factor in biliary pathophysiology.Mariotti V, Fiorotto R, Cadamuro M, Fabris L, Strazzabosco M. JHEP Rep. 2021 Jun; 2021 Feb 4. PMID: 34151244.
Reliable prediction of survival in advanced-stage hepatocellular carcinoma treated with sorafenib: comparing 1D and 3D quantitative tumor response criteria on MRI.Doemel LA, Chapiro J, Laage Gaupp F, Savic LJ, Kucukkaya AS, Petukhova A, Tefera J, Zeevi T, Lin M, Schlachter T, Jaffe A, Strazzabosco M, Patel T, Stein SM. Eur Radiol. 2021 May; 2020 Oct 30. PMID: 33123796.
Fibrocystic liver disease: novel concepts and translational perspectives.Lasagni A, Cadamuro M, Morana G, Fabris L, Strazzabosco M. Transl Gastroenterol Hepatol. 2021; 2021 Apr 5. PMID: 33824930.
Rare and undiagnosed liver diseases: challenges and opportunities.Fabris L, Strazzabosco M. Transl Gastroenterol Hepatol. 2021; 2021 Apr 5. PMID: 33824922.
Targeted therapies for extrahepatic cholangiocarcinoma: preclinical and clinical development and prospects for the clinic.Cadamuro M, Lasagni A, Lamarca A, Fouassier L, Guido M, Sarcognato S, Gringeri E, Cillo U, Strazzabosco M, Marin JJ, Banales JM, Fabris L. Expert Opin Investig Drugs. 2021 Apr; 2021 Feb 23. PMID: 33622120.
IL-17A/F enable cholangiocytes to restrict T cell-driven experimental cholangitis by upregulating PD-L1 expression.Stein S, Henze L, Poch T, Carambia A, Krech T, Preti M, Schuran FA, Reich M, Keitel V, Fiorotto R, Strazzabosco M, Fischer L, Li J, Müller LM, Wagner J, Gagliani N, Herkel J, Schwinge D, Schramm C. J Hepatol. 2021 Apr; 2020 Nov 13. PMID: 33197512.
Intrahepatic cholangiocarcinoma: Morpho-molecular pathology, tumor reactive microenvironment, and malignant progression.Sirica AE, Strazzabosco M, Cadamuro M. Adv Cancer Res. 2021; 2020 Dec 9. PMID: 33579427.
The Tumor Microenvironment in Cholangiocarcinoma Progression.Fabris L, Sato K, Alpini G, Strazzabosco M. Hepatology. 2021 Jan; 2020 Nov 6. PMID: 32500550.
Health related quality of life in chronic liver diseases.Cortesi PA, Conti S, Scalone L, Jaffe A, Ciaccio A, Okolicsanyi S, Rota M, Fabris L, Colledan M, Fagiuoli S, Belli LS, Cesana G, Strazzabosco M, Mantovani LG. Liver Int. 2020 Nov. PMID: 32851764.
Abnormal Liver Function Tests in Patients With COVID-19: Relevance and Potential Pathogenesis.Bertolini A, van de Peppel IP, Bodewes FAJA, Moshage H, Fantin A, Farinati F, Fiorotto R, Jonker JW, Strazzabosco M, Verkade HJ, Peserico G. Hepatology. 2020 Nov; 2020 Oct 20. PMID: 32702162.
Value-based medicine, a compass to guide healthcare decisions in the COVID-19 aftermath.Strazzabosco M. Liver Int. 2020 Sep. PMID: 32677111.
Cholangiocarcinoma 2020: the next horizon in mechanisms and management.Banales JM, Marin JJG, Lamarca A, Rodrigues PM, Khan SA, Roberts LR, Cardinale V, Carpino G, Andersen JB, Braconi C, Calvisi DF, Perugorria MJ, Fabris L, Boulter L, Macias RIR, Gaudio E, Alvaro D, Gradilone SA, Strazzabosco M, Marzioni M, Coulouarn C, Fouassier L, Raggi C, Invernizzi P, Mertens JC, Moncsek A, Ilyas SI, Heimbach J, Koerkamp BG, Bruix J, Forner A, Bridgewater J, Valle JW, Gores GJ. Nat Rev Gastroenterol Hepatol. 2020 Sep; 2020 Jun 30. PMID: 32606456.
Liver Matrix in Benign and Malignant Biliary Tract Disease.Fabris L, Cadamuro M, Cagnin S, Strazzabosco M, Gores GJ. Semin Liver Dis. 2020 Aug; 2020 Mar 11. PMID: 32162285.
Surveillance for Hepatocellular Carcinoma in Patients with Non-Alcoholic Fatty Liver Disease: Universal or Selective?Plaz Torres MC, Bodini G, Furnari M, Marabotto E, Zentilin P, Strazzabosco M, Giannini EG. Cancers (Basel). 2020 May 31; 2020 May 31. PMID: 32486355.
The Emerging Role of Macrophages in Chronic Cholangiopathies Featuring Biliary Fibrosis: An Attractive Therapeutic Target for Orphan Diseases.Cadamuro M, Girardi N, Gores GJ, Strazzabosco M, Fabris L. Front Med (Lausanne). 2020; 2020 Apr 21. PMID: 32373615.
Clinical outcome indicators in chronic hepatitis B and C: A primer for value-based medicine in hepatology.Strazzabosco M, Cortesi PA, Conti S, Okolicsanyi S, Rota M, Ciaccio A, Cozzolino P, Fornari C, Gemma M, Scalone L, Cesana G, Fabris L, Colledan M, Fagiuoli S, Ideo G, Zavaglia C, Perricone G, Munari LM, Mantovani LG, Belli LS. Liver Int. 2020 Jan; 2019 Nov 12. PMID: 31654608.
The challenges of primary biliary cholangitis: What is new and what needs to be done.Terziroli Beretta-Piccoli B, Mieli-Vergani G, Vergani D, Vierling JM, Adams D, Alpini G, Banales JM, Beuers U, Björnsson E, Bowlus C, Carbone M, Chazouillères O, Dalekos G, De Gottardi A, Harada K, Hirschfield G, Invernizzi P, Jones D, Krawitt E, Lanzavecchia A, Lian ZX, Ma X, Manns M, Mavilio D, Quigley EM, Sallusto F, Shimoda S, Strazzabosco M, Swain M, Tanaka A, Trauner M, Tsuneyama K, Zigmond E, Gershwin ME. J Autoimmun. 2019 Dec; 2019 Sep 20. PMID: 31548157.
Modeling of implementation of the new Organ Procurement and Transplantation Network/United Network for Organ Sharing policy for patients with hepatocellular carcinoma.Kokabi N, Nezami N, Xing M, Ludwig JM, Strazzabosco M, Kim HS. J Comp Eff Res. 2019 Sep; 2019 Sep 12. PMID: 31512955.
Pathobiology of inherited biliary diseases: a roadmap to understand acquired liver diseases.Fabris L, Fiorotto R, Spirli C, Cadamuro M, Mariotti V, Perugorria MJ, Banales JM, Strazzabosco M. Nat Rev Gastroenterol Hepatol. 2019 Aug. PMID: 31165788.
The tumour microenvironment and immune milieu of cholangiocarcinoma.Fabris L, Perugorria MJ, Mertens J, Björkström NK, Cramer T, Lleo A, Solinas A, Sänger H, Lukacs-Kornek V, Moncsek A, Siebenhüner A, Strazzabosco M. Liver Int. 2019 May. PMID: 30907492.
Cholangiocyte pathobiology.Banales JM, Huebert RC, Karlsen T, Strazzabosco M, LaRusso NF, Gores GJ. Nat Rev Gastroenterol Hepatol. 2019 May. PMID: 30850822.
Animal models of cholestasis: An update on inflammatory cholangiopathies.Mariotti V, Cadamuro M, Spirli C, Fiorotto R, Strazzabosco M, Fabris L. Biochim Biophys Acta Mol Basis Dis. 2019 May 1; 2018 Aug 11. PMID: 30398152.
Liver diseases in the dish: iPSC and organoids as a new approach to modeling liver diseases.Fiorotto R, Amenduni M, Mariotti V, Fabris L, Spirli C, Strazzabosco M. Biochim Biophys Acta Mol Basis Dis. 2019 May 1; 2018 Sep 5. PMID: 30264693.
Animal models for cystic fibrosis liver disease (CFLD).Fiorotto R, Amenduni M, Mariotti V, Cadamuro M, Fabris L, Spirli C, Strazzabosco M. Biochim Biophys Acta Mol Basis Dis. 2019 May 1; 2018 Jul 30. PMID: 30071276.
Platelet-derived growth factor-D enables liver myofibroblasts to promote tumor lymphangiogenesis in cholangiocarcinoma.Cadamuro M, Brivio S, Mertens J, Vismara M, Moncsek A, Milani C, Fingas C, Cristina Malerba M, Nardo G, Dall'Olmo L, Milani E, Mariotti V, Stecca T, Massani M, Spirli C, Fiorotto R, Indraccolo S, Strazzabosco M, Fabris L. J Hepatol. 2019 Apr; 2018 Dec 14. PMID: 30553841.
Intrahepatic Cholangiocarcinoma: Continuing Challenges and Translational Advances.Sirica AE, Gores GJ, Groopman JD, Selaru FM, Strazzabosco M, Wei Wang X, Zhu AX. Hepatology. 2019 Apr; 2019 Mar 25. PMID: 30251463.
Pathophysiology of Cystic Fibrosis Liver Disease: A Channelopathy Leading to Alterations in Innate Immunity and in Microbiota.Fiorotto R, Strazzabosco M. Cell Mol Gastroenterol Hepatol. 2019; 2019 May 7. PMID: 31075352.
Fibroinflammatory Liver Injuries as Preneoplastic Condition in Cholangiopathies.Cannito S, Milani C, Cappon A, Parola M, Strazzabosco M, Cadamuro M. Int J Mol Sci. 2018 Dec 4; 2018 Dec 4. PMID: 30518128.
Valproic Acid Inhibits Proliferation and Reduces Invasiveness in Glioma Stem Cells Through Wnt/β Catenin Signalling Activation.Riva G, Cilibrasi C, Bazzoni R, Cadamuro M, Negroni C, Butta V, Strazzabosco M, Dalprà L, Lavitrano M, Bentivegna A. Genes (Basel). 2018 Oct 26; 2018 Oct 26. PMID: 30373123.
Impact of DAAs on liver transplantation: Major effects on the evolution of indications and results. An ELITA study based on the ELTR registry.Belli LS, Perricone G, Adam R, Cortesi PA, Strazzabosco M, Facchetti R, Karam V, Salizzoni M, Andujar RL, Fondevila C, De Simone P, Morelli C, Fabregat-Prous J, Samuel D, Agarwaal K, Moreno Gonzales E, Charco R, Zieniewicz K, De Carlis L, Duvoux C. J Hepatol. 2018 Oct; 2018 Jun 27. PMID: 29940268.
Animal models of cholangiocarcinoma: What they teach us about the human disease.Cadamuro M, Brivio S, Stecca T, Kaffe E, Mariotti V, Milani C, Fiorotto R, Spirli C, Strazzabosco M, Fabris L. Clin Res Hepatol Gastroenterol. 2018 Oct; 2018 May 9. PMID: 29753731.
Dynamic contrast enhanced perfusion CT imaging: A diagnostic biomarker tool for survival prediction of tumour response to antiangiogenetic treatment in patients with advanced HCC lesions.Ippolito D, Querques G, Okolicsanyi S, Talei Franzesi C, Pecorelli A, Lombardi S, Orsini E, Strazzabosco M, Sironi S. Eur J Radiol. 2018 Sep; 2018 Jul 20. PMID: 30150052.
The optimal timing of hepatitis C therapy in liver transplant-eligible patients: Cost-effectiveness analysis of new opportunities.Cortesi PA, Belli LS, Facchetti R, Mazzarelli C, Perricone G, De Nicola S, Cesana G, Duvoux C, Mantovani LG, Strazzabosco M. J Viral Hepat. 2018 Jul; 2018 Mar 8. PMID: 29406608.
β-Catenin and interleukin-1β-dependent chemokine (C-X-C motif) ligand 10 production drives progression of disease in a mouse model of congenital hepatic fibrosis.Kaffe E, Fiorotto R, Pellegrino F, Mariotti V, Amenduni M, Cadamuro M, Fabris L, Strazzabosco M, Spirli C. Hepatology. 2018 May; 2018 Mar 25. PMID: 29140564.
Optimising the clinical strategy for autoimmune liver diseases: Principles of value-based medicine.Carbone M, Cristoferi L, Cortesi PA, Rota M, Ciaccio A, Okolicsanyi S, Gemma M, Scalone L, Cesana G, Fabris L, Colledan M, Fagiuoli S, Ideo G, Belli LS, Munari LM, Mantovani L, Strazzabosco M. Biochim Biophys Acta Mol Basis Dis. 2018 Apr; 2017 Aug 24. PMID: 28844954.
The deleterious interplay between tumor epithelia and stroma in cholangiocarcinoma.Cadamuro M, Stecca T, Brivio S, Mariotti V, Fiorotto R, Spirli C, Strazzabosco M, Fabris L. Biochim Biophys Acta Mol Basis Dis. 2018 Apr; 2017 Jul 27. PMID: 28757170.
Pathophysiologic implications of innate immunity and autoinflammation in the biliary epithelium.Strazzabosco M, Fiorotto R, Cadamuro M, Spirli C, Mariotti V, Kaffe E, Scirpo R, Fabris L. Biochim Biophys Acta Mol Basis Dis. 2018 Apr; 2017 Jul 25. PMID: 28754453.
Animal models of biliary injury and altered bile acid metabolism.Mariotti V, Strazzabosco M, Fabris L, Calvisi DF. Biochim Biophys Acta Mol Basis Dis. 2018 Apr; 2017 Jul 11. PMID: 28709963.
Src kinase inhibition reduces inflammatory and cytoskeletal changes in ΔF508 human cholangiocytes and improves cystic fibrosis transmembrane conductance regulator correctors efficacy.Fiorotto R, Amenduni M, Mariotti V, Fabris L, Spirli C, Strazzabosco M. Hepatology. 2018 Mar; 2018 Jan 26. PMID: 28836688.
Notch signaling and progenitor/ductular reaction in steatohepatitis.Morell CM, Fiorotto R, Meroni M, Raizner A, Torsello B, Cadamuro M, Spagnuolo G, Kaffe E, Sutti S, Albano E, Strazzabosco M. PLoS One. 2017; 2017 Nov 15. PMID: 29140985.
ELITA consensus statements on the use of DAAs in liver transplant candidates and recipients.Belli LS, Duvoux C, Berenguer M, Berg T, Coilly A, Colle I, Fagiuoli S, Khoo S, Pageaux GP, Puoti M, Samuel D, Strazzabosco M. J Hepatol. 2017 Sep; 2017 Mar 18. PMID: 28323126.
Emerging concepts in biliary repair and fibrosis.Fabris L, Spirli C, Cadamuro M, Fiorotto R, Strazzabosco M. Am J Physiol Gastrointest Liver Physiol. 2017 Aug 1; 2017 May 19. PMID: 28526690.
Direct-acting antivirals combination for elderly patients with chronic hepatitis C: A cost-effectiveness analysis.Ciaccio A, Cortesi PA, Bellelli G, Rota M, Conti S, Okolicsanyi S, Rota M, Cesana G, Mantovani LG, Annoni G, Strazzabosco M. Liver Int. 2017 Jul; 2017 Mar 2. PMID: 27943549.
Diagnostic value of dynamic contrast-enhanced CT with perfusion imaging in the quantitative assessment of tumor response to sorafenib in patients with advanced hepatocellular carcinoma: A feasibility study.Ippolito D, Querques G, Okolicsanyi S, Franzesi CT, Strazzabosco M, Sironi S. Eur J Radiol. 2017 May; 2017 Feb 20. PMID: 28583645.
Value-based care in hepatology.Strazzabosco M, Allen JI, Teisberg EO. Hepatology. 2017 May. PMID: 28073146.
Adenylyl cyclase 5 links changes in calcium homeostasis to cAMP-dependent cyst growth in polycystic liver disease.Spirli C, Mariotti V, Villani A, Fabris L, Fiorotto R, Strazzabosco M. J Hepatol. 2017 Mar; 2016 Nov 5. PMID: 27826057.
Autocrine and Paracrine Mechanisms Promoting Chemoresistance in Cholangiocarcinoma.Cadamuro M, Brivio S, Spirli C, Joplin RE, Strazzabosco M, Fabris L. Int J Mol Sci. 2017 Jan 13; 2017 Jan 13. PMID: 28098760.
Liver-allocation policies for patients affected by HCC in Europe.De Carlis L, Di Sandro S, Centonze L, Lauterio A, Buscemi V, De Carlis R, Ferla F, Sguinzi R, Okolicsanyi S, Belli L, Strazzabosco M. Curr Transplant Rep. 2016 Dec; 2016 Oct 7. PMID: 28473952.
The cystic fibrosis transmembrane conductance regulator controls biliary epithelial inflammation and permeability by regulating Src tyrosine kinase activity.Fiorotto R, Villani A, Kourtidis A, Scirpo R, Amenduni M, Geibel PJ, Cadamuro M, Spirli C, Anastasiadis PZ, Strazzabosco M. Hepatology. 2016 Dec; 2016 Oct 27. PMID: 27629435.
Cystic Fibrosis-Related Liver Diseases: New Paradigm for Treatment Based on Pathophysiology.Fiorotto R, Strazzabosco M. Clin Liver Dis (Hoboken). 2016 Nov; 2016 Nov 30. PMID: 31041076.
Effective but costly: How to tackle difficult trade-offs in evaluating health improving technologies in liver diseases.Mantovani LG, Cortesi PA, Strazzabosco M. Hepatology. 2016 Oct; 2016 Apr 4. PMID: 26926906.
Delisting of liver transplant candidates with chronic hepatitis C after viral eradication: A European study.Belli LS, Berenguer M, Cortesi PA, Strazzabosco M, Rockenschaub SR, Martini S, Morelli C, Donato F, Volpes R, Pageaux GP, Coilly A, Fagiuoli S, Amaddeo G, Perricone G, Vinaixa C, Berlakovich G, Facchetti R, Polak W, Muiesan P, Duvoux C. J Hepatol. 2016 Sep; 2016 May 17. PMID: 27212241.
Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma.Cadamuro M, Spagnuolo G, Sambado L, Indraccolo S, Nardo G, Rosato A, Brivio S, Caslini C, Stecca T, Massani M, Bassi N, Novelli E, Spirli C, Fabris L, Strazzabosco M. Cancer Res. 2016 Aug 15; 2016 Jun 21. PMID: 27328733.
Macrophage recruitment by fibrocystin-defective biliary epithelial cells promotes portal fibrosis in congenital hepatic fibrosis.Locatelli L, Cadamuro M, Spirlì C, Fiorotto R, Lecchi S, Morell CM, Popov Y, Scirpo R, De Matteis M, Amenduni M, Pietrobattista A, Torre G, Schuppan D, Fabris L, Strazzabosco M. Hepatology. 2016 Mar; 2016 Jan 16. PMID: 26645994.
Revisiting Epithelial-to-Mesenchymal Transition in Liver Fibrosis: Clues for a Better Understanding of the "Reactive" Biliary Epithelial Phenotype.Fabris L, Brivio S, Cadamuro M, Strazzabosco M. Stem Cells Int. 2016; 2016 Jan 6. PMID: 26880950.
Epithelial-to-Mesenchymal Transition and Cancer Invasiveness: What Can We Learn from Cholangiocarcinoma?Brivio S, Cadamuro M, Fabris L, Strazzabosco M. J Clin Med. 2015 Dec 19; 2015 Dec 19. PMID: 26703747.
Posttranslational regulation of polycystin-2 protein expression as a novel mechanism of cholangiocyte reaction and repair from biliary damage.Spirli C, Villani A, Mariotti V, Fabris L, Fiorotto R, Strazzabosco M. Hepatology. 2015 Dec; 2015 Oct 10. PMID: 26313562.
Stimulation of nuclear receptor peroxisome proliferator-activated receptor-γ limits NF-κB-dependent inflammation in mouse cystic fibrosis biliary epithelium.Scirpo R, Fiorotto R, Villani A, Amenduni M, Spirli C, Strazzabosco M. Hepatology. 2015 Nov; 2015 Aug 28. PMID: 26199136.
Leukemia inhibitory factor protects cholangiocarcinoma cells from drug-induced apoptosis via a PI3K/AKT-dependent Mcl-1 activation.Morton SD, Cadamuro M, Brivio S, Vismara M, Stecca T, Massani M, Bassi N, Furlanetto A, Joplin RE, Floreani A, Fabris L, Strazzabosco M. Oncotarget. 2015 Sep 22. PMID: 26296968.
Recipient female gender is a risk factor for graft loss after liver transplantation for chronic hepatitis C: Evidence from the prospective Liver Match cohort.Belli LS, Romagnoli R, Nardi A, Marianelli T, Donato F, Corradini SG, Iemmolo RM, Morelli C, Pasulo L, Rendina M, De Martin E, Ponziani FR, Volpes R, Strazzabosco M, Angelico M. Dig Liver Dis. 2015 Aug; 2015 Apr 16. PMID: 26055490.
Cost-Effectiveness of New Direct-Acting Antivirals to Prevent Post-Liver Transplant Recurrent Hepatitis.Cortesi PA, Mantovani LG, Ciaccio A, Rota M, Mazzarelli C, Cesana G, Strazzabosco M, Belli LS. Am J Transplant. 2015 Jul. PMID: 26086300.
Osteopontin: a new player in regulating hepatic ductular reaction and hepatic progenitor cell responses during chronic liver injury.Strazzabosco M, Fabris L, Albano E. Gut. 2014 Nov; 2014 Jul 23. PMID: 25056656.
Neural cell adhesion molecule and polysialic acid in ductular reaction: the puzzle is far from completed, but the picture is becoming more clear.Strazzabosco M, Fabris L. Hepatology. 2014 Nov; 2014 Oct 1. PMID: 24995463.
Characterization of animal models for primary sclerosing cholangitis (PSC).Fickert P, Pollheimer MJ, Beuers U, Lackner C, Hirschfield G, Housset C, Keitel V, Schramm C, Marschall HU, Karlsen TH, Melum E, Kaser A, Eksteen B, Strazzabosco M, Manns M, Trauner M. J Hepatol. 2014 Jun; 2014 Feb 19. PMID: 24560657.
A Bayesian methodology to improve prediction of early graft loss after liver transplantation derived from the liver match study.Angelico M, Nardi A, Romagnoli R, Marianelli T, Corradini SG, Tandoi F, Gavrila C, Salizzoni M, Pinna AD, Cillo U, Gridelli B, De Carlis LG, Colledan M, Gerunda GE, Costa AN, Strazzabosco M. Dig Liver Dis. 2014 Apr; 2014 Jan 9. PMID: 24411484.

Tamar Hamosh Taddei, MD

Albumin for Spontaneous Bacterial Peritonitis: Care Variation, Disparities and Outcomes.Serper M, Pulaski ME, Zhang S, Taddei TH, Kaplan DE, Mahmud N. Am J Gastroenterol. 2024 Nov 12; 2024 Nov 12. PMID: 39530516.
Risk Score for Hepatocellular Cancer in Adults Without Viral Hepatitis or Cirrhosis.Ilagan-Ying YC, Gordon KS, Tate JP, Lim JK, Torgersen J, Lo Re V 3rd, Justice AC, Taddei TH. JAMA Netw Open. 2024 Nov 4; 2024 Nov 4. PMID: 39504020.
A Validated Algorithm to Identify Hepatic Decompensation in the Veterans Health Administration Electronic Health Record System.Haque LY, Tate JP, Chew M, Caniglia EC, Taddei TH, Re VL 3rd. Pharmacoepidemiol Drug Saf. 2024 Nov. PMID: 39477692.
Severe Acute Liver Injury After Hepatotoxic Medication Initiation in Real-World Data.Torgersen J, Mezochow AK, Newcomb CW, Carbonari DM, Hennessy S, Rentsch CT, Park LS, Tate JP, Bräu N, Bhattacharya D, Lim JK, Mezzacappa C, Njei B, Roy JA, Taddei TH, Justice AC, Lo Re V 3rd. JAMA Intern Med. 2024 Aug 1. PMID: 38913369.
Screening for Hepatocellular Carcinoma and Survival in Patients With Cirrhosis After Hepatitis C Virus Cure.Mezzacappa C, Kim NJ, Vutien P, Kaplan DE, Ioannou GN, Taddei TH. JAMA Netw Open. 2024 Jul 1; 2024 Jul 1. PMID: 38985470.
Identification of hepatic steatosis among persons with and without HIV using natural language processing.Torgersen J, Skanderson M, Kidwai-Khan F, Carbonari DM, Tate JP, Park LS, Bhattacharya D, Lim JK, Taddei TH, Justice AC, Lo Re V 3rd. Hepatol Commun. 2024 Jul 1; 2024 Jun 19. PMID: 38896066.
Organizational and Implementation Factors Associated with Cirrhosis Care in the Veterans Health Administration.McCurdy H, Nobbe A, Scott D, Patton H, Morgan TR, Bajaj JS, Yakovchenko V, Merante M, Gibson S, Lamorte C, Baffy G, Ioannou GN, Taddei TH, Rozenberg-Ben-Dror K, Anwar J, Dominitz JA, Rogal SS. Dig Dis Sci. 2024 Jun; 2024 Apr 14. PMID: 38616215.
Systemic Therapy for Advanced Hepatocellular Carcinoma: ASCO Guideline Update.Gordan JD, Kennedy EB, Abou-Alfa GK, Beal E, Finn RS, Gade TP, Goff L, Gupta S, Guy J, Hoang HT, Iyer R, Jaiyesimi I, Jhawer M, Karippot A, Kaseb AO, Kelley RK, Kortmansky J, Leaf A, Remak WM, Sohal DPS, Taddei TH, Wilson Woods A, Yarchoan M, Rose MG. J Clin Oncol. 2024 May 20; 2024 Mar 19. PMID: 38502889.
Liver Stiffness Measurement and Risk Prediction of Hepatocellular Carcinoma After HCV Eradication in Veterans With Cirrhosis.John BV, Dang Y, Kaplan DE, Jou JH, Taddei TH, Spector SA, Martin P, Bastaich DR, Chao HH, Dahman B. Clin Gastroenterol Hepatol. 2024 Apr; 2023 Dec 5. PMID: 38061410.
Refractory hepatic hydrothorax is associated with increased mortality with death occurring at lower MELD-Na compared to cirrhosis and refractory ascites.Chin A, Bastaich DR, Dahman B, Kaplan DE, Taddei TH, John BV. Hepatology. 2024 Apr 1; 2023 Aug 25. PMID: 37625139.
AASLD Practice Guideline on noninvasive liver disease assessment of portal hypertension.Sterling RK, Asrani SK, Levine D, Duarte-Rojo A, Patel K, Fiel MI, Leung DH, Taouli B, Alsawas M, Murad MH, Dranoff JA, Taddei TH, Rockey DC. Hepatology. 2024 Mar 15; 2024 Mar 15. PMID: 38489663.
AASLD Practice Guideline on blood-based noninvasive liver disease assessment of hepatic fibrosis and steatosis.Sterling RK, Patel K, Duarte-Rojo A, Asrani SK, Alsawas M, Dranoff JA, Fiel MI, Murad MH, Leung DH, Levine D, Taddei TH, Taouli B, Rockey DC. Hepatology. 2024 Mar 15; 2024 Mar 15. PMID: 38489523.
AASLD Practice Guideline on imaging-based noninvasive liver disease assessment of hepatic fibrosis and steatosis.Sterling RK, Duarte-Rojo A, Patel K, Asrani SK, Alsawas M, Dranoff JA, Fiel MI, Murad MH, Leung DH, Levine D, Taddei TH, Taouli B, Rockey DC. Hepatology. 2024 Mar 15; 2024 Mar 15. PMID: 38489518.
Accuracy of blood-based biomarkers for staging liver fibrosis in chronic liver disease: A systematic review supporting the AASLD Practice Guideline.Patel K, Asrani SK, Fiel MI, Levine D, Leung DH, Duarte-Rojo A, Dranoff JA, Nayfeh T, Hasan B, Taddei TH, Alsawaf Y, Saadi S, Majzoub AM, Manolopoulos A, Alzuabi M, Ding J, Sofiyeva N, Murad MH, Alsawas M, Rockey DC, Sterling RK. Hepatology. 2024 Mar 15; 2024 Mar 15. PMID: 38489517.
Deploying a national clinical text processing infrastructure.McManus KF, Stringer JM, Corson N, Fodeh S, Steinhardt S, Levin FL, Shotqara AS, D'Auria J, Fielstein EM, Gobbel GT, Scott J, Trafton JA, Taddei TH, Erdos J, Tamang SR. J Am Med Inform Assoc. 2024 Feb 16. PMID: 38146986.
Community-Level Factors Associated with Hepatocellular Carcinoma Incidence and Mortality: An Observational Registry Study.Mezzacappa C, Rossi R, Jaffe A, Taddei TH, Strazzabosco M. Cancer Epidemiol Biomarkers Prev. 2024 Feb 6. PMID: 38059831.
The Association Between Homelessness and Key Liver-Related Outcomes in Veterans With Cirrhosis.Pulaski M, Bittermann T, Taddei TH, Kaplan DE, Mahmud N. Am J Gastroenterol. 2024 Feb 1; 2023 Oct 27. PMID: 37782293.
Hepatocellular Carcinoma Diagnosis and Management in 2021: A National Veterans Affairs Quality Improvement Project.Rogal SS, Taddei TH, Monto A, Yakovchenko V, Patton H, Merante M, Spoutz P, Chia L, Yudkevich J, Aytaman A, Rabiee A, John BV, Blechacz B, Cai CX, Gilles H, Shah AS, McCurdy H, Puri P, Jou J, Mazhar K, Dominitz JA, Anwar J, Morgan TR, Ioannou GN. Clin Gastroenterol Hepatol. 2024 Feb; 2023 Jul 15. PMID: 37460005.
HCC is associated with diabetes and longitudinal blood glucose control in a national cohort with cirrhosis.Mezzacappa C, Mahmud N, Serper M, John BV, Taddei TH, Kaplan DE. Hepatol Commun. 2023 Dec 1; 2023 Dec 7. PMID: 38055642.
AASLD Practice Guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma.Singal AG, Llovet JM, Yarchoan M, Mehta N, Heimbach JK, Dawson LA, Jou JH, Kulik LM, Agopian VG, Marrero JA, Mendiratta-Lala M, Brown DB, Rilling WS, Goyal L, Wei AC, Taddei TH. Hepatology. 2023 Dec 1; 2023 May 22. PMID: 37199193.
Performance of an automated deep learning algorithm to identify hepatic steatosis within noncontrast computed tomography scans among people with and without HIV.Torgersen J, Akers S, Huo Y, Terry JG, Carr JJ, Ruutiainen AT, Skanderson M, Levin W, Lim JK, Taddei TH, So-Armah K, Bhattacharya D, Rentsch CT, Shen L, Carr R, Shinohara RT, McClain M, Freiberg M, Justice AC, Lo Re V 3rd. Pharmacoepidemiol Drug Saf. 2023 Oct; 2023 Jun 8. PMID: 37276449.
Multidisciplinary teams, efficient communication, procedure services, and telehealth improve cirrhosis care: A qualitative study.Serper M, Agha A, Garren PA, Taddei TH, Kaplan DE, Groeneveld PW, Werner RM, Shea JA. Hepatol Commun. 2023 Jun 1; 2023 May 23. PMID: 37219845.
Using Telemedicine to Facilitate Patient Communication and Treatment Decision-Making Following Multidisciplinary Tumor Board Review for Patients with Hepatocellular Carcinoma.Choi DT, Sada YH, Sansgiry S, Kaplan DE, Taddei TH, Aguilar JK, Strayhorn M, Hernaez R, Davila JA. J Gastrointest Cancer. 2023 Jun; 2022 Jun 30. PMID: 35773376.
Adherence to Tumor Board Recommendations in the Treatment of Patients with Hepatocellular Carcinoma.Cao Y, Mezzacappa C, Jaffe A, Strazzabosco M, Taddei TH. J Multidiscip Healthc. 2023; 2023 May 31. PMID: 37283950.
Ursodeoxycholic acid is associated with a reduction in SARS-CoV-2 infection and reduced severity of COVID-19 in patients with cirrhosis.John BV, Bastaich D, Webb G, Brevini T, Moon A, Ferreira RD, Chin AM, Kaplan DE, Taddei TH, Serper M, Mahmud N, Deng Y, Chao HH, Sampaziotis F, Dahman B. J Intern Med. 2023 May; 2023 Apr 5. PMID: 37018129.
The association between mental illness and all-cause mortality in patients with cirrhosis: a Veterans Affairs retrospective cohort study.Shaffer LR, Kaplan DE, Taddei TH, Mahmud N. Hepatol Commun. 2023 Apr 1; 2023 Mar 30. PMID: 36996031.
Enhanced Identification of Hispanic Ethnicity Using Clinical Data: A Study in the Largest Integrated United States Health Care System.Ochoa-Allemant P, Tate JP, Williams EC, Gordon KS, Marconi VC, Bensley KMK, Rentsch CT, Wang KH, Taddei TH, Justice AC. Med Care. 2023 Apr 1; 2023 Feb 3. PMID: 36893404.
Type of Infection Is Associated with Prognosis in Acute-on-Chronic Liver Failure: A National Veterans Health Administration Study.Mahmud N, Reddy KR, Taddei TH, Kaplan DE. Dig Dis Sci. 2023 Apr; 2022 Sep 9. PMID: 36083379.
Attacking the public health crisis of hepatocellular carcinoma at its roots.Lee HM, Lidofsky SD, Taddei TH, Townshend-Bulson LJ. Hepatology. 2023 Apr 1; 2022 Oct 11. PMID: 35989555.
When to Stop Screening-Liver Cancer.Taddei TH, Jou JH. Am J Gastroenterol. 2023 Mar 1; 2022 Dec 23. PMID: 36563304.
"Am I Going to Die?": Delivering Serious News to Patients With Liver Disease.Patel AA, Arnold RM, Taddei TH, Woodrell CD. Gastroenterology. 2023 Feb; 2022 Nov 12. PMID: 36379246.
Patterns of Care Utilization and Hepatocellular Carcinoma Surveillance: Tracking Care Across the Pandemic.Serper M, Tapper EB, Kaplan DE, Taddei TH, Mahmud N. Am J Gastroenterol. 2023 Feb 1; 2022 Sep 6. PMID: 36114778.
Nonselective beta blockers, hepatic decompensation, and mortality in cirrhosis: A national cohort study.Serper M, Kaplan DE, Taddei TH, Tapper EB, Cohen JB, Mahmud N. Hepatology. 2023 Feb 1; 2022 Oct 17. PMID: 35984731.
Alternative HCC prognostic biomarkers and use of artificial intelligence in the management of HCC.Jaffe A, Taddei TH, Giannini EG, Ilagan-Ying YC, Colombo M, Strazzabosco M. Liver Int. 2023 Jan; 2022 Dec 5. PMID: 36426717.
Comparison of infection-induced and vaccine-induced immunity against COVID-19 in patients with cirrhosis.John BV, Doshi A, Ferreira RD, Taddei TH, Kaplan DE, Spector SA, Deng Y, Bastaich D, Dahman B. Hepatology. 2023 Jan 1; 2022 Jul 5. PMID: 35712794.
Holistic management of hepatocellular carcinoma: The hepatologist's comprehensive playbook.Jaffe A, Taddei TH, Giannini EG, Ilagan-Ying YC, Colombo M, Strazzabosco M. Liver Int. 2022 Dec; 2022 Oct 11. PMID: 36161463.
Third dose of COVID-19 mRNA vaccine appears to overcome vaccine hyporesponsiveness in patients with cirrhosis.John BV, Ferreira RD, Doshi A, Kaplan DE, Taddei TH, Spector SA, Paulus E, Deng Y, Bastaich D, Dahman B. J Hepatol. 2022 Nov; 2022 Sep 28. PMID: 36181987.
Effectiveness of COVID-19 Viral Vector Ad.26.COV2.S Vaccine and Comparison with mRNA Vaccines in Cirrhosis.John BV, Sidney Barritt A 4th, Moon A, Taddei TH, Kaplan DE, Dahman B, Doshi A, Deng Y, Mansour N, Ioannou G, Martin P, Chao HH. Clin Gastroenterol Hepatol. 2022 Oct; 2022 Jun 16. PMID: 35716904.
Impact of NAFLD on clinical outcomes in hepatocellular carcinoma treated with sorafenib: an international cohort study.Howell J, Samani A, Mannan B, Hajiev S, Motedayen Aval L, Abdelmalak R, Tam VC, Bettinger D, Thimme R, Taddei TH, Kaplan DE, Seidensticker M, Sharma R. Therap Adv Gastroenterol. 2022; 2022 Sep 30. PMID: 36199289.
Cancer tracking system improves timeliness of liver cancer care at a Veterans Hospital: A comparison of cohorts before and after implementation of an automated care coordination tool.Zhang Y, Mezzacappa C, Shen L, Ivatorov A, Petukhova-Greenstein A, Mehta R, Ciarleglio M, Deng Y, Levin W, Steinhardt S, Connery D, Pineau M, Onyiuke I, Taylor C, Rose MG, Taddei TH. PLOS Digit Health. 2022 Aug; 2022 Aug 1. PMID: 36812575.
The Association Between Proton Pump Inhibitor Exposure and Key Liver-Related Outcomes in Patients With Cirrhosis: A Veterans Affairs Cohort Study.Mahmud N, Serper M, Taddei TH, Kaplan DE. Gastroenterology. 2022 Jul; 2022 Apr 6. PMID: 35398042.
Reply to: "Is it safe to treat chronic hepatitis C patients with decompensated cirrhosis with PI-based DAAs?".Torgersen J, Taddei TH, Lo Re V 3rd. J Hepatol. 2022 Jul; 2022 Mar 10. PMID: 35283213.
Postvaccination COVID-19 infection is associated with reduced mortality in patients with cirrhosis.John BV, Deng Y, Schwartz KB, Taddei TH, Kaplan DE, Martin P, Chao HH, Dahman B. Hepatology. 2022 Jul; 2022 Feb 22. PMID: 35023206.
Inpatient Gastroenterology Consultation and Outcomes of Cirrhosis-Related Hospitalizations in Two Large National Cohorts.Serper M, Kaplan DE, Lin M, Taddei TH, Parikh ND, Werner RM, Tapper EB. Dig Dis Sci. 2022 Jun; 2021 Aug 10. PMID: 34374917.
Statin exposure is associated with reduced development of acute-on-chronic liver failure in a Veterans Affairs cohort.Mahmud N, Chapin S, Goldberg DS, Reddy KR, Taddei TH, Kaplan DE. J Hepatol. 2022 May; 2022 Jan 21. PMID: 35066085.
Risk Prediction Models for Postoperative Decompensation and Infection in Patients With Cirrhosis: A Veterans Affairs Cohort Study.Mahmud N, Fricker Z, Lewis JD, Taddei TH, Goldberg DS, Kaplan DE. Clin Gastroenterol Hepatol. 2022 May; 2021 Jul 8. PMID: 34246794.
Palliative Care Always: Hepatology-Virtual Primary Palliative Care Training for Hepatologists.DeNofrio JC, Verma M, Kosinski AS, Navarro V, Taddei TH, Volk ML, Bakitas M, Ramchandran K. Hepatol Commun. 2022 Apr; 2021 Oct 31. PMID: 34719137.
Race Adjustment in eGFR Equations Does Not Improve Estimation of Acute Kidney Injury Events in Patients with Cirrhosis.Mahmud N, Asrani SK, Reese PP, Kaplan DE, Taddei TH, Nadim MK, Serper M. Dig Dis Sci. 2022 Apr; 2021 Mar 24. PMID: 33761091.
Coronavirus Disease 2019 Vaccination Is Associated With Reduced Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Death in Liver Transplant Recipients.John BV, Deng Y, Khakoo NS, Taddei TH, Kaplan DE, Dahman B. Gastroenterology. 2022 Feb; 2021 Nov 7. PMID: 34758352.
Rates of decompensation, hepatocellular carcinoma and mortality in AMA-negative primary biliary cholangitis cirrhosis.John BV, Dahman B, Deng Y, Khakoo NS, Taddei TH, Kaplan DE, Levy C. Liver Int. 2022 Feb; 2021 Oct 12. PMID: 34614294.
Oral Cyanobacteria and Hepatocellular Carcinoma.Hernandez BY, Zhu X, Risch HA, Lu L, Ma X, Irwin ML, Lim JK, Taddei TH, Pawlish KS, Stroup AM, Brown R, Wang Z, Wong LL, Yu H. Cancer Epidemiol Biomarkers Prev. 2022 Jan; 2021 Oct 25. PMID: 34697061.
Evaluation Within 30 Days of Referral for Liver Transplantation is Associated with Reduced Mortality: A Multicenter Analysis of Patients Referred Within the VA Health System.John BV, Schwartz K, Scheinberg AR, Dahman B, Spector S, Deng Y, Goldberg D, Martin P, Taddei TH, Kaplan DE. Transplantation. 2022 Jan 1. PMID: 33587434.
Protease inhibitor-based direct-acting antivirals are associated with increased risk of aminotransferase elevations but not hepatic dysfunction or decompensation.Torgersen J, Newcomb CW, Carbonari DM, Rentsch CT, Park LS, Mezochow A, Mehta RL, Buchwalder L, Tate JP, Bräu N, Bhattacharya D, Lim JK, Taddei TH, Justice AC, Lo Re V 3rd. J Hepatol. 2021 Dec; 2021 Jul 29. PMID: 34333102.
Association of BNT162b2 mRNA and mRNA-1273 Vaccines With COVID-19 Infection and Hospitalization Among Patients With Cirrhosis.John BV, Deng Y, Scheinberg A, Mahmud N, Taddei TH, Kaplan D, Labrada M, Baracco G, Dahman B. JAMA Intern Med. 2021 Oct 1. PMID: 34254978.
REPLY.John BV, Deng Y, Martin P, Levy C, Taddei TH, Kaplan DE, Dahman B. Hepatology. 2021 Oct; 2021 Aug 15. PMID: 34021933.
REPLY.John BV, Dahman B, Taddei TH, Levy C, Kaplan DE. Hepatology. 2021 Oct; 2021 Jul 20. PMID: 33942361.
Ursodeoxycholic Acid Response Is Associated With Reduced Mortality in Primary Biliary Cholangitis With Compensated Cirrhosis.John BV, Khakoo NS, Schwartz KB, Aitchenson G, Levy C, Dahman B, Deng Y, Goldberg DS, Martin P, Kaplan DE, Taddei TH. Am J Gastroenterol. 2021 Sep 1. PMID: 33989225.
The effect of chronic viral hepatitis on prognostic value of inflammatory biomarkers in hepatocellular carcinoma.Sellers CM, Uhlig J, Ludwig JM, Pollak JS, Taddei TH, Stein SM, Lim JK, Kim HS. Cancer Med. 2021 Aug; 2021 Jul 28. PMID: 34318618.
Changes in Hepatocellular Carcinoma Surveillance and Risk Factors for Noncompletion in the Veterans Health Administration Cohort During the Coronavirus Disease 2019 Pandemic.Mahmud N, Kaplan DE, Goldberg DS, Taddei TH, Serper M. Gastroenterology. 2021 May; 2021 Jan 9. PMID: 33434604.
Frailty Is a Risk Factor for Postoperative Mortality in Patients With Cirrhosis Undergoing Diverse Major Surgeries.Mahmud N, Kaplan DE, Taddei TH, Goldberg DS. Liver Transpl. 2021 May; 2021 Feb 15. PMID: 33226691.
The Predictive Role of Model for End-Stage Liver Disease-Lactate and Lactate Clearance for In-Hospital Mortality Among a National Cirrhosis Cohort.Mahmud N, Asrani SK, Kaplan DE, Ogola GO, Taddei TH, Kamath PS, Serper M. Liver Transpl. 2021 Feb; 2020 Dec 9. PMID: 33025731.
Patient Frailty Is Independently Associated With the Risk of Hospitalization for Acute-on-Chronic Liver Failure.Shah S, Goldberg DS, Kaplan DE, Sundaram V, Taddei TH, Mahmud N. Liver Transpl. 2021 Jan; 2020 Oct 28. PMID: 32946660.
Risk Prediction Models for Post-Operative Mortality in Patients With Cirrhosis.Mahmud N, Fricker Z, Hubbard RA, Ioannou GN, Lewis JD, Taddei TH, Rothstein KD, Serper M, Goldberg DS, Kaplan DE. Hepatology. 2021 Jan; 2020 Dec 10. PMID: 32939786.
Mortality and Hepatic Decompensation in Patients With Cirrhosis and Atrial Fibrillation Treated With Anticoagulation.Serper M, Weinberg EM, Cohen JB, Reese PP, Taddei TH, Kaplan DE. Hepatology. 2021 Jan; 2020 Nov 9. PMID: 32267547.
Systemic Therapy for Advanced Hepatocellular Carcinoma: ASCO Guideline.Gordan JD, Kennedy EB, Abou-Alfa GK, Beg MS, Brower ST, Gade TP, Goff L, Gupta S, Guy J, Harris WP, Iyer R, Jaiyesimi I, Jhawer M, Karippot A, Kaseb AO, Kelley RK, Knox JJ, Kortmansky J, Leaf A, Remak WM, Shroff RT, Sohal DPS, Taddei TH, Venepalli NK, Wilson A, Zhu AX, Rose MG. J Clin Oncol. 2020 Dec 20; 2020 Nov 16. PMID: 33197225.
Brief Report: Accuracy of FIB-4 for Cirrhosis in People Living With HIV and Hepatocellular Carcinoma.Torgersen J, Kallan MJ, Carbonari DM, Park LS, Mehta RL, D'Addeo K, Tate JP, Lim JK, Goetz MB, Rodriguez-Barradas MC, Bräu N, Brown ST, Taddei TH, Justice AC, Lo Re V 3rd. J Acquir Immune Defic Syndr. 2020 Dec 15. PMID: 33185999.
Assessing the Impact of Referral on Multidisciplinary Tumor Board Outcomes in Patients With Hepatocellular Carcinoma.Zhang Y, Weinreb JC, Czeyda-Pommersheim F, Taddei TH. J Am Coll Radiol. 2020 Dec; 2020 Jun 10. PMID: 32533924.
Correction to: Excess Weight Gain After Cure of Hepatitis C Infection with Direct-Acting Antivirals.Do A, Esserman DA, Krishnan S, Lim JK, Taddei TH, Hauser RG 3rd, Tate JP, Re VL 3rd, Justice AC. J Gen Intern Med. 2020 Oct. PMID: 33021712.
Patterns of COVID-19 testing and mortality by race and ethnicity among United States veterans: A nationwide cohort study.Rentsch CT, Kidwai-Khan F, Tate JP, Park LS, King JT Jr, Skanderson M, Hauser RG, Schultze A, Jarvis CI, Holodniy M, Lo Re V 3rd, Akgün KM, Crothers K, Taddei TH, Freiberg MS, Justice AC. PLoS Med. 2020 Sep; 2020 Sep 22. PMID: 32960880.
Models for acute on chronic liver failure development and mortality in a veterans affairs cohort.Xiao KY, Hubbard RA, Kaplan DE, Taddei TH, Goldberg DS, Mahmud N. Hepatol Int. 2020 Jul; 2020 Jun 9. PMID: 32519219.
Excess Weight Gain After Cure of Hepatitis C Infection with Direct-Acting Antivirals.Do A, Esserman DA, Krishnan S, Lim JK, Taddei TH, Hauser RG 3rd, Tate JP, Re VL 3rd, Justice AC. J Gen Intern Med. 2020 Jul; 2020 Apr 27. PMID: 32342483.
HIV RNA, CD4+ Percentage, and Risk of Hepatocellular Carcinoma by Cirrhosis Status.Torgersen J, Kallan MJ, Carbonari DM, Park LS, Mehta RL, D'Addeo K, Tate JP, Lim JK, Goetz MB, Rodriguez-Barradas MC, Gibert CL, Bräu N, Brown ST, Roy JA, Taddei TH, Justice AC, Lo Re V. J Natl Cancer Inst. 2020 Jul 1. PMID: 31687755.
Grade 1 Acute on Chronic Liver Failure Is a Predictor for Subsequent Grade 3 Failure.Mahmud N, Sundaram V, Kaplan DE, Taddei TH, Goldberg DS. Hepatology. 2020 Jul; 2020 Apr 3. PMID: 31677284.
Covid-19 by Race and Ethnicity: A National Cohort Study of 6 Million United States Veterans.Rentsch CT, Kidwai-Khan F, Tate JP, Park LS, King JT Jr, Skanderson M, Hauser RG, Schultze A, Jarvis CI, Holodniy M, Re VL 3rd, Akgün KM, Crothers K, Taddei TH, Freiberg MS, Justice AC. medRxiv. 2020 May 18; 2020 May 18. PMID: 32511524.
Risk prediction scores for acute on chronic liver failure development and mortality.Mahmud N, Hubbard RA, Kaplan DE, Taddei TH, Goldberg DS. Liver Int. 2020 May; 2019 Dec 26. PMID: 31840390.
Covid-19 Testing, Hospital Admission, and Intensive Care Among 2,026,227 United States Veterans Aged 54-75 Years.Rentsch CT, Kidwai-Khan F, Tate JP, Park LS, King JT Jr, Skanderson M, Hauser RG, Schultze A, Jarvis CI, Holodniy M, Re VL 3rd, Akgün KM, Crothers K, Taddei TH, Freiberg MS, Justice AC. medRxiv. 2020 Apr 14; 2020 Apr 14. PMID: 32511595.
Analysis of weekend effect in severe acute liver injury: A nationwide database study.Do A, Ilagan-Ying YC, Taddei TH. Health Sci Rep. 2020 Mar; 2019 Nov 22. PMID: 32166187.
Differences in Pathology, Staging, and Treatment between HIV(+) and Uninfected Patients with Microscopically Confirmed Hepatocellular Carcinoma.Torgersen J, Taddei TH, Park LS, Carbonari DM, Kallan MJ, Mitchell Richards K, Zhang X, Jhala D, Bräu N, Homer R, D'Addeo K, Mehta R, Skanderson M, Kidwai-Khan F, Justice AC, Lo Re V 3rd. Cancer Epidemiol Biomarkers Prev. 2020 Jan; 2019 Oct 1. PMID: 31575557.
Survival Benefit of Liver Transplantation for Hepatocellular Carcinoma.Kanneganti M, Mahmud N, Kaplan DE, Taddei TH, Goldberg DS. Transplantation. 2020 Jan. PMID: 31283688.
Reply.Mahmud N, Kaplan DE, Taddei TH, Goldberg DS. Hepatology. 2019 Dec. PMID: 31243784.
Quality Measures, All-Cause Mortality, and Health Care Use in a National Cohort of Veterans With Cirrhosis.Serper M, Kaplan DE, Shults J, Reese PP, Beste LA, Taddei TH, Werner RM. Hepatology. 2019 Dec; 2019 Jun 26. PMID: 31107967.
Increased Risk for Hepatocellular Carcinoma Persists Up to 10 Years After HCV Eradication in Patients With Baseline Cirrhosis or High FIB-4 Scores.Ioannou GN, Beste LA, Green PK, Singal AG, Tapper EB, Waljee AK, Sterling RK, Feld JJ, Kaplan DE, Taddei TH, Berry K. Gastroenterology. 2019 Nov; 2019 Jul 26. PMID: 31356807.
Pre-transplant alpha-fetoprotein is associated with post-transplant hepatocellular carcinoma recurrence mortality.Mahmud N, John B, Taddei TH, Goldberg DS. Clin Transplant. 2019 Jul; 2019 Jun 25. PMID: 31177570.
Aspirin Use and Risk of Hepatocellular Carcinoma in Hepatitis B.Fox RK, Taddei TH, Kaplan DE. JAMA Intern Med. 2019 May 1. PMID: 30882884.
Incidence and Mortality of Acute-on-Chronic Liver Failure Using Two Definitions in Patients with Compensated Cirrhosis.Mahmud N, Kaplan DE, Taddei TH, Goldberg DS. Hepatology. 2019 May; 2019 Mar 20. PMID: 30615211.
Systemic Management for Advanced Hepatocellular Carcinoma: A Review of the Molecular Pathways of Carcinogenesis, Current and Emerging Therapies, and Novel Treatment Strategies.Saffo S, Taddei TH. Dig Dis Sci. 2019 Apr. PMID: 30887150.
Hepatocellular Carcinoma Outcome Is Predicted by Expression of Neuronal Calcium Sensor 1.Schuette D, Moore LM, Robert ME, Taddei TH, Ehrlich BE. Cancer Epidemiol Biomarkers Prev. 2018 Sep; 2018 May 22. PMID: 29789326.
Palliative care in decompensated cirrhosis: A review.Langberg KM, Kapo JM, Taddei TH. Liver Int. 2018 May; 2018 Jan 15. PMID: 29112338.
Transarterial Chemoembolization within First 3 Months of Sorafenib Initiation Improves Overall Survival in Hepatocellular Carcinoma: A Retrospective, Multi-Institutional Study with Propensity Matching.Kaplan DE, Mehta R, D'Addeo K, Gade TP, Taddei TH. J Vasc Interv Radiol. 2018 Apr; 2018 Feb 22. PMID: 29477619.
Sorafenib prescribed by gastroenterologists and hepatologists for hepatocellular carcinoma: A retrospective, multi-institutional cohort study.Kaplan DE, Mehta R, D'Addeo K, Valderrama A, Taddei TH. Medicine (Baltimore). 2018 Jan. PMID: 29369224.
Starting Dose of Sorafenib for the Treatment of Hepatocellular Carcinoma: A Retrospective, Multi-Institutional Study.Reiss KA, Yu S, Mamtani R, Mehta R, D'Addeo K, Wileyto EP, Taddei TH, Kaplan DE. J Clin Oncol. 2017 Nov 1; 2017 Sep 5. PMID: 28872925.
Pursuing a Gastroenterology Fellowship as a Foreign Medical Graduate.Njei B, Taddei TH. Dig Dis Sci. 2017 Aug. PMID: 28555326.
Comparing Child-Pugh, MELD, and FIB-4 to Predict Clinical Outcomes in Hepatitis C Virus-Infected Persons: Results From ERCHIVES.Butt AA, Ren Y, Lo Re V 3rd, Taddei TH, Kaplan DE. Clin Infect Dis. 2017 Jul 1. PMID: 28369305.
Exome analysis of the evolutionary path of hepatocellular adenoma-carcinoma transition, vascular invasion and brain dissemination.Vilarinho S, Erson-Omay EZ, Mitchell-Richards K, Cha C, Nelson-Williams C, Harmancı AS, Yasuno K, Günel M, Taddei TH. J Hepatol. 2017 Jul; 2017 Mar 18. PMID: 28323122.
HIV, Aging, and Viral Coinfections: Taking the Long View.Taddei TH, Lo Re V 3rd, Justice AC. Curr HIV/AIDS Rep. 2016 Oct. PMID: 27614654.
Balancing quality with quantity: The role of palliative care in managing decompensated cirrhosis.Langberg KM, Taddei TH. Hepatology. 2016 Oct; 2016 Aug 5. PMID: 27388118.
Protective altruistic phlebotomy: hereditary haemochromatosis presenting as hepatocellular carcinoma in a non-cirrhotic 83-year-old man.Ooka K, Onyiuke I, Zhang X, Taddei TH. BMJ Case Rep. 2016 Sep 2; 2016 Sep 2. PMID: 27591041.
Learning from the Melbourne experience: How reliable are cancer registry data for hepatocellular carcinoma?Taddei TH. Hepatology. 2016 Apr; 2016 Mar 1. PMID: 26764271.
New frontier in liver cancer treatment: oncolytic viral therapy.Vilarinho S, Taddei TH. Hepatology. 2014 Jan; 2013 Nov 15. PMID: 23836532.
Emphysematous Cholecystitis Resulting in Secondary Biliary Cirrhosis: A Rare Complication of Endoscopic Retrograde Cholangiopancreatography.Bari K, Aslanian HR, Pollak J, Reiner E, Salem RR, Taddei TH, Emre SH, Jamidar PA. ACG Case Rep J. 2013 Oct; 2013 Oct 8. PMID: 26157820.

Jittima Weerachayaphorn, PhD

Molecular determinants of peri-apical targeting of inositol 1,4,5-trisphosphate receptor type 3 in cholangiocytes.Rodrigues MA, Gomes DA, Fiorotto R, Guerra MT, Weerachayaphorn J, Bo T, Sessa WC, Strazzabosco M, Nathanson MH. Hepatol Commun. 2022 Oct; 2022 Jul 19. PMID: 35852334.
Neutrophils interact with cholangiocytes to cause cholestatic changes in alcoholic hepatitis.Takeuchi M, Vidigal PT, Guerra MT, Hundt MA, Robert ME, Olave-Martinez M, Aoki S, Khamphaya T, Kersten R, Kruglov E, de la Rosa Rodriguez R, Banales JM, Nathanson MH, Weerachayaphorn J. Gut. 2021 Feb; 2020 Nov 19. PMID: 33214166.
Type 3 Inositol 1,4,5-Trisphosphate Receptor Is Increased and Enhances Malignant Properties in Cholangiocarcinoma.Ueasilamongkol P, Khamphaya T, Guerra MT, Rodrigues MA, Gomes DA, Kong Y, Wei W, Jain D, Trampert DC, Ananthanarayanan M, Banales JM, Roberts LR, Farshidfar F, Nathanson MH, Weerachayaphorn J. Hepatology. 2020 Feb; 2019 Aug 19. PMID: 31251815.
Effects of Endotoxin on Type 3 Inositol 1,4,5-Trisphosphate Receptor in Human Cholangiocytes.Franca A, Carlos Melo Lima Filho A, Guerra MT, Weerachayaphorn J, Loiola Dos Santos M, Njei B, Robert M, Xavier Lima C, Vieira Teixeira Vidigal P, Banales JM, Ananthanarayanam M, Leite MF, Nathanson MH. Hepatology. 2019 Feb; 2018 Dec 31. PMID: 30141207.
Dysregulated microRNA expression profiles in cholangiocarcinoma cell-derived exosomes.Kitdumrongthum S, Metheetrairut C, Charoensawan V, Ounjai P, Janpipatkul K, Panvongsa W, Weerachayaphorn J, Piyachaturawat P, Chairoungdua A. Life Sci. 2018 Oct 1; 2018 Aug 27. PMID: 30165035.
Nonalcoholic fatty liver disease impairs expression of the type II inositol 1,4,5-trisphosphate receptor.Khamphaya T, Chukijrungroat N, Saengsirisuwan V, Mitchell-Richards KA, Robert ME, Mennone A, Ananthanarayanan M, Nathanson MH, Weerachayaphorn J. Hepatology. 2018 Feb; 2018 Jan 2. PMID: 29023819.
Type 2 inositol trisphosphate receptor gene expression in hepatocytes is regulated by cyclic AMP.Kruglov E, Ananthanarayanan M, Sousa P, Weerachayaphorn J, Guerra MT, Nathanson MH. Biochem Biophys Res Commun. 2017 May 6; 2017 Mar 19. PMID: 28327356.
Effects of andrographolide on intrahepatic cholestasis induced by alpha-naphthylisothiocyanate in rats.Khamphaya T, Chansela P, Piyachaturawat P, Suksamrarn A, Nathanson MH, Weerachayaphorn J. Eur J Pharmacol. 2016 Oct 15; 2016 Jul 27. PMID: 27475677.
Nuclear Factor, Erythroid 2-Like 2 Regulates Expression of Type 3 Inositol 1,4,5-Trisphosphate Receptor and Calcium Signaling in Cholangiocytes.Weerachayaphorn J, Amaya MJ, Spirli C, Chansela P, Mitchell-Richards KA, Ananthanarayanan M, Nathanson MH. Gastroenterology. 2015 Jul; 2015 Mar 18. PMID: 25796361.
Deleterious effect of oltipraz on extrahepatic cholestasis in bile duct-ligated mice.Weerachayaphorn J, Luo Y, Mennone A, Soroka CJ, Harry K, Boyer JL. J Hepatol. 2014 Jan; 2013 Aug 23. PMID: 23978715.
Nuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestine.Weerachayaphorn J, Mennone A, Soroka CJ, Harry K, Hagey LR, Kensler TW, Boyer JL. Am J Physiol Gastrointest Liver Physiol. 2012 May 1; 2012 Feb 16. PMID: 22345550.
Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression.Xu S, Weerachayaphorn J, Cai SY, Soroka CJ, Boyer JL. Am J Physiol Gastrointest Liver Physiol. 2010 Jul; 2010 Apr 15. PMID: 20395535.
Nuclear factor erythroid 2-related factor 2 is a positive regulator of human bile salt export pump expression.Weerachayaphorn J, Cai SY, Soroka CJ, Boyer JL. Hepatology. 2009 Nov. PMID: 19821532.

Xinshou Ouyang, PhD

Inadequate induction of suppressor of cytokine signaling-1 causes systemic autoimmune diseases.Fujimoto M, Tsutsui H, Xinshou O, Tokumoto M, Watanabe D, Shima Y, Yoshimoto T, Hirakata H, Kawase I, Nakanishi K, Kishimoto T, Naka T. Int Immunol. 2004 Feb. PMID: 14734616.