2021
Effects of Somatic Methylation in Colonic Polyps on Risk of Developing Metachronous Advanced Colorectal Lesions
Murcia O, Martínez-Roca A, Juárez M, Giner-Calabuig M, Alustiza M, Mira C, Mangas-Sanjuan C, Serrano E, Ruiz-Gómez FA, Baile-Maxia S, Medina L, Alenda C, Payá A, Rodriguez-Soler M, Zapater P, Jover R. Effects of Somatic Methylation in Colonic Polyps on Risk of Developing Metachronous Advanced Colorectal Lesions. Cancers 2021, 13: 246. PMID: 33440809, PMCID: PMC7827613, DOI: 10.3390/cancers13020246.Peer-Reviewed Original ResearchCpG island methylator phenotypeAdvanced colorectal lesionsColorectal lesionsColonic polypsRetrospective cohort studyHigh-grade dysplasiaNegative predictive valueBaseline colonoscopyCohort studyConsecutive patientsEndoscopic surveillancePathological characteristicsVillous componentSerrated lesionsPredictive valuePatientsUseful markerSomatic hypermethylationPolyp sizePolypsLesionsMethylator phenotypeSomatic methylationDysplasiaRisk
2018
Genetic profile of polyps and risk of advanced metachronous lesions.
Murcia O, Juárez M, Rodriguez-Soler M, Hernández-Illán E, Egoavil C, Giner-Calabuig M, Alustiza M, Alenda C, Mangas C, García A, Aparicio J, Ruiz F, Martínez J, Casellas J, Soto J, Zapater P, Jover R. Genetic profile of polyps and risk of advanced metachronous lesions. Journal Of Clinical Oncology 2018, 36: 555-555. DOI: 10.1200/jco.2018.36.4_suppl.555.Peer-Reviewed Original ResearchMetachronous lesionsFirst colonoscopyUnivariate analysisHigh riskMultivariate analysisKaplan-Meier survival curvesLogistic regressionGenetic profileMeier survival curvesCox regression modelHigh-grade dysplasiaLog-rank testNumber of colonoscopiesFamilial colorectal cancerChi-square testCohort studyColonoscopy surveillanceCharacteristics of polypsColorectal cancerGrade dysplasiaVillous componentKRAS mutationsReal-time PCRBRAF mutationsIndependent marker
2017
KRAS and BRAF somatic mutations in colonic polyps and the risk of metachronous neoplasia
Juárez M, Egoavil C, Rodríguez-Soler M, Hernández-Illán E, Guarinos C, García-Martínez A, Alenda C, Giner-Calabuig M, Murcia O, Mangas C, Payá A, Aparicio JR, Ruiz FA, Martínez J, Casellas JA, Soto JL, Zapater P, Jover R. KRAS and BRAF somatic mutations in colonic polyps and the risk of metachronous neoplasia. PLOS ONE 2017, 12: e0184937. PMID: 28953955, PMCID: PMC5617162, DOI: 10.1371/journal.pone.0184937.Peer-Reviewed Original ResearchConceptsAdvanced adenomasKRAS mutationsColonic polypsAdvanced neoplasiaAdvanced polypsMetachronous advanced neoplasiaHigh-grade dysplasiaSomatic KRAS mutationsBRAF somatic mutationsMetachronous neoplasiaSurveillance colonoscopyPathologic characteristicsSplenic flexureGrade dysplasiaVillous componentUnivariate analysisSerrated polypsRisk featuresSomatic BRAFMultivariate analysisAdenomasAbstractTextPolypsPatientsNeoplasia