2017
Liver myofibroblasts of murine origins express mesothelin: Identification of novel rat mesothelin splice variants*
Fausther M, Lavoie E, Dranoff JA. Liver myofibroblasts of murine origins express mesothelin: Identification of novel rat mesothelin splice variants*. PLOS ONE 2017, 12: e0184499. PMID: 28898276, PMCID: PMC5595315, DOI: 10.1371/journal.pone.0184499.Peer-Reviewed Original ResearchConceptsHepatic stellate cellsLiver myofibroblastsStellate cellsFibrosis progressionLiver diseasePortal fibroblastsMesothelial cellsChronic cholestatic liver diseaseProgressive scar formationChronic liver diseaseCholestatic liver diseaseNormal mesothelial cellsSplice variantsEffector cellsOrgan failureCell surface moleculesHepatic fibrosisMyofibroblast proliferationMyofibroblast functionScar formationMesothelinPolyclonal ratCell markersMyofibroblastsCholangiocarcinoma cells
2009
Transcriptional regulation of IL-6 in bile duct epithelia by extracellular ATP
Yu J, Sheung N, Soliman EM, Spirli C, Dranoff JA. Transcriptional regulation of IL-6 in bile duct epithelia by extracellular ATP. AJP Gastrointestinal And Liver Physiology 2009, 296: g563-g571. PMID: 19136380, PMCID: PMC2660176, DOI: 10.1152/ajpgi.90502.2008.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsAntibodiesBile DuctsCalciumCalcium SignalingCell Line, TransformedCell Line, TumorCyclic AMPEpithelial CellsExtracellular SpaceFibroblastsHumansImmunoblottingInterleukin-6MaleMutagenesis, Site-DirectedPromoter Regions, GeneticRatsRats, Sprague-DawleyReceptors, Purinergic P2Response ElementsRNA, MessengerSignal TransductionTranscriptional ActivationConceptsBile duct epitheliumIL-6IL-6 transcriptionDuct epitheliumLiver injuryCAMP response elementP2Y11 receptorInflammatory cytokines IL-6Extracellular ATPIL-6 upregulationUse of agonistsRat bile duct epitheliaCytokines IL-6IL-6 releaseIL-6 promoter activityIL-6 mRNAExtracellular ATP actsCalcium agonistP2Y receptorsPharmacological profileHepatic responseCalcium-dependent fashionExtracellular nucleotidesCytosolic calciumPurinergic signals
2005
The Anti-apoptotic Protein Mcl-1 Inhibits Mitochondrial Ca2+ Signals*
Minagawa N, Kruglov EA, Dranoff JA, Robert ME, Gores GJ, Nathanson MH. The Anti-apoptotic Protein Mcl-1 Inhibits Mitochondrial Ca2+ Signals*. Journal Of Biological Chemistry 2005, 280: 33637-33644. PMID: 16027162, DOI: 10.1074/jbc.m503210200.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAniline CompoundsAntibodies, MonoclonalApoptosisBile Duct NeoplasmsCalcium SignalingCarbocyaninesCell LineCell Line, TumorCell NucleusFluorescent Antibody Technique, IndirectFluorescent DyesHeterocyclic Compounds, 3-RingHumansHydrazinesImmunohistochemistryMicroscopy, ConfocalMitochondriaModels, BiologicalMyeloid Cell Leukemia Sequence 1 ProteinNeoplasm ProteinsProto-Oncogene Proteins c-bcl-2Signal TransductionTissue DistributionXanthenesConceptsAnti-apoptotic proteinsMcl-1Mitochondrial Ca2Mcl-1 expressionApoptotic stimuliEndoplasmic reticulum Ca2Trisphosphate receptorCell growthNovel mechanismApoptosisMechanism of actionProteinExpressionDevelopment of neoplasiaCa2Reticulum Ca2CellsMitochondriaInositolRegulationPathwayMechanismSignalsReceptorsRegeneration