2017
Liver myofibroblasts of murine origins express mesothelin: Identification of novel rat mesothelin splice variants*
Fausther M, Lavoie E, Dranoff JA. Liver myofibroblasts of murine origins express mesothelin: Identification of novel rat mesothelin splice variants*. PLOS ONE 2017, 12: e0184499. PMID: 28898276, PMCID: PMC5595315, DOI: 10.1371/journal.pone.0184499.Peer-Reviewed Original ResearchConceptsHepatic stellate cellsLiver myofibroblastsStellate cellsFibrosis progressionLiver diseasePortal fibroblastsMesothelial cellsChronic cholestatic liver diseaseProgressive scar formationChronic liver diseaseCholestatic liver diseaseNormal mesothelial cellsSplice variantsEffector cellsOrgan failureCell surface moleculesHepatic fibrosisMyofibroblast proliferationMyofibroblast functionScar formationMesothelinPolyclonal ratCell markersMyofibroblastsCholangiocarcinoma cells
2013
Contribution of Myofibroblasts of Different Origins to Liver Fibrosis
Fausther M, Lavoie EG, Dranoff JA. Contribution of Myofibroblasts of Different Origins to Liver Fibrosis. Current Pathobiology Reports 2013, 1: 225-230. PMID: 23997993, PMCID: PMC3755779, DOI: 10.1007/s40139-013-0020-0.Peer-Reviewed Original ResearchHepatic fibrosisLiver fibrosisLiver myofibroblastsContribution of myofibroblastsProgressive liver fibrosisPrimary effector cellsTissue repair responseExtracellular matrix accumulationMajor fibrogenic cellsLiver failureLiver injuryEffector cellsCurrent therapiesAntifibrotic therapyCommon causeScar formationFibrogenic cellsFibrosisMatrix accumulationExtracellular matrix synthesisMyofibroblastsPromising targetWound healingRepair responseTherapy