2023
Coffee, adenosine, and the liver
Dranoff J. Coffee, adenosine, and the liver. Purinergic Signalling 2023, 20: 21-28. PMID: 37755557, PMCID: PMC10828332, DOI: 10.1007/s11302-023-09968-5.Peer-Reviewed Original Research
2020
The Role of Sirtuin 3 in Radiation-Induced Long-Term Persistent Liver Injury
LoBianco FV, Krager KJ, Carter GS, Alam S, Yuan Y, Lavoie EG, Dranoff JA, Aykin-Burns N. The Role of Sirtuin 3 in Radiation-Induced Long-Term Persistent Liver Injury. Antioxidants 2020, 9: 409. PMID: 32403251, PMCID: PMC7278565, DOI: 10.3390/antiox9050409.Peer-Reviewed Original ResearchLong-term liver injuryLiver injurySirtuin 3Chronic responsesRole of SIRT3Mature bile ductsPersistent liver injuryAcute liver injuryTotal body irradiationUse of radiotherapyFibrotic factorsInflammatory infiltrationBody irradiationBile ductInflammatory chemokinesMale miceGy radiationHigher DNA damageMajor mitochondrial deacetylaseAbsence of SIRT3Mitochondrial deacetylaseInjuryGlutathione peroxidaseMouse liverGy IR
2009
Portal fibroblasts: Underappreciated mediators of biliary fibrosis
Dranoff JA, Wells RG. Portal fibroblasts: Underappreciated mediators of biliary fibrosis. Hepatology 2009, 51: 1438-1444. PMID: 20209607, PMCID: PMC2850946, DOI: 10.1002/hep.23405.Peer-Reviewed Original ResearchConceptsPortal fibroblastsNonparenchymal cell populationBiliary fibrosisStellate cellsCell populationsHepatic stellate cellsFibrogenic myofibroblastsChronic injuryBiliary epitheliumDuct epitheliumFibrotic liverUnderappreciated mediatorCollagen productionFurther studiesFibrosisLiverEpitheliumFibroblastsCellsFibrogenesisInjuryPopulationMyofibroblastsPathobiologyImportant role