2020
The Role of Sirtuin 3 in Radiation-Induced Long-Term Persistent Liver Injury
LoBianco FV, Krager KJ, Carter GS, Alam S, Yuan Y, Lavoie EG, Dranoff JA, Aykin-Burns N. The Role of Sirtuin 3 in Radiation-Induced Long-Term Persistent Liver Injury. Antioxidants 2020, 9: 409. PMID: 32403251, PMCID: PMC7278565, DOI: 10.3390/antiox9050409.Peer-Reviewed Original ResearchLong-term liver injuryLiver injurySirtuin 3Chronic responsesRole of SIRT3Mature bile ductsPersistent liver injuryAcute liver injuryTotal body irradiationUse of radiotherapyFibrotic factorsInflammatory infiltrationBody irradiationBile ductInflammatory chemokinesMale miceGy radiationHigher DNA damageMajor mitochondrial deacetylaseAbsence of SIRT3Mitochondrial deacetylaseInjuryGlutathione peroxidaseMouse liverGy IR
2012
Advances in cholangiocyte immunobiology
Syal G, Fausther M, Dranoff JA. Advances in cholangiocyte immunobiology. AJP Gastrointestinal And Liver Physiology 2012, 303: g1077-g1086. PMID: 22961800, PMCID: PMC3517647, DOI: 10.1152/ajpgi.00227.2012.Peer-Reviewed Original ResearchConceptsImmune responseMajor histocompatibility complex antigensExtrahepatic bile ductAdaptive immune responsesHistocompatibility complex antigensHepatic stellate cellsBiliary infectionBiliary cirrhosisInflammatory mediatorsBiliary tractPortal fibroblastsBile ductProfessional APCsBiliary systemInflammatory modulatorsImmune cellsComplex antigensStellate cellsDuct epitheliumMyofibroblastic differentiationIntracellular signaling cascadesCholangiocytesFirst lineAdhesion moleculesCytokines
2010
Biliary Cirrhosis
Dranoff J. Biliary Cirrhosis. Molecular Pathology Library 2010, 5: 467-473. DOI: 10.1007/978-1-4419-7107-4_31.Peer-Reviewed Original Research
2002
The ecto‐nucleoside triphosphate diphosphohydrolase NTPDase2/CD39L1 is expressed in a novel functional compartment within the liver
Dranoff JA, Kruglov EA, Robson SC, Braun N, Zimmermann H, Sévigny J. The ecto‐nucleoside triphosphate diphosphohydrolase NTPDase2/CD39L1 is expressed in a novel functional compartment within the liver. Hepatology 2002, 36: 1135-1144. PMID: 12395323, DOI: 10.1053/jhep.2002.36823.Peer-Reviewed Original ResearchConceptsIntrahepatic bile ductsExtracellular nucleotidesBile ductDiverse biological functionsBlot analysisEcto-nucleoside triphosphate diphosphohydrolasesNTPDase2/CD39L1Portal fibroblastsNorthern blot analysisCellular compartmentsBiological functionsPotential regulatorConfocal immunofluorescenceWestern blot analysisHepatic blood flowBile duct epitheliumReverse transcription-polymerase chain reactionFunctional assaysTriphosphate diphosphohydrolasesImmunoelectron microscopyFunctional compartmentsHepatic central veinNucleotidesNTPDase1NTPDase2