2012
Tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone initiates and enhances pancreatitis responses
Alexandre M, Uduman AK, Minervini S, Raoof A, Shugrue CA, Akinbiyi EO, Patel V, Shitia M, Kolodecik TR, Patton R, Gorelick FS, Thrower EC. Tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone initiates and enhances pancreatitis responses. AJP Gastrointestinal And Liver Physiology 2012, 303: g696-g704. PMID: 22837343, PMCID: PMC3468532, DOI: 10.1152/ajpgi.00138.2012.Peer-Reviewed Original ResearchConceptsNicotinic acetylcholine receptorsAcetylcholine receptorsCigarette smoke toxinsParameters of pancreatitisPancreatitis responsesTobacco carcinogen 4Acinar cell responsesRat pancreatic aciniSmoke toxinsAcute pancreatitisCigarette smokingIntraperitoneal injectionAcinar cell preparationsClinical studiesLong-term effectsCarcinogen 4Pancreatitis modelAdrenergic receptorsReceptor typesCell responsesTobacco toxinsPyknotic nucleiNNKPancreatic aciniPancreatitis
1994
Effect of buprenorphine on pancreatic enzyme synthesis and secretion in normal rats and rats with acute edematous pancreatitis
Ogden JM, Modlin IM, Gorelick FS, Marks IN. Effect of buprenorphine on pancreatic enzyme synthesis and secretion in normal rats and rats with acute edematous pancreatitis. Digestive Diseases And Sciences 1994, 39: 2407-2415. PMID: 7525167, DOI: 10.1007/bf02087658.Peer-Reviewed Original ResearchConceptsAcute pancreatitisPancreatic enzyme secretionPancreatic enzyme synthesisAmylase secretionAmylase contentDevelopment of APEnzyme secretionSevere acute pancreatitisEffects of buprenorphineEffects of opiatesExperimental acute pancreatitisAcute edematous pancreatitisGroups of ratsSite of administrationNegative feedback inhibitionPancreatic edemaPancreatic stimulantsEdematous pancreatitisNormal ratsPancreatic massPancreatic secretionPancreatitisGroup IIControl groupGroup I