2018
Anatomy, Histology, and Fine Structure of the Pancreas
Longnecker D, Gorelick F, Thompson E. Anatomy, Histology, and Fine Structure of the Pancreas. 2018, 10-23. DOI: 10.1002/9781119188421.ch2.Peer-Reviewed Original ResearchPancreatic stellate cellsStellate cellsPrevention of pancreatitisPancreatic surgeryChronic pancreatitisMajor cell typesBlood supplyPancreatic fibrosisPancreatic anatomyClinical experienceEndocrine componentUltrastructural anatomyPancreatitisPancreasDuct systemCell typesAnatomyCellsSurgeryFibrosisHistologicHistologyCancerNew findingsExocrine
2011
The Emerging Role of Smoking in the Development of Pancreatitis
Alexandre M, Pandol SJ, Gorelick FS, Thrower EC. The Emerging Role of Smoking in the Development of Pancreatitis. Pancreatology 2011, 11: 469-474. PMID: 21986098, PMCID: PMC3222114, DOI: 10.1159/000332196.Peer-Reviewed Original ResearchConceptsDevelopment of pancreatitisTobacco smokingChronic pancreatitisAcute pancreatitisCigarette smokingPancreatic cancerBACKGROUND/Cigarette smokeElectronic searchSmokingPancreatitisOnly articlesEmerging RolePancreasNicotineOriginal articlesRiskMetabolitesSpecific constituentsPubMedCancerDiseaseDoseProgression
2010
Low Extracellular pH Induces Damage in the Pancreatic Acinar Cell by Enhancing Calcium Signaling*
Reed AM, Husain SZ, Thrower E, Alexandre M, Shah A, Gorelick FS, Nathanson MH. Low Extracellular pH Induces Damage in the Pancreatic Acinar Cell by Enhancing Calcium Signaling*. Journal Of Biological Chemistry 2010, 286: 1919-1926. PMID: 21084290, PMCID: PMC3023488, DOI: 10.1074/jbc.m110.158329.Peer-Reviewed Original ResearchConceptsPathogenesis of pancreatitisAcinar cellsRyR inhibitorsLow pHeDevelopment of pancreatitisRyanodine receptor inhibitorPancreatic acinar cellsReceptor inhibitorsClinical conditionsCellular injuryPancreatitisBasolateral regionExocrine pancreasPancreatitis responsesInjurious effectsCalcium signalingPathogenesisInduces damageInhibitorsCellsRyRsInjuryEarly stepsPancreasSensitizationAlcohol Abuse, Endoplasmic Reticulum Stress and Pancreatitis
Pandol SJ, Gorelick FS, Gerloff A, Lugea A. Alcohol Abuse, Endoplasmic Reticulum Stress and Pancreatitis. Digestive Diseases 2010, 28: 776-782. PMID: 21525762, PMCID: PMC3211518, DOI: 10.1159/000327212.Peer-Reviewed Original ResearchConceptsX-box binding protein 1Alcohol abuseChronic pancreatitisEthanol feedingUnfolded protein responseER stressSignificant pathological responseAcinar cellsAfrican American ethnicityEndoplasmic reticulum stressPancreatic manifestationAlcoholic pancreatitisAdaptive unfolded protein responseMinority of individualsChronic inflammationMost individualsPathological responseCommon causePancreatic diseaseApparent diseasePancreatitisBinding protein 1Heavy drinkersExocrine pancreasPancreas
2009
T1834 Role of XBP1 in the Protective Unfolded Protein Response to Limit Chronic Ethanol-Induced Endoplasmic Reticulum Stress and Damage in the Pancreas
Lugea A, Gukovsky I, French S, Gorelick F, Pandol S. T1834 Role of XBP1 in the Protective Unfolded Protein Response to Limit Chronic Ethanol-Induced Endoplasmic Reticulum Stress and Damage in the Pancreas. Gastroenterology 2009, 136: a-589. DOI: 10.1016/s0016-5085(09)62715-3.Peer-Reviewed Original Research
2005
Epidemiology and Pathophysiology of Acute Pancreatitis
Nagar A, Gorelick F. Epidemiology and Pathophysiology of Acute Pancreatitis. Clinical Gastroenterology 2005, 3-15. DOI: 10.1385/1-59259-815-3:003.Peer-Reviewed Original ResearchAcute pancreatitisNatural historyPathogenesis of APMultiorgan system failureRemote organ systemsAcute inflammatory processDegree of inflammationAcute attacksClinical courseCommon etiologyPancreatic inflammationSevere pancreatitisInflammatory processMild discomfortAlcohol abusePancreatitisRegional tissuesVariable involvementOrgan systemsComplete recoveryProapoptotic mediatorsPancreasInflammationIntracellular eventsZymogen granules
1997
Alcohol and Acute Pancreatitis
Robles-Diaz G, Gorelick F. Alcohol and Acute Pancreatitis. The Yale Journal Of Biology And Medicine 1997, 70: 77-87. PMCID: PMC2589130.Peer-Reviewed Original Research