2010
Molecular and cellular mechanisms of pancreatic injury
Thrower EC, Gorelick FS, Husain SZ. Molecular and cellular mechanisms of pancreatic injury. Current Opinion In Gastroenterology 2010, 26: 484-489. PMID: 20651589, PMCID: PMC3023172, DOI: 10.1097/mog.0b013e32833d119e.Peer-Reviewed Original ResearchConceptsPancreatic injuryCellular mechanismsFibroblast growth factor 21Antiapoptotic effectGrowth factor 21Ameliorate injuryEndoplasmic reticulum stressChronic pancreatitisFactor 21Immune cellsExendin-4Endogenous trypsin inhibitorBile acidsDisease severityInjuryPancreatitisCausative factorsSensitizing factorTrypsinogen activationProtein CReticulum stressTrypsinogen mutationsBcl-2Intracellular eventsUpregulation of proteins
2005
Epidemiology and Pathophysiology of Acute Pancreatitis
Nagar A, Gorelick F. Epidemiology and Pathophysiology of Acute Pancreatitis. Clinical Gastroenterology 2005, 3-15. DOI: 10.1385/1-59259-815-3:003.Peer-Reviewed Original ResearchAcute pancreatitisNatural historyPathogenesis of APMultiorgan system failureRemote organ systemsAcute inflammatory processDegree of inflammationAcute attacksClinical courseCommon etiologyPancreatic inflammationSevere pancreatitisInflammatory processMild discomfortAlcohol abusePancreatitisRegional tissuesVariable involvementOrgan systemsComplete recoveryProapoptotic mediatorsPancreasInflammationIntracellular eventsZymogen granules