2012
Sterile Inflammatory Response in Acute Pancreatitis
Hoque R, Malik AF, Gorelick F, Mehal WZ. Sterile Inflammatory Response in Acute Pancreatitis. Pancreas 2012, 41: 353-357. PMID: 22415665, PMCID: PMC3306133, DOI: 10.1097/mpa.0b013e3182321500.Peer-Reviewed Original ResearchConceptsDamage-associated molecular patternsSterile inflammatory responseAcute pancreatitisInterleukin-1βInflammatory responseExperimental pancreatitisNOD-like receptor protein 3High mobility group box protein 1Toll-like receptor 4Remote organ injuryReceptor protein 3Acinar cellsExperimental acute pancreatitisIL-1 receptorNovel therapeutic targetBox protein 1Necrotic acinar cellsDAMP receptorsShock protein 70Disease resolutionPancreatic injuryOrgan injuryInitial injuryIL-18Pharmacologic antagonism
2004
Acute pancreatitis
Nagar AB, Gorelick FS. Acute pancreatitis. Current Opinion In Gastroenterology 2004, 20: 439-443. PMID: 15689676, DOI: 10.1097/00001574-200409000-00004.Peer-Reviewed Original ResearchAcute pancreatitisExperimental acute pancreatitisNeurokinin-1 receptor antagonistPostendoscopic retrograde cholangiopancreatography pancreatitisTranscription factor nuclear factor-kappaBPancreatic duct stentingPrimary sensory neuronsUse of cytokinesHigh-risk peopleCyclo-oxygenase-2Use of diclofenacRegulation of inflammationFinal common pathwayNuclear factor-kappaBEarly eventsDuct stentingLung injuryInflammatory inhibitorPancreatic inflammationCholangiopancreatography pancreatitisCytokine responsesPathologic activationSignificant morbidityMet-RANTESReceptor antagonist
2002
Acute pancreatitis
Nagar AB, Gorelick FS. Acute pancreatitis. Current Opinion In Gastroenterology 2002, 18: 552-557. PMID: 17033332, DOI: 10.1097/00001574-200209000-00005.Peer-Reviewed Original ResearchSystemic inflammatory responseAcute pancreatitisInflammatory responseDistant organ failureMultiple inciting factorsEndoscopic retrograde cholangiopancreatography (ERCP) resultsSpecific inflammatory mediatorsAcute pancreatic injuryHuman acute pancreatitisExperimental acute pancreatitisIntra-acinar activationRelease of cytokinesClinical acute pancreatitisMultiorgan failurePancreatic injuryOrgan failureProinflammatory mediatorsInflammatory mediatorsCascade of eventsClinical syndromePancreatitisAnimal modelsInciting factorsMajor determinantMediatorsNeutrophils and NADPH oxidase mediate intrapancreatic trypsin activation in murine experimental acute pancreatitis
Gukovskaya AS, Vaquero E, Zaninovic V, Gorelick FS, Lusis AJ, Brennan M, Holland S, Pandol SJ. Neutrophils and NADPH oxidase mediate intrapancreatic trypsin activation in murine experimental acute pancreatitis. Gastroenterology 2002, 122: 974-984. PMID: 11910350, DOI: 10.1053/gast.2002.32409.Peer-Reviewed Original ResearchConceptsIntrapancreatic trypsin activationAcute pancreatitisNADPH oxidaseTrypsin activationAdenine Dinucleotide Phosphate OxidaseParenchymal cell injuryExperimental acute pancreatitisNADPH oxidase activityPancreatic acinar tissueDigestive enzymesWestern blot analysisAntineutrophil serumPathologic activationCell injuryPancreatitisExperimental pancreatitisHigh dosesMarked attenuationNeutrophilsAbstractTextAcinar tissuePancreatic homogenatesReactive oxygen speciesMyeloperoxidaseMice
1994
Effect of buprenorphine on pancreatic enzyme synthesis and secretion in normal rats and rats with acute edematous pancreatitis
Ogden JM, Modlin IM, Gorelick FS, Marks IN. Effect of buprenorphine on pancreatic enzyme synthesis and secretion in normal rats and rats with acute edematous pancreatitis. Digestive Diseases And Sciences 1994, 39: 2407-2415. PMID: 7525167, DOI: 10.1007/bf02087658.Peer-Reviewed Original ResearchConceptsAcute pancreatitisPancreatic enzyme secretionPancreatic enzyme synthesisAmylase secretionAmylase contentDevelopment of APEnzyme secretionSevere acute pancreatitisEffects of buprenorphineEffects of opiatesExperimental acute pancreatitisAcute edematous pancreatitisGroups of ratsSite of administrationNegative feedback inhibitionPancreatic edemaPancreatic stimulantsEdematous pancreatitisNormal ratsPancreatic massPancreatic secretionPancreatitisGroup IIControl groupGroup I