2021
Sex Differences in the Exocrine Pancreas and Associated Diseases
Wang M, Gorelick F, Bhargava A. Sex Differences in the Exocrine Pancreas and Associated Diseases. Cellular And Molecular Gastroenterology And Hepatology 2021, 12: 427-441. PMID: 33895424, PMCID: PMC8255941, DOI: 10.1016/j.jcmgh.2021.04.005.Peer-Reviewed Original ResearchConceptsPancreatic diseaseSex differencesExocrine pancreasLevels of estrogenAcute pancreatitis modelOverall health outcomesSex-specific mechanismsNormal exocrine pancreasG protein-coupled receptorsSex-specific changesMajor sex differencesObstructive etiologyPremenopausal womenProtein-coupled receptorsPancreatic surgeryAdrenal glandPancreatic histopathologyPancreatic secretionProtective effectLow prevalenceGranule numberDiagnostic criteriaPancreatitis modelPancreatic anatomyAssociated disease
2011
Environmental and Genetic Stressors and the Unfolded Protein Response in Exocrine Pancreatic Function – A Hypothesis
Pandol SJ, Gorelick FS, Lugea A. Environmental and Genetic Stressors and the Unfolded Protein Response in Exocrine Pancreatic Function – A Hypothesis. Frontiers In Physiology 2011, 2: 8. PMID: 21483727, PMCID: PMC3070477, DOI: 10.3389/fphys.2011.00008.Peer-Reviewed Original ResearchProtein responseER stressProtein synthetic machineryUnfolded protein responseDigestive enzymesProtein synthetic capacityRecent findingsAdaptive UPREndoplasmic reticulum stressGenetic stressorsSynthetic machineryMammalian organsEnvironmental stressorsProtein synthesisKey pathwaysUPRReticulum stressExocrine cellsExocrine pancreasSynthetic capacityEnzymePathwayPathologic pathwaysStressorsMachinery
2010
Low Extracellular pH Induces Damage in the Pancreatic Acinar Cell by Enhancing Calcium Signaling*
Reed AM, Husain SZ, Thrower E, Alexandre M, Shah A, Gorelick FS, Nathanson MH. Low Extracellular pH Induces Damage in the Pancreatic Acinar Cell by Enhancing Calcium Signaling*. Journal Of Biological Chemistry 2010, 286: 1919-1926. PMID: 21084290, PMCID: PMC3023488, DOI: 10.1074/jbc.m110.158329.Peer-Reviewed Original ResearchConceptsPathogenesis of pancreatitisAcinar cellsRyR inhibitorsLow pHeDevelopment of pancreatitisRyanodine receptor inhibitorPancreatic acinar cellsReceptor inhibitorsClinical conditionsCellular injuryPancreatitisBasolateral regionExocrine pancreasPancreatitis responsesInjurious effectsCalcium signalingPathogenesisInduces damageInhibitorsCellsRyRsInjuryEarly stepsPancreasSensitizationAlcohol Abuse, Endoplasmic Reticulum Stress and Pancreatitis
Pandol SJ, Gorelick FS, Gerloff A, Lugea A. Alcohol Abuse, Endoplasmic Reticulum Stress and Pancreatitis. Digestive Diseases 2010, 28: 776-782. PMID: 21525762, PMCID: PMC3211518, DOI: 10.1159/000327212.Peer-Reviewed Original ResearchConceptsX-box binding protein 1Alcohol abuseChronic pancreatitisEthanol feedingUnfolded protein responseER stressSignificant pathological responseAcinar cellsAfrican American ethnicityEndoplasmic reticulum stressPancreatic manifestationAlcoholic pancreatitisAdaptive unfolded protein responseMinority of individualsChronic inflammationMost individualsPathological responseCommon causePancreatic diseaseApparent diseasePancreatitisBinding protein 1Heavy drinkersExocrine pancreasPancreas
1983
Diabetes mellitus and the exocrine pancreas.
Gorelick FS. Diabetes mellitus and the exocrine pancreas. The Yale Journal Of Biology And Medicine 1983, 56: 271-5. PMID: 6367237, PMCID: PMC2589620.Peer-Reviewed Original ResearchConceptsDiabetes mellitusAcute pancreatitisChronic pancreatitisConcurrent hepatic diseasePrimary diabetes mellitusPancreatic exocrine functionEffect of insulinCarbohydrate intoleranceAcute illnessGlucose intolerancePancreatic calcificationGlucagon releaseExocrine functionHepatic diseaseInsulin administrationInsulin secretionPeripheral tissuesPancreatitisEndocrine pancreasInsulin productionGlucose utilizationMellitusPortal systemDiabetesExocrine pancreas