2024
Severe Acute Liver Injury After Hepatotoxic Medication Initiation in Real-World Data
Torgersen J, Mezochow A, Newcomb C, Carbonari D, Hennessy S, Rentsch C, Park L, Tate J, Bräu N, Bhattacharya D, Lim J, Mezzacappa C, Njei B, Roy J, Taddei T, Justice A, Re V. Severe Acute Liver Injury After Hepatotoxic Medication Initiation in Real-World Data. JAMA Internal Medicine 2024, 184: 943-952. PMID: 38913369, PMCID: PMC11197444, DOI: 10.1001/jamainternmed.2024.1836.Peer-Reviewed Original ResearchIncidence rateUS Department of Veterans AffairsMedication initiationDepartment of Veterans AffairsInitiation of medicationVeterans AffairsMain OutcomesPotential of medicationsOutpatient settingDischarge diagnosisCohort studyDay of admissionCase reportReal World DataReport countsMedicationMedical cohortSevere acute liver injuryUS DepartmentFollow-upAcute liver injuryHospitalCohortHepatotoxic medicationsIncidenceIntegrated Telemedicine to Treat HCV Through Opioid Treatment Programs
Mezzacappa C. Integrated Telemedicine to Treat HCV Through Opioid Treatment Programs. Gastroenterology 2024 PMID: 39025413, DOI: 10.1053/j.gastro.2024.07.010.Peer-Reviewed Original ResearchScreening for Hepatocellular Carcinoma and Survival in Patients With Cirrhosis After Hepatitis C Virus Cure
Mezzacappa C, Kim N, Vutien P, Kaplan D, Ioannou G, Taddei T. Screening for Hepatocellular Carcinoma and Survival in Patients With Cirrhosis After Hepatitis C Virus Cure. JAMA Network Open 2024, 7: e2420963. PMID: 38985470, PMCID: PMC11238019, DOI: 10.1001/jamanetworkopen.2024.20963.Peer-Reviewed Original ResearchConceptsHepatitis C virus cureHepatitis C virusAssociated with improved overall survivalHepatocellular carcinoma diagnosisEarly-stage hepatocellular carcinomaImproved overall survivalOverall survivalHepatocellular carcinomaFollow-upHCC screeningCurative treatmentCumulative incidence of hepatocellular carcinomaDirect-acting antiviral (DAA) therapyCohort studyVeterans Affairs health care systemIncidence of hepatocellular carcinomaRisk of hepatocellular carcinomaCohort study of personsHepatitis C virus cirrhosisDiagnosis of hepatocellular carcinomaLikelihood of curative treatmentYears of follow-upHealth care systemHepatocellular carcinoma screeningHCV-related cirrhosisReview of the cost-effectiveness of surveillance for hereditary pancreatic cancer
Wang L, Levinson R, Mezzacappa C, Katona B. Review of the cost-effectiveness of surveillance for hereditary pancreatic cancer. Familial Cancer 2024, 23: 351-360. PMID: 38795221, PMCID: PMC11255025, DOI: 10.1007/s10689-024-00392-1.Peer-Reviewed Original ResearchHigh-risk individualsHereditary pancreatic cancerSusceptibility to pancreatic cancerPancreatic cancer riskFamily history of PCSurveillance strategiesPancreatic cancerCost-effectiveness of surveillanceHistory of PCCost-effectiveness studiesCost-effectiveCancer riskCost-effectiveness analysisPancreatic surveillanceHigh-risk groupOptimal surveillance strategyFamily historyNew-onset diabetesRisk individualsSporadic PCHealth benefitsPotential health benefitsPC diagnosisSub-groupsSurveillanceManagement of HBV reactivation: Challenges and opportunities
Mezzacappa C, Lim J. Management of HBV reactivation: Challenges and opportunities. Clinical Liver Disease 2024, 23: e0143. PMID: 38720793, PMCID: PMC11078521, DOI: 10.1097/cld.0000000000000143.Peer-Reviewed Original ResearchTu1420 THE ASSOCIATION OF HEPATITIS C VIRUS ON THE RISK OF PANCREATIC CANCER
Levinson R, Larki N, Tate J, Skanderson M, Mezzacappa C, Park L, Hauser R, Brandt C, Schuster K, Ketwaroo G, Yang Y, Justice A, Wang L. Tu1420 THE ASSOCIATION OF HEPATITIS C VIRUS ON THE RISK OF PANCREATIC CANCER. Gastroenterology 2024, 166: s-1333. DOI: 10.1016/s0016-5085(24)03510-8.Peer-Reviewed Original ResearchCo-occurring MASLD and Diabetes Is Associated With Increased Incidence of Cardiovascular Events and Mortality
Mezzacappa C. Co-occurring MASLD and Diabetes Is Associated With Increased Incidence of Cardiovascular Events and Mortality. Gastroenterology 2024, 167: 812-813. PMID: 38670284, DOI: 10.1053/j.gastro.2024.04.021.Peer-Reviewed Original ResearchDetection of hepatocellular carcinoma methylation markers in salivary DNA
Mezzacappa C, Wang Z, Lu L, Risch H, Taddei T, Yu H. Detection of hepatocellular carcinoma methylation markers in salivary DNA. Bioscience Reports 2024, 44: bsr20232063. PMID: 38457142, PMCID: PMC10958141, DOI: 10.1042/bsr20232063.Peer-Reviewed Original ResearchHepatocellular carcinoma screeningCase patientsHepatocellular carcinomaControl subjectsDiagnosis of hepatocellular carcinomaAssociated with hepatocellular carcinomaScreening testSalivary DNASaliva-based testCpG sitesStudy of risk factorsSalivary DNA methylationDNA methylationViral hepatitisCirculating DNAAlterations to DNA methylationRisk factorsMethylation markersPatientsRegulation of cell cycle progressionBlood samplesCell cycle progressionAffected individualsAlternative to blood samplingMultiple comparisonsDevelopment and Validation of Case-Finding Algorithms to Identify Pancreatic Cancer in the Veterans Health Administration
Mezzacappa C, Larki N, Skanderson M, Park L, Brandt C, Hauser R, Justice A, Yang Y, Wang L. Development and Validation of Case-Finding Algorithms to Identify Pancreatic Cancer in the Veterans Health Administration. Digestive Diseases And Sciences 2024, 69: 1507-1513. PMID: 38453743, DOI: 10.1007/s10620-024-08324-w.Peer-Reviewed Original ResearchElectronic health recordsVeterans Health AdministrationHealth AdministrationElectronic health records data elementsElectronic health record dataDiagnosis of exocrine pancreatic cancerNational Cancer RegistryCancer RegistryHealth recordsExocrine pancreatic cancerOncology settingOutpatient encountersInpatient encountersData elementsExpert adjudicationPancreatic ductal adenocarcinomaEpidemiological studiesRandom sampleInterquartile rangeIdentification of patientsRange of patientsPancreatic cancerVeteransLate diagnosisExcellent PPV
2023
HCC is associated with diabetes and longitudinal blood glucose control in a national cohort with cirrhosis
Mezzacappa C, Mahmud N, Serper M, John B, Taddei T, Kaplan D. HCC is associated with diabetes and longitudinal blood glucose control in a national cohort with cirrhosis. Hepatology Communications 2023, 7: e0344. PMID: 38055642, PMCID: PMC10984661, DOI: 10.1097/hc9.0000000000000344.Peer-Reviewed Original ResearchRate of HCCBlood glucose controlBG controlIncident HCCGlucose controlCox proportional hazards regressionEtiology of cirrhosisProportional hazards regressionUnited States veteransHemoglobin A1c measurementsCirrhosis careHgb A1cHCC ratesHazards regressionNational cohortHCC riskA1c measurementStates veteransCirrhosisHigh riskDiabetesSustained controlHCCControl stateCohortCommunity-Level Factors Associated with Hepatocellular Carcinoma Incidence and Mortality: An Observational Registry Study.
Mezzacappa C, Rossi R, Jaffe A, Taddei T, Strazzabosco M. Community-Level Factors Associated with Hepatocellular Carcinoma Incidence and Mortality: An Observational Registry Study. Cancer Epidemiology Biomarkers & Prevention 2023, 33: 270-278. PMID: 38059831, PMCID: PMC10872555, DOI: 10.1158/1055-9965.epi-23-0902.Peer-Reviewed Original ResearchS3865 A Protein Paradox: A Case of Spontaneous Portosystemic Shunt Encephalopathy and Protein-Losing Enteropathy
Maxwell M, Mezzacappa C, Hussain N, Protiva P, Cornman-Homonoff J, DiDomenico P, Ketwaroo G, Taddei T. S3865 A Protein Paradox: A Case of Spontaneous Portosystemic Shunt Encephalopathy and Protein-Losing Enteropathy. The American Journal Of Gastroenterology 2023, 118: s2470-s2471. DOI: 10.14309/01.ajg.0000965100.38497.c8.Peer-Reviewed Original ResearchS3383 A Rare Case of Hemobilia Secondary to Choledochal Varices in a Patient With Chronic Schistosomiasis
White M, Mezzacappa C, Hass D, Schlachter T, Muniraj T. S3383 A Rare Case of Hemobilia Secondary to Choledochal Varices in a Patient With Chronic Schistosomiasis. The American Journal Of Gastroenterology 2023, 118: s2238-s2239. DOI: 10.14309/01.ajg.0000963172.06896.9d.Peer-Reviewed Original ResearchSurvival in Unresectable Hepatocellular Carcinoma Treated With a New Immune Checkpoint and Anti-angiogenic Drug Combination
Mezzacappa C. Survival in Unresectable Hepatocellular Carcinoma Treated With a New Immune Checkpoint and Anti-angiogenic Drug Combination. Gastroenterology 2023, 166: 350. PMID: 37683705, DOI: 10.1053/j.gastro.2023.09.003.Commentaries, Editorials and LettersProteomic Panels for Alcohol-Associated Liver Disease: Accurate, but Different Enough From Existing Clinical Tests?
Mezzacappa C, Bhat M. Proteomic Panels for Alcohol-Associated Liver Disease: Accurate, but Different Enough From Existing Clinical Tests? Gastroenterology 2023, 165: 1576. PMID: 37683704, DOI: 10.1053/j.gastro.2023.09.002.Commentaries, Editorials and LettersDo Polygenic Risk Scores Add to Clinical Data in Predicting Pancreatic Cancer? A Scoping Review.
Wang L, Grimshaw A, Mezzacappa C, Rahimi Larki N, Yang Y, Justice A. Do Polygenic Risk Scores Add to Clinical Data in Predicting Pancreatic Cancer? A Scoping Review. Cancer Epidemiology Biomarkers & Prevention 2023, 32: 1490-1497. PMID: 37610426, PMCID: PMC10873036, DOI: 10.1158/1055-9965.epi-23-0468.Peer-Reviewed Original ResearchConceptsRoutine risk factorsPancreatic cancerRisk factorsPolygenic risk scoresClinical dataRisk scoreAddition of PRSClinical risk factorsRoutine clinical dataCancer risk predictionDatabase inceptionCancerClinical applicabilityRelevant exposuresGenetic riskRisk predictionCancer-specific polygenic risk scoresScoping ReviewRiskEuropean ancestryPopulation representativeScoresMost studiesAppropriate controlsFactorsAdherence to Tumor Board Recommendations in the Treatment of Patients with Hepatocellular Carcinoma
Cao Y, Mezzacappa C, Jaffe A, Strazzabosco M, Taddei T. Adherence to Tumor Board Recommendations in the Treatment of Patients with Hepatocellular Carcinoma. Journal Of Multidisciplinary Healthcare 2023, 16: 1531-1540. PMID: 37283950, PMCID: PMC10239642, DOI: 10.2147/jmdh.s407908.Peer-Reviewed Original ResearchMultidisciplinary liver tumor boardBarcelona Clinic Liver CancerHepatocellular carcinomaBCLC stageLocoregional therapyTreatment-naïve hepatocellular carcinomaTreatment of HCCTumor board recommendationsRetrospective cohort studyTertiary care centerChronic liver diseaseMultivariate Cox regressionKaplan-Meier analysisManagement of patientsTreatment of patientsUnifocal hepatocellular carcinomaCases of discordanceBCLC guidelinesPalliative intentTreatment discordanceUnifocal diseaseChart reviewCohort studyCurative therapyCurative treatment
2022
Disparities in Access to Endoscopy for Patients With Upper Gastrointestinal Bleeding Presenting to Emergency Departments
Rodriguez NJ, Zheng N, Mezzacappa C, Canavan M, Laine L, Shung D. Disparities in Access to Endoscopy for Patients With Upper Gastrointestinal Bleeding Presenting to Emergency Departments. Gastroenterology 2022, 164: 1044-1046.e4. PMID: 36228735, PMCID: PMC10083188, DOI: 10.1053/j.gastro.2022.10.001.Peer-Reviewed Original ResearchSystems approach to enhance Lynch syndrome diagnosis through tumour testing
Singh V, Mezzacappa C, Gershkovich P, Di Giovanna J, Ganzak A, Gibson J, Sinard J, Xicola RM, Llor X. Systems approach to enhance Lynch syndrome diagnosis through tumour testing. Journal Of Medical Genetics 2022, 60: 533-539. PMID: 36115663, PMCID: PMC10020126, DOI: 10.1136/jmg-2022-108770.Peer-Reviewed Original ResearchConceptsOriginal cohortColorectal adenocarcinomaLynch syndromeTumor testingGenetic testingPercentage of patientsProportion of patientsLynch syndrome diagnosisCG evaluationCancer genetic testingRace/ethnicityCRC testingCohort studyMMR immunohistochemistryLS diagnosisNew diagnosisMMR lossAcademic centersPatientsSyndrome diagnosisCohortCase identificationMethylation testingReferral differencesReferral mechanismsCancer tracking system improves timeliness of liver cancer care at a Veterans Hospital: A comparison of cohorts before and after implementation of an automated care coordination tool
Zhang Y, Mezzacappa C, Shen L, Ivatorov A, Petukhova-Greenstein A, Mehta R, Ciarleglio M, Deng Y, Levin W, Steinhardt S, Connery D, Pineau M, Onyiuke I, Taylor C, Rose M, Taddei T. Cancer tracking system improves timeliness of liver cancer care at a Veterans Hospital: A comparison of cohorts before and after implementation of an automated care coordination tool. PLOS Digital Health 2022, 1: e0000080. PMID: 36812575, PMCID: PMC9931271, DOI: 10.1371/journal.pdig.0000080.Peer-Reviewed Original Research