2021
Post-reconstruction attenuation correction for SPECT myocardium perfusion imaging facilitated by deep learning-based attenuation map generation
Liu H, Wu J, Shi L, Liu Y, Miller E, Sinusas A, Liu YH, Liu C. Post-reconstruction attenuation correction for SPECT myocardium perfusion imaging facilitated by deep learning-based attenuation map generation. Journal Of Nuclear Cardiology 2021, 29: 2881-2892. PMID: 34671940, DOI: 10.1007/s12350-021-02817-1.Peer-Reviewed Original ResearchDiagnostic accuracy of stress-only myocardial perfusion SPECT improved by deep learning
Liu H, Wu J, Miller EJ, Liu C, Yaqiang, Liu, Liu YH. Diagnostic accuracy of stress-only myocardial perfusion SPECT improved by deep learning. European Journal Of Nuclear Medicine And Molecular Imaging 2021, 48: 2793-2800. PMID: 33511425, DOI: 10.1007/s00259-021-05202-9.Peer-Reviewed Original ResearchMeSH KeywordsCoronary Artery DiseaseDeep LearningFemaleHumansMaleMyocardial Perfusion ImagingPerfusionRetrospective StudiesSensitivity and SpecificityTomography, Emission-Computed, Single-PhotonConceptsMyocardial perfusion imagingCoronary artery diseaseMyocardial perfusion abnormalitiesPerfusion abnormalitiesDiagnostic accuracyConvolutional neural networkTomography myocardial perfusion imagingYale-New Haven HospitalMyocardial perfusion defect sizeSPECT myocardial perfusion imagingAbnormal myocardial perfusionReceiver-operating characteristic curvePerfusion defect sizeNew Haven HospitalAUC valuesSingle photon emissionMyocardial perfusion SPECTDeep learningHigh diagnostic accuracyArtery diseaseDL methodsFinal diagnosisPatient genderMyocardial perfusionPerfusion SPECT
2016
High-Sensitivity and High-Resolution SPECT/CT Systems Provide Substantial Dose Reduction Without Compromising Quantitative Precision for Assessment of Myocardial Perfusion and Function
Palyo RJ, Sinusas A, Liu YH. High-Sensitivity and High-Resolution SPECT/CT Systems Provide Substantial Dose Reduction Without Compromising Quantitative Precision for Assessment of Myocardial Perfusion and Function. Journal Of Nuclear Medicine 2016, 57: 893-899. PMID: 26848173, DOI: 10.2967/jnumed.115.164632.Peer-Reviewed Original ResearchConceptsMyocardial perfusion SPECTEjection fractionDose reductionMyocardial perfusionAnterior descendingRight coronary artery territoryTetrofosmin myocardial perfusion SPECTNormal MPS resultsNuclear Cardiology guidelinesCoronary artery territoryLarge perfusion defectsLV ejection fractionLeft anterior descendingData of patientsNormal myocardial perfusionEnd-systolic volumeRelative dose reductionDefect sizeMPS resultsShort imaging protocolsTetrofosmin scanArtery territoryCardiology guidelinesSubstantial dose reductionLV function
2011
Accuracy and Reproducibility of Absolute Quantification of Myocardial Focal Tracer Uptake from Molecularly Targeted SPECT/CT: A Canine Validation
Liu YH, Sahul Z, Weyman CA, Dione DP, Dobrucki WL, Mekkaoui C, Brennan MP, Ryder WJ, Sinusas AJ. Accuracy and Reproducibility of Absolute Quantification of Myocardial Focal Tracer Uptake from Molecularly Targeted SPECT/CT: A Canine Validation. Journal Of Nuclear Medicine 2011, 52: 453-460. PMID: 21321271, PMCID: PMC3137905, DOI: 10.2967/jnumed.110.082214.Peer-Reviewed Original ResearchAnimalsDogsFemaleHeartImage Interpretation, Computer-AssistedMaleMetabolic Clearance RateMolecular ImagingMyocardial Perfusion ImagingMyocardiumRadiopharmaceuticalsReproducibility of ResultsSensitivity and SpecificitySubtraction TechniqueTissue DistributionTomography, Emission-Computed, Single-PhotonTomography, X-Ray Computed
2009
A novel three‐dimensional image reconstruction method for near‐field coded aperture single photon emission computerized tomography
Mu Z, Hong B, Li S, Liu Y. A novel three‐dimensional image reconstruction method for near‐field coded aperture single photon emission computerized tomography. Medical Physics 2009, 36: 1533-1542. PMID: 19544769, PMCID: PMC2832028, DOI: 10.1118/1.3103490.Peer-Reviewed Original Research
2006
Aperture Collimation Correction and Maximum-Likelihood Image Reconstruction for Near-Field Coded Aperture Imaging of Single Photon Emission Computerized Tomography
Mu Z, Liu YH. Aperture Collimation Correction and Maximum-Likelihood Image Reconstruction for Near-Field Coded Aperture Imaging of Single Photon Emission Computerized Tomography. IEEE Transactions On Medical Imaging 2006, 25: 701-711. PMID: 16768235, DOI: 10.1109/tmi.2006.873298.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsArtifactsData Interpretation, StatisticalFeasibility StudiesHumansImage EnhancementImage Interpretation, Computer-AssistedImaging, Three-DimensionalInformation Storage and RetrievalLikelihood FunctionsPhantoms, ImagingReproducibility of ResultsSensitivity and SpecificityTomography, Emission-Computed, Single-PhotonConceptsX-ray astronomySingle projectionCA imagesCoded Aperture ImagingMLEM reconstruction algorithmNear-field artifactsCollimation effectMaximum-likelihood image reconstructionSPECT systemParallel-hole collimatorImage reconstruction methodImage resolutionAperture imagingCollimationDeconvolution methodDual acquisitionImage reconstructionCount sensitivityImaging techniquesPhoton emissionPinholesReconstruction algorithm
2005
Clinical validation of SPECT attenuation correction using x-ray computed tomography–derived attenuation maps: Multicenter clinical trial with angiographic correlation
Masood Y, Liu Y, DePuey G, Taillefer R, Araujo LI, Allen S, Delbeke D, Anstett F, Peretz A, Zito M, Tsatkin V, Wackers FJ. Clinical validation of SPECT attenuation correction using x-ray computed tomography–derived attenuation maps: Multicenter clinical trial with angiographic correlation. Journal Of Nuclear Cardiology 2005, 12: 676-686. PMID: 16344230, DOI: 10.1016/j.nuclcard.2005.08.006.Peer-Reviewed Original ResearchNew hybrid count- and geometry-based method for quantification of left ventricular volumes and ejection fraction from ECG-gated SPECT: Methodology and validation
Liu YH, Sinusas AJ, Khaimov D, Gebuza BI, Wackers FJ. New hybrid count- and geometry-based method for quantification of left ventricular volumes and ejection fraction from ECG-gated SPECT: Methodology and validation. Journal Of Nuclear Cardiology 2005, 12: 55-65. PMID: 15682366, DOI: 10.1016/j.nuclcard.2004.09.015.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlgorithmsElectrocardiographyFemaleGated Blood-Pool ImagingHumansImage Interpretation, Computer-AssistedMaleMiddle AgedPhantoms, ImagingReproducibility of ResultsSensitivity and SpecificitySeverity of Illness IndexStroke VolumeTomography, Emission-Computed, Single-PhotonVentricular Dysfunction, LeftA New Method for SPECT Quantification of Targeted Radiotracers Uptake in the Myocardium
Li S, Dobrucki LW, Sinusas AJ, Liu YH. A New Method for SPECT Quantification of Targeted Radiotracers Uptake in the Myocardium. Lecture Notes In Computer Science 2005, 8: 684-691. PMID: 16686019, DOI: 10.1007/11566489_84.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDrug Delivery SystemsHeartImage Interpretation, Computer-AssistedMyocardiumNeovascularization, PathologicRadioisotopesRadiopharmaceuticalsRatsReperfusion InjuryReproducibility of ResultsSensitivity and SpecificityTomography, Emission-Computed, Single-PhotonVentricular Dysfunction, Left
1999
Quantification of SPECT myocardial perfusion images: Methodology and validation of the Yale-CQ method
Liu Y, Sinusas A, DeMan P, Zaret B, Wackers F. Quantification of SPECT myocardial perfusion images: Methodology and validation of the Yale-CQ method. Journal Of Nuclear Cardiology 1999, 6: 190-203. PMID: 10327104, DOI: 10.1016/s1071-3581(99)90080-6.Peer-Reviewed Original Research